Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.

abstract：:Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro; thus, we hypothesize that this pathway can mitigate cardiomyocyte ...

journal_title：Theranostics

authors： Grisanti LA,Thomas TP,Carter RL,de Lucia C,Gao E,Koch WJ,Benovic JL,Tilley DG

更新日期：2018-09-09 00:00:00

abstract：:Rationale: Colitis-associated colorectal cancer (CAC) usually exhibits an accelerated disease progression, an increased resistance to therapeutic drugs and a higher mortality rate than sporadic colorectal cancer (CRC). PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family; however, little is known...

journal_title：Theranostics

authors： Ma J,Yang Y,Fu Y,Guo F,Zhang X,Xiao S,Zhu W,Huang Z,Zhang J,Chen J

更新日期：2018-04-30 00:00:00

abstract：:To enhance effective drug accumulation in drug-resistant tumors, a site-specific drug-releasing polypeptide system (PEG-Phis/Pasp-DOX/CA4) was exploited in response to tumor extracellular and intracellular pH. This system could firstly release the embedded tumor vascular inhibitor (CA4) to transiently 'normalize' vasc...

journal_title：Theranostics

authors： Dong Y,Yang J,Liu H,Wang T,Tang S,Zhang J,Zhang X

更新日期：2015-04-28 00:00:00

abstract：:Up to one-third of diffuse large B cell lymphoma (DLBCL) patients eventually develop resistance to R-CHOP regimen, while the remaining therapeutic options are limited. Thus, understanding the underlying mechanisms and developing therapeutic approaches are urgently needed. Methods: We generated two germinal center B ce...

journal_title：Theranostics

authors： Chen J,Ge X,Zhang W,Ding P,Du Y,Wang Q,Li L,Fang L,Sun Y,Zhang P,Zhou Y,Zhang L,Lv X,Li L,Zhang X,Zhang Q,Xue K,Gu H,Lei Q,Wong J,Hu W

更新日期：2020-02-10 00:00:00

abstract：:Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...

journal_title：Theranostics

authors： Tang Q,Hu Z,Jin H,Zheng G,Yu X,Wu G,Liu H,Zhu Z,Xu H,Zhang C,Shen L

更新日期：2019-01-30 00:00:00

abstract：:Rationale: Spatial-temporal control of cell fate in vivo is of great importance for regenerative medicine. Currently, there remain no practical strategies to tune cell-fate spatial-temporally. Optogenetics is a biological technique that widely used to control cell activity in genetically defined neurons in a spatiotem...

journal_title：Theranostics

authors： Wang W,Huang D,Ren J,Li R,Feng Z,Guan C,Bao B,Cai B,Ling J,Zhou C

更新日期：2019-10-18 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (...

journal_title：Theranostics

authors： Chi YH,Hsiao JK,Lin MH,Chang C,Lan CH,Wu HC

更新日期：2017-04-10 00:00:00

abstract：:Because of the unparalleled efficiency and universal utility in treating a variety of disease types, siRNA agents have evolved as the future drug-of-choice. Yet, the inability of the polyanionic siRNA macromolecules to cross the cell membrane remains as the bottleneck of possible clinical applications. With the cell p...

journal_title：Theranostics

authors： Ye J,Liu E,Gong J,Wang J,Huang Y,He H,Yang VC

更新日期：2017-06-25 00:00:00

abstract：:Background: Metastasis is the major reason for high recurrence rates and poor survival among patients with colorectal cancer (CRC). However, the underlying molecular mechanism of CRC metastasis is unclear. This study aimed to investigate the role of forkhead box K2 (FOXK2), one of the most markedly increased FOX genes...

journal_title：Theranostics

authors： Du F,Qiao C,Li X,Chen Z,Liu H,Wu S,Hu S,Qiu Z,Qian M,Tian D,Wu K,Fan D,Nie Y,Xia L

更新日期：2019-05-31 00:00:00

abstract：:Systemic infusion of bone marrow-derived mesenchymal stem cells (BMSCs) has become a promising strategy for disease treatment and tissue regeneration. Strategies to enhance the efficiency of BMSC cell therapy are crucial to promote its clinical application. Here, we aimed to improve BMSC cell therapy by inhibiting the...

journal_title：Theranostics

authors： Liao L,Shi B,Chang H,Su X,Zhang L,Bi C,Shuai Y,Du X,Deng Z,Jin Y

更新日期：2017-01-01 00:00:00

abstract：:The application of blood plasma for soft tissue wound healing is receiving much more attention recently. Exosomes are critical paracrine mediators that can be obtained from biological fluids including plasma and be able to induce regenerative effects by transferring bioactive molecules such as microRNAs (miRNAs). This...

