Role of ITAM-containing adapter proteins and their receptors in the immune system and bone.


:The immunoreceptor tyrosine-based activation motif (ITAM) is a highly conserved region in the cytoplasmic domain of signaling chains and receptors and is a critical mediator of intracellular signals. ITAM-mediated signals depend on the Syk or zeta-associated protein of 70 kDa tyrosine kinases, and ITAM signaling is required for the differentiation and function of B and T cells in adaptive immunity. ITAM-dependent receptors also regulate the function of innate immune cells, including natural killer cells, and myeloid-derived cells such as macrophages, neutrophils, dendritic cells, and mast cells. Myeloid lineage cells also include osteoclasts (OCLs), the cells required for bone resorption, and recent studies show a critical role for the ITAM-containing adapter proteins DAP12 and the FcRgamma chain (Fcepsilon receptor I gamma chain) in OCL differentiation. Mice deficient in both the DAP12 and FcRgamma ITAM-bearing adapters are significantly osteopetrotic with a severe defect in OCL differentiation, demonstrating the requirement for ITAM signals in bone and further implicating this pathway in the development of highly specialized cell functions in hematopoietic cells. Regulation of osteoclastogenesis by ITAM-dependent receptors suggests that OCLs, similar to related myeloid cells, are tightly controlled by arrays of receptors that allow them to sense and respond to their local microenvironment like other innate immune cells.


Immunol Rev


Immunological reviews


Humphrey MB,Lanier LL,Nakamura MC





Has Abstract


2005-12-01 00:00:00












  • Transdifferentiation and nuclear reprogramming in hematopoietic development and neoplasia.

    abstract::Cell transplantation and tissue regeneration studies indicate a surprisingly broad developmental potential for lineage-committed hematopoietic stem cells (HSCs). Under these conditions HSCs transition into myocytes, neurons, hepatocytes or other types of nonhematopoietic effector cells. Equally impressive is the progr...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: French SW,Hoyer KK,Shen RR,Teitell MA

    更新日期:2002-09-01 00:00:00

  • The high-affinity receptor for IgG, FcγRI, of humans and non-human primates.

    abstract::Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characteri...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Chenoweth AM,Trist HM,Tan PS,Wines BD,Hogarth PM

    更新日期:2015-11-01 00:00:00

  • T cell and dendritic cell interactions in lymphoid organs: More than just being in the right place at the right time.

    abstract::The initiation of T lymphocyte responses within secondary lymphoid organs involves interactions with different subsets of dendritic cells (DCs). Recent studies have revealed the complexity of microanatomical organization within lymphoid organs. Exactly how T cells and DCs locate each other and the type of cellular int...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Ugur M,Mueller SN

    更新日期:2019-05-01 00:00:00

  • The functional network of ion channels in T lymphocytes.

    abstract::For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to trigger T-lymphocyte activation. Patch clamp analysis, molecular identification, and functional studies using blockers and genetic manipulation have shown that a unique contingent of ion channels orchestrates the initiation, intens...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Cahalan MD,Chandy KG

    更新日期:2009-09-01 00:00:00

  • Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation.

    abstract::Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T-cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we disc...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Das V,Nal B,Roumier A,Meas-Yedid V,Zimmer C,Olivo-Marin JC,Roux P,Ferrier P,Dautry-Varsat A,Alcover A

    更新日期:2002-11-01 00:00:00

  • S1PR2 links germinal center confinement and growth regulation.

    abstract::Germinal centers (GCs) are sites of rapid B-cell proliferation and somatic mutation. These ovoid structures develop within the center of follicles and grow to a stereotypic size. The cell migration and interaction dynamics underlying GC B-cell selection events are currently under intense scrutiny. In recent study, we ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Green JA,Cyster JG

    更新日期:2012-05-01 00:00:00

  • Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection.

    abstract::Because of its intrinsic virulence, Toxoplasma gondii induces a potent interleukin-12 (IL-12)-dependent cell-mediated immune response that shuts down the growth of the replicative tachyzoite stage, thus promoting host survival and successful transmission through predation. At the same time, this response must be tight...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Aliberti J,Jankovic D,Sher A

    更新日期:2004-10-01 00:00:00

  • Critical roles for immunoglobulin translocations and cyclin D dysregulation in multiple myeloma.

    abstract::Multiple myeloma (MM) is a tumor of long-lived bone marrow plasma cells (PCs). Nearly 40% of MM tumors have immunoglobulin H (IgH) translocations involving four recurrent chromosomal loci (oncogenes): 11q13 (cyclin D1), 6p21 (cyclin D3), 4p16 (MMSET and FGFR3), and 16q23 (c-maf). Other MM tumors have Ig translocations...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Bergsagel PL,Kuehl WM

    更新日期:2003-08-01 00:00:00

  • Establishment and functional implications of B-cell connectivity.

