Assessing Therapeutic Potential of Magnetic Mesoporous Nanoassemblies for Chemo-Resistant Tumors.

abstract：:Uncontrollable cell proliferation and irreversible neurological damage make glioma one of the most deadly diseases in clinic. Besides the multiple biological barriers, glioma stem cells (GSCs) that are responsible for the maintenance and recurrence of tumor tissues also hinder the therapeutic efficacy of chemotherapy....

journal_title：Theranostics

authors： Ran D,Zhou J,Chai Z,Li J,Xie C,Mao J,Lu L,Zhang Y,Wu S,Zhan C,Lu W

更新日期：2020-03-04 00:00:00

abstract：:During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells chemotaxis being accompanied by activation of diverse intercellular s...

journal_title：Theranostics

authors： Jin J,Zhao Q

更新日期：2020-05-15 00:00:00

abstract：:CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface protein that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2. Its potential as a cancer target is supported by studies showing that anti-CDCP1 antibodies inhibit cell migration and survival in vitro, and tumor g...

journal_title：Theranostics

authors： Harrington BS,He Y,Khan T,Puttick S,Conroy PJ,Kryza T,Cuda T,Sokolowski KA,Tse BW,Robbins KK,Arachchige BJ,Stehbens SJ,Pollock PM,Reed S,Weroha SJ,Haluska P,Salomon C,Lourie R,Perrin LC,Law RHP,Whisstock JC,Hoop

更新日期：2020-01-12 00:00:00

abstract：:Rationale: Tumor metastasis is the main cause for cancer-related death. However, the driving molecules of metastasis remain largely unknown. Here, we aim to identify long non-coding RNAs (lncRNAs) critical for human hepatocellular carcinoma (HCC) metastasis. Methods: Microarrays were used to screen a comprehensive set...

journal_title：Theranostics

authors： Kang CL,Qi B,Cai QQ,Fu LS,Yang Y,Tang C,Zhu P,Chen QW,Pan J,Chen MH,Wu XZ

更新日期：2019-06-09 00:00:00

abstract：:Background: Accumulating evidences indicate that nanomedicines greatly decrease the side effects and enhance the efficacy of colorectal cancer (CRC) treatment. In particular, the use of rectal delivery of nanomedicines, with advantages such as fast therapeutic effects and a diminishing hepatic first-pass effect, is cu...

journal_title：Theranostics

authors： Zhao R,Du S,Liu Y,Lv C,Song Y,Chen X,Zhang B,Li D,Gao S,Cui W,Plikus MV,Hou X,Wu K,Liu Z,Liu Z,Cong Y,Li Y,Yu Z

更新日期：2020-02-18 00:00:00

abstract：:Constructing nanosystems that synergistically combine therapeutic and diagnostic features is of great interest to the nanomedicine community but also remains a tremendous challenge. Methods: In this work, we report novel catalytic nanoparticles composed of the enzyme catalase, encapsulated in a polymer shell and surfa...

journal_title：Theranostics

authors： Zhu J,Li Z,Zhang C,Lin L,Cao S,Che H,Shi X,Wang H,van Hest JCM

更新日期：2019-10-17 00:00:00

abstract：:With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO2 core-shell nanoparticles, which showed that they could selectivel...

journal_title：Theranostics

authors： Zheng T,Wang W,Wu F,Zhang M,Shen J,Sun Y

更新日期：2019-07-09 00:00:00

abstract：:Rationale: Tumor microenvironment interacts with tumor cells to regulate their stemness properties through various cytokines and cytokine receptors. Previous studies revealed the possible role of interleukin 20 receptor subunit alpha (IL20RA) signaling in the progression of several types of tumors. However, its regula...

journal_title：Theranostics

authors： Gao W,Wen H,Liang L,Dong X,Du R,Zhou W,Zhang X,Zhang C,Xiang R,Li N

更新日期：2021-01-01 00:00:00

abstract：:Developing ultrasensitive contrast agents for the early detection of malignant tumors in liver is highly demanded. Constructing hepatic tumors specific targeting probes could provide more sensitive imaging information but still faces great challenges. Here we report a novel approach for the synthesis of ultra-small Fe...

