Metabolic regulation of macrophage phenotype and function.

Abstract:

:Studies in the last 20 years have given us a remarkable insight into the functional and phenotypic diversity of macrophages which reflects their integral role in host defence, homeostasis and pathogenesis. Mouse genetics, transcriptomic and epigenetic studies have provided an ontogenic and molecular perspective to the phenotypic diversity of these cells. Recently, metabolic studies have revealed the crucial role of metabolism and metabolites in shaping the phenotype and function of macrophages. Evidence pertaining to this aspect will be reviewed here.

journal_name

Immunol Rev

journal_title

Immunological reviews

authors

Saha S,Shalova IN,Biswas SK

doi

10.1111/imr.12603

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

102-111

issue

1

eissn

0105-2896

issn

1600-065X

journal_volume

280

pub_type

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