Abstract：
:More than 20 years ago, immunologists discovered that resistance and susceptibility to experimental infection with the intracellular protozoan Leishmania major was associated with the development of T-helper 1 (Th1)- and Th2-dominated immune responses, respectively. This infectious disease model was later used to identify and assess the role of key factors, such as interleukin-12 (IL-12) and IL-4, in Th1 and Th2 maturation. While infection by Leishmania remains a popular model for immunologists who wish to assess the role of their favorite molecule in T-cell differentiation, other investigators have tried to better understand how Leishmania interact with its insect and mammalian hosts. In this review, we discuss some of these new data with an emphasis on the early events that shape the immune response to Leishmania and on the immune evasion mechanisms that allow this parasite to avoid the development of sterilizing immunity and to secure its transmission to a new host.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Mougneau E,Bihl F,Glaichenhaus Ndoi
10.1111/j.1600-065X.2010.00983.xsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
286-96issue
1eissn
0105-2896issn
1600-065Xjournal_volume
240pub_type
杂志文章,评审abstract：:We review a novel strategy for tolerance induction developed in rhesus macaques and termed STEALTH. We summarize the evolution of the STEALTH model, the results of successful trials in inducing long-term, stable transplant tolerance in rhesus kidney and diabetic islet recipients and discuss information related to the ...
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journal_title：Immunological reviews
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更新日期：1991-02-01 00:00:00
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