Autoantibody profiling identifies predictive biomarkers of response to anti-PD1 therapy in cancer patients.

abstract：:In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bon...

journal_title：Theranostics

authors： Peng Y,Wu S,Li Y,Crane JL

更新日期：2020-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) play a crucial role in cancer formation and development, especially cancer metastasis. However, lack of a precise tool, which could accurately distinguish specific types of ROS, restricts an in-depth study of ROS in cancer development and progression. Herein, we designed smart and versati...

journal_title：Theranostics

authors： Chen X,Wang T,Le W,Huang X,Gao M,Chen Q,Xu S,Yin D,Fu Q,Shao C,Chen B,Shi D

更新日期：2020-02-10 00:00:00

abstract：:Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during...

journal_title：Theranostics

authors： Liu Z,Wang F,Chen X

更新日期：2011-03-01 00:00:00

abstract：:Successful anticancer chemotherapy requires targeting tumors efficiently and further potential to eliminate cancer stem cell (CSC) subpopulations. Since CD44 is present on many types of CSCs, and it binds specially to hyaluronic acid (HA), we tested whether coating solid lipid nanoparticles with hyaluronan (HA-SLNs)wo...

journal_title：Theranostics

authors： Shen H,Shi S,Zhang Z,Gong T,Sun X

更新日期：2015-04-05 00:00:00

abstract：:Long term pulmonary exposure to crystalline silica leads to silicosis that manifests progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite efforts to eliminate silicosis, clinical cases continue to occur in both developing and developed countries. The exact mechanisms of cryst...

journal_title：Theranostics

authors： Li C,Du S,Lu Y,Lu X,Liu F,Chen Y,Weng D,Chen J

更新日期：2016-09-09 00:00:00

abstract：:Mesenchymal stem cells (MSC) derived from adult tissues effectively promote wound healing. However, MSC quality varies, and the quantity of MSC is limited, as MSC are acquired through donations. Moreover, the survival and functioning of dissociated MSC delivered to an inflammatory lesion are subject to challenges. Met...

journal_title：Theranostics

authors： Wang X,Jiang B,Sun H,Zheng D,Zhang Z,Yan L,Li E,Wu Y,Xu RH

更新日期：2019-08-14 00:00:00

abstract：:Rationale: Treating diseases of the brain such as Alzheimer's disease (AD) is challenging as the blood-brain barrier (BBB) effectively restricts access of a large number of potentially useful drugs. A potential solution to this problem is presented by therapeutic ultrasound, a novel treatment modality that can achieve...

journal_title：Theranostics

authors： Pelekanos M,Leinenga G,Odabaee M,Odabaee M,Saifzadeh S,Steck R,Götz J

更新日期：2018-04-03 00:00:00

abstract：:Comprehensive analysis of the expression level and location of tumor-associated membrane proteins (TMPs) is of vital importance for the profiling of tumor cells. Currently, two kinds of independent techniques, i.e. ex situ detection and in situ imaging, are usually required for the quantification and localization of T...

journal_title：Theranostics

authors： Chen X,Zhao J,Chen T,Gao T,Zhu X,Li G

更新日期：2018-01-01 00:00:00

abstract：:Hypoxia is a key hallmark of solid tumors and tumor hypoxia usually contributes to cancer progression, therapeutic resistance and poor outcome. Accurately detecting and imaging tumor hypoxia with high spatial resolution would be conducive to formulating optimized treatment plan and thus achieving better patient outcom...

journal_title：Theranostics

authors： Huang J,Wu Y,Zeng F,Wu S

更新日期：2019-09-25 00:00:00

abstract：:Emerging evidence indicates that reprogramming of energy metabolism involving disturbances in energy production from a defect in cellular respiration with a shift to glycolysis is a core hallmark of cancer. Alterations in cancer cell energy metabolism are linked to abnormalities in mitochondrial function. Mitochondria...

journal_title：Theranostics

authors： Sun C,Liu X,Wang B,Wang Z,Liu Y,Di C,Si J,Li H,Wu Q,Xu D,Li J,Li G,Wang Y,Wang F,Zhang H