journal_title：Theranostics

authors： Jia Z,Song L,Zang F,Song J,Zhang W,Yan C,Xie J,Ma Z,Ma M,Teng G,Gu N,Zhang Y

更新日期：2016-07-15 00:00:00

abstract：:Transcription factor FOXM1 is involved in stimulating cell proliferation, enhancing DNA damage repair, promoting metastasis of cancer cells, and the inhibition of FOXM1 has been shown to prevent the initiation and progression of multiple cancers and FOXM1 is considered to be an effective target for tumor therapeutic d...

journal_title：Theranostics

authors： Zhang Z,Bu H,Yu J,Chen Y,Pei C,Yu L,Huang X,Tan G,Tan Y

更新日期：2019-04-25 00:00:00

abstract：:Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channe...

journal_title：Theranostics

authors： Burks SR,Lorsung RM,Nagle ME,Tu TW,Frank JA

更新日期：2019-07-28 00:00:00

abstract：:Radiotherapy is an extensively used treatment modality in the clinic and can kill malignant cells by generating cytotoxic reactive oxygen species (ROS). Unfortunately, excessive dosages of radiation are typically required because only a small proportion of the radiative energy is adsorbed by the soft tissues of a tumo...

journal_title：Theranostics

authors： Chen Y,Li N,Wang J,Zhang X,Pan W,Yu L,Tang B

更新日期：2019-01-01 00:00:00

abstract：:RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mice when administered...

journal_title：Theranostics

authors： Gao S,Hein S,Dagnæs-Hansen F,Weyer K,Yang C,Nielsen R,Christensen EI,Fenton RA,Kjems J

更新日期：2014-08-13 00:00:00

abstract：:Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent for novel cancer treatment by using an NB-encapsulated hybrid nanosystem that can be monitored by US and fluorescent imaging and acti...

journal_title：Theranostics

authors： Huang WT,Chan MH,Chen X,Hsiao M,Liu RS

更新日期：2020-01-01 00:00:00

abstract：:Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during...

journal_title：Theranostics

authors： Liu Z,Wang F,Chen X

更新日期：2011-03-01 00:00:00

abstract：:Intraoperative imaging with antibodies labeled with both a radionuclide for initial guidance and a near-infrared dye for adequate tumor delineation may overcome the main limitation of fluorescence imaging: the limited penetration depth of light in biological tissue. In this study, we demonstrate the feasibility and sa...

journal_title：Theranostics

authors： Hekman MC,Rijpkema M,Muselaers CH,Oosterwijk E,Hulsbergen-Van de Kaa CA,Boerman OC,Oyen WJ,Langenhuijsen JF,Mulders PF

更新日期：2018-03-08 00:00:00

abstract：:Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, copper homeostasis is considered as an emerging target for anticancer drug design. Monitoring copper levels in vivo is therefore of paramount importance when assessing the efficacy of copper-targeting drugs. ...

journal_title：Theranostics

authors： Parmar A,Pascali G,Voli F,Lerra L,Yee E,Ahmed-Cox A,Kimpton K,Cirillo G,Arthur A,Zahra D,Rahardjo G,Liu GJ,Lengkeek N,Saletta F,Charil A,Kavallaris M,Vittorio O

更新日期：2018-11-09 00:00:00

abstract：:Rationale: Treating diseases of the brain such as Alzheimer's disease (AD) is challenging as the blood-brain barrier (BBB) effectively restricts access of a large number of potentially useful drugs. A potential solution to this problem is presented by therapeutic ultrasound, a novel treatment modality that can achieve...

journal_title：Theranostics

authors： Pelekanos M,Leinenga G,Odabaee M,Odabaee M,Saifzadeh S,Steck R,Götz J

更新日期：2018-04-03 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.27882.]. ...

journal_title：Theranostics

authors： Qin C,Liu Q,Hu ZW,Zhou LQ,Shang K,Bosco DB,Wu LJ,Tian DS,Wang W

更新日期：2020-07-10 00:00:00

abstract：:Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis...

journal_title：Theranostics

authors： Jiang Y,Mao C,Yang R,Yan B,Shi Y,Liu X,Lai W,Liu Y,Wang X,Xiao D,Zhou H,Cheng Y,Yu F,Cao Y,Liu S,Yan Q,Tao Y

