Abstract:
:Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread pathogen- and host-derived molecules during infections to alter immune responses and pathophysiological processes. New research is beginning to decipher how EVs influence viral and bacterial pathogenesis. In this review, we will describe how EVs influence viral and bacterial pathogenesis by spreading pathogen-derived factors and how they can promote and inhibit the immune response to these pathogens. We will also discuss the emerging potential of EVs as diagnostic and therapeutic tools.
journal_name
Theranosticsjournal_title
Theranosticsauthors
Rodrigues M,Fan J,Lyon C,Wan M,Hu Ydoi
10.7150/thno.20576subject
Has Abstractpub_date
2018-04-09 00:00:00pages
2709-2721issue
10issn
1838-7640pii
thnov08p2709journal_volume
8pub_type
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