    abstract::We have discussed some aspects of the structure of the normal immune system, particularly the B-cell compartment. We have argued: that a basic property of the natural antibody repertoire is constituted by high degrees of connectivity within the immune system as well as between the system and other components of the or...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Holmberg D,Andersson A,Carlsson L,Forsgren S

    更新日期:1989-08-01 00:00:00

  • The roles for cytokines in the generation and maintenance of regulatory T cells.

    abstract::As an essential mechanism for self-tolerance, immune suppression has attracted much attention since the discovery of suppressor T cells, now called regulatory T cells (Tregs), in the 1990s. Different types of Tregs have been described based on distinct expression patterns of surface markers and cytokines. Cytokines ar...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Wan YY,Flavell RA

    更新日期:2006-08-01 00:00:00

  • Persisting viruses and chronic inflammation: understanding their relation to autoimmunity.

    abstract::Viral infections may induce and sustain autoimmune processes via several and overlapping mechanisms. We outline how chronic inflammation, sustained by persisting viruses, may be "the prerequisite" for initiation and maintenance of the multistep process leading to autoimmunity. Chronic inflammation may favour priming o...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Di Rosa F,Barnaba V

    更新日期:1998-08-01 00:00:00

  • Fast-acting γδ T-cell subpopulation and protective immunity against infections.

    abstract::Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non-human primates, account for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T-cell subpopulation capable of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathoge...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Shen L,Huang D,Qaqish A,Frencher J,Yang R,Shen H,Chen ZW

    更新日期:2020-11-01 00:00:00

  • Integrin-associated proteins as potential therapeutic targets.

    abstract:SUMMARY:Integrins are adhesion receptors important for hematopoiesis, leukocyte trafficking, and formation of immunological synapses; hence, they may provide targets for therapeutic intervention in leukocyte-driven pathologies. Blocking integrin-ligand binding is one strategy for inhibiting integrins; however, a comple...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Cantor JM,Ginsberg MH,Rose DM

    更新日期:2008-06-01 00:00:00

  • Cell biology and immunology of Leishmania.

    abstract::More than 20 years ago, immunologists discovered that resistance and susceptibility to experimental infection with the intracellular protozoan Leishmania major was associated with the development of T-helper 1 (Th1)- and Th2-dominated immune responses, respectively. This infectious disease model was later used to iden...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Mougneau E,Bihl F,Glaichenhaus N

    更新日期:2011-03-01 00:00:00

  • Autophagy limits activation of the inflammasomes.

    abstract::Inflammasomes are multiprotein complexes that control the maturation and production of interleukin-1 family members and play crucial roles in host defense against pathogens. However, dysregulated activation of inflammasomes is associated with intense inflammation, leading to the development of inflammatory diseases. T...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Takahama M,Akira S,Saitoh T

    更新日期:2018-01-01 00:00:00

  • T and B cell tolerance and responses to viral antigens in transgenic mice: implications for the pathogenesis of autoimmune versus immunopathological disease.

    abstract::Experiments with transgenic mice illustrate clonal elimination of T cells specific for antigens expressed appropriately in the thymus, but presence of inducible T cells when the antigen presented on class I MHC antigens is expressed exclusively on non-lymphohemopoietic cells in the periphery (pancreatic beta islet cel...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Zinkernagel RM,Pircher HP,Ohashi P,Oehen S,Odermatt B,Mak T,Arnheiter H,Bürki K,Hengartner H

    更新日期:1991-08-01 00:00:00

  • Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.

    abstract::Human immunodeficiency virus-1 (HIV-1) envelope protein (Env) and influenza hemagglutinin (HA) are the surface glycoproteins responsible for viral entry into host cells, the first step in the virus life cycle necessary to initiate infection. These glycoproteins exhibit a high degree of sequence variability and glycosy...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Julien JP,Lee PS,Wilson IA

    更新日期:2012-11-01 00:00:00

  • Spatial and temporal coordination of antiviral responses by group 1 ILCs.

    abstract::Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context-dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic pert...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Adams NM,Sun JC

    更新日期:2018-11-01 00:00:00

  • Therapy with cultured T cells: principles revisited.

    abstract::In animals and in humans, T-cell therapy can cure advanced disseminated leukemia that would otherwise be fatal. The therapeutic effect of immune T cells is quantitative. As the dose of effector T cells is increased, survival is proportionately increased. Therefore, effective T-cell therapy is predicated on the ability...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Cheever MA,Chen W

    更新日期:1997-06-01 00:00:00

  • Analysis of the B-cell repertoire against antigens expressed by human neoplasms.

    abstract::The screening of tumor-derived expression libraries for antigens detected by high-titer immunoglobulin G antibodies from the sera of patients with cancer by SEREX (serological identification of antigens by recombinant expression cloning) allows a systematic search for antigens of human cancers. SEREX has led to the id...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Preuss KD,Zwick C,Bormann C,Neumann F,Pfreundschuh M

