Modulation of Respiration and Mitochondrial Dynamics by SMAC-Mimetics for Combination Therapy in Chemoresistant Cancer.

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and diffuse form of interstitial lung disease of unknown etiology with a fatal outcome. Although various strategies for IPF have been developed over the last few decades, no significant positive impact on the prognosis of IPF has been observed. According to the current ...

journal_title：Theranostics

authors： Pan T,Zhou Q,Miao K,Zhang L,Wu G,Yu J,Xu Y,Xiong W,Li Y,Wang Y

更新日期：2021-01-01 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous in their clinical behavior and require therapies specially tailored according to staging, grading, origin and expression of peptide receptors. Despite extensive scientific efforts, the therapy options are still not satisfactory. The main reasons are due...

journal_title：Theranostics

authors： Briest F,Grabowski P

更新日期：2014-01-29 00:00:00

abstract：:Deciphering the molecular and cellular processes involved in foam cell formation is critical to understanding the pathogenesis of atherosclerosis. Interferon regulatory factor 1 (IRF1) was first identified as a transcriptional regulator of type-I interferons (IFNs) and IFN inducible genes. Our study aims to explore th...

journal_title：Theranostics

authors： Du M,Wang X,Mao X,Yang L,Huang K,Zhang F,Wang Y,Luo X,Wang C,Peng J,Liang M,Huang D,Huang K

更新日期：2019-07-09 00:00:00

abstract：:During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells chemotaxis being accompanied by activation of diverse intercellular s...

journal_title：Theranostics

authors： Jin J,Zhao Q

更新日期：2020-05-15 00:00:00

abstract：:Metastasis is a major cause of death in patients with colorectal cancer (CRC). Cysteine-rich protein 2 (CSRP2) has been recently implicated in the progression and metastasis of a variety of cancers. However, the biological functions and underlying mechanisms of CSRP2 in the regulation of CRC progression are largely un...

journal_title：Theranostics

authors： Chen L,Long X,Duan S,Liu X,Chen J,Lan J,Liu X,Huang W,Geng J,Zhou J

更新日期：2020-09-02 00:00:00

abstract：:Mesenchymal stem cells (MSC) derived from adult tissues effectively promote wound healing. However, MSC quality varies, and the quantity of MSC is limited, as MSC are acquired through donations. Moreover, the survival and functioning of dissociated MSC delivered to an inflammatory lesion are subject to challenges. Met...

journal_title：Theranostics

authors： Wang X,Jiang B,Sun H,Zheng D,Zhang Z,Yan L,Li E,Wu Y,Xu RH

更新日期：2019-08-14 00:00:00

abstract：:Rationale: Chromodomain Y-like 2 (CDYL2) is a member of the CDY gene family involved in spermatogenesis, but its role in human cancer has not been reported. Analyses of publicly available databases demonstrate that CDYL2 is abundantly expressed in breast tumors. However, whether CDYL2 is involved in breast cancer prog...

journal_title：Theranostics

authors： Yang LF,Yang F,Zhang FL,Xie YF,Hu ZX,Huang SL,Shao ZM,Li DQ

更新日期：2020-04-06 00:00:00

abstract：:Conventional immunosuppressants cause side effects and do not prevent the recurrence of autoimmune diseases. Moreover, they may not inhibit autoimmunity mediated by pathogenic memory T-cells. Dihydroartemisinin (DHA) has been shown to regulate autoimmunity. However, it remains unknown whether DHA impacts psoriasis and...

journal_title：Theranostics

authors： Chen Y,Yan Y,Liu H,Qiu F,Liang CL,Zhang Q,Huang RY,Han L,Lu C,Dai Z

更新日期：2020-08-21 00:00:00

abstract：:Exosomes play critical roles in intercellular communication in both nearby and distant cells in individuals and organs. Polymerase I and transcript release factor (PTRF), also known as Cavin1, has previously been described as a critical factor in caveola formation, and aberrant PTRF expression has been reported in var...

journal_title：Theranostics

authors： Huang K,Fang C,Yi K,Liu X,Qi H,Tan Y,Zhou J,Li Y,Liu M,Zhang Y,Yang J,Zhang J,Li M,Kang C

更新日期：2018-02-07 00:00:00

abstract：:Cell sheet technology opens new perspectives in tissue regeneration therapy by providing readily implantable, scaffold-free 3D tissue constructs. Many studies have focused on the therapeutic effects of cell sheet implantation while relatively little attention has concerned the fate of the implanted cells in vivo. The ...

journal_title：Theranostics

authors： Rahmi G,Pidial L,Silva AK,Blondiaux E,Meresse B,Gazeau F,Autret G,Balvay D,Cuenod CA,Perretta S,Tavitian B,Wilhelm C,Cellier C,Clément O

