Determination of cerebrospinal fluid leakage by selective deletion of transferrin glycoform using an immunochromatographic assay.

abstract：:The development of nanomedicine is expected to provide an innovative direction for addressing challenges associated with multidrug-resistant (MDR) bacteria. In the past decades, although nanotechnology-based phototherapy has been developed for antimicrobial treatment since it rarely causes bacterial resistance, the cl...

journal_title：Theranostics

authors： Wei G,Yang G,Wang Y,Jiang H,Fu Y,Yue G,Ju R

更新日期：2020-10-30 00:00:00

abstract：:The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant ex...

journal_title：Theranostics

authors： Corti A,Belcastro E,Pompella A

更新日期：2018-11-15 00:00:00

abstract：:Iron oxide nanoparticles are a useful diagnostic contrast agent and have great potential for therapeutic applications. Multiple emerging diagnostic and therapeutic applications and the numerous versatile parameters of the nanoparticle platform require a robust biological model for characterization and assessment. Here...

journal_title：Theranostics

authors： Ho DN,Kohler N,Sigdel A,Kalluri R,Morgan JR,Xu C,Sun S

更新日期：2012-01-01 00:00:00

abstract：:In pancreatic cancer (PDAC) intratumor infiltration of polymorphonuclear neutrophils (PMN) is associated with histologically apparent alterations of the tumor growth pattern. The aim of this study was to examine possible associations between PMN infiltration, tumor microarchitecture, and water diffusivity in diffusion...

journal_title：Theranostics

authors： Mayer P,Dinkic C,Jesenofsky R,Klauss M,Schirmacher P,Dapunt U,Hackert T,Uhle F,Hänsch GM,Gaida MM

更新日期：2018-01-01 00:00:00

abstract：:Dynamic positron emission tomography (PET) can monitor spatiotemporal distribution of radiotracer in vivo. The spatiotemporal information can be used to estimate parametric images of radiotracer kinetics that are of physiological and biochemical interests. Direct estimation of parametric images from raw projection dat...

journal_title：Theranostics

authors： Wang G,Qi J

更新日期：2013-11-20 00:00:00

abstract：:Despite significant advances in cancer diagnostics and treatment, ovarian cancers (OC) continue to kill more than 150,000 women every year worldwide. Due to the relatively asymptomatic nature and the advanced stage of the disease at the time of diagnosis, OC is the most lethal gynecologic malignancy. The current treat...

journal_title：Theranostics

authors： Di Lorenzo G,Ricci G,Severini GM,Romano F,Biffi S

更新日期：2018-07-30 00:00:00

abstract：:Rationale: Tumor metastasis is the main cause for cancer-related death. However, the driving molecules of metastasis remain largely unknown. Here, we aim to identify long non-coding RNAs (lncRNAs) critical for human hepatocellular carcinoma (HCC) metastasis. Methods: Microarrays were used to screen a comprehensive set...

journal_title：Theranostics

authors： Kang CL,Qi B,Cai QQ,Fu LS,Yang Y,Tang C,Zhu P,Chen QW,Pan J,Chen MH,Wu XZ

更新日期：2019-06-09 00:00:00

abstract：:Blood vessels are conduits distributed throughout the body, supporting tissue growth and homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the linings of the blood vessels, and together with pericytes, are essential for organ development and tissue homeostasis through producing ...

journal_title：Theranostics

authors： Zhu S,Bennett S,Kuek V,Xiang C,Xu H,Rosen V,Xu J

更新日期：2020-05-01 00:00:00

abstract：:One of the major challenges in the hepatocellular carcinoma (HCC) treatment is its insensitivity to chemotherapeutic drugs. Here, we report the development of novel lipid-coated cisplatin nanoparticles co-loaded with microRNA-375 (NPC/miR-375) as a potential treatment for chemotherapy insensitive HCC. The NPC/miR-375 ...

journal_title：Theranostics

authors： Yang T,Zhao P,Rong Z,Li B,Xue H,You J,He C,Li W,He X,Lee RJ,Ma X,Xiang G

更新日期：2016-01-01 00:00:00

abstract：:Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared...

journal_title：Theranostics

authors： Li Y,Li Y,Zhang X,Xu X,Zhang Z,Hu C,He Y,Gu Z

更新日期：2016-06-05 00:00:00

abstract：:The unique features of noble-metal nanostructures (NMNs) are leading to unprecedented expansion of research and exploration of their application in therapeutics, diagnostics and bioimaging fields. With the ever-growing applications of NMNs, both therapeutic and environmental NMNs are likely to be exposed to tissues an...

