Abstract:
:Rationale: Among the biothiols-related diseases, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and can result in severe oxidative stress and damage to multiple organs. In this study, we aimed to develop a fluorescence chemosensor that can both detect GSH and further predict sepsis. Methods: In this study, two new naphthalene dialdehyde compounds containing different functional groups were synthesized, and the sensing abilities of these compounds towards biothiols and its applications for prediction of sepsis were investigated. Results: Our study revealed that the newly developed probe 6-methoxynaphthalene-2, 3-dicarbaldehyde (MNDA) has two-photon is capable of detecting GSH in live cells with two-photon microscopy (TPM) under the excitation at a wavelength of 900 nm. Furthermore, two GSH detection probes naphthalene-2,3-dicarboxaldehyde (NDA) and 6-fluoronaphthalene-2,3-dicarbaldehyde (FNDA) not only can detect GSH in living cells, but also showed clinical significance for the diagnosis and prediction of mortality in patients with sepsis. Conclusions: These results open up a promising direction for further medical diagnostic techniques.
journal_name
Theranosticsjournal_title
Theranosticsauthors
Li J,Kwon Y,Chung KS,Lim CS,Lee D,Yue Y,Yoon J,Kim G,Nam SJ,Chung YW,Kim HM,Yin C,Ryu JH,Yoon Jdoi
10.7150/thno.22252subject
Has Abstractpub_date
2018-02-03 00:00:00pages
1411-1420issue
5issn
1838-7640pii
thnov08p1411journal_volume
8pub_type
杂志文章相关文献
Theranostics文献大全abstract::Targeted therapy and immunotherapy have become mainstream in cancer treatment. However, only patient subsets benefit from these expensive therapies, and often responses are short-lived or coincide with side effects. A growing modality in precision oncology is the development of theranostics, as this enables patient se...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.34941
更新日期:2019-10-15 00:00:00
abstract::Angiogenesis enhances cancer metastasis and progression, however, the roles of transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc-finger transcription factor. Here, we demonstrate a new mechanism of Kras mutation-driven ZNF322A transcriptional activation and elucidate the inte...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.47491
更新日期:2020-08-08 00:00:00
abstract::Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17573
更新日期:2017-04-10 00:00:00
abstract::This article aims at alerting scientists working with nanoparticles or microparticles about the specific adverse reactions due to the intravascular pulmonary macrophages present in pigs and other cloven-hoof animals, but not in humans. The history of a 25-year old study of an ultrasound contrast agent is used to illus...
journal_title:Theranostics
pub_type: 评论,杂志文章
doi:10.7150/thno.22420
更新日期:2017-10-23 00:00:00
abstract::Overexpression of CD146 has been correlated with aggressiveness, recurrence rate, and poor overall survival in hepatocellular carcinoma (HCC) patients. In this study, we set out to develop a CD146-targeting probe for high-contrast noninvasive in vivo positron emission tomography (PET) and near-infrared fluorescence (N...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.15568
更新日期:2016-08-08 00:00:00
abstract::Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.15081
更新日期:2016-06-05 00:00:00
abstract::Rationale: Colitis-associated colorectal cancer (CAC) usually exhibits an accelerated disease progression, an increased resistance to therapeutic drugs and a higher mortality rate than sporadic colorectal cancer (CRC). PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family; however, little is known...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.23046
更新日期:2018-04-30 00:00:00
abstract::Despite significant advances in cancer diagnostics and treatment, ovarian cancers (OC) continue to kill more than 150,000 women every year worldwide. Due to the relatively asymptomatic nature and the advanced stage of the disease at the time of diagnosis, OC is the most lethal gynecologic malignancy. The current treat...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.26345
更新日期:2018-07-30 00:00:00
abstract::[This retracts the article DOI: 10.7150/thno.14306.]. ...
