Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling.

abstract：:Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative ...

journal_title：Theranostics

authors： Bai J,Wang JT,Rubio N,Protti A,Heidari H,Elgogary R,Southern P,Al-Jamal WT,Sosabowski J,Shah AM,Bals S,Pankhurst QA,Al-Jamal KT

更新日期：2016-01-01 00:00:00

abstract：:This work reports that when PEG-lipid-shelled microbubbles with fluorocarbon interior (C4F10, C5F12, or C6F14) are subjected to ultrasound pulses, they produce metastable, fluid-filled nanoparticles that can be re-imaged upon administration of HIFU. The nanoparticles produced by destruction of the microbubbles (MBNPs)...

journal_title：Theranostics

authors： Blum NT,Yildirim A,Chattaraj R,Goodwin AP

更新日期：2017-01-15 00:00:00

abstract：:Müller glia are specialized retinal cells with stem cell properties in fish and frogs but not in mammals. Current efforts to develop gene therapies to activate mammalian Müller glia for retinal repair will require safe and effective delivery strategies for recombinant adeno-associated viruses (AAVs), vectors of choice...

journal_title：Theranostics

authors： Touahri Y,Dixit R,Kofoed RH,Miloska K,Park E,Raeisossadati R,Markham-Coultes K,David LA,Rijal H,Zhao J,Lynch M,Hynynen K,Aubert I,Schuurmans C

更新日期：2020-02-10 00:00:00

abstract：:Cancer stem cells (CSCs) are believed to be a principal cellular source for tumour progression and therapeutic drug resistance as they are capable of self-renewal and can differentiate into cancer cells. Importantly, CSCs acquire the ability to evade the killing effects of cytotoxic agents through changes at the genet...

journal_title：Theranostics

authors： Zhou G,Latchoumanin O,Bagdesar M,Hebbard L,Duan W,Liddle C,George J,Qiao L

更新日期：2017-09-13 00:00:00

abstract：:With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO2 core-shell nanoparticles, which showed that they could selectivel...

journal_title：Theranostics

authors： Zheng T,Wang W,Wu F,Zhang M,Shen J,Sun Y

更新日期：2019-07-09 00:00:00

abstract：:Cancer vaccines have encountered their ideal personalized partner along with evidence for great breakthroughs in the identification and synthesis of neoantigens. Individual cancer neoantigen vaccines are capable of eliciting robust T-cell responses and have been demonstrated to achieve striking clinical efficacy due t...

journal_title：Theranostics

authors： Chu Y,Liu Q,Wei J,Liu B

更新日期：2018-07-30 00:00:00

abstract：:Zinc-finger proteins (ZFPs) are the largest transcription factor family in mammals, involved in the regulation of multiple physiologic processes including cell differentiation, proliferation, apoptosis and neoplastic transformation. Approximately one-third of ZFPs are Krüppel-associated box domain (KRAB)-ZFPs. Methods...

journal_title：Theranostics

authors： Sun R,Xiang T,Tang J,Peng W,Luo J,Li L,Qiu Z,Tan Y,Ye L,Zhang M,Ren G,Tao Q

更新日期：2020-01-12 00:00:00

abstract：:Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the im...

journal_title：Theranostics

authors： Chen Y,Zhang M,Jin H,Li D,Xu F,Wu A,Wang J,Huang Y

更新日期：2017-08-15 00:00:00

abstract：:Rationale: The evaluation of early treatment response is critical for patient prognosis and treatment planning. When the current methods rely on invasive protocols that evaluate the expression of DNA damage markers on patient biopsy samples, we aim to evaluate a non-invasive PET imaging approach to monitor the early e...

journal_title：Theranostics

authors： Poty S,Mandleywala K,O'Neill E,Knight JC,Cornelissen B,Lewis JS

更新日期：2020-04-27 00:00:00

abstract：:Successful anticancer chemotherapy requires targeting tumors efficiently and further potential to eliminate cancer stem cell (CSC) subpopulations. Since CD44 is present on many types of CSCs, and it binds specially to hyaluronic acid (HA), we tested whether coating solid lipid nanoparticles with hyaluronan (HA-SLNs)wo...

journal_title：Theranostics

authors： Shen H,Shi S,Zhang Z,Gong T,Sun X

更新日期：2015-04-05 00:00:00

abstract：:Reactive oxygen species (ROS) play a crucial role in cancer formation and development, especially cancer metastasis. However, lack of a precise tool, which could accurately distinguish specific types of ROS, restricts an in-depth study of ROS in cancer development and progression. Herein, we designed smart and versati...