journal_title：Theranostics

authors： Huang Q,Zhang J,Zhang Y,Timashev P,Ma X,Liang XJ

更新日期：2020-04-27 00:00:00

abstract：:Background: Lysophosphatidic acid (LPA) is a small glycerophospholipid that acts as a potent extracellular signal in various biological processes and diseases. Our previous work demonstrated that the expression of the LPA receptors LPA1 and LPA3 is elevated in the early postnatal heart. However, the role of this stage...

journal_title：Theranostics

authors： Wang F,Liu S,Pei J,Cai L,Liu N,Liang T,Dong X,Cong X,Chun J,Chen J,Hu S,Chen X

更新日期：2020-08-29 00:00:00

abstract：:Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine. Nerve autograft is the gold standard for clinical PNI repair. Due to its significant drawbacks, artificial nerve guidance conduits (NGCs) have drawn much attention as replacement therapies. We developed a combinatorial NGC consist...

journal_title：Theranostics

authors： Zheng C,Yang Z,Chen S,Zhang F,Rao Z,Zhao C,Quan D,Bai Y,Shen J

更新日期：2021-01-01 00:00:00

abstract：:Dendritic cells (DC) and tumor cell fusion vaccine (DC/tumor cell fusion vaccine) is considered an effective approach in cancer biotherapy. However, its therapeutic effects in early clinical trials have been suboptimal partially due to the immunosuppressive tumor environment. In this study, we used nanoparticles of fo...

journal_title：Theranostics

authors： Hu Z,Chen J,Zhou S,Yang N,Duan S,Zhang Z,Su J,He J,Zhang Z,Lu X,Zhao Y

更新日期：2017-05-02 00:00:00

abstract：:To enhance effective drug accumulation in drug-resistant tumors, a site-specific drug-releasing polypeptide system (PEG-Phis/Pasp-DOX/CA4) was exploited in response to tumor extracellular and intracellular pH. This system could firstly release the embedded tumor vascular inhibitor (CA4) to transiently 'normalize' vasc...

journal_title：Theranostics

authors： Dong Y,Yang J,Liu H,Wang T,Tang S,Zhang J,Zhang X

更新日期：2015-04-28 00:00:00

abstract：:Immuno-oncological treatment strategies that target abnormal receptor profiles of tumors are an increasingly important feature of cancer therapy. Yet, assessing receptor availability (RA) and drug-target engagement, important determinants of therapeutic efficacy, is challenging with current imaging strategies, largely...

journal_title：Theranostics

authors： Meng B,Folaron MR,Strawbridge RR,Sadeghipour N,Samkoe KS,Tichauer K,Davis SC

更新日期：2020-09-14 00:00:00

abstract：:RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and ...

journal_title：Theranostics

authors： Lin YX,Wang Y,Blake S,Yu M,Mei L,Wang H,Shi J

更新日期：2020-01-01 00:00:00

abstract：:Purpose: Colitis-associated colorectal cancer (CAC) poses substantial challenges for effective treatment. Currently, there is a considerable need for the development of orally bioavailable dosage forms that enable the safe and effective delivery of therapeutic drugs to local diseased lesions in the gastrointestinal tr...

journal_title：Theranostics

authors： Han W,Xie B,Li Y,Shi L,Wan J,Chen X,Wang H

更新日期：2019-10-12 00:00:00

abstract：:Arachidonic acid (AA) is a polyunsaturated fatty acid present at high concentrations in the ovarian cancer (OC) microenvironment and associated with a poor clinical outcome. In the present study, we have unraveled a potential link between AA and macrophage functions. Methods: AA-triggered signal transduction was studi...

journal_title：Theranostics

authors： Dietze R,Hammoud MK,Gómez-Serrano M,Unger A,Bieringer T,Finkernagel F,Sokol AM,Nist A,Stiewe T,Reinartz S,Ponath V,Preußer C,von Strandmann EP,Müller-Brüsselbach S,Graumann J,Müller R

更新日期：2021-01-01 00:00:00

abstract：:Biological cancer therapies, such as oncolytic, or replication-selective viruses have advantages over traditional therapeutics as they can employ multiple different mechanisms to target and destroy cancers (including direct cell lysis, immune activation and vascular collapse). This has led to their rapid recent clinic...

journal_title：Theranostics

authors： Rojas JJ,Thorne SH

更新日期：2012-01-01 00:00:00

abstract：:During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells chemotaxis being accompanied by activation of diverse intercellular s...

