PIAS3-mediated feedback loops promote chronic colitis-associated malignant transformation.

abstract：:Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we d...

journal_title：Theranostics

authors： Bao K,Nasr KA,Hyun H,Lee JH,Gravier J,Gibbs SL,Choi HS

更新日期：2015-03-01 00:00:00

abstract：:Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro; thus, we hypothesize that this pathway can mitigate cardiomyocyte ...

journal_title：Theranostics

authors： Grisanti LA,Thomas TP,Carter RL,de Lucia C,Gao E,Koch WJ,Benovic JL,Tilley DG

更新日期：2018-09-09 00:00:00

abstract：:Rationale: Emerging evidence suggests that noncentrosomal microtubules play an essential role in intracellular transport, cell polarity and cell motility. Whether these noncentrosomal microtubules exist or function in cancer cells remains unclear. Methods: The expression and prognostic values of CAMSAP2 and its functi...

journal_title：Theranostics

authors： Li D,Ding X,Xie M,Huang Z,Han P,Tian D,Xia L

更新日期：2020-02-19 00:00:00

abstract：:Molecular subtyping of breast cancer is of considerable interest owing to its potential for personalized therapy and prognosis. However, current methodologies cannot be used for precise subtyping, thereby posing a challenge in clinical practice. The aim of the present study is to develop a cell-specific single-strande...

journal_title：Theranostics

authors： Liu M,Wang Z,Tan T,Chen Z,Mou X,Yu X,Deng Y,Lu G,He N

更新日期：2018-11-10 00:00:00

abstract：:To enhance effective drug accumulation in drug-resistant tumors, a site-specific drug-releasing polypeptide system (PEG-Phis/Pasp-DOX/CA4) was exploited in response to tumor extracellular and intracellular pH. This system could firstly release the embedded tumor vascular inhibitor (CA4) to transiently 'normalize' vasc...

journal_title：Theranostics

authors： Dong Y,Yang J,Liu H,Wang T,Tang S,Zhang J,Zhang X

更新日期：2015-04-28 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a transmembrane cell surface receptor that is frequently overexpressed and/or mutated in many cancers. Therapies targeting EGFR have poor outcomes due to the lack of reliable diagnostic tests to monitor EGFR. Current in vitro EGFR diagnostic methods are invasive, requiring bi...

journal_title：Theranostics

authors： Bernhard W,El-Sayed A,Barreto K,Gonzalez C,Fonge H,Geyer CR

更新日期：2019-01-30 00:00:00

abstract：:5-Fluorouracil (5-FU) combined with radiotherapy is a common treatment strategy to treat human cancers, but the underlying mechanisms of this combination treatment remain unclear. Here, we report that NAD+-dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due to 5-FU exposure rendering colorectal c...

journal_title：Theranostics

authors： Tang M,Lu X,Zhang C,Du C,Cao L,Hou T,Li Z,Tu B,Cao Z,Li Y,Chen Y,Jiang L,Wang H,Wang L,Liu B,Xu X,Luo J,Wang J,Gu J,Wang H,Zhu WG

更新日期：2017-03-22 00:00:00

abstract：:Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilize...

journal_title：Theranostics

authors： Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

更新日期：2021-01-01 00:00:00

abstract：:Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent thrombus organization limits direct blood contact with fibrin, the target of blood-based fibri...

journal_title：Theranostics

authors： Stein-Merlob AF,Kessinger CW,Erdem SS,Zelada H,Hilderbrand SA,Lin CP,Tearney GJ,Jaff MR,Reed GL,Henke PK,McCarthy JR,Jaffer FA

更新日期：2015-09-13 00:00:00

abstract：:Background: Circular RNAs (circRNAs) are a new class of non-coding RNAs (ncRNAs) that are derived from exons or introns by special selective shearing. circRNAs have been shown to play critical roles in various human cancers. However, their roles in renal cell carcinoma (RCC) and the underlying mechanisms remain largel...