journal_title:Theranostics
pub_type: 撤回出版物
doi:10.7150/thno.52610
更新日期:2020-09-30 00:00:00
abstract::In this study, we investigated the induction of apoptosis by ultrasound in the presence of the novel porphyrin derivative DCPH-P-Na(I). HL-60 cells were exposed to ultrasound for up to 3 min in the presence and absence of DCPH-P-Na(I), and the induction of apoptosis was examined by analyzing cell morphology, DNA fragm...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.3899
更新日期:2012-01-01 00:00:00
abstract::Rationale: Subjects unable to sustain β-cell compensation develop type 2 diabetes. Early growth response-1 protein (EGR-1), implicated in the regulation of cell differentiation, proliferation, and apoptosis, is induced by diverse metabolic challenges, such as glucose or other nutrients. Therefore, we hypothesized that...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.40664
更新日期:2020-03-04 00:00:00
abstract::Rationale: Tumor vascular normalization (TVN) is emerging to enhance the efficacy of anticancer treatment in many cancers including glioblastoma (GBM). However, a common and severe challenge being currently faced is the transient TVN effect, hampering the sustained administration of anticancer therapy during TVN windo...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44427
更新日期:2020-06-05 00:00:00
abstract::Iron oxide nanoparticles are a useful diagnostic contrast agent and have great potential for therapeutic applications. Multiple emerging diagnostic and therapeutic applications and the numerous versatile parameters of the nanoparticle platform require a robust biological model for characterization and assessment. Here...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.3568
更新日期:2012-01-01 00:00:00
abstract::Emerging evidence indicates that reprogramming of energy metabolism involving disturbances in energy production from a defect in cellular respiration with a shift to glycolysis is a core hallmark of cancer. Alterations in cancer cell energy metabolism are linked to abnormalities in mitochondrial function. Mitochondria...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33100
更新日期:2019-05-26 00:00:00
abstract::Norepinephrine modulates cognitive processes such as working and episodic memory. Pathological changes in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the whole norepinephrine system, disrupting cognitive processes. Monitor...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.29740
更新日期:2019-01-01 00:00:00
abstract::Rationale: Chronic ethanol consumption as a public health problem worldwide boosts the development of chronic liver diseases in hepatitis B virus (HBV)-infected patients. Arachidonic acid metabolite prostaglandin E2 (PGE2) activates regulatory T cells (Tregs) function. Here, we aim to investigate the underlying mechan...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.46005
更新日期:2020-07-23 00:00:00
abstract::Up to one-third of diffuse large B cell lymphoma (DLBCL) patients eventually develop resistance to R-CHOP regimen, while the remaining therapeutic options are limited. Thus, understanding the underlying mechanisms and developing therapeutic approaches are urgently needed. Methods: We generated two germinal center B ce...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41362
更新日期:2020-02-10 00:00:00
abstract::Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the im...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.20578
更新日期:2017-08-15 00:00:00
abstract::Müller glia are specialized retinal cells with stem cell properties in fish and frogs but not in mammals. Current efforts to develop gene therapies to activate mammalian Müller glia for retinal repair will require safe and effective delivery strategies for recombinant adeno-associated viruses (AAVs), vectors of choice...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42611
更新日期:2020-02-10 00:00:00
abstract::Due to their tunable surface plasmon and photothermal effects, gold nanorods (AuNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery. All these applications can be remotely controlled by near infrared (NIR) light which can penetrate deep in...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.5409
更新日期:2013-01-01 00:00:00
abstract::Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute myeloid leukemia (AML). The uridine-cytidine kinase 1 (UCK1) has an established role in activating 5'-AZA and its protein level is significantly downregulated in patients resistant to the drug. H...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36503
更新日期:2020-01-01 00:00:00
abstract::The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat an...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.11802
更新日期:2015-05-20 00:00:00
abstract::Liquid biopsy of tumor through isolation of circulating tumor cells (CTCs) allows non-invasive, repetitive, and systemic sampling of disease. Although detecting and enumerating CTCs is of prognostic significance in metastatic cancer, it is conceivable that performing molecular and functional characterization on CTCs w...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.15359
更新日期:2016-06-15 00:00:00
abstract::Rationale: Saliva as a sample matrix is rapidly gaining interest for disease diagnosis and point-of-care assays because it is easy to collect (non-invasive) and contains many health-related biomarkers. However, saliva poses particular problems relative to more common urine and blood matrices, which includes low analyt...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.24941
更新日期:2018-06-13 00:00:00
abstract::Many drug controlled release methods have been integrated in multifunctional nanoparticles, such as pH-, redox-, temperature-, enzyme-, and light-responsive release. However, few report is associated with the ROS responsive drug controlled release. Herein, a thioketal linker-based ROS responsive drug (camptothecin con...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.14101
更新日期:2016-02-05 00:00:00
abstract::The relatively new field of nanotheranostics combines the advantages of in vivo diagnosis with the ability to administer treatment through a single nano-sized carrier, offering new opportunities for cancer diagnosis and therapy. Nanotheranostics has facilitated the development of nanomedicine through direct visualizat...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.4381
更新日期:2012-01-01 00:00:00
abstract::Immunity is the most critical and well-regulated protection to the body. Immunity is implicated in a wide range of diseases and serves as the foundation for immunotherapy. Immunotheranostics is the idea of improving immunotherapy through the organic integration of therapeutic, diagnostic, and screening technologies. T...
journal_title:Theranostics
pub_type: 社论
doi:10.7150/thno.48966
更新日期:2020-06-11 00:00:00
abstract::This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using 225Ac and its theranostic pair, 111In. We call our novel tumor-targeting DOTA-hapten PRIT system "proteus-DOTA" or "Pr." Herein we report the first results of radiochemistry development, radiopharmacology, and stoichiometry of tumor ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.48810
更新日期:2020-09-14 00:00:00
abstract::Fast clearance, metabolism and systemic toxicity are major limits for the clinical use of anti-cancer drugs. Histone deacetylase inhibitors (HDACi) present these defects despite displaying promising anti-tumor properties on tumor cells in vitro and in in vivo model of cancers. Specific delivery of anti-cancer drugs in...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.13725
更新日期:2016-03-25 00:00:00
abstract::During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells chemotaxis being accompanied by activation of diverse intercellular s...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.45219
更新日期:2020-05-15 00:00:00