journal_title：Theranostics

authors： Chen X,Wang T,Le W,Huang X,Gao M,Chen Q,Xu S,Yin D,Fu Q,Shao C,Chen B,Shi D

更新日期：2020-02-10 00:00:00

abstract：:Norepinephrine modulates cognitive processes such as working and episodic memory. Pathological changes in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the whole norepinephrine system, disrupting cognitive processes. Monitor...

journal_title：Theranostics

authors： López-Picón FR,Kirjavainen AK,Forsback S,Takkinen JS,Peters D,Haaparanta-Solin M,Solin O

更新日期：2019-01-01 00:00:00

abstract：:Mitochondria in cancer cells maintain a more negative membrane potential than normal cells. Mitochondria are the primary source of cellular reactive oxygen species (ROS), which are necessary for photodynamic therapy. Thus, the strategy of targeting mitochondria can maximize the photodynamic therapeutic efficiency for ...

journal_title：Theranostics

authors： Yue C,Yang Y,Zhang C,Alfranca G,Cheng S,Ma L,Liu Y,Zhi X,Ni J,Jiang W,Song J,de la Fuente JM,Cui D

更新日期：2016-10-01 00:00:00

abstract：:Peripheral arterial disease affects nearly 202 million individuals worldwide, sometimes leading to non-healing ulcers or limb amputations in severe cases. Genetically modified stem cells offer potential advantages for therapeutically inducing angiogenesis via augmented paracrine release mechanisms and tuned dynamic re...

journal_title：Theranostics

authors： Deveza L,Choi J,Lee J,Huang N,Cooke J,Yang F

更新日期：2016-05-23 00:00:00

abstract：:Long term pulmonary exposure to crystalline silica leads to silicosis that manifests progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite efforts to eliminate silicosis, clinical cases continue to occur in both developing and developed countries. The exact mechanisms of cryst...

journal_title：Theranostics

authors： Li C,Du S,Lu Y,Lu X,Liu F,Chen Y,Weng D,Chen J

更新日期：2016-09-09 00:00:00

abstract：:Background: Accumulating evidences indicate that nanomedicines greatly decrease the side effects and enhance the efficacy of colorectal cancer (CRC) treatment. In particular, the use of rectal delivery of nanomedicines, with advantages such as fast therapeutic effects and a diminishing hepatic first-pass effect, is cu...

journal_title：Theranostics

authors： Zhao R,Du S,Liu Y,Lv C,Song Y,Chen X,Zhang B,Li D,Gao S,Cui W,Plikus MV,Hou X,Wu K,Liu Z,Liu Z,Cong Y,Li Y,Yu Z

更新日期：2020-02-18 00:00:00

abstract：:Chronic kidney disease (CKD) is a serious healthcare dilemma, associated with specific changes in gut microbiota and circulating metabolome. Yet, the functional capacity of CKD microbiome and its intricate relationship with the host metabolism at different stages of disease are less understood. METHODS:Here, shotgun ...

journal_title：Theranostics

authors： Wu IW,Gao SS,Chou HC,Yang HY,Chang LC,Kuo YL,Dinh MCV,Chung WH,Yang CW,Lai HC,Hsieh WP,Su SC

更新日期：2020-04-06 00:00:00

abstract：:In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic app...

journal_title：Theranostics

authors： Xie W,Guo Z,Gao F,Gao Q,Wang D,Liaw BS,Cai Q,Sun X,Wang X,Zhao L

更新日期：2018-05-11 00:00:00

abstract：:This paper reports a sensitive method with electrochemical technique to detect various proteases, which can be used for the diagnosis of prostate cancer. For the proposed assay method, the working electrode is modified with the peptide probes for the target proteases. These probes contain the substrate sequence of tar...

journal_title：Theranostics

authors： Li H,Huang Y,Zhang B,Yang D,Zhu X,Li G

更新日期：2014-04-25 00:00:00

abstract：:Extracellular vesicles (EVs), including exosomes and microvesicles, derived from bone marrow stromal cells (BMSCs) have been demonstrated as key factors in the progression and drug resistance of multiple myeloma (MM). EV uptake involves a variety of mechanisms which largely depend on the vesicle origin and recipient c...

