Abstract:
:Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative Zeta potential and shown to be spherical in shape. The loading efficiency of superparamagnetic iron oxide nanoparticles in the m-NC was ~100%. Up to ~3- and ~2.2-fold increase in tumour uptake at 1 and 24 h was achieved, when a static magnetic field was applied to the tumour for 1 hour. m-NCs, with multiple imaging probes (e.g. indocyanine green, superparamagnetic iron oxide nanoparticles and indium-111), were capable of triple-modal imaging (fluorescence/magnetic resonance/nuclear imaging) in vivo. Using triple-modal imaging is to overcome the intrinsic limitations of single modality imaging and provides complementary information on the spatial distribution of the nanocarrier within the tumour. The significant findings of this study could open up new research perspectives in using novel magnetically-responsive nanomaterials in magnetic-drug targeting combined with multi-modal imaging.
journal_name
Theranosticsjournal_title
Theranosticsauthors
Bai J,Wang JT,Rubio N,Protti A,Heidari H,Elgogary R,Southern P,Al-Jamal WT,Sosabowski J,Shah AM,Bals S,Pankhurst QA,Al-Jamal KTdoi
10.7150/thno.11918subject
Has Abstractpub_date
2016-01-01 00:00:00pages
342-56issue
3issn
1838-7640pii
thnov06p0342journal_volume
6pub_type
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