Theranostic nanobubble encapsulating a plasmon-enhanced upconversion hybrid nanosystem for cancer therapy.

Abstract:

:Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent for novel cancer treatment by using an NB-encapsulated hybrid nanosystem that can be monitored by US and fluorescent imaging and activated by near-infrared (NIR) light. The nanosystem was transported to the tumor through the enhanced permeability and retention effect. The hybrid nanosystem comprised upconversion nanoparticle (UCNP) and mesoporous silica-coated gold nanorod (AuNR@mS) with the photosensitizer merocyanine 540 to realize dual phototherapy. Results: With the NIR light-triggered, the luminous intensity of the UCNP was enhanced by doping holmium ion and emitted visible green and red lights at 540 and 660 nm. The high optical density state between the UCNP and AuNR@mS can induce plasmonic enhancement to improve the photothermal and photodynamic effects, resulting in cell death by apoptosis. The nanosystem showed excellent stability to avoid the aggregation of nanoparticles during the treatment. JC-1 dye was used as an indicator of mitochondrial membrane potential to identify the mechanism of cell death. The results of in vitro and in vivo analyses confirmed the curative effect of improved dual phototherapy. Conclusion: We developed and showed the therapeutic functions of a novel nanosystem with the combination of multiple theranostic nanoplatforms that can be triggered and activated by 808 nm NIR laser and US.

journal_name

Theranostics

journal_title

Theranostics

authors

Huang WT,Chan MH,Chen X,Hsiao M,Liu RS

doi

10.7150/thno.38684

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

782-796

issue

2

issn

1838-7640

pii

thnov10p0782

journal_volume

10

pub_type

杂志文章
  • Intravital molecular imaging reveals the restrained capacity of CTLs in the killing of tumor cells in the liver.

    abstract::Cytotoxic T lymphocytes (CTLs) and their gene-engineered cells display great application prospects in tumor immunotherapy. The timing of CTL-induced molecular events in tumor cells is unclear, and we also unknow whether the killing efficiency of CTLs is restrained in the liver, an immunotolerant organ with a high tumo...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44979

    authors: Liu L,Dai B,Li R,Liu Z,Zhang Z

    更新日期:2021-01-01 00:00:00

  • Spontaneous evolution of human skin fibroblasts into wound-healing keratinocyte-like cells.

    abstract::Producing keratinocyte cells (KCs) in large scale is difficult due to their slow proliferation, disabling their use as seed cells for skin regeneration and wound healing. Cell reprogramming is a promising inducer-based approach to KC production but only reaches very low cellular conversion. Here we reported a unique c...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.31526

    authors: Zhang F,Zhang D,Cheng K,Zhou Z,Liu S,Chen L,Hu Y,Mao C,Liu S

    更新日期:2019-07-09 00:00:00

  • MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer.

    abstract::Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of several human cancers, including breast cancer (BC), as strong evidence has been found that miRNAs can act as oncogenes or tumor suppressor genes. This review presents the state of the art on the role of miRNAs in the diagnosis, progn...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.11543

    authors: Bertoli G,Cava C,Castiglioni I

    更新日期:2015-07-13 00:00:00

  • An Aptamer-Based Probe for Molecular Subtyping of Breast Cancer.

    abstract::Molecular subtyping of breast cancer is of considerable interest owing to its potential for personalized therapy and prognosis. However, current methodologies cannot be used for precise subtyping, thereby posing a challenge in clinical practice. The aim of the present study is to develop a cell-specific single-strande...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.28949

    authors: Liu M,Wang Z,Tan T,Chen Z,Mou X,Yu X,Deng Y,Lu G,He N

    更新日期:2018-11-10 00:00:00

  • Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story.

    abstract::The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant ex...

    journal_title:Theranostics

    pub_type: 评论,社论

    doi:10.7150/thno.29864

    authors: Corti A,Belcastro E,Pompella A

    更新日期:2018-11-15 00:00:00

  • Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis.

