Pretargeted molecular imaging and radioimmunotherapy.

abstract：:Metastasis is the primary cause of death in patients with advanced cancer. Recently, a high-fat diet was shown to specifically promote the metastatic potential of specific cancer cells in a CD36-dependent manner. However, the molecular basis of the fatty acid (FA)-induced upregulation of CD36 has remained unclear. Met...

journal_title：Theranostics

authors： Jiang M,Wu N,Xu B,Chu Y,Li X,Su S,Chen D,Li W,Shi Y,Gao X,Zhang H,Zhang Z,Du W,Nie Y,Liang J,Fan D

更新日期：2019-07-09 00:00:00

abstract：:This paper reports a sensitive method with electrochemical technique to detect various proteases, which can be used for the diagnosis of prostate cancer. For the proposed assay method, the working electrode is modified with the peptide probes for the target proteases. These probes contain the substrate sequence of tar...

journal_title：Theranostics

authors： Li H,Huang Y,Zhang B,Yang D,Zhu X,Li G

更新日期：2014-04-25 00:00:00

abstract：:In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bon...

journal_title：Theranostics

authors： Peng Y,Wu S,Li Y,Crane JL

更新日期：2020-01-01 00:00:00

abstract：:Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells (HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with transcriptional and epigenetic remodeling. We aimed to characterize t...

journal_title：Theranostics

authors： Jiang Y,Xiang C,Zhong F,Zhang Y,Wang L,Zhao Y,Wang J,Ding C,Jin L,He F,Wang H

更新日期：2021-01-01 00:00:00

abstract：:Ocular neovascularization is a pathological sequel of multiple eye diseases. Based on the anatomical site into which the abnormal neovessels grow, ocular neovascularization can be categorized into corneal neovascularization, choroidal neovascularization, and retinal neovascularization. Each category is intractable, an...

journal_title：Theranostics

authors： Zhang Y,Cai S,Jia Y,Qi C,Sun J,Zhang H,Wang F,Cao Y,Li X

更新日期：2017-07-22 00:00:00

abstract：:Rationale: Increasing frequency of human exposure to PEG-related products means that healthy people are likely to have pre-existing anti-PEG antibodies (pre-αPEG Ab). However, the influence of pre-αPEG Abs on the pharmacokinetics (PK) and therapeutic efficacy of LipoDox is unknown. Methods: We generated two pre-αPEG A...

journal_title：Theranostics

authors： Hsieh YC,Wang HE,Lin WW,Roffler SR,Cheng TC,Su YC,Li JJ,Chen CC,Huang CH,Chen BM,Wang JY,Cheng TL,Chen FM

更新日期：2018-05-09 00:00:00

abstract：:Using non-covalent interactions between nucleic acids (DNA, siRNA, miRNA, and mRNA) with peptides or nucleopeptides is a promising strategy to construct supramolecular assemblies for gene delivery and therapy. Comparing to conventional strategies for gene delivery, the assemblies of peptides or nucleopeptides provide ...

journal_title：Theranostics

authors： Wang H,Feng Z,Xu B

更新日期：2019-05-18 00:00:00

abstract：:Cell-derived microparticles (MPs) are nano-sized vesicles released by activated cells in the extracellular milieu. They act as vectors of biological activity by carrying membrane-anchored and cytoplasmic constituents of the parental cells. Although detection and characterization of cell-derived MPs may be of high diag...

journal_title：Theranostics

authors： Briens A,Gauberti M,Parcq J,Montaner J,Vivien D,Martinez de Lizarrondo S

更新日期：2016-03-02 00:00:00

abstract：:Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute myeloid leukemia (AML). The uridine-cytidine kinase 1 (UCK1) has an established role in activating 5'-AZA and its protein level is significantly downregulated in patients resistant to the drug. H...

journal_title：Theranostics

authors： Zhang H,Huang H,Feng X,Song H,Zhang Z,Shen A,Qiu X

更新日期：2020-01-01 00:00:00

abstract：:Background: Lysophosphatidic acid (LPA) is a small glycerophospholipid that acts as a potent extracellular signal in various biological processes and diseases. Our previous work demonstrated that the expression of the LPA receptors LPA1 and LPA3 is elevated in the early postnatal heart. However, the role of this stage...