更新日期：2016-03-21 00:00:00

abstract：:The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range of drugs. Here, we aimed to clarify the impact of circadian clock on intestinal MRP2, and to determine the molecular mechanisms for generation of diurnal MRP2 expression. Methods: The regulatory effects of Bmal1 on inte...

journal_title：Theranostics

authors： Yu F,Zhang T,Zhou C,Xu H,Guo L,Chen M,Wu B

更新日期：2019-04-13 00:00:00

abstract：:Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of soyasaponin II in acute liver failure and establish the...

journal_title：Theranostics

authors： Wang F,Gong S,Wang T,Li L,Luo H,Wang J,Huang C,Zhou H,Chen G,Liu Z,Zhang Q,Jiang Y,Chen P

更新日期：2020-02-03 00:00:00

abstract：:The distorted and unique expression of microRNAs (miRNAs) in cancer makes them an attractive source of biomarker. There is much evidence indicating that a panel of miRNAs, termed "miRNA fingerprints", is more specific and informative than an individual miRNA as biomarker. Thus, multiplex assays for simultaneous quanti...

journal_title：Theranostics

authors： Xu F,Zhou W,Cao J,Xu Q,Jiang D,Chen Y

更新日期：2017-07-08 00:00:00

abstract：:Protein therapeutics is playing an increasingly critical role in treatment of human diseases. However, current vectors are captured by the digestive endo-lysosomal system, which results in an extremely low fraction (<2%) of protein being released in the cytoplasm. This paper reports a drug-delivering-drug platform (HA...

journal_title：Theranostics

authors： Xin X,Teng C,Du X,Lv Y,Xiao Q,Wu Y,He W,Yin L

更新日期：2018-06-06 00:00:00

abstract：:Recent studies have highlighted the biological significance of RNA N6-methyladenosine (m6A) modification in tumorigenicity and progression. However, it remains unclear whether m6A modifications also have potential roles in immune regulation and tumor microenvironment (TME) formation. Methods: In this study, we curated...

journal_title：Theranostics

authors： Chong W,Shang L,Liu J,Fang Z,Du F,Wu H,Liu Y,Wang Z,Chen Y,Jia S,Chen L,Li L,Chen H

更新日期：2021-01-01 00:00:00

abstract：:Topical administration permits targeted, sustained delivery of therapeutics to human skin. Delivery to the skin, however, is typically limited to lipophilic molecules with molecular weight of < 500 Da, capable of crossing the stratum corneum. Nevertheless, there are indications protein delivery may be possible in barr...

journal_title：Theranostics

authors： Giulbudagian M,Yealland G,Hönzke S,Edlich A,Geisendörfer B,Kleuser B,Hedtrich S,Calderón M

更新日期：2018-01-01 00:00:00

abstract：:Molecular subtyping of breast cancer is of considerable interest owing to its potential for personalized therapy and prognosis. However, current methodologies cannot be used for precise subtyping, thereby posing a challenge in clinical practice. The aim of the present study is to develop a cell-specific single-strande...

journal_title：Theranostics

authors： Liu M,Wang Z,Tan T,Chen Z,Mou X,Yu X,Deng Y,Lu G,He N

更新日期：2018-11-10 00:00:00

abstract：:Intraoperative fluorescence imaging is particularly well-suited for surgical applications due to its inherently high sensitivity, resolution, and ability to provide images in real-time. To date, the intraoperative observation of fluorescence has largely been subjective. With the need to show objective evidence in orde...

journal_title：Theranostics

authors： Tummers WS,Warram JM,van den Berg NS,Miller SE,Swijnenburg RJ,Vahrmeijer AL,Rosenthal EL

更新日期：2018-10-22 00:00:00

abstract：:Producing keratinocyte cells (KCs) in large scale is difficult due to their slow proliferation, disabling their use as seed cells for skin regeneration and wound healing. Cell reprogramming is a promising inducer-based approach to KC production but only reaches very low cellular conversion. Here we reported a unique c...

journal_title：Theranostics

authors： Zhang F,Zhang D,Cheng K,Zhou Z,Liu S,Chen L,Hu Y,Mao C,Liu S

更新日期：2019-07-09 00:00:00

abstract：:MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-...

journal_title：Theranostics

authors： Novák J,Kružliak P,Bienertová-Vašků J,Slabý O,Novák M

更新日期：2014-01-02 00:00:00

abstract：:Rationale: Glioma stem-like cells (GSCs) contribute to temozolomide (TMZ) resistance in gliomas, although the mechanisms have not been delineated. Methods:In vitro functional experiments (colony formation assay, flow cytometric analysis, TUNEL assay) were used to assess the ability of extracellular vesicles (EVs) from...