更新日期：2019-05-26 00:00:00

abstract：:Photodynamic therapy (PDT) is an emerging theranostic modality for various cancers and diseases. The focus of this study was the development of tumor-targeting albumin nanoparticles containing photosensitizers for efficient PDT. To produce tumor-targeting albumin nanoparticles, the hydrophobic photosensitizer, chlorin...

journal_title：Theranostics

authors： Jeong H,Huh M,Lee SJ,Koo H,Kwon IC,Jeong SY,Kim K

更新日期：2011-04-06 00:00:00

abstract：:Aberrant activation of the Src kinase is implicated in the development of a variety of human malignancies. However, it is almost impossible to monitor Src activity in an in vivo setting with current biochemical techniques. To facilitate the noninvasive investigation of the activity of Src kinase both in vitro and in v...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2016-02-24 00:00:00

abstract：:Rationale: Tumor metastasis is the main cause for cancer-related death. However, the driving molecules of metastasis remain largely unknown. Here, we aim to identify long non-coding RNAs (lncRNAs) critical for human hepatocellular carcinoma (HCC) metastasis. Methods: Microarrays were used to screen a comprehensive set...

journal_title：Theranostics

authors： Kang CL,Qi B,Cai QQ,Fu LS,Yang Y,Tang C,Zhu P,Chen QW,Pan J,Chen MH,Wu XZ

更新日期：2019-06-09 00:00:00

abstract：:Cell sheet technology opens new perspectives in tissue regeneration therapy by providing readily implantable, scaffold-free 3D tissue constructs. Many studies have focused on the therapeutic effects of cell sheet implantation while relatively little attention has concerned the fate of the implanted cells in vivo. The ...

journal_title：Theranostics

authors： Rahmi G,Pidial L,Silva AK,Blondiaux E,Meresse B,Gazeau F,Autret G,Balvay D,Cuenod CA,Perretta S,Tavitian B,Wilhelm C,Cellier C,Clément O

更新日期：2016-03-21 00:00:00

abstract：:Luminal androgen receptor (LAR) breast cancer accounts for 10% of all triple-negative breast cancers (TNBC). Anti-androgen therapy for this subtype is in development, but yields only partial clinical benefits. In this study, we aimed to characterize the genomic alterations of LAR TNBC, to analyze activation of the PI3...

journal_title：Theranostics

authors： Coussy F,Lavigne M,de Koning L,Botty RE,Nemati F,Naguez A,Bataillon G,Ouine B,Dahmani A,Montaudon E,Painsec P,Chateau-Joubert S,Laetitia F,Larcher T,Vacher S,Chemlali W,Briaux A,Melaabi S,Salomon AV,Guinebretiere JM

更新日期：2020-01-01 00:00:00

abstract：:Rationale: PLAGL2 (pleomorphic adenoma gene like-2), a zinc finger PLAG transcription factor, is aberrantly expressed in several malignant tumors. However, the biological roles of PLAGL2 and its underlying mechanism in gastric cancer (GC) remain unclear. Methods: A series of experiments in vitro and in vivo were condu...

journal_title：Theranostics

authors： Wu L,Zhao N,Zhou Z,Chen J,Han S,Zhang X,Bao H,Yuan W,Shu X

更新日期：2021-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (...

journal_title：Theranostics

authors： Chi YH,Hsiao JK,Lin MH,Chang C,Lan CH,Wu HC

更新日期：2017-04-10 00:00:00

abstract：:Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of soyasaponin II in acute liver failure and establish the...

journal_title：Theranostics

authors： Wang F,Gong S,Wang T,Li L,Luo H,Wang J,Huang C,Zhou H,Chen G,Liu Z,Zhang Q,Jiang Y,Chen P

更新日期：2020-02-03 00:00:00

abstract：:Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...

journal_title：Theranostics

authors： Tang Q,Hu Z,Jin H,Zheng G,Yu X,Wu G,Liu H,Zhu Z,Xu H,Zhang C,Shen L

更新日期：2019-01-30 00:00:00

abstract：:Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic administration. Here...

journal_title：Theranostics

authors： Fan B,Kang L,Chen L,Sun P,Jin M,Wang Q,Bae YH,Huang W,Gao Z

更新日期：2017-01-01 00:00:00

abstract：:Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for d...