journal_title：Theranostics

authors： Hu Y,Rao SS,Wang ZX,Cao J,Tan YJ,Luo J,Li HM,Zhang WS,Chen CY,Xie H

更新日期：2018-01-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an emerging theranostic modality for various cancers and diseases. The focus of this study was the development of tumor-targeting albumin nanoparticles containing photosensitizers for efficient PDT. To produce tumor-targeting albumin nanoparticles, the hydrophobic photosensitizer, chlorin...

journal_title：Theranostics

authors： Jeong H,Huh M,Lee SJ,Koo H,Kwon IC,Jeong SY,Kim K

更新日期：2011-04-06 00:00:00

abstract：:This paper reports a sensitive method with electrochemical technique to detect various proteases, which can be used for the diagnosis of prostate cancer. For the proposed assay method, the working electrode is modified with the peptide probes for the target proteases. These probes contain the substrate sequence of tar...

journal_title：Theranostics

authors： Li H,Huang Y,Zhang B,Yang D,Zhu X,Li G

更新日期：2014-04-25 00:00:00

abstract：:Constructing nanosystems that synergistically combine therapeutic and diagnostic features is of great interest to the nanomedicine community but also remains a tremendous challenge. Methods: In this work, we report novel catalytic nanoparticles composed of the enzyme catalase, encapsulated in a polymer shell and surfa...

journal_title：Theranostics

authors： Zhu J,Li Z,Zhang C,Lin L,Cao S,Che H,Shi X,Wang H,van Hest JCM

更新日期：2019-10-17 00:00:00

abstract：:The most frequent malignancy of the pancreas is the pancreatic ductal adenocarcinoma (PDAC). Despite many efforts PDAC has still a dismal prognosis. Biomarkers for early disease stage diagnosis as a prerequisite for a potentially curative treatment are still missing. Novel blood-based markers may help to overcome this...

journal_title：Theranostics

authors： Berger AW,Schwerdel D,Reinacher-Schick A,Uhl W,Algül H,Friess H,Janssen KP,König A,Ghadimi M,Gallmeier E,Bartsch DK,Geissler M,Staib L,Tannapfel A,Kleger A,Beutel A,Schulte LA,Kornmann M,Ettrich TJ,Seufferlein T

更新日期：2019-02-12 00:00:00

abstract：:Inadequate diagnostic methods for prostate cancer lead to over- and undertreatment, and the inability to intraoperatively visualize positive margins may limit the success of surgical resection. Prostate cancer visualization could be improved by combining the complementary modalities of immuno-positron emission tomogra...

journal_title：Theranostics

authors： Tsai WK,Zettlitz KA,Tavaré R,Kobayashi N,Reiter RE,Wu AM

更新日期：2018-11-12 00:00:00

abstract：:Metastasis is the primary cause of death in patients with advanced cancer. Recently, a high-fat diet was shown to specifically promote the metastatic potential of specific cancer cells in a CD36-dependent manner. However, the molecular basis of the fatty acid (FA)-induced upregulation of CD36 has remained unclear. Met...

journal_title：Theranostics

authors： Jiang M,Wu N,Xu B,Chu Y,Li X,Su S,Chen D,Li W,Shi Y,Gao X,Zhang H,Zhang Z,Du W,Nie Y,Liang J,Fan D

更新日期：2019-07-09 00:00:00

abstract：:Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of soyasaponin II in acute liver failure and establish the...

journal_title：Theranostics

authors： Wang F,Gong S,Wang T,Li L,Luo H,Wang J,Huang C,Zhou H,Chen G,Liu Z,Zhang Q,Jiang Y,Chen P

更新日期：2020-02-03 00:00:00

abstract：:In the field of ischemic cerebral injury, precise characterization of neurovascular hemodynamic is required to select candidates for reperfusion treatments. It is thus admitted that advanced imaging-based approaches would be able to better diagnose and prognose those patients and would contribute to better clinical ca...

journal_title：Theranostics

authors： Hingot V,Brodin C,Lebrun F,Heiles B,Chagnot A,Yetim M,Gauberti M,Orset C,Tanter M,Couture O,Deffieux T,Vivien D

更新日期：2020-06-12 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.27882.]. ...

