The linkage between T-cell and dendritic cell development in the mouse thymus.

Abstract:

:Thymic dendritic cells (DC) mediate negative selection at a relatively late stage of the T-cell developmental pathway. We present evidence that the development of thymic DC and of T-lineage cells is linked via a common precursor at an early stage of thymocyte development. T-lineage precursor populations from the adult mouse thymus, prior to T-cell receptor gene rearrangement, display a capacity to produce DC as well as T cells in the thymus, and are very efficient precursors of DC in culture. These lymphoid/DC precursors have little capacity to form myeloid cells, indicating that thymic DC are a lymphoid-related rather than myeloid-related lineage. In contrast to myeloid-related DC, granulocyte-macrophage colony-stimulating factor is not required for the development of these lymphoid-related DC in vivo or in vitro. DC can develop in mutant mice lacking mature T cells, provided the common precursors are present. However, in mutant mice lacking functional Ikaros transcription factors, there are deficiencies in lymphoid precursor cells, in mature lymphoid cells and in DC.

journal_name

Immunol Rev

journal_title

Immunological reviews

authors

Shortman K,Vremec D,Corcoran LM,Georgopoulos K,Lucas K,Wu L

doi

10.1111/j.1600-065x.1998.tb01228.x

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

39-46

eissn

0105-2896

issn

1600-065X

journal_volume

165

pub_type

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