Multivalent Targeting Based Delivery of Therapeutic Peptide using AP1-ELP Carrier for Effective Cancer Therapy.

abstract：:Background: By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. Accurate imaging of PCa recurrent lymph node metastases (LNM) is crucial for metasta...

journal_title：Theranostics

authors： Jilg CA,Drendel V,Rischke HC,Beck T,Vach W,Schaal K,Wetterauer U,Schultze-Seemann W,Meyer PT

更新日期：2017-04-10 00:00:00

abstract：:Rationale: Dimethyl sulfoxide (DMSO) is commonly used as a solvent for water-insoluble substances, a vehicle for drug therapy, and a cryoprotectant for cultured cells. DMSO induced embryonic defects and its mechanism of action remains unclear. The rationale is based on the assumption that DMSO supplementation should i...

journal_title：Theranostics

authors： Kang MH,Das J,Gurunathan S,Park HW,Song H,Park C,Kim JH

更新日期：2017-10-17 00:00:00

abstract：:Peripheral arterial disease affects nearly 202 million individuals worldwide, sometimes leading to non-healing ulcers or limb amputations in severe cases. Genetically modified stem cells offer potential advantages for therapeutically inducing angiogenesis via augmented paracrine release mechanisms and tuned dynamic re...

journal_title：Theranostics

authors： Deveza L,Choi J,Lee J,Huang N,Cooke J,Yang F

更新日期：2016-05-23 00:00:00

abstract：:Long term pulmonary exposure to crystalline silica leads to silicosis that manifests progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite efforts to eliminate silicosis, clinical cases continue to occur in both developing and developed countries. The exact mechanisms of cryst...

journal_title：Theranostics

authors： Li C,Du S,Lu Y,Lu X,Liu F,Chen Y,Weng D,Chen J

更新日期：2016-09-09 00:00:00

abstract：:Development of a rapid and sensitive method for Aβ(1-42) aggregation detection is of great importance to overcome the limitations of conventional techniques. In this study, we developed a label-free paper-based electrochemiluminescence sensor for amyloid-β aggregation detection toward potential diagnosis of Alzheimer'...

journal_title：Theranostics

authors： Liu H,Zhou X,Shen Q,Xing D

更新日期：2018-03-11 00:00:00

abstract：:Rationale: Within the field of personalized medicine there is an increasing focus on designing flexible, multifunctional drug delivery systems that combine high efficacy with minimal side effects, by tailoring treatment to the individual. Methods: We synthesized a chemically stabilized ~4 nm nucleic acid nanoscaffold,...

journal_title：Theranostics

authors： Andersen VL,Vinther M,Kumar R,Ries A,Wengel J,Nielsen JS,Kjems J

更新日期：2019-04-13 00:00:00

abstract：:Rationale: Subjects unable to sustain β-cell compensation develop type 2 diabetes. Early growth response-1 protein (EGR-1), implicated in the regulation of cell differentiation, proliferation, and apoptosis, is induced by diverse metabolic challenges, such as glucose or other nutrients. Therefore, we hypothesized that...

journal_title：Theranostics

authors： Leu SY,Kuo LH,Weng WT,Lien IC,Yang CC,Hsieh TT,Cheng YN,Chien PH,Ho LC,Chen SH,Shan YS,Chen YW,Tsai PJ,Sung JM,Tsai YS

更新日期：2020-03-04 00:00:00

abstract：:Background: Tumor cells require proficient autophagy to meet high metabolic demands and resist chemotherapy, which suggests that reducing autophagic flux might be an attractive route for cancer therapy. However, this theory in clinical cancer research remains controversial due to the limited number of drugs that speci...

journal_title：Theranostics

authors： Liu PF,Tsai KL,Hsu CJ,Tsai WL,Cheng JS,Chang HW,Shiau CW,Goan YG,Tseng HH,Wu CH,Reed JC,Yang LW,Shu CW

更新日期：2018-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.27882.]. ...

journal_title：Theranostics

authors： Qin C,Liu Q,Hu ZW,Zhou LQ,Shang K,Bosco DB,Wu LJ,Tian DS,Wang W

更新日期：2020-07-10 00:00:00

abstract：:Patients with cervical cancer (CCa) with lymph node metastasis (LNM) have an extremely poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide clinical therapeutic strategies for CCa. Upregulation of fatty acid-binding protein 5 (FABP5) expression in CCa tumours was demonstrated to positivel...

journal_title：Theranostics

authors： Zhang C,Liao Y,Liu P,Du Q,Liang Y,Ooi S,Qin S,He S,Yao S,Wang W

更新日期：2020-05-17 00:00:00

abstract：:Müller glia are specialized retinal cells with stem cell properties in fish and frogs but not in mammals. Current efforts to develop gene therapies to activate mammalian Müller glia for retinal repair will require safe and effective delivery strategies for recombinant adeno-associated viruses (AAVs), vectors of choice...

