Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer.

abstract：:[This retracts the article DOI: 10.7150/thno.14306.]. ...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2020-09-30 00:00:00

abstract：:This paper reports a sensitive method with electrochemical technique to detect various proteases, which can be used for the diagnosis of prostate cancer. For the proposed assay method, the working electrode is modified with the peptide probes for the target proteases. These probes contain the substrate sequence of tar...

journal_title：Theranostics

authors： Li H,Huang Y,Zhang B,Yang D,Zhu X,Li G

更新日期：2014-04-25 00:00:00

abstract：:The delivery of therapeutics into tumors remains a challenge in nanoparticle-mediated drug delivery. However, effective therapies such as photothermal therapy (PTT) are limited by quick systemic clearance and non-specific biodistribution. Anti-tumor strategies tailored to accommodate both tumor accumulation/retention ...

journal_title：Theranostics

authors： Cherukula K,Uthaman S,Park IK

更新日期：2019-04-13 00:00:00

abstract：:Objective: Vascular smooth muscle cells (VSMCs) undergo the phenotypic changes from contractile to synthetic state during vascular remodeling after ischemia. SIRT1 protects against stress-induced vascular remodeling via maintaining VSMC differentiated phenotype. However, the effect of smooth muscle SIRT1 on the functi...

journal_title：Theranostics

authors： Dou YQ,Kong P,Li CL,Sun HX,Li WW,Yu Y,Nie L,Zhao LL,Miao SB,Li XK,Dong C,Zhang JW,Liu Y,Huo XX,Chi K,Gao X,Zhang N,Weng L,Yang H,Zhang F,Han M

更新日期：2020-01-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent in Asia. The survival rate of OSCC patients has not improved over the past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes. Improvement in therapeutic st...

journal_title：Theranostics

authors： Su SC,Lin CW,Liu YF,Fan WL,Chen MK,Yu CP,Yang WE,Su CW,Chuang CY,Li WH,Chung WH,Yang SF

更新日期：2017-02-26 00:00:00

abstract：:Peripheral arterial disease affects nearly 202 million individuals worldwide, sometimes leading to non-healing ulcers or limb amputations in severe cases. Genetically modified stem cells offer potential advantages for therapeutically inducing angiogenesis via augmented paracrine release mechanisms and tuned dynamic re...

journal_title：Theranostics

authors： Deveza L,Choi J,Lee J,Huang N,Cooke J,Yang F

更新日期：2016-05-23 00:00:00

abstract：:Dynamic positron emission tomography (PET) can monitor spatiotemporal distribution of radiotracer in vivo. The spatiotemporal information can be used to estimate parametric images of radiotracer kinetics that are of physiological and biochemical interests. Direct estimation of parametric images from raw projection dat...

journal_title：Theranostics

authors： Wang G,Qi J

更新日期：2013-11-20 00:00:00

abstract：:Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine. Nerve autograft is the gold standard for clinical PNI repair. Due to its significant drawbacks, artificial nerve guidance conduits (NGCs) have drawn much attention as replacement therapies. We developed a combinatorial NGC consist...

journal_title：Theranostics

authors： Zheng C,Yang Z,Chen S,Zhang F,Rao Z,Zhao C,Quan D,Bai Y,Shen J

更新日期：2021-01-01 00:00:00

abstract：:Rationale: Basal-like breast cancer (BLBC) is associated with high grade, distant metastasis, and poor prognosis; however, the mechanism underlying aggressiveness of BLBC is still unclear. Emerging evidence has suggested that phospholipid scramblase 1 (PLSCR1) is involved in tumor progression. Here, we aimed to study ...

journal_title：Theranostics

authors： Huang P,Liao R,Chen X,Wu X,Li X,Wang Y,Cao Q,Dong C

更新日期：2020-03-25 00:00:00

abstract：:Exosomes (Exo) secreted from hypoxia-conditioned bone marrow mesenchymal stem cells (BM-MSCs) were found to be protective for ischemic disease. However, the role of exosomal miRNA in the protective effect of hypoxia-conditioned BM-MSCs-derived Exo (Hypo-Exo) remains largely uncharacterized and the poor specificity of ...

journal_title：Theranostics

authors： Zhu LP,Tian T,Wang JY,He JN,Chen T,Pan M,Xu L,Zhang HX,Qiu XT,Li CC,Wang KK,Shen H,Zhang GG,Bai YP

更新日期：2018-11-29 00:00:00

abstract：:Marfan syndrome (MFS) is a rare genetic disease characterized by a matrix metalloproteases (MMPs) dysregulation that leads to extracellular matrix degradation. Consequently, MFS patients are prone to develop progressive thoracic aortic enlargement and detrimental aneurysm. Since MMPs are activated by the extracellular...