    abstract::Background: Colorectal cancer (CRC) progression and related mortality are highly associated with metabolic disorders. However, the molecular mechanism involved in the regulation of hyperlipidemia-associated CRC metastasis remains unclear. This study aimed to investigate the effects of angiopoietin-like 4 (ANGPTL4) on ...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44744

    authors: Shen CJ,Chang KY,Lin BW,Lin WT,Su CM,Tsai JP,Liao YH,Hung LY,Chang WC,Chen BK

    更新日期:2020-05-30 00:00:00

  • Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles.

    abstract::Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been a popular strategy...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.25228

    authors: Johnsen KB,Bak M,Kempen PJ,Melander F,Burkhart A,Thomsen MS,Nielsen MS,Moos T,Andresen TL

    更新日期:2018-05-24 00:00:00

  • Lipid- and polymer-based nanostructures for cancer theranostics.

    abstract::The relatively new field of nanotheranostics combines the advantages of in vivo diagnosis with the ability to administer treatment through a single nano-sized carrier, offering new opportunities for cancer diagnosis and therapy. Nanotheranostics has facilitated the development of nanomedicine through direct visualizat...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.4381

    authors: Luk BT,Fang RH,Zhang L

    更新日期:2012-01-01 00:00:00

  • Integrating Stimuli-Responsive Properties in Host-Guest Supramolecular Drug Delivery Systems.

    abstract::Host-guest motifs are likely the most recognizable manifestation of supramolecular chemistry. These complexes are characterized by the organization of small molecules on the basis of preferential association of a guest within the portal of a host. In the context of their therapeutic use, the primary application of the...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.31913

    authors: Braegelman AS,Webber MJ

    更新日期:2019-05-15 00:00:00

  • Microporous polysaccharide multilayer coated BCP composite scaffolds with immobilised calcitriol promote osteoporotic bone regeneration both in vitro and in vivo.

    abstract::Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.29566

    authors: Tang Q,Hu Z,Jin H,Zheng G,Yu X,Wu G,Liu H,Zhu Z,Xu H,Zhang C,Shen L

    更新日期:2019-01-30 00:00:00

  • Magnetic Nanoparticles in Cancer Theranostics.

    abstract::In a report from 2008, The International Agency for Research on Cancer predicted a tripled cancer incidence from 1975, projecting a possible 13-17 million cancer deaths worldwide by 2030. While new treatments are evolving and reaching approval for different cancer types, the main prevention of cancer mortality is thro...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.11544

    authors: Gobbo OL,Sjaastad K,Radomski MW,Volkov Y,Prina-Mello A

    更新日期:2015-09-01 00:00:00

  • Ultrasmall gold nanoparticles in cancer diagnosis and therapy.

    abstract::Due to their lower systemic toxicity, faster kidney clearance and higher tumor accumulation, ultrasmall gold nanoparticles (less than 10 nm in diameter) have been proved to be promising in biomedical applications. However, their potential applications in cancer imaging and treatment have not been reviewed yet. This re...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.42471

    authors: Fan M,Han Y,Gao S,Yan H,Cao L,Li Z,Liang XJ,Zhang J

    更新日期:2020-03-31 00:00:00

  • Theranostics in immuno-oncology using nanobody derivatives.

    abstract::Targeted therapy and immunotherapy have become mainstream in cancer treatment. However, only patient subsets benefit from these expensive therapies, and often responses are short-lived or coincide with side effects. A growing modality in precision oncology is the development of theranostics, as this enables patient se...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.34941

    authors: Lecocq Q,De Vlaeminck Y,Hanssens H,D'Huyvetter M,Raes G,Goyvaerts C,Keyaerts M,Devoogdt N,Breckpot K

    更新日期:2019-10-15 00:00:00

  • Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia.

