Abstract：
:Directed cellular migrations underlie immune system organization. Chemokines and their receptors (along with surface-adhesion molecules) are central to these migrations, targeting developing and mature leukocytes to tissues and microenvironments suitable for their differentiation and function. The chemokine CXCL12 and its receptor CXCR4 play a central role in the migration of hematopoietic stem cells, and several chemokine receptors are transiently expressed during distinct stages of B- and T-cell development. In the periphery, mature naïve B and T cells utilize the receptors CCR7, CXCR4, and CXCR5 to recirculate through specialized microenvironments within the secondary lymphoid tissues, while effector and memory lymphocytes express bewildering patterns of adhesion molecules and chemokine receptors that allow them to function within microenvironments and non-lymphoid tissues inaccessible to naïve cells. Here, we summarize the role of chemokines and their receptors in the spatial organization of the immune system and consider the implications for immune function.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Campbell DJ,Kim CH,Butcher ECdoi
10.1034/j.1600-065x.2003.00067.xkeywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
58-71eissn
0105-2896issn
1600-065Xpii
067journal_volume
195pub_type
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更新日期：2007-08-01 00:00:00
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更新日期：2007-12-01 00:00:00
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更新日期：1998-08-01 00:00:00
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更新日期：1997-06-01 00:00:00
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更新日期：2013-03-01 00:00:00
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更新日期：1999-08-01 00:00:00
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更新日期：2000-10-01 00:00:00
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更新日期：2013-05-01 00:00:00
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更新日期：2005-10-01 00:00:00
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更新日期：2020-12-17 00:00:00
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更新日期：2005-08-01 00:00:00
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更新日期：2009-03-01 00:00:00
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更新日期：2018-11-01 00:00:00
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更新日期：2000-02-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2004-10-01 00:00:00
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更新日期：2005-08-01 00:00:00
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更新日期：2017-01-01 00:00:00