更新日期：2017-07-23 00:00:00

abstract：:The diseases caused by viruses posed a great challenge to human health, the development of which was driven by the imbalanced host immune response. Host innate immunity is an evolutionary old defense system that is critical for the elimination of the virus. The overactive innate immune response also leads to inflammat...

journal_title：Theranostics

authors： Wang Y,Wang Y,Luo W,Song X,Huang L,Xiao J,Jin F,Ren Z,Wang Y

更新日期：2020-07-23 00:00:00

abstract：:The relatively new field of nanotheranostics combines the advantages of in vivo diagnosis with the ability to administer treatment through a single nano-sized carrier, offering new opportunities for cancer diagnosis and therapy. Nanotheranostics has facilitated the development of nanomedicine through direct visualizat...

journal_title：Theranostics

authors： Luk BT,Fang RH,Zhang L

更新日期：2012-01-01 00:00:00

abstract：:The most important requirements of biomedical substitutes used in muscle tissue regeneration are appropriate topographical cues and bioactive components for the induction of myogenic differentiation/maturation. Here, we developed an electric field-assisted 3D cell-printing process to fabricate cell-laden fibers with a...

journal_title：Theranostics

authors： Yang GH,Kim W,Kim J,Kim G

更新日期：2021-01-01 00:00:00

abstract：:Iron oxide nanoparticles are a useful diagnostic contrast agent and have great potential for therapeutic applications. Multiple emerging diagnostic and therapeutic applications and the numerous versatile parameters of the nanoparticle platform require a robust biological model for characterization and assessment. Here...

journal_title：Theranostics

authors： Ho DN,Kohler N,Sigdel A,Kalluri R,Morgan JR,Xu C,Sun S

更新日期：2012-01-01 00:00:00

abstract：:Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems. The application of these new materials and techniques with combined properties of diagnosis and therapy can benefit the development of targeted drug deliv...

journal_title：Theranostics

authors： Ding H,Wu F

更新日期：2012-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (...

journal_title：Theranostics

authors： Chi YH,Hsiao JK,Lin MH,Chang C,Lan CH,Wu HC

更新日期：2017-04-10 00:00:00

abstract：:Recently, researchers identified a distinct vessel subtype called type H vessels that couple angiogenesis and osteogenesis. We previously found that type H vessels are reduced in ovariectomy (OVX)-induced osteoporotic mice, and preosteoclasts are able to secrete platelet-derived growth factor-BB (PDGF-BB) to stimulate...

journal_title：Theranostics

authors： Huang J,Yin H,Rao SS,Xie PL,Cao X,Rao T,Liu SY,Wang ZX,Cao J,Hu Y,Zhang Y,Luo J,Tan YJ,Liu ZZ,Wu B,Hu XK,Chen TH,Chen CY,Xie H

更新日期：2018-03-28 00:00:00

abstract：:Tumor hypoxia is an important reason for the limited therapeutic efficacy of photodynamic therapy (PDT) because of the oxygen requirement of the therapeutic process. PDT consumes tissue oxygen and destroys tumor vasculature, further hampering its own efficacy in promoting tumor deterioration. Therefore, overcoming the...

journal_title：Theranostics

authors： Yang Z,Wang J,Ai S,Sun J,Mai X,Guan W

更新日期：2019-09-20 00:00:00

abstract：:The α-chemokine CXCL12 (stromal derived factor-1; SDF-1) and its corresponding G(αI) protein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell niches. CXCL12 has also been identified as a strong chemoattractant for HSPCs and imp...

journal_title：Theranostics

authors： Ratajczak MZ,Serwin K,Schneider G

更新日期：2013-01-01 00:00:00

abstract：:Liquid biopsy of tumor through isolation of circulating tumor cells (CTCs) allows non-invasive, repetitive, and systemic sampling of disease. Although detecting and enumerating CTCs is of prognostic significance in metastatic cancer, it is conceivable that performing molecular and functional characterization on CTCs w...

journal_title：Theranostics

authors： Chen JF,Zhu Y,Lu YT,Hodara E,Hou S,Agopian VG,Tomlinson JS,Posadas EM,Tseng HR

更新日期：2016-06-15 00:00:00