journal_title：Theranostics

authors： Touahri Y,Dixit R,Kofoed RH,Miloska K,Park E,Raeisossadati R,Markham-Coultes K,David LA,Rijal H,Zhao J,Lynch M,Hynynen K,Aubert I,Schuurmans C

更新日期：2020-02-10 00:00:00

abstract：:Background: Lung cancer has a high mortality rate and is resistant to multiple chemotherapeutics. Natural Borneol (NB) is a monoterpenoid compound that facilitates the bioavailability of drugs. In this study, we investigated the effects of NB on chemosensitivity in the A549 human lung adenocarcinoma cell line and to e...

journal_title：Theranostics

authors： Lai H,Liu C,Hou L,Lin W,Chen T,Hong A

更新日期：2020-08-13 00:00:00

abstract：:Luminal androgen receptor (LAR) breast cancer accounts for 10% of all triple-negative breast cancers (TNBC). Anti-androgen therapy for this subtype is in development, but yields only partial clinical benefits. In this study, we aimed to characterize the genomic alterations of LAR TNBC, to analyze activation of the PI3...

journal_title：Theranostics

authors： Coussy F,Lavigne M,de Koning L,Botty RE,Nemati F,Naguez A,Bataillon G,Ouine B,Dahmani A,Montaudon E,Painsec P,Chateau-Joubert S,Laetitia F,Larcher T,Vacher S,Chemlali W,Briaux A,Melaabi S,Salomon AV,Guinebretiere JM

更新日期：2020-01-01 00:00:00

abstract：:Rationale: The incidence of hepatocellular carcinoma is rising worldwide. It is predicted that nearly half of the early-stage hepatocellular carcinoma (E-HCC) patients will develop recurrence. Dysregulated pH, a hallmark of E-HCC, is correlated with poor prognosis. The acidic microenvironment has been shown to promote...

journal_title：Theranostics

authors： Tian XP,Wang CY,Jin XH,Li M,Wang FW,Huang WJ,Yun JP,Xu RH,Cai QQ,Xie D

更新日期：2019-03-16 00:00:00

abstract：:Cancer metastasis is a Gordian knot for tumor diagnosis and therapy. Many studies have demonstrated that metastatic processes are inevitably affected by the tumor microenvironment. Histopathology is used universally as the gold standard for cancer diagnosis despite the lengthy preparation process and invasiveness. Met...

journal_title：Theranostics

authors： Shen B,Yan J,Wang S,Zhou F,Zhao Y,Hu R,Qu J,Liu L

更新日期：2020-01-01 00:00:00

abstract：:Cancer vaccines have encountered their ideal personalized partner along with evidence for great breakthroughs in the identification and synthesis of neoantigens. Individual cancer neoantigen vaccines are capable of eliciting robust T-cell responses and have been demonstrated to achieve striking clinical efficacy due t...

journal_title：Theranostics

authors： Chu Y,Liu Q,Wei J,Liu B

更新日期：2018-07-30 00:00:00

abstract：:Background: Patients with advanced soft tissue sarcomas (STS) have a dismal prognosis with few effective therapeutic options. A defect in the homologous recombination repair (HRR) pathway can accumulate DNA repair errors and gene mutations, which can lead to tumorigenesis. BRCAness describes tumors with an HRR deficie...

journal_title：Theranostics

authors： Li H,Tu J,Zhao Z,Chen L,Qu Y,Li H,Yao H,Wang X,Lee DF,Shen J,Wen L,Huang G,Xie X

更新日期：2020-07-25 00:00:00

abstract：:Immuno-oncological treatment strategies that target abnormal receptor profiles of tumors are an increasingly important feature of cancer therapy. Yet, assessing receptor availability (RA) and drug-target engagement, important determinants of therapeutic efficacy, is challenging with current imaging strategies, largely...

journal_title：Theranostics

authors： Meng B,Folaron MR,Strawbridge RR,Sadeghipour N,Samkoe KS,Tichauer K,Davis SC

更新日期：2020-09-14 00:00:00

abstract：:Catalytic nanomaterials with intrinsic enzyme-like activities, called nanozymes, have recently attracted significant research interest due to their unique advantages relative to natural enzymes and conventional artificial enzymes. Among the nanozymes developed, particular interests have been devoted to nanozymes with ...

journal_title：Theranostics

authors： Wang X,Cao W,Qin L,Lin T,Chen W,Lin S,Yao J,Zhao X,Zhou M,Hang C,Wei H

更新日期：2017-06-01 00:00:00

abstract：:[This retracts the article DOI: 10.7150/thno.14306.]. ...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2020-09-30 00:00:00

abstract：:Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. Here, we show the upregulated expression of EGFR ligand epiregulin in a subset of SACC cells correlates with lung metastasis and unfavora...