journal_title：Theranostics

authors： Tu C,Du Z,Zhang H,Feng Y,Qi Y,Zheng Y,Liu J,Wang J

更新日期：2021-01-01 00:00:00

abstract：:Small interfering RNA (siRNA) has proved to be a powerful tool for target-specific gene silencing via RNA interference (RNAi). Its ability to control targeted gene expression gives new hope to gene therapy as a treatment for cancers and genetic diseases. However, siRNA shows poor pharmacological properties, such as lo...

journal_title：Theranostics

authors： Hong CA,Nam YS

更新日期：2014-09-19 00:00:00

abstract：:Osteoarthritis (OA) is a rheumatic disease leading to chronic pain and disability with no effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells (MSC) entered clinical trials as a novel therapy for OA. Increasing evidence suggests that therapeutic efficacy of MSC depends on paracrine ...

journal_title：Theranostics

authors： Vonk LA,van Dooremalen SFJ,Liv N,Klumperman J,Coffer PJ,Saris DBF,Lorenowicz MJ

更新日期：2018-01-01 00:00:00

abstract：:Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread pathogen- and host-derived molecules duri...

journal_title：Theranostics

authors： Rodrigues M,Fan J,Lyon C,Wan M,Hu Y

更新日期：2018-04-09 00:00:00

abstract：:In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel netrin-1 interference therapy requires the assessment of netrin-1 expression prior to ...

journal_title：Theranostics

authors： Wischhusen J,Wilson KE,Delcros JG,Molina-Peña R,Gibert B,Jiang S,Ngo J,Goldschneider D,Mehlen P,Willmann JK,Padilla F

更新日期：2018-10-06 00:00:00

abstract：:Generating oxidative stress is a critical mechanism by which host cells defend against infection by pathogenic microorganisms. Radiation resistance is a critical problem in radiotherapy against cancer. Epstein-Barr virus (EBV) is a cancer-causing virus and its reactivation plays an important role in the development of...

journal_title：Theranostics

authors： Hu J,Li Y,Li H,Shi F,Xie L,Zhao L,Tang M,Luo X,Jia W,Fan J,Zhou J,Gao Q,Qiu S,Wu W,Zhang X,Liao W,Bode AM,Cao Y

更新日期：2020-10-25 00:00:00

abstract：:Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for d...

journal_title：Theranostics

authors： Son DJ,Zheng J,Jung YY,Hwang CJ,Lee HP,Woo JR,Baek SY,Ham YW,Kang MW,Shong M,Kweon GR,Song MJ,Jung JK,Han SB,Kim BY,Yoon DY,Choi BY,Hong JT

更新日期：2017-10-16 00:00:00

abstract：:Elastin-like polypeptide (ELP)-based drug delivery has been utilized for various applications including cancer therapies for many years. Genetic incorporation of internalization ligands and cell-targeting peptides along with ELP polymer enhanced tumor accumulation and retention time as well as stability and activities...

journal_title：Theranostics

authors： Sarangthem V,Kim Y,Singh TD,Seo BY,Cheon SH,Lee YJ,Lee BH,Park RW

更新日期：2016-09-25 00:00:00

abstract：:In this study, we investigated the induction of apoptosis by ultrasound in the presence of the novel porphyrin derivative DCPH-P-Na(I). HL-60 cells were exposed to ultrasound for up to 3 min in the presence and absence of DCPH-P-Na(I), and the induction of apoptosis was examined by analyzing cell morphology, DNA fragm...

journal_title：Theranostics

authors： Yumita N,Iwase Y,Nishi K,Komatsu H,Takeda K,Onodera K,Fukai T,Ikeda T,Umemura S,Okudaira K,Momose Y

更新日期：2012-01-01 00:00:00

abstract：:In a report from 2008, The International Agency for Research on Cancer predicted a tripled cancer incidence from 1975, projecting a possible 13-17 million cancer deaths worldwide by 2030. While new treatments are evolving and reaching approval for different cancer types, the main prevention of cancer mortality is thro...

journal_title：Theranostics

authors： Gobbo OL,Sjaastad K,Radomski MW,Volkov Y,Prina-Mello A

更新日期：2015-09-01 00:00:00

abstract：:Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channe...

journal_title：Theranostics

authors： Burks SR,Lorsung RM,Nagle ME,Tu TW,Frank JA

更新日期：2019-07-28 00:00:00