journal_title：Theranostics

authors： Liu H,Hu G,Wang Z,Liu Q,Zhang J,Chen Y,Huang Y,Xue W,Xu Y,Zhai W

更新日期：2020-08-29 00:00:00

abstract：:Patients with cervical cancer (CCa) with lymph node metastasis (LNM) have an extremely poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide clinical therapeutic strategies for CCa. Upregulation of fatty acid-binding protein 5 (FABP5) expression in CCa tumours was demonstrated to positivel...

journal_title：Theranostics

authors： Zhang C,Liao Y,Liu P,Du Q,Liang Y,Ooi S,Qin S,He S,Yao S,Wang W

更新日期：2020-05-17 00:00:00

abstract：:Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic administration. Here...

journal_title：Theranostics

authors： Fan B,Kang L,Chen L,Sun P,Jin M,Wang Q,Bae YH,Huang W,Gao Z

更新日期：2017-01-01 00:00:00

abstract：:Rationale: Glioma stem-like cells (GSCs) contribute to temozolomide (TMZ) resistance in gliomas, although the mechanisms have not been delineated. Methods:In vitro functional experiments (colony formation assay, flow cytometric analysis, TUNEL assay) were used to assess the ability of extracellular vesicles (EVs) from...

journal_title：Theranostics

authors： Yin J,Ge X,Shi Z,Yu C,Lu C,Wei Y,Zeng A,Wang X,Yan W,Zhang J,You Y

更新日期：2021-01-01 00:00:00

abstract：:The combination of chemotherapy and RNA interference is a promising approach for efficient cancer therapy. However, the success of such a strategy is hampered by the lack of suitable vectors to coordinate small interfering RNA (siRNA) and chemotherapeutic drug into one single platform. We herein report a novel triple-...

journal_title：Theranostics

authors： Yu H,Guo C,Feng B,Liu J,Chen X,Wang D,Teng L,Li Y,Yin Q,Zhang Z,Li Y

更新日期：2016-01-01 00:00:00

abstract：:Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent for novel cancer treatment by using an NB-encapsulated hybrid nanosystem that can be monitored by US and fluorescent imaging and acti...

journal_title：Theranostics

authors： Huang WT,Chan MH,Chen X,Hsiao M,Liu RS

更新日期：2020-01-01 00:00:00

abstract：:Rationale: Busulfan is currently an indispensable anti-cancer drug, particularly for children, but the side effects on male reproduction are so serious that critical drug management is needed to minimize any negative impact. Meanwhile, alginate oligosaccharides (AOS) are natural products with many consequent advantage...

journal_title：Theranostics

authors： Zhao Y,Zhang P,Ge W,Feng Y,Li L,Sun Z,Zhang H,Shen W

更新日期：2020-02-10 00:00:00

abstract：:Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor 2 (Klf2) in ECs, ameliorates press...

journal_title：Theranostics

authors： Li H,Wang Y,Liu J,Chen X,Duan Y,Wang X,Shen Y,Kuang Y,Zhuang T,Tomlinson B,Chan P,Yu Z,Cheng Y,Zhang L,Liu Z,Zhang Y,Zhao Z,Zhang Q,Liu J

更新日期：2021-01-01 00:00:00

abstract：:Using non-covalent interactions between nucleic acids (DNA, siRNA, miRNA, and mRNA) with peptides or nucleopeptides is a promising strategy to construct supramolecular assemblies for gene delivery and therapy. Comparing to conventional strategies for gene delivery, the assemblies of peptides or nucleopeptides provide ...

journal_title：Theranostics

authors： Wang H,Feng Z,Xu B

更新日期：2019-05-18 00:00:00

abstract：:Rationale: Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor alpha (ER-α), human epidermal growth factor receptor 2 (HER2) and progesterone receptor (PR) expression, but the effect of lacking the three factors on TNBC is unclear. Whether loss of the three factors contributes to ...

journal_title：Theranostics

authors： Zhao Z,Li L,Du P,Ma L,Zhang W,Zheng L,Lan B,Zhang B,Ma F,Xu B,Zhan Q,Song Y