journal_title：Theranostics

authors： Son DJ,Zheng J,Jung YY,Hwang CJ,Lee HP,Woo JR,Baek SY,Ham YW,Kang MW,Shong M,Kweon GR,Song MJ,Jung JK,Han SB,Kim BY,Yoon DY,Choi BY,Hong JT

更新日期：2017-10-16 00:00:00

abstract：:Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome. Here we performed an integrative genomic analysis and identified the bromodomain and extraterminal domain (BET) protein BRD4 as a potential therapeutic target ...

journal_title：Theranostics

authors： Zhang Z,Ma P,Jing Y,Yan Y,Cai MC,Zhang M,Zhang S,Peng H,Ji ZL,Di W,Gu Z,Gao WQ,Zhuang G

更新日期：2016-01-01 00:00:00

abstract：:Colitis-associated colon cancer (CAC) is a widely recognized cancer, while treatment with the existing chemotherapeutic drugs affords limited clinical benefits. Herein we proposed a site-specific, combination nanotherapy strategy for targeted treatment of CAC by the oral route. Methods: A reactive oxygen species (ROS)...

journal_title：Theranostics

authors： Zhang Q,Zhang F,Li S,Liu R,Jin T,Dou Y,Zhou Z,Zhang J

更新日期：2019-05-31 00:00:00

abstract：:Cancer stem cells (CSCs) are believed to be a principal cellular source for tumour progression and therapeutic drug resistance as they are capable of self-renewal and can differentiate into cancer cells. Importantly, CSCs acquire the ability to evade the killing effects of cytotoxic agents through changes at the genet...

journal_title：Theranostics

authors： Zhou G,Latchoumanin O,Bagdesar M,Hebbard L,Duan W,Liddle C,George J,Qiao L

更新日期：2017-09-13 00:00:00

abstract：:Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we d...

journal_title：Theranostics

authors： Bao K,Nasr KA,Hyun H,Lee JH,Gravier J,Gibbs SL,Choi HS

更新日期：2015-03-01 00:00:00

abstract：:Despite significant advances in cancer diagnostics and treatment, ovarian cancers (OC) continue to kill more than 150,000 women every year worldwide. Due to the relatively asymptomatic nature and the advanced stage of the disease at the time of diagnosis, OC is the most lethal gynecologic malignancy. The current treat...

journal_title：Theranostics

authors： Di Lorenzo G,Ricci G,Severini GM,Romano F,Biffi S

更新日期：2018-07-30 00:00:00

abstract：:Folate receptor (FR) has proven to be a valuable target for chemotherapy using folic acid (FA) conjugates. However, FA-conjugated chemotherapeutics still have low therapeutic efficacy accompanied with side effects, resulting from complications such as short circulation half-life, limited tumor delivery, as well as hig...

journal_title：Theranostics

authors： Shan L,Zhuo X,Zhang F,Dai Y,Zhu G,Yung BC,Fan W,Zhai K,Jacobson O,Kiesewetter DO,Ma Y,Gao G,Chen X

更新日期：2018-02-16 00:00:00

abstract：:Optical sensing plays an important role in theranostics due to its capability to detect hint biochemical entities or molecular targets as well as to precisely monitor specific fundamental psychological processes. Rare-earth (RE) doped upconversion nanoparticles (UCNPs) are promising for these endeavors due to their un...

journal_title：Theranostics

authors： Hao S,Chen G,Yang C

更新日期：2013-03-26 00:00:00

abstract：:The unique features of noble-metal nanostructures (NMNs) are leading to unprecedented expansion of research and exploration of their application in therapeutics, diagnostics and bioimaging fields. With the ever-growing applications of NMNs, both therapeutic and environmental NMNs are likely to be exposed to tissues an...

journal_title：Theranostics

authors： Huang Q,Zhang J,Zhang Y,Timashev P,Ma X,Liang XJ

更新日期：2020-04-27 00:00:00

abstract：:A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positi...

journal_title：Theranostics

authors： Hou FQ,Song LW,Yuan Q,Fang LL,Ge SX,Zhang J,Sheng JF,Xie DY,Shang J,Wu SH,Sun YT,Wei SF,Wang MR,Wan MB,Jia JD,Luo GH,Tang H,Li SC,Niu JQ,Zhou WD,Sun L,Xia NS,Wang GQ

更新日期：2015-01-01 00:00:00