Abstract:
:Marfan syndrome (MFS) is a rare genetic disease characterized by a matrix metalloproteases (MMPs) dysregulation that leads to extracellular matrix degradation. Consequently, MFS patients are prone to develop progressive thoracic aortic enlargement and detrimental aneurysm. Since MMPs are activated by the extracellular MMP inducer (EMMPRIN) protein, we determined whether its plasmatic soluble form (sEMMPRIN) may be considered a marker of thoracic aortic ectasia (AE). Methods: We compared plasma sEMMPRIN levels of 42 adult Caucasian MFS patients not previously subjected to aortic surgery with those of matched healthy controls (HC) by ELISA. In the MFS cohort we prospectively evaluated the relationship between plasma sEMMPRIN levels and the main MFS-related manifestations. Results: MFS patients had lower plasma sEMMPRIN levels (mean±SD: 2071±637 pg/ml) than HC (2441±642 pg/ml, p=0.009). Amongst all considered MFS-related clinical features, we found that only aortic root dilatation associated with circulating sEMMPRIN levels. Specifically, plasma sEMMPRIN levels negatively correlated with aortic Z-score (r=-0.431, p=0.004), and were significantly lower in patients with AE (Z-score≥2, 1788±510 pg/ml) compared to those without AE (Z-score<2, 2355±634 pg/ml; p=0.003). ROC curve analysis revealed that plasma sEMMPRIN levels discriminated patients with AE (AUC [95%CI]: 0.763 [0.610-0.916], p=0.003) with 85.7% sensitivity, 76.2% specificity, and 81% accuracy. We defined plasma sEMMPRIN levels ≤2246 pg/ml as the best threshold discriminating the presence of AE in MFS patients with an odds ratio [95%CI] of 19.2 [3.947-93.389] (p<0.001). Conclusions: MFS patients are characterized by lower sEMMPRIN levels than HC. Notably, plasma sEMMPRIN levels are strongly associated with thoracic AE.
journal_name
Theranosticsjournal_title
Theranosticsauthors
Rurali E,Perrucci GL,Gaetano R,Pini A,Moschetta D,Gentilini D,Nigro P,Pompilio Gdoi
10.7150/thno.30714subject
Has Abstractpub_date
2019-04-12 00:00:00pages
2224-2234issue
8issn
1838-7640pii
thnov09p2224journal_volume
9pub_type
杂志文章相关文献
Theranostics文献大全abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in a variety of tumor cells, but not most normal cells. Nevertheless, its therapeutic potential is limited due to the frequent occurrence of resistance in tumor cells, especially hepatocellular carcinoma cell lines. Theref...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21707
更新日期:2017-10-12 00:00:00
abstract:PURPOSE:The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared 68Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) for diagnosis and tumour delineation in patients with primary PCa based on slice by slice correlation ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.16638
更新日期:2017-01-01 00:00:00
abstract::Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recen...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.3692
更新日期:2012-01-01 00:00:00
abstract::With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO2 core-shell nanoparticles, which showed that they could selectivel...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35418
更新日期:2019-07-09 00:00:00
abstract::In pancreatic cancer (PDAC) intratumor infiltration of polymorphonuclear neutrophils (PMN) is associated with histologically apparent alterations of the tumor growth pattern. The aim of this study was to examine possible associations between PMN infiltration, tumor microarchitecture, and water diffusivity in diffusion...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21089
更新日期:2018-01-01 00:00:00
abstract::In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel netrin-1 interference therapy requires the assessment of netrin-1 expression prior to ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.27221
更新日期:2018-10-06 00:00:00
abstract::Peptide-derived nanocomposites have been exhibiting fascinating biological advantages, including but not limited to excellent biocompatibility, biological degradation, high targetability and subsequent potent therapeutic efficacy. While some successes have been achieved in the nanoengineering of peptide-based architec...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.47243
更新日期:2020-07-09 00:00:00
abstract::Cell-based immunotherapy for the treatment of hematologic malignancies, such as leukemia and lymphoma, has seen much success and played an increasingly important role in clinical studies. Nevertheless, the efficacy of immunotherapy in solid tumors still needs improvements due to the immunosuppressive properties of tum...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35900
更新日期:2019-10-14 00:00:00
abstract::Rationale: Chronic ethanol consumption as a public health problem worldwide boosts the development of chronic liver diseases in hepatitis B virus (HBV)-infected patients. Arachidonic acid metabolite prostaglandin E2 (PGE2) activates regulatory T cells (Tregs) function. Here, we aim to investigate the underlying mechan...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.46005
更新日期:2020-07-23 00:00:00
abstract::Comprehensive analysis of the expression level and location of tumor-associated membrane proteins (TMPs) is of vital importance for the profiling of tumor cells. Currently, two kinds of independent techniques, i.e. ex situ detection and in situ imaging, are usually required for the quantification and localization of T...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22794
更新日期:2018-01-01 00:00:00
abstract::Tumor hypoxia is an important reason for the limited therapeutic efficacy of photodynamic therapy (PDT) because of the oxygen requirement of the therapeutic process. PDT consumes tissue oxygen and destroys tumor vasculature, further hampering its own efficacy in promoting tumor deterioration. Therefore, overcoming the...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36988
更新日期:2019-09-20 00:00:00
abstract::Uncontrollable cell proliferation and irreversible neurological damage make glioma one of the most deadly diseases in clinic. Besides the multiple biological barriers, glioma stem cells (GSCs) that are responsible for the maintenance and recurrence of tumor tissues also hinder the therapeutic efficacy of chemotherapy....