更新日期：2019-02-20 00:00:00

abstract：:In pancreatic cancer (PDAC) intratumor infiltration of polymorphonuclear neutrophils (PMN) is associated with histologically apparent alterations of the tumor growth pattern. The aim of this study was to examine possible associations between PMN infiltration, tumor microarchitecture, and water diffusivity in diffusion...

journal_title：Theranostics

authors： Mayer P,Dinkic C,Jesenofsky R,Klauss M,Schirmacher P,Dapunt U,Hackert T,Uhle F,Hänsch GM,Gaida MM

更新日期：2018-01-01 00:00:00

abstract：:Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been a popular strategy...

journal_title：Theranostics

authors： Johnsen KB,Bak M,Kempen PJ,Melander F,Burkhart A,Thomsen MS,Nielsen MS,Moos T,Andresen TL

更新日期：2018-05-24 00:00:00

abstract：:Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against "self" antigens (Ags). In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust activation of T-cells against tumor Ags pr...

journal_title：Theranostics

authors： Kwon S,Velasquez FC,Rasmussen JC,Greives MR,Turner KD,Morrow JR,Hwu WJ,Ross RF,Zhang S,Sevick-Muraca EM

更新日期：2019-10-22 00:00:00

abstract：:Autophagy is a dynamic and complicated catabolic process. Imaging autophagic flux can clearly advance knowledge of its pathophysiology significance. While the most common way autophagy is imaged relies on fluorescent protein-based probes, this method requires substantial genetic manipulation that severely restricts th...

journal_title：Theranostics

authors： Lei Y,Ren W,Wang CK,Tao RR,Xiang HJ,Feng LL,Gao YP,Jiang Q,Li X,Hu Y,Han F

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared 68Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) for diagnosis and tumour delineation in patients with primary PCa based on slice by slice correlation ...

journal_title：Theranostics

authors： Zamboglou C,Drendel V,Jilg CA,Rischke HC,Beck TI,Schultze-Seemann W,Krauss T,Mix M,Schiller F,Wetterauer U,Werner M,Langer M,Bock M,Meyer PT,Grosu AL

更新日期：2017-01-01 00:00:00

abstract：:Cell-derived microparticles (MPs) are nano-sized vesicles released by activated cells in the extracellular milieu. They act as vectors of biological activity by carrying membrane-anchored and cytoplasmic constituents of the parental cells. Although detection and characterization of cell-derived MPs may be of high diag...

journal_title：Theranostics

authors： Briens A,Gauberti M,Parcq J,Montaner J,Vivien D,Martinez de Lizarrondo S

更新日期：2016-03-02 00:00:00

abstract：:Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could a...

journal_title：Theranostics

authors： Ai XY,Liu HJ,Lu C,Liang CL,Sun Y,Chen S,Sun B,Li Y,Liu YR,Zhang Q,Liu XQ,Xiao T,Jing XS,Sun T,Zhou HG,Yang C

更新日期：2017-01-05 00:00:00

abstract：:In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bon...

journal_title：Theranostics

authors： Peng Y,Wu S,Li Y,Crane JL

更新日期：2020-01-01 00:00:00

abstract：:Due to their tunable surface plasmon and photothermal effects, gold nanorods (AuNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery. All these applications can be remotely controlled by near infrared (NIR) light which can penetrate deep in...

journal_title：Theranostics

authors： Zhang Z,Wang J,Chen C

更新日期：2013-01-01 00:00:00

abstract：:The ability of brain tissue to regenerate is limited; therefore, brain diseases (i.e., trauma, stroke, tumors) often lead to irreversible motor and cognitive impairments. Therapeutic interventions using various types of injectable biomaterials have been investigated to promote endogenous neural differentiation. Despit...

journal_title：Theranostics

authors： Park GK,Kim SH,Kim K,Das P,Kim BG,Kashiwagi S,Choi HS,Hwang NS

更新日期：2019-05-31 00:00:00

abstract：:Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of soyasaponin II in acute liver failure and establish the...

journal_title：Theranostics

authors： Wang F,Gong S,Wang T,Li L,Luo H,Wang J,Huang C,Zhou H,Chen G,Liu Z,Zhang Q,Jiang Y,Chen P

更新日期：2020-02-03 00:00:00