journal_title：Theranostics

authors： Rurali E,Perrucci GL,Gaetano R,Pini A,Moschetta D,Gentilini D,Nigro P,Pompilio G

更新日期：2019-04-12 00:00:00

abstract：:Hair regenerative medicine, a promising strategy for the treatment of hair loss, will likely involve the transplantation of autologous hair follicular stem cells (HFSCs) and dermal papilla cells (DPCs) into regions of hair loss. Cyclic hair regeneration results from the periodic partial activation of HFSCs. However, p...

journal_title：Theranostics

authors： Chen P,Miao Y,Zhang F,Huang J,Chen Y,Fan Z,Yang L,Wang J,Hu Z

更新日期：2020-09-22 00:00:00

abstract：:Transcription factor FOXM1 is involved in stimulating cell proliferation, enhancing DNA damage repair, promoting metastasis of cancer cells, and the inhibition of FOXM1 has been shown to prevent the initiation and progression of multiple cancers and FOXM1 is considered to be an effective target for tumor therapeutic d...

journal_title：Theranostics

authors： Zhang Z,Bu H,Yu J,Chen Y,Pei C,Yu L,Huang X,Tan G,Tan Y

更新日期：2019-04-25 00:00:00

abstract：:Rationale: The evaluation of early treatment response is critical for patient prognosis and treatment planning. When the current methods rely on invasive protocols that evaluate the expression of DNA damage markers on patient biopsy samples, we aim to evaluate a non-invasive PET imaging approach to monitor the early e...

journal_title：Theranostics

authors： Poty S,Mandleywala K,O'Neill E,Knight JC,Cornelissen B,Lewis JS

更新日期：2020-04-27 00:00:00

abstract：:Cell-based immunotherapy for the treatment of hematologic malignancies, such as leukemia and lymphoma, has seen much success and played an increasingly important role in clinical studies. Nevertheless, the efficacy of immunotherapy in solid tumors still needs improvements due to the immunosuppressive properties of tum...

journal_title：Theranostics

authors： Qian X,Shi Z,Qi H,Zhao M,Huang K,Han D,Zhou J,Liu C,Liu Y,Lu Y,Yuan X,Zhao J,Kang C

更新日期：2019-10-14 00:00:00

abstract：:Rationale: Chronic ethanol consumption as a public health problem worldwide boosts the development of chronic liver diseases in hepatitis B virus (HBV)-infected patients. Arachidonic acid metabolite prostaglandin E2 (PGE2) activates regulatory T cells (Tregs) function. Here, we aim to investigate the underlying mechan...

journal_title：Theranostics

authors： Liu Z,Wang J,Liu L,Yuan H,Bu Y,Feng J,Liu Y,Yang G,Zhao M,Yuan Y,Zhang H,Yun H,Zhang X

更新日期：2020-07-23 00:00:00

abstract：:Smart drug delivery system with strategic drug distribution is the future state-of-the-art treatment for any malignancy. To investigate therapeutic potential of such nanoparticle mediated delivery system, we examined the efficacy of dual drug-loaded, pH and thermo liable lipid coated mesoporous iron oxide-based magnet...

journal_title：Theranostics

authors： Pradhan L,Thakur B,Srivastava R,Ray P,Bahadur D

更新日期：2016-06-18 00:00:00

abstract：:Extracellular vesicles (EVs), including exosomes and microvesicles, derived from bone marrow stromal cells (BMSCs) have been demonstrated as key factors in the progression and drug resistance of multiple myeloma (MM). EV uptake involves a variety of mechanisms which largely depend on the vesicle origin and recipient c...

journal_title：Theranostics

authors： Tu C,Du Z,Zhang H,Feng Y,Qi Y,Zheng Y,Liu J,Wang J

更新日期：2021-01-01 00:00:00

abstract：:Rationale: Saliva as a sample matrix is rapidly gaining interest for disease diagnosis and point-of-care assays because it is easy to collect (non-invasive) and contains many health-related biomarkers. However, saliva poses particular problems relative to more common urine and blood matrices, which includes low analyt...

journal_title：Theranostics

authors： Noiphung J,Nguyen MP,Punyadeera C,Wan Y,Laiwattanapaisal W,Henry CS

更新日期：2018-06-13 00:00:00

abstract：:Non-invasive PET imaging of CXCR4 expression in cancer and inflammation as well as CXCR4-targeted radioligand therapy (RLT) have recently found their way into clinical research by the development of the theranostic agents [68Ga]PentixaFor (cyclo(D-Tyr1-D-[NMe]Orn2(AMBS-[68Ga]DOTA)-Arg3-Nal4-Gly5) = [68Ga]DOTA-AMBS-CPC...