    abstract::Objective: Vascular smooth muscle cells (VSMCs) undergo the phenotypic changes from contractile to synthetic state during vascular remodeling after ischemia. SIRT1 protects against stress-induced vascular remodeling via maintaining VSMC differentiated phenotype. However, the effect of smooth muscle SIRT1 on the functi...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.39320

    authors: Dou YQ,Kong P,Li CL,Sun HX,Li WW,Yu Y,Nie L,Zhao LL,Miao SB,Li XK,Dong C,Zhang JW,Liu Y,Huo XX,Chi K,Gao X,Zhang N,Weng L,Yang H,Zhang F,Han M

    更新日期:2020-01-01 00:00:00

  • Molecular analysis of circulating tumor cells of metastatic castration-resistant Prostate Cancer Patients receiving 177Lu-PSMA-617 Radioligand Therapy.

    abstract::Rationale: Lu-177-PSMA-617 radioligand therapy (RLT) is currently under approval for treatment of metastatic castration resistant prostate cancer (mCRPC) patients with late stage disease. However, previous studies demonstrated both heterogeneity of prostate specific membrane antigen (PSMA) expression, as well as respo...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44556

    authors: Kessel K,Seifert R,Weckesser M,Roll W,Humberg V,Schlack K,Bögemann M,Bernemann C,Rahbar K

    更新日期:2020-06-18 00:00:00

  • Nanoscale microenvironment engineering based on layer-by-layer self-assembly to regulate hair follicle stem cell fate for regenerative medicine.

    abstract::Hair regenerative medicine, a promising strategy for the treatment of hair loss, will likely involve the transplantation of autologous hair follicular stem cells (HFSCs) and dermal papilla cells (DPCs) into regions of hair loss. Cyclic hair regeneration results from the periodic partial activation of HFSCs. However, p...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.48723

    authors: Chen P,Miao Y,Zhang F,Huang J,Chen Y,Fan Z,Yang L,Wang J,Hu Z

    更新日期:2020-09-22 00:00:00

  • Integrin targeted delivery of radiotherapeutics.

    abstract::Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno/v01p0201

    authors: Liu Z,Wang F,Chen X

    更新日期:2011-03-01 00:00:00

  • Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action.

    abstract::Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could a...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.17073

    authors: Ai XY,Liu HJ,Lu C,Liang CL,Sun Y,Chen S,Sun B,Li Y,Liu YR,Zhang Q,Liu XQ,Xiao T,Jing XS,Sun T,Zhou HG,Yang C

    更新日期:2017-01-05 00:00:00

  • Changes in the microarchitecture of the pancreatic cancer stroma are linked to neutrophil-dependent reprogramming of stellate cells and reflected by diffusion-weighted magnetic resonance imaging.

    abstract::In pancreatic cancer (PDAC) intratumor infiltration of polymorphonuclear neutrophils (PMN) is associated with histologically apparent alterations of the tumor growth pattern. The aim of this study was to examine possible associations between PMN infiltration, tumor microarchitecture, and water diffusivity in diffusion...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.21089

    authors: Mayer P,Dinkic C,Jesenofsky R,Klauss M,Schirmacher P,Dapunt U,Hackert T,Uhle F,Hänsch GM,Gaida MM

    更新日期:2018-01-01 00:00:00

  • Nanotopography-based lymphatic delivery for improved anti-tumor responses to checkpoint blockade immunotherapy.

    abstract::Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against "self" antigens (Ags). In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust activation of T-cells against tumor Ags pr...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.35280

    authors: Kwon S,Velasquez FC,Rasmussen JC,Greives MR,Turner KD,Morrow JR,Hwu WJ,Ross RF,Zhang S,Sevick-Muraca EM

    更新日期:2019-10-22 00:00:00

  • Role of Extracellular Vesicles in Viral and Bacterial Infections: Pathogenesis, Diagnostics, and Therapeutics.

    abstract::Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread pathogen- and host-derived molecules duri...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.20576

    authors: Rodrigues M,Fan J,Lyon C,Wan M,Hu Y

    更新日期:2018-04-09 00:00:00

  • Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats.