journal_title：Theranostics

authors： Yang WW,Yang LQ,Zhao F,Chen CW,Xu LH,Fu J,Li SL,Ge XY

更新日期：2017-08-23 00:00:00

abstract：:Acute myocardial infarction (AMI) is one of the leading causes of mortality around the world, and the inflammatory response plays a pivotal role in the progress of myocardial necrosis and ventricular remodeling, dysfunction and heart failure after AMI. Therapies aimed at modulating immune response after AMI on a molec...

journal_title：Theranostics

authors： Xiong YY,Gong ZT,Tang RJ,Yang YJ

更新日期：2021-01-01 00:00:00

abstract：:Rationale: Spatial-temporal control of cell fate in vivo is of great importance for regenerative medicine. Currently, there remain no practical strategies to tune cell-fate spatial-temporally. Optogenetics is a biological technique that widely used to control cell activity in genetically defined neurons in a spatiotem...

journal_title：Theranostics

authors： Wang W,Huang D,Ren J,Li R,Feng Z,Guan C,Bao B,Cai B,Ling J,Zhou C

更新日期：2019-10-18 00:00:00

abstract：:Targeting cancer stem cells (CSCs) has been proposed as a new strategy to eradicate malignancies, including hepatocellular carcinoma (HCC). However, the mechanisms by which CSCs sustain their self-renewal and chemoresistance remain elusive. Nanog is a master transcriptional regulator of stemness, especially in CSCs. I...

journal_title：Theranostics

authors： Cao J,Zhao M,Liu J,Zhang X,Pei Y,Wang J,Yang X,Shen B,Zhang J

更新日期：2019-01-24 00:00:00

abstract：:Purpose: The tumor homing characteristics of mesenchymal stem cells (MSCs) make them attractive vehicles for the tumor-specific delivery of therapeutic agents, such as the sodium iodide symporter (NIS). NIS is a theranostic protein that allows non-invasive monitoring of the in vivo biodistribution of functional NIS ex...

journal_title：Theranostics

authors： Tutter M,Schug C,Schmohl KA,Urnauer S,Schwenk N,Petrini M,Lokerse WJM,Zach C,Ziegler S,Bartenstein P,Weber WA,Wagner E,Lindner LH,Nelson PJ,Spitzweg C

更新日期：2020-03-15 00:00:00

abstract：:Rationale: Basal-like breast cancer (BLBC) is associated with high grade, distant metastasis, and poor prognosis; however, the mechanism underlying aggressiveness of BLBC is still unclear. Emerging evidence has suggested that phospholipid scramblase 1 (PLSCR1) is involved in tumor progression. Here, we aimed to study ...

journal_title：Theranostics

authors： Huang P,Liao R,Chen X,Wu X,Li X,Wang Y,Cao Q,Dong C

更新日期：2020-03-25 00:00:00

abstract：:Molecular photoacoustic imaging (PA) is a promising technology to understand tumor pathology and guide precision therapeutics. Despite the capability of activatable PA probes to image tumor-specific biomarkers, limitations in their molecular structure hamper them from effective drug delivery and the drug release monit...

journal_title：Theranostics

authors： Yang Z,Song J,Tang W,Fan W,Dai Y,Shen Z,Lin L,Cheng S,Liu Y,Niu G,Rong P,Wang W,Chen X

更新日期：2019-01-01 00:00:00

abstract：:High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to co...

journal_title：Theranostics

authors： El Kaffas A,Gangeh MJ,Farhat G,Tran WT,Hashim A,Giles A,Czarnota GJ

更新日期：2018-01-01 00:00:00

abstract：:Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute myeloid leukemia (AML). The uridine-cytidine kinase 1 (UCK1) has an established role in activating 5'-AZA and its protein level is significantly downregulated in patients resistant to the drug. H...

journal_title：Theranostics

authors： Zhang H,Huang H,Feng X,Song H,Zhang Z,Shen A,Qiu X

更新日期：2020-01-01 00:00:00

abstract：:Rational: Ischemic injury of the skeletal muscle remains a serious clinical problem and currently there is no effective therapy. The aim of the present study is to determine whether human umbilical cord mesenchymal stem cells- derived exosomes (UMSC-Exo) could repair ischemic injury by releasing circular RNA. Methods ...

journal_title：Theranostics

authors： Yan B,Zhang Y,Liang C,Liu B,Ding F,Wang Y,Zhu B,Zhao R,Yu XY,Li Y

更新日期：2020-05-18 00:00:00