journal_title：Theranostics

authors： Osl T,Schmidt A,Schwaiger M,Schottelius M,Wester HJ

更新日期：2020-07-09 00:00:00

abstract：:Gold nanoparticles (AuNPs) have been reported to promote osteogenic differentiation of mesenchymal stem cells and osteoblasts, but little is known about their effects on human periodontal ligament progenitor cells (PDLPs). In this study, we evaluated the effects of AuNPs with various diameters (5, 13 and 45 nm) on the...

journal_title：Theranostics

authors： Zhang Y,Kong N,Zhang Y,Yang W,Yan F

更新日期：2017-03-06 00:00:00

abstract：:Purpose: Cancer immunotherapy depends on a systemic immune response, but the basic underlying mechanisms are still largely unknown. Despite the very successful and widespread use of checkpoint inhibitors in the clinic, the majority of cancer patients do not benefit from this type of treatment. In this translational st...

journal_title：Theranostics

authors： Schwenck J,Schörg B,Fiz F,Sonanini D,Forschner A,Eigentler T,Weide B,Martella M,Gonzalez-Menendez I,Campi C,Sambuceti G,Seith F,Quintanilla-Martinez L,Garbe C,Pfannenberg C,Röcken M,la Fougere C,Pichler BJ,Kneilling M

更新日期：2020-01-01 00:00:00

abstract：:Uncontrollable cell proliferation and irreversible neurological damage make glioma one of the most deadly diseases in clinic. Besides the multiple biological barriers, glioma stem cells (GSCs) that are responsible for the maintenance and recurrence of tumor tissues also hinder the therapeutic efficacy of chemotherapy....

journal_title：Theranostics

authors： Ran D,Zhou J,Chai Z,Li J,Xie C,Mao J,Lu L,Zhang Y,Wu S,Zhan C,Lu W

更新日期：2020-03-04 00:00:00

abstract：:Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, unders...

journal_title：Theranostics

authors： De Sarno F,Ponsiglione AM,Russo M,Grimaldi AM,Forte E,Netti PA,Torino E

更新日期：2019-02-28 00:00:00

abstract：:Aplastic anemia (AA) is characterized as hypoplasia of bone marrow hematopoietic cells and hematopenia of peripheral blood cells. Though the supplement of exogenous erythropoietin (EPO) has been clinically approved for AA treatment, the side-effects hinder its further application. Here a robust treatment for AA induce...

journal_title：Theranostics

authors： Jia W,Zhen M,Li L,Zhou C,Sun Z,Liu S,Zhao Z,Li J,Wang C,Bai C

更新日期：2020-05-23 00:00:00

abstract：:Rationale: Among the biothiols-related diseases, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and can result in severe oxidative stress and damage to multiple organs. In this study, we aimed to develop a fluorescence chemosensor that can both detect GSH an...

journal_title：Theranostics

authors： Li J,Kwon Y,Chung KS,Lim CS,Lee D,Yue Y,Yoon J,Kim G,Nam SJ,Chung YW,Kim HM,Yin C,Ryu JH,Yoon J

更新日期：2018-02-03 00:00:00

abstract：PURPOSE:The efficacy of pro-angiogenic therapy is difficult to evaluate with current diagnostic modalities. The objectives were to develop a non-invasive imaging strategy to define the temporal characteristics of angiogenesis and to evaluate the response to pro-angiogenic therapy in diabetic stroke mouse models. METHO...

journal_title：Theranostics

authors： Bai YY,Gao X,Wang YC,Peng XG,Chang D,Zheng S,Li C,Ju S

更新日期：2014-05-25 00:00:00

abstract：:Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during...

journal_title：Theranostics

authors： Liu Z,Wang F,Chen X

更新日期：2011-03-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of several human cancers, including breast cancer (BC), as strong evidence has been found that miRNAs can act as oncogenes or tumor suppressor genes. This review presents the state of the art on the role of miRNAs in the diagnosis, progn...

journal_title：Theranostics

authors： Bertoli G,Cava C,Castiglioni I

更新日期：2015-07-13 00:00:00

abstract：:Background: Circular RNAs (circRNAs) are a new class of non-coding RNAs (ncRNAs) that are derived from exons or introns by special selective shearing. circRNAs have been shown to play critical roles in various human cancers. However, their roles in renal cell carcinoma (RCC) and the underlying mechanisms remain largel...

journal_title：Theranostics

authors： Liu H,Hu G,Wang Z,Liu Q,Zhang J,Chen Y,Huang Y,Xue W,Xu Y,Zhai W

更新日期：2020-08-29 00:00:00