    abstract::Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilize...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.49426

    authors: Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

    更新日期:2021-01-01 00:00:00

  • pH-Sensitive Nano-Complexes Overcome Drug Resistance and Inhibit Metastasis of Breast Cancer by Silencing Akt Expression.

    abstract::The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX ...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.21516

    authors: Yin J,Lang T,Cun D,Zheng Z,Huang Y,Yin Q,Yu H,Li Y

    更新日期:2017-09-26 00:00:00

  • EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes.

    abstract::Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.19988

    authors: Jiang Y,Mao C,Yang R,Yan B,Shi Y,Liu X,Lai W,Liu Y,Wang X,Xiao D,Zhou H,Cheng Y,Yu F,Cao Y,Liu S,Yan Q,Tao Y

    更新日期:2017-07-23 00:00:00

  • Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice.

    abstract::Aberrant activation of the Src kinase is implicated in the development of a variety of human malignancies. However, it is almost impossible to monitor Src activity in an in vivo setting with current biochemical techniques. To facilitate the noninvasive investigation of the activity of Src kinase both in vitro and in v...

    journal_title:Theranostics

    pub_type: 杂志文章,收录出版

    doi:10.7150/thno.14306

    authors: Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

    更新日期:2016-02-24 00:00:00

  • Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice.

    abstract::In the field of ischemic cerebral injury, precise characterization of neurovascular hemodynamic is required to select candidates for reperfusion treatments. It is thus admitted that advanced imaging-based approaches would be able to better diagnose and prognose those patients and would contribute to better clinical ca...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44233

    authors: Hingot V,Brodin C,Lebrun F,Heiles B,Chagnot A,Yetim M,Gauberti M,Orset C,Tanter M,Couture O,Deffieux T,Vivien D

    更新日期:2020-06-12 00:00:00

  • Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI.

    abstract::Rationale: Tumor vascular normalization (TVN) is emerging to enhance the efficacy of anticancer treatment in many cancers including glioblastoma (GBM). However, a common and severe challenge being currently faced is the transient TVN effect, hampering the sustained administration of anticancer therapy during TVN windo...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44427

    authors: Zhang J,Xue W,Xu K,Yi L,Guo Y,Xie T,Tong H,Zhou B,Wang S,Li Q,Liu H,Chen X,Fang J,Zhang W

    更新日期:2020-06-05 00:00:00

  • FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism.

    abstract::Patients with cervical cancer (CCa) with lymph node metastasis (LNM) have an extremely poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide clinical therapeutic strategies for CCa. Upregulation of fatty acid-binding protein 5 (FABP5) expression in CCa tumours was demonstrated to positivel...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44868

    authors: Zhang C,Liao Y,Liu P,Du Q,Liang Y,Ooi S,Qin S,He S,Yao S,Wang W

    更新日期:2020-05-17 00:00:00

  • Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer.

    abstract::Rationale: Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor alpha (ER-α), human epidermal growth factor receptor 2 (HER2) and progesterone receptor (PR) expression, but the effect of lacking the three factors on TNBC is unclear. Whether loss of the three factors contributes to ...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.30701

    authors: Zhao Z,Li L,Du P,Ma L,Zhang W,Zheng L,Lan B,Zhang B,Ma F,Xu B,Zhan Q,Song Y

    更新日期:2019-02-20 00:00:00

  • Molecular signatures of BRCAness analysis identifies PARP inhibitor Niraparib as a novel targeted therapeutic strategy for soft tissue Sarcomas.

    abstract::Background: Patients with advanced soft tissue sarcomas (STS) have a dismal prognosis with few effective therapeutic options. A defect in the homologous recombination repair (HRR) pathway can accumulate DNA repair errors and gene mutations, which can lead to tumorigenesis. BRCAness describes tumors with an HRR deficie...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.45763

    authors: Li H,Tu J,Zhao Z,Chen L,Qu Y,Li H,Yao H,Wang X,Lee DF,Shen J,Wen L,Huang G,Xie X

    更新日期:2020-07-25 00:00:00