journal_title：Theranostics

authors： Qin C,Liu Q,Hu ZW,Zhou LQ,Shang K,Bosco DB,Wu LJ,Tian DS,Wang W

更新日期：2020-07-10 00:00:00

abstract：:Purpose: Systemic administration of free chemotherapeutic drugs leads to severe toxic effects, and physiological characteristics of solid tumors restrain the drugs from reaching the hypoxic regions. E. coli Nissle 1917 (EcN) has been known to penetrate the barrier and proliferate in the interface between the viable an...

journal_title：Theranostics

authors： Zhang Y,Ji W,He L,Chen Y,Ding X,Sun Y,Hu S,Yang H,Huang W,Zhang Y,Liu F,Xia L

更新日期：2018-02-12 00:00:00

abstract：:A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positi...

journal_title：Theranostics

authors： Hou FQ,Song LW,Yuan Q,Fang LL,Ge SX,Zhang J,Sheng JF,Xie DY,Shang J,Wu SH,Sun YT,Wei SF,Wang MR,Wan MB,Jia JD,Luo GH,Tang H,Li SC,Niu JQ,Zhou WD,Sun L,Xia NS,Wang GQ

更新日期：2015-01-01 00:00:00

abstract：:Autophagy is a dynamic and complicated catabolic process. Imaging autophagic flux can clearly advance knowledge of its pathophysiology significance. While the most common way autophagy is imaged relies on fluorescent protein-based probes, this method requires substantial genetic manipulation that severely restricts th...

journal_title：Theranostics

authors： Lei Y,Ren W,Wang CK,Tao RR,Xiang HJ,Feng LL,Gao YP,Jiang Q,Li X,Hu Y,Han F

更新日期：2019-08-01 00:00:00

abstract：:Peripheral arterial disease affects nearly 202 million individuals worldwide, sometimes leading to non-healing ulcers or limb amputations in severe cases. Genetically modified stem cells offer potential advantages for therapeutically inducing angiogenesis via augmented paracrine release mechanisms and tuned dynamic re...

journal_title：Theranostics

authors： Deveza L,Choi J,Lee J,Huang N,Cooke J,Yang F

更新日期：2016-05-23 00:00:00

abstract：:In advanced atherosclerotic plaques, defective efferocytosis of apoptotic foam cells and decreased cholesterol efflux contribute to lesion progression. In our previous study, we demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (SDT) could induce foam cells apoptosis via the mitochondrial-casp...

journal_title：Theranostics

authors： Wang H,Yang Y,Sun X,Tian F,Guo S,Wang W,Tian Z,Jin H,Zhang Z,Tian Y

更新日期：2018-09-29 00:00:00

abstract：:In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel netrin-1 interference therapy requires the assessment of netrin-1 expression prior to ...

journal_title：Theranostics

authors： Wischhusen J,Wilson KE,Delcros JG,Molina-Peña R,Gibert B,Jiang S,Ngo J,Goldschneider D,Mehlen P,Willmann JK,Padilla F

更新日期：2018-10-06 00:00:00

abstract：:Müller glia are specialized retinal cells with stem cell properties in fish and frogs but not in mammals. Current efforts to develop gene therapies to activate mammalian Müller glia for retinal repair will require safe and effective delivery strategies for recombinant adeno-associated viruses (AAVs), vectors of choice...

journal_title：Theranostics

authors： Touahri Y,Dixit R,Kofoed RH,Miloska K,Park E,Raeisossadati R,Markham-Coultes K,David LA,Rijal H,Zhao J,Lynch M,Hynynen K,Aubert I,Schuurmans C

更新日期：2020-02-10 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of several human cancers, including breast cancer (BC), as strong evidence has been found that miRNAs can act as oncogenes or tumor suppressor genes. This review presents the state of the art on the role of miRNAs in the diagnosis, progn...

journal_title：Theranostics

authors： Bertoli G,Cava C,Castiglioni I

更新日期：2015-07-13 00:00:00

abstract：:Heart diseases are one of the leading causes of death for humans in the world. Increasing evidence has shown that myocardial injury induced innate and adaptive immune responses upon early cellular damage but also during chronic phases post-injury. The immune cells can not only aggravate the injury but also play an ess...

journal_title：Theranostics

authors： Wang J,Duan Y,Sluijter JP,Xiao J

更新日期：2019-05-31 00:00:00

abstract：:Molecular subtyping of breast cancer is of considerable interest owing to its potential for personalized therapy and prognosis. However, current methodologies cannot be used for precise subtyping, thereby posing a challenge in clinical practice. The aim of the present study is to develop a cell-specific single-strande...

journal_title：Theranostics

authors： Liu M,Wang Z,Tan T,Chen Z,Mou X,Yu X,Deng Y,Lu G,He N

更新日期：2018-11-10 00:00:00