    更新日期:2002-10-01 00:00:00

  • Two-photon imaging of effector T-cell behavior: lessons from a tumor model.

    abstract::Recent advances in two-photon microscopy have provided a new way of visualizing the behavior of fluorescently tagged cells within their natural microenvironment. This technology has allowed for generating a detailed picture of the cellular interaction dynamics operant in the activation of T cells and B cells during pr...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Ng LG,Mrass P,Kinjyo I,Reiner SL,Weninger W

    更新日期:2008-02-01 00:00:00

  • STEALTH matters: a novel paradigm of durable primate allograft tolerance.

    abstract::We review a novel strategy for tolerance induction developed in rhesus macaques and termed STEALTH. We summarize the evolution of the STEALTH model, the results of successful trials in inducing long-term, stable transplant tolerance in rhesus kidney and diabetic islet recipients and discuss information related to the ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,收录出版,评审


    authors: Thomas JM,Hubbard WJ,Sooudi SK,Thomas FT

    更新日期:2001-10-01 00:00:00

  • The role of the non-homologous end-joining pathway in lymphocyte development.

    abstract::One of the most toxic insults a cell can incur is a disruption of its linear DNA in the form of a double-strand break (DSB). Left unrepaired, or repaired improperly, these lesions can result in cell death or neoplastic transformation. Despite these dangers, lymphoid cells purposely introduce DSBs into their genome to ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Rooney S,Chaudhuri J,Alt FW

    更新日期:2004-08-01 00:00:00

  • Regulatory T-cell, endogenous antigen and neonatal environment in the prevention and induction of autoimmune disease.

    abstract::Recent studies on autoimmune ovarian disease (AOD) induced by thymectomy on d3 (d3tx), and AOD induced by immunization with the ovary-specific zona pellucida 3 peptide (pZP3), have yielded the following results. First, female tolerance to pZP3 depends on the persistence of endogenous antigen (Ag). Second, following re...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Tung KS,Agersborg SS,Alard P,Garza KM,Lou YH

    更新日期:2001-08-01 00:00:00

  • Fate of T-lymphocyte injected into immunodeficient allogeneic nude or semi-allogeneic F1 mice: correlation with manifestations of graft-versus-host reaction.

    abstract::This review emphasizes some of the differences between the fate of allogeneic H2-incompatible T-cells, when injected into immunodeficient, T-depleted mice, or as parental cells injected into F1 hybrids. In both conditions, allogeneic cells are eliminated, a rejection which cannot be predicted from the fate of a skin g...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Piguet PF,Vassalli P

    更新日期:1983-01-01 00:00:00

  • Regulation of the immune response by stress-activated protein kinases.

    abstract::Activation of immune cells to mediate an immune response is often triggered by potential 'danger' or 'stress' stimuli that the organism receives. Within the mitogen-activated protein kinases (MAPKs) family, the stress-activated protein kinase (SAPK) group was defined as group of kinases that activated by stimuli that ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Rincón M,Davis RJ

    更新日期:2009-03-01 00:00:00

  • T cells and follicular dendritic cells in germinal center B-cell formation and selection.

    abstract::Germinal centers (GCs) are specialized microenvironments formed after infection where activated B cells can mutate their B-cell receptors to undergo affinity maturation. A stringent process of selection allows high affinity, non-self-reactive B cells to become long-lived memory B cells and plasma cells. While the prec...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Vinuesa CG,Linterman MA,Goodnow CC,Randall KL

    更新日期:2010-09-01 00:00:00

  • Positive and negative regulation of antigen receptor signaling by the Shc family of protein adapters.

    abstract::The Shc adapter family includes four members that are expressed as multiple isoforms and participate in signaling by a variety of cell-surface receptors. The biological relevance of Shc proteins as well as their variegated function, which relies on their highly conserved modular structure, is underscored by the distin...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Finetti F,Savino MT,Baldari CT

    更新日期:2009-11-01 00:00:00

  • Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers.

    abstract::The characterization of the microenvironment of human tumors led to the description of tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T-cell zone adjacent to B-cell follicle including a germinal center. TLS represent sites of lymphoid neogenesis that develop in most solid cancers. Anal...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Dieu-Nosjean MC,Giraldo NA,Kaplon H,Germain C,Fridman WH,Sautès-Fridman C

    更新日期:2016-05-01 00:00:00

  • Wiskott-Aldrich syndrome protein--dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes.

    abstract::The actin cytoskeleton network forms a key link between T-cell antigen receptor (TCR) stimulation and T-cell effector functions, providing a structural basis for T-cell morphological changes and signal transduction. Accumulating evidence positions the Wiskott-Aldrich syndrome protein (WASp), a scaffolding protein that...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Matalon O,Reicher B,Barda-Saad M

    更新日期:2013-11-01 00:00:00