Abstract：
:The expression of L3T4 and Lyt-2 cell surface molecules separates T cells into two broad, non-overlapping subsets: typical T helper cells are L3T4+ Lyt-2- whereas most T killer cells and their precursors are L3T4- Lyt-2+. This review compares highly purified populations of unprimed L3T4+ and Lyt-2+ cells for their capacity to respond to class I vs. class II H-2 alloantigens. Various parameters are considered, including generation of mixed lymphocyte reactions (MLR) and cell mediated lympholysis (CML) in vitro, proliferative responses in irradiated mice, graft-versus-host reactions and skin allograft rejection. In all of these assays the two T cell subsets exhibit marked specificity in their response to H-2 alloantigens, L3T4+ cells responding only to class II and not class I differences and Lyt-2+ cells showing reciprocal specificity. Contrary to current dogma, the bulk of the evidence suggests that primary responses of Lyt-2+ cells do not depend on exogenous help provided by other T cells.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Sprent J,Schaefer M,Lo D,Korngold Rdoi
10.1111/j.1600-065x.1986.tb01489.xsubject
Has Abstractpub_date
1986-06-01 00:00:00pages
195-218eissn
0105-2896issn
1600-065Xjournal_volume
91pub_type
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journal_title：Immunological reviews
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更新日期：1990-08-01 00:00:00
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更新日期：1997-06-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1998-02-01 00:00:00
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