journal_title：Theranostics

authors： Jin J,Zhao Q

更新日期：2020-05-15 00:00:00

abstract：:Cancer metastasis is a Gordian knot for tumor diagnosis and therapy. Many studies have demonstrated that metastatic processes are inevitably affected by the tumor microenvironment. Histopathology is used universally as the gold standard for cancer diagnosis despite the lengthy preparation process and invasiveness. Met...

journal_title：Theranostics

authors： Shen B,Yan J,Wang S,Zhou F,Zhao Y,Hu R,Qu J,Liu L

更新日期：2020-01-01 00:00:00

abstract：:Purpose: The tumor homing characteristics of mesenchymal stem cells (MSCs) make them attractive vehicles for the tumor-specific delivery of therapeutic agents, such as the sodium iodide symporter (NIS). NIS is a theranostic protein that allows non-invasive monitoring of the in vivo biodistribution of functional NIS ex...

journal_title：Theranostics

authors： Tutter M,Schug C,Schmohl KA,Urnauer S,Schwenk N,Petrini M,Lokerse WJM,Zach C,Ziegler S,Bartenstein P,Weber WA,Wagner E,Lindner LH,Nelson PJ,Spitzweg C

更新日期：2020-03-15 00:00:00

abstract：:Background: Programmed cell death protein 1 (PD1) inhibitors have revolutionized cancer therapy, yet many patients fail to respond. Thus, the identification of accurate predictive biomarkers of therapy response will improve the clinical benefit of anti-PD1 therapy. Method: We assessed the baseline serological autoanti...

journal_title：Theranostics

authors： Tan Q,Wang D,Yang J,Xing P,Yang S,Li Y,Qin Y,He X,Liu Y,Zhou S,Duan H,Liang T,Wang H,Wang Y,Jiang S,Zhao F,Zhong Q,Zhou Y,Wang S,Dai J,Yao J,Wu D,Zhang Z,Sun Y,Han X,Yu X,Shi Y

更新日期：2020-05-16 00:00:00

abstract：:Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, unders...

journal_title：Theranostics

authors： De Sarno F,Ponsiglione AM,Russo M,Grimaldi AM,Forte E,Netti PA,Torino E

更新日期：2019-02-28 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a transmembrane cell surface receptor that is frequently overexpressed and/or mutated in many cancers. Therapies targeting EGFR have poor outcomes due to the lack of reliable diagnostic tests to monitor EGFR. Current in vitro EGFR diagnostic methods are invasive, requiring bi...

journal_title：Theranostics

authors： Bernhard W,El-Sayed A,Barreto K,Gonzalez C,Fonge H,Geyer CR

更新日期：2019-01-30 00:00:00

abstract：:Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent for novel cancer treatment by using an NB-encapsulated hybrid nanosystem that can be monitored by US and fluorescent imaging and acti...

journal_title：Theranostics

authors： Huang WT,Chan MH,Chen X,Hsiao M,Liu RS

更新日期：2020-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) research has focused on moderate to severe injuries as their outcomes are significantly worse than those of a mild TBI (mTBI). However, recent epidemiological evidence has indicated that a series of even mild TBIs greatly increases the risk of neurodegenerative and psychiatric disorders. N...

journal_title：Theranostics

authors： Adams C,Bazzigaluppi P,Beckett TL,Bishay J,Weisspapir I,Dorr A,Mester JR,Steinman J,Hirschler L,Warnking JM,Barbier EL,McLaurin J,Sled JG,Stefanovic B

更新日期：2018-09-09 00:00:00

abstract：:Background: Lung cancer has a high mortality rate and is resistant to multiple chemotherapeutics. Natural Borneol (NB) is a monoterpenoid compound that facilitates the bioavailability of drugs. In this study, we investigated the effects of NB on chemosensitivity in the A549 human lung adenocarcinoma cell line and to e...

journal_title：Theranostics

authors： Lai H,Liu C,Hou L,Lin W,Chen T,Hong A

更新日期：2020-08-13 00:00:00

abstract：:SIRT6, NAD+-dependent deacetylase sirtuin 6, has recently shown to suppress tumor growth in several types of cancer. Colon cancer is a challenging carcinoma associated with high morbidity and death. However, whether SIRT6 play a direct role in colon tumorigenesis and the underlying mechanism are not understood. Method...

journal_title：Theranostics

authors： Zhang Y,Nie L,Xu K,Fu Y,Zhong J,Gu K,Zhang L

更新日期：2019-04-13 00:00:00