journal_title：Theranostics

authors： Wang F,Liu S,Pei J,Cai L,Liu N,Liang T,Dong X,Cong X,Chun J,Chen J,Hu S,Chen X

更新日期：2020-08-29 00:00:00

abstract：:Rationale: Hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (hiPSCs) have been developed to address the shortage of primary human hepatocytes (PHHs) for therapeutic applications. However, the in vivo repopulation capacity of HLCs remains limited. This study investigated the roles of agoni...

journal_title：Theranostics

authors： Yuan L,Zhang Y,Liu X,Chen Y,Zhang L,Cao J,Li X,Wang M,Wu K,Zhang J,Liu G,Tang Q,Yuan Q,Cheng T,Xia N

更新日期：2019-04-06 00:00:00

abstract：:New ways to target and treat metastatic disease are urgently needed. Tumor "self-homing" describes the recruitment of circulating tumor cells (CTCs) back to a previously excised primary tumor location, contributing to tumor recurrence, as well as their migration to established metastatic lesions. Recently, self-homing...

journal_title：Theranostics

authors： Parkins KM,Dubois VP,Kelly JJ,Chen Y,Knier NN,Foster PJ,Ronald JA

更新日期：2020-06-29 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.27882.]. ...

journal_title：Theranostics

authors： Qin C,Liu Q,Hu ZW,Zhou LQ,Shang K,Bosco DB,Wu LJ,Tian DS,Wang W

更新日期：2020-07-10 00:00:00

abstract：:Blood vessels are conduits distributed throughout the body, supporting tissue growth and homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the linings of the blood vessels, and together with pericytes, are essential for organ development and tissue homeostasis through producing ...

journal_title：Theranostics

authors： Zhu S,Bennett S,Kuek V,Xiang C,Xu H,Rosen V,Xu J

更新日期：2020-05-01 00:00:00

abstract：:Purpose: Breast cancer imaging methods lack diagnostic accuracy, in particular for patients with dense breast tissue, and improved techniques are critically needed. The purpose of this study was to evaluate antibody-indocyanine green (ICG) conjugates, which undergo dynamic absorption spectrum shifts after cellular end...

journal_title：Theranostics

authors： Wilson KE,Bachawal SV,Abou-Elkacem L,Jensen K,Machtaler S,Tian L,Willmann JK

更新日期：2017-04-03 00:00:00

abstract：:Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine. Nerve autograft is the gold standard for clinical PNI repair. Due to its significant drawbacks, artificial nerve guidance conduits (NGCs) have drawn much attention as replacement therapies. We developed a combinatorial NGC consist...

journal_title：Theranostics

authors： Zheng C,Yang Z,Chen S,Zhang F,Rao Z,Zhao C,Quan D,Bai Y,Shen J

更新日期：2021-01-01 00:00:00

abstract：:Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread pathogen- and host-derived molecules duri...

journal_title：Theranostics

authors： Rodrigues M,Fan J,Lyon C,Wan M,Hu Y

更新日期：2018-04-09 00:00:00

abstract：:Rationale: Lu-177-PSMA-617 radioligand therapy (RLT) is currently under approval for treatment of metastatic castration resistant prostate cancer (mCRPC) patients with late stage disease. However, previous studies demonstrated both heterogeneity of prostate specific membrane antigen (PSMA) expression, as well as respo...

journal_title：Theranostics

authors： Kessel K,Seifert R,Weckesser M,Roll W,Humberg V,Schlack K,Bögemann M,Bernemann C,Rahbar K

更新日期：2020-06-18 00:00:00

abstract：:Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared...

journal_title：Theranostics

authors： Li Y,Li Y,Zhang X,Xu X,Zhang Z,Hu C,He Y,Gu Z

更新日期：2016-06-05 00:00:00

abstract：:Constructing nanosystems that synergistically combine therapeutic and diagnostic features is of great interest to the nanomedicine community but also remains a tremendous challenge. Methods: In this work, we report novel catalytic nanoparticles composed of the enzyme catalase, encapsulated in a polymer shell and surfa...

journal_title：Theranostics

authors： Zhu J,Li Z,Zhang C,Lin L,Cao S,Che H,Shi X,Wang H,van Hest JCM

更新日期：2019-10-17 00:00:00

abstract：:The diseases caused by viruses posed a great challenge to human health, the development of which was driven by the imbalanced host immune response. Host innate immunity is an evolutionary old defense system that is critical for the elimination of the virus. The overactive innate immune response also leads to inflammat...

