S1PR2 links germinal center confinement and growth regulation.

Abstract:

:Germinal centers (GCs) are sites of rapid B-cell proliferation and somatic mutation. These ovoid structures develop within the center of follicles and grow to a stereotypic size. The cell migration and interaction dynamics underlying GC B-cell selection events are currently under intense scrutiny. In recent study, we identified a role for a migration inhibitory receptor, S1PR2, in promoting GC B-cell confinement to GCs. S1PR2 also dampens Akt activation and deficiency in S1PR2 or components of its signaling pathway result in a loss of growth control in chronically stimulated mucosal GCs. Herein, we detail present understanding of S1PR2 and S1P biology as it pertains to GC B cells and place this information in the context of a current model of GC function.

journal_name

Immunol Rev

journal_title

Immunological reviews

authors

Green JA,Cyster JG

doi

10.1111/j.1600-065X.2012.01114.x

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

36-51

issue

1

eissn

0105-2896

issn

1600-065X

journal_volume

247

pub_type

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