journal_title：Theranostics

authors： Yin J,Ge X,Shi Z,Yu C,Lu C,Wei Y,Zeng A,Wang X,Yan W,Zhang J,You Y

更新日期：2021-01-01 00:00:00

abstract：:Angiogenesis enhances cancer metastasis and progression, however, the roles of transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc-finger transcription factor. Here, we demonstrate a new mechanism of Kras mutation-driven ZNF322A transcriptional activation and elucidate the inte...

journal_title：Theranostics

authors： Lin CC,Kuo IY,Wu LT,Kuan WH,Liao SY,Jen J,Yang YE,Tang CW,Chen YR,Wang YC

更新日期：2020-08-08 00:00:00

abstract：:Rationale: Chronic ethanol consumption as a public health problem worldwide boosts the development of chronic liver diseases in hepatitis B virus (HBV)-infected patients. Arachidonic acid metabolite prostaglandin E2 (PGE2) activates regulatory T cells (Tregs) function. Here, we aim to investigate the underlying mechan...

journal_title：Theranostics

authors： Liu Z,Wang J,Liu L,Yuan H,Bu Y,Feng J,Liu Y,Yang G,Zhao M,Yuan Y,Zhang H,Yun H,Zhang X

更新日期：2020-07-23 00:00:00

abstract：:Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis...

journal_title：Theranostics

authors： Jiang Y,Mao C,Yang R,Yan B,Shi Y,Liu X,Lai W,Liu Y,Wang X,Xiao D,Zhou H,Cheng Y,Yu F,Cao Y,Liu S,Yan Q,Tao Y

更新日期：2017-07-23 00:00:00

abstract：:Rationale: Emerging evidence suggests that noncentrosomal microtubules play an essential role in intracellular transport, cell polarity and cell motility. Whether these noncentrosomal microtubules exist or function in cancer cells remains unclear. Methods: The expression and prognostic values of CAMSAP2 and its functi...

journal_title：Theranostics

authors： Li D,Ding X,Xie M,Huang Z,Han P,Tian D,Xia L

更新日期：2020-02-19 00:00:00

abstract：:Background: Accumulating evidences indicate that nanomedicines greatly decrease the side effects and enhance the efficacy of colorectal cancer (CRC) treatment. In particular, the use of rectal delivery of nanomedicines, with advantages such as fast therapeutic effects and a diminishing hepatic first-pass effect, is cu...

journal_title：Theranostics

authors： Zhao R,Du S,Liu Y,Lv C,Song Y,Chen X,Zhang B,Li D,Gao S,Cui W,Plikus MV,Hou X,Wu K,Liu Z,Liu Z,Cong Y,Li Y,Yu Z

更新日期：2020-02-18 00:00:00

abstract：:Targeted therapy and immunotherapy have become mainstream in cancer treatment. However, only patient subsets benefit from these expensive therapies, and often responses are short-lived or coincide with side effects. A growing modality in precision oncology is the development of theranostics, as this enables patient se...

journal_title：Theranostics

authors： Lecocq Q,De Vlaeminck Y,Hanssens H,D'Huyvetter M,Raes G,Goyvaerts C,Keyaerts M,Devoogdt N,Breckpot K

更新日期：2019-10-15 00:00:00

abstract：:Rationale: Subjects unable to sustain β-cell compensation develop type 2 diabetes. Early growth response-1 protein (EGR-1), implicated in the regulation of cell differentiation, proliferation, and apoptosis, is induced by diverse metabolic challenges, such as glucose or other nutrients. Therefore, we hypothesized that...

journal_title：Theranostics

authors： Leu SY,Kuo LH,Weng WT,Lien IC,Yang CC,Hsieh TT,Cheng YN,Chien PH,Ho LC,Chen SH,Shan YS,Chen YW,Tsai PJ,Sung JM,Tsai YS

更新日期：2020-03-04 00:00:00

abstract：:A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positi...

journal_title：Theranostics

authors： Hou FQ,Song LW,Yuan Q,Fang LL,Ge SX,Zhang J,Sheng JF,Xie DY,Shang J,Wu SH,Sun YT,Wei SF,Wang MR,Wan MB,Jia JD,Luo GH,Tang H,Li SC,Niu JQ,Zhou WD,Sun L,Xia NS,Wang GQ

更新日期：2015-01-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) leakage can lead to brain and spine pathologies and there is an urgent need for a rapid diagnostic method for determining CSF leakage. Beta-2 transferrin (β2TF), asialotransferrin, is a specific CSF glycoprotein biomarker used to determine CSF leakage when distinguished from serum sialotransf...

journal_title：Theranostics

authors： Oh J,Kwon SJ,Dordick JS,Sonstein WJ,Linhardt RJ,Kim MG

更新日期：2019-05-31 00:00:00