T cell and dendritic cell interactions in lymphoid organs: More than just being in the right place at the right time.

Abstract:

:The initiation of T lymphocyte responses within secondary lymphoid organs involves interactions with different subsets of dendritic cells (DCs). Recent studies have revealed the complexity of microanatomical organization within lymphoid organs. Exactly how T cells and DCs locate each other and the type of cellular interactions required for optimal priming of effector and memory T cell responses are beginning to be unraveled. Here we review advances in our understanding of how T cell priming is choreographed during infections, highlight the importance of cell positioning in this process and discuss how a spectrum of cellular interactions shapes T cell activation and differentiation.

journal_name

Immunol Rev

journal_title

Immunological reviews

authors

Ugur M,Mueller SN

doi

10.1111/imr.12753

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

115-128

issue

1

eissn

0105-2896

issn

1600-065X

journal_volume

289

pub_type

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