gammadelta T-cell receptors: functional correlations.

Abstract:

:The gammadelta T-cell receptors (TCRs) are limited in their diversity, suggesting that their natural ligands may be few in number. Ligands for gammadeltaTCRs that have thus far been determined are predominantly of host rather than foreign origin. Correlations have been noted between the Vgamma and/or Vdelta genes a gammadelta T cell expresses and its functional role. The reason for these correlations is not yet known, but several different mechanisms are conceivable. One possibility is that interactions between particular TCR-V domains and ligands determine function or functional development. However, a recent study showed that at least for one ligand, receptor specificity is determined by the complementarity-determining region 3 (CDR3) component of the TCR-delta chain, regardless of the Vgamma and/or Vdelta. To determine what is required in the TCR for other specificities and to test whether recognition of certain ligands is connected to cell function, more gammadeltaTCR ligands must be defined. The use of recombinant soluble versions of gammadeltaTCRs appears to be a promising approach to finding new ligands, and recent results using this method are reviewed.

journal_name

Immunol Rev

journal_title

Immunological reviews

authors

O'Brien RL,Roark CL,Jin N,Aydintug MK,French JD,Chain JL,Wands JM,Johnston M,Born WK

doi

10.1111/j.1600-065X.2006.00477.x

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

77-88

eissn

0105-2896

issn

1600-065X

pii

IMR477

journal_volume

215

pub_type

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