Abstract:
:Considerable progress has been made in defining intermediate stages in the process leading from stem cells to mature B cells. Cell-bound and secreted molecules direct the progression through these stages and regulate the selection of clones from which the immune repertoire emerges. In fact, a myriad of signals derived from B-cell progenitors themselves and the microenvironment in which they develop direct the differentiation process. These signals are provided by B-cell antigen receptors (BCR) and their surrogates, and by adhesion and cytokine receptors. The co-operation of these receptors to control survival, expansion, and differentiation of early B-cell progenitors is the topic of this review. Specifically, we will summarize recent findings from our laboratory demonstrating that preBCR expression lowers the threshold for interleukin (IL)-7 responsiveness. How signals initiated by these receptors may intersect at this critical point of B-cell selection will be discussed. At the stage following IL-7 responsiveness we have shown that interactions between B-cell progenitors themselves promote their differentiation to immunoglobulin-secreting B cells. We propose that one function of stromal cells, known to be central to B lymphopoiesis, is to promote critical preB-preB homotypic interactions and ensuing signals.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Stoddart A,Fleming HE,Paige CJkeywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
47-58eissn
0105-2896issn
1600-065Xjournal_volume
175pub_type
杂志文章,评审abstract::Interleukin-18 (IL-18) has been regarded as a proinflammatory cytokine because of its potent interferon-gamma-inducing activity. However, mutant mice that release excess amounts of IL-18 spontaneously develop pruritic chronic dermatitis-like atopic dermatitis (AD), suggesting the importance of IL-18 for the developmen...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2004.00205.x
更新日期:2004-12-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2002.18805.x
更新日期:2002-10-01 00:00:00
abstract::Shc is a prototype adapter protein that is expressed from the earliest stages of T-cell development. Shc becomes rapidly tyrosine phosphorylated after T-cell receptor (TCR) engagement. Expression of dominant negative forms of Shc in T-cell lines had also suggested a role for this adapter downstream of the TCR. However...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2003.00025.x
更新日期:2003-02-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2003.00028.x
更新日期:2003-04-01 00:00:00
abstract::The initiation of T lymphocyte responses within secondary lymphoid organs involves interactions with different subsets of dendritic cells (DCs). Recent studies have revealed the complexity of microanatomical organization within lymphoid organs. Exactly how T cells and DCs locate each other and the type of cellular int...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12753
更新日期:2019-05-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
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更新日期:1989-12-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2010.00923.x
更新日期:2010-07-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12707
更新日期:2018-11-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2008.00753.x
更新日期:2009-03-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1999.tb01298.x
更新日期:1999-04-01 00:00:00
abstract::Hematopoietic stem cells (HSC) have the capacity to reconstitute all the blood cells in the body. HSC are rare, representing on average 0.05% of the mononuclear cells present in healthy human bone marrow. Due to their capacity for self-renewal and their pluripotent, long-term reconstituting potential, HSC are consider...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1997.tb00972.x
更新日期:1997-06-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2003.00050.x
更新日期:2003-06-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12714
更新日期:2019-01-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1999.tb01381.x
更新日期:1999-02-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2000.17720.x
更新日期:2000-10-01 00:00:00
abstract::Hookworm infection is a major parasitic cause of morbidity in the developing nations of the tropics. Development of a genetically engineered vaccine would be a useful tool in the control of this infection in highly endemic areas. Recombinant polypeptides belonging to the Ancylostoma secreted protein (ASP)-1 family hav...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1999.tb01347.x
更新日期:1999-10-01 00:00:00
abstract::On the basis of cell surface markers, mature T cells are considered to have either a naïve or a memory phenotype. These cells exhibit distinct types of kinetic behaviour in vivo. While naïve-phenotype cells persist long term in a non-dividing state, memory-phenotype T cells include cycling cells and exhibit a more rap...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1999.tb01327.x
更新日期:1999-08-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2007.00554.x
更新日期:2007-10-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1995.tb00063.x
更新日期:1995-04-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2001.1820111.x
更新日期:2001-08-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2009.00826.x
更新日期:2009-11-01 00:00:00
abstract::Hepatitis B virus (HBV) is a major human pathogen that causes chronic infection and life-threatening liver diseases in millions of individuals. While pathological and epidemiological consequences of clinically evident HBV infections are well recognized, there is no similar knowledge on an asymptomatic, silently progre...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0528.2002.017406.x
更新日期:2000-04-01 00:00:00
abstract::Because of its intrinsic virulence, Toxoplasma gondii induces a potent interleukin-12 (IL-12)-dependent cell-mediated immune response that shuts down the growth of the replicative tachyzoite stage, thus promoting host survival and successful transmission through predation. At the same time, this response must be tight...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2004.00179.x
更新日期:2004-10-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is an important cause of respiratory disease causing high rates of hospitalizations in infants, significant morbidity in children and adults, and excess mortality in the elderly. Major barriers to vaccine development include early age of RSV infection, capacity of RSV to evade innate ...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2010.00972.x
更新日期:2011-01-01 00:00:00
abstract::Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T-cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we disc...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2002.18911.x
更新日期:2002-11-01 00:00:00
abstract::Expressed predominantly on myeloid and natural killer (NK) cells, DAP12 is an adapter protein that can associate with a variety of receptors. To date, DAP12 has predominantly been characterized as an adapter protein that activates various myeloid and NK cell effector functions; however, recent findings have demonstrat...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2006.00466.x
更新日期:2006-12-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12528
更新日期:2017-03-01 00:00:00
abstract::There is now convincing evidence that autoreactive CD8+ T cells can contribute to the pathogenesis of organ-specific autoimmune diseases. In the non-obese diabetic mouse, there is direct evidence that beta-islet cell-specific CD8+ cytotoxic T cells have a pathogenic effect. In human diseases such as autoimmune diabete...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1999.tb01308.x
更新日期:1999-06-01 00:00:00
abstract::Recent advances in two-photon microscopy have provided a new way of visualizing the behavior of fluorescently tagged cells within their natural microenvironment. This technology has allowed for generating a detailed picture of the cellular interaction dynamics operant in the activation of T cells and B cells during pr...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2008.00596.x
更新日期:2008-02-01 00:00:00