journal_title：Theranostics

authors： Wang Y,Wang Y,Luo W,Song X,Huang L,Xiao J,Jin F,Ren Z,Wang Y

更新日期：2020-07-23 00:00:00

abstract：:The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat an...

journal_title：Theranostics

authors： Yu J,Yin W,Zheng X,Tian G,Zhang X,Bao T,Dong X,Wang Z,Gu Z,Ma X,Zhao Y

更新日期：2015-05-20 00:00:00

abstract：:Purpose: Cancer immunotherapy depends on a systemic immune response, but the basic underlying mechanisms are still largely unknown. Despite the very successful and widespread use of checkpoint inhibitors in the clinic, the majority of cancer patients do not benefit from this type of treatment. In this translational st...

journal_title：Theranostics

authors： Schwenck J,Schörg B,Fiz F,Sonanini D,Forschner A,Eigentler T,Weide B,Martella M,Gonzalez-Menendez I,Campi C,Sambuceti G,Seith F,Quintanilla-Martinez L,Garbe C,Pfannenberg C,Röcken M,la Fougere C,Pichler BJ,Kneilling M

更新日期：2020-01-01 00:00:00

abstract：:Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilize...

journal_title：Theranostics

authors： Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

更新日期：2021-01-01 00:00:00

abstract：:Over 70% of head & neck squamous cell carcinoma (HNSCC) patients carry TP53 oncogenic mutations. Here we studied the role of specific tumor-derived mutant p53 proteins in the aberrant transcription of long non-coding (lnc) MIR205HG gene in head and neck cancer cells. Methods: To understand the role of lncMIR205HG, tha...

journal_title：Theranostics

authors： Di Agostino S,Valenti F,Sacconi A,Fontemaggi G,Pallocca M,Pulito C,Ganci F,Muti P,Strano S,Blandino G

更新日期：2018-02-12 00:00:00

abstract：:Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems. The application of these new materials and techniques with combined properties of diagnosis and therapy can benefit the development of targeted drug deliv...

journal_title：Theranostics

authors： Ding H,Wu F

更新日期：2012-01-01 00:00:00

abstract：:This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using 225Ac and its theranostic pair, 111In. We call our novel tumor-targeting DOTA-hapten PRIT system "proteus-DOTA" or "Pr." Herein we report the first results of radiochemistry development, radiopharmacology, and stoichiometry of tumor ...

journal_title：Theranostics

authors： Cheal SM,McDevitt MR,Santich BH,Patel M,Yang G,Fung EK,Veach DR,Bell M,Ahad A,Vargas DB,Punzalan B,Pillarsetty NVK,Xu H,Guo HF,Monette S,Michel AO,Piersigilli A,Scheinberg DA,Ouerfelli O,Cheung NV,Larson SM

更新日期：2020-09-14 00:00:00

abstract：:Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for d...

journal_title：Theranostics

authors： Son DJ,Zheng J,Jung YY,Hwang CJ,Lee HP,Woo JR,Baek SY,Ham YW,Kang MW,Shong M,Kweon GR,Song MJ,Jung JK,Han SB,Kim BY,Yoon DY,Choi BY,Hong JT

更新日期：2017-10-16 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated gene regulatory networks (GRNs), but their implication in advanced or treatment-refractory malignancy is unknown. Methods: We combined high-throughput transcriptomic approaches with bioinformatics and structure modeling to search for ...

journal_title：Theranostics

authors： Logotheti S,Marquardt S,Gupta SK,Richter C,Edelhäuser BAH,Engelmann D,Brenmoehl J,Söhnchen C,Murr N,Alpers M,Singh KP,Wolkenhauer O,Heckl D,Spitschak A,Pützer BM

更新日期：2020-07-29 00:00:00

abstract：:Rationale: The overall success rate of prostate cancer (PCa) diagnosis and therapy has been improved over the years. However, genomic and phenotypic heterogeneity remains a major challenge for effective detection and treatment of PCa. Efforts to better classify PCa into functional subtypes and elucidate the molecular ...

journal_title：Theranostics

authors： Bai Y,Yang Y,Yan Y,Zhong J,Blee AM,Pan Y,Ma T,Karnes RJ,Jimenez R,Xu W,Huang H

更新日期：2019-05-24 00:00:00