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41382
更新日期:2020-03-04 00:00:00
abstract::Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field still suffers from poor data reproducibility. This is especially true in cases of infants, conside...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.31502
更新日期:2019-06-19 00:00:00
abstract::Patients with cervical cancer (CCa) with lymph node metastasis (LNM) have an extremely poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide clinical therapeutic strategies for CCa. Upregulation of fatty acid-binding protein 5 (FABP5) expression in CCa tumours was demonstrated to positivel...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44868
更新日期:2020-05-17 00:00:00
abstract::The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant ex...
journal_title:Theranostics
pub_type: 评论,社论
doi:10.7150/thno.29864
更新日期:2018-11-15 00:00:00
abstract::Purpose: Cancer immunotherapy depends on a systemic immune response, but the basic underlying mechanisms are still largely unknown. Despite the very successful and widespread use of checkpoint inhibitors in the clinic, the majority of cancer patients do not benefit from this type of treatment. In this translational st...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35989
更新日期:2020-01-01 00:00:00
abstract::Background: Biofilm infection caused by multidrug-resistant bacteria is difficult to eradicate by conventional therapies. Photodynamic therapy (PDT) is an effective antibacterial method for fighting against biofilm infection. However, the blocked photosensitizers outside of biofilm greatly limit the efficacy of PDT. M...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42922
更新日期:2020-03-26 00:00:00
abstract::Background: Tumor cells require proficient autophagy to meet high metabolic demands and resist chemotherapy, which suggests that reducing autophagic flux might be an attractive route for cancer therapy. However, this theory in clinical cancer research remains controversial due to the limited number of drugs that speci...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22012
更新日期:2018-01-01 00:00:00
abstract::Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent for novel cancer treatment by using an NB-encapsulated hybrid nanosystem that can be monitored by US and fluorescent imaging and acti...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.38684
更新日期:2020-01-01 00:00:00
abstract::Traumatic brain injury (TBI) research has focused on moderate to severe injuries as their outcomes are significantly worse than those of a mild TBI (mTBI). However, recent epidemiological evidence has indicated that a series of even mild TBIs greatly increases the risk of neurodegenerative and psychiatric disorders. N...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.24747
更新日期:2018-09-09 00:00:00
abstract::Constructing nanosystems that synergistically combine therapeutic and diagnostic features is of great interest to the nanomedicine community but also remains a tremendous challenge. Methods: In this work, we report novel catalytic nanoparticles composed of the enzyme catalase, encapsulated in a polymer shell and surfa...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.37054
更新日期:2019-10-17 00:00:00
abstract::The most frequent malignancy of the pancreas is the pancreatic ductal adenocarcinoma (PDAC). Despite many efforts PDAC has still a dismal prognosis. Biomarkers for early disease stage diagnosis as a prerequisite for a potentially curative treatment are still missing. Novel blood-based markers may help to overcome this...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.29247
更新日期:2019-02-12 00:00:00
abstract::Inhibitor of apoptosis proteins (IAP) are cell death regulators that bind caspases and interfere with apoptotic signalling via death receptors or intrinsic cell death pathways. BIRC4/XIAP is the most potent anti-apoptotic IAP-member and it physically interacts with caspases via its BIR2 and its BIR3 domain. These doma...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33758
更新日期:2019-07-09 00:00:00
abstract::The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range of drugs. Here, we aimed to clarify the impact of circadian clock on intestinal MRP2, and to determine the molecular mechanisms for generation of diurnal MRP2 expression. Methods: The regulatory effects of Bmal1 on inte...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33395
更新日期:2019-04-13 00:00:00
abstract::Treatments of high specificity are desirable for cancer therapy. Light-triggered nanotheranostics (LTN) mediated cancer therapy could be one such treatment, as they make it possible to visualize and treat the tumor specifically in a light-controlled manner with a single injection. Because of their great potential in c...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.15217
更新日期:2016-04-27 00:00:00
abstract::Non-invasive PET imaging of CXCR4 expression in cancer and inflammation as well as CXCR4-targeted radioligand therapy (RLT) have recently found their way into clinical research by the development of the theranostic agents [68Ga]PentixaFor (cyclo(D-Tyr1-D-[NMe]Orn2(AMBS-[68Ga]DOTA)-Arg3-Nal4-Gly5) = [68Ga]DOTA-AMBS-CPC...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.45537
更新日期:2020-07-09 00:00:00
abstract::Optical sensing plays an important role in theranostics due to its capability to detect hint biochemical entities or molecular targets as well as to precisely monitor specific fundamental psychological processes. Rare-earth (RE) doped upconversion nanoparticles (UCNPs) are promising for these endeavors due to their un...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.5305
更新日期:2013-03-26 00:00:00
abstract::The mineral dust-induced gene (mdig) is overexpressed in a number of human cancers, suggesting critical roles of this gene played on the pathogenesis of cancers. Unlike several other JmjC-domain containing proteins that exhibit histone demethylase activity, it remains enigmatic whether mdig is involved in the demethyl...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36220
更新日期:2020-01-01 00:00:00
abstract::The α-chemokine CXCL12 (stromal derived factor-1; SDF-1) and its corresponding G(αI) protein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell niches. CXCL12 has also been identified as a strong chemoattractant for HSPCs and imp...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.4621
更新日期:2013-01-01 00:00:00
abstract::Aim: Immune responsive 12/15 lipoxygenase (12/15LOX)-orchestrate biosynthesis of essential inflammation-resolution mediators during acute inflammatory response in post-myocardial infarction (MI). Lack of 12/15LOX dampens proinflammatory mediator 12-(S)-hydroxyeicosatetraenoic acid (12-(S)-HETE), improves post-MI survi...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.51183
更新日期:2021-01-01 00:00:00