Abstract：
:Over the past 20 years, major progress has been made in our understanding of natural killer (NK) cells. It has become clear that NK cells are regulated by a number of receptors with opposite functions that finely tune potent effector functions such as cytolytic activity and release of cytokines that play a major role in inflammation and immunoregulation. This review traces the major advances in human NK cell biology from the original discovery of human leukocyte antigen class I-specific inhibitory receptors to recent groundbreaking clinical applications. These, in turn, led to major achievements and further expectations in the cure of high risk of otherwise fatal leukemias. It has become evident that there is a role of donor-derived 'alloreactive' NK cells in eradicating acute myeloid (and now also lymphoid) leukemias in the T-cell-depleted haploidentical hemopoietic stem cell transplantation setting. The key role played also in preventing graft rejection and graft versus host disease renders alloreactive NK cells an ideal tool for successful haploidentical hematopoietic stem cell transplantation.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Moretta A,Locatelli F,Moretta Ldoi
10.1111/j.1600-065X.2008.00651.xsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
58-69eissn
0105-2896issn
1600-065Xpii
IMR651journal_volume
224pub_type
杂志文章,评审abstract：:Experiments with transgenic mice illustrate clonal elimination of T cells specific for antigens expressed appropriately in the thymus, but presence of inducible T cells when the antigen presented on class I MHC antigens is expressed exclusively on non-lymphohemopoietic cells in the periphery (pancreatic beta islet cel...
journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1997-10-01 00:00:00
abstract：:X-linked lymphoproliferative disease (XLP) is an inherited immune defect caused by mutations in the Src homology 2 domain-containing gene 1A, which encodes the adapter protein, signaling lymphocytic activation molecule (SLAM)-associated protein (SAP). SAP is expressed in T cells, natural killer (NK) cells, and NKT cel...
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更新日期：2006-04-01 00:00:00
abstract：:Mycobacterium tuberculosis has evolved from a Mycobacterium canettii-like progenitor pool into one of the most successful and widespread human pathogens. The pathogenicity of M. tuberculosis is linked to its ability to secrete/export/release selected mycobacterial proteins, and it is also established that active relea...
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pub_type： 杂志文章,评审
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更新日期：2015-03-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2000-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-09-01 00:00:00
abstract：:A key unresolved challenge for developing an effective HIV-1 vaccine is the discovery of strategies to elicit immune responses that are able to cross-protect against a significant fraction of the diverse viruses that are circulating worldwide. Here, we summarize some of the immunological implications of HIV-1 diversit...
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更新日期：2017-01-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1991.tb00615.x
更新日期：1991-12-01 00:00:00
abstract：:A detailed analysis of the genes and proteins that participate in the murine immune response to PC has provided key insights at the structural level into the phenomenon of somatic mutation in B cells. Most anti-PC antibodies are encoded by 1 VH gene of the S107 subfamily, and 3 VK genes, VKT15 of the VK22 subfamily, V...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1987-04-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2004.00161.x
更新日期：2004-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
abstract：:The destiny of activated T cells is critical to the ultimate fate of immune response. After encountering antigen, naïve T cells receive signal 1 through the T-cell receptor (TCR)-major histocompatibility complex (MHC) plus antigenic peptide complex and signal 2 through "positive" costimulatory molecules leading to ful...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2003-12-01 00:00:00
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更新日期：2013-09-01 00:00:00
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更新日期：2009-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2015-11-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Immunological reviews
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doi：10.1111/j.1600-065x.1993.tb01509.x
更新日期：1993-06-01 00:00:00
abstract：:Inflammasome biology is one of the most exciting and rapidly growing areas in immunology. Over the past 10 years, inflammasomes have been recognized for their roles in the host defense against invading pathogens and in the development of cancer, auto-inflammatory, metabolic, and neurodegenerative diseases. Assembly of...
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更新日期：2015-05-01 00:00:00
abstract：:Rabbits have helped elucidate one of the major immunologic puzzles, namely the genetic control of antibody diversity. The primary IgH antibody repertoire in rabbits is dominated by B cells that use the same germline VH-gene segment in VDJ gene rearrangements. The VDJ genes of essentially all B lymphocytes undergo soma...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1998.tb01427.x
更新日期：1998-04-01 00:00:00
abstract：:The preceding paragraphs describe several uses of specific antibodies to IL-1. Standard radioimmunoassays and ELISA procedures were developed with demonstrated utility in studies attempting to quantitate the cytokine in cell culture fluids. In part, antibody-based assays circumvent the problems associated with bioassa...
journal_title：Immunological reviews
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更新日期：1991-02-01 00:00:00
abstract：:The lung constantly interacts with the environment through thousands of liters of air that are inhaled daily. This continually transports toxic chemicals and particles or pathogenic microorganisms deep into the respiratory system, posing a challenge to physicochemical barriers and the local immune system. Thus, comple...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
abstract：:Multiple myeloma (MM) is a tumor of long-lived bone marrow plasma cells (PCs). Nearly 40% of MM tumors have immunoglobulin H (IgH) translocations involving four recurrent chromosomal loci (oncogenes): 11q13 (cyclin D1), 6p21 (cyclin D3), 4p16 (MMSET and FGFR3), and 16q23 (c-maf). Other MM tumors have Ig translocations...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1034/j.1600-065x.2003.00052.x
更新日期：2003-08-01 00:00:00
