BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1.

abstract：:Rationale: PLAGL2 (pleomorphic adenoma gene like-2), a zinc finger PLAG transcription factor, is aberrantly expressed in several malignant tumors. However, the biological roles of PLAGL2 and its underlying mechanism in gastric cancer (GC) remain unclear. Methods: A series of experiments in vitro and in vivo were condu...

journal_title：Theranostics

authors： Wu L,Zhao N,Zhou Z,Chen J,Han S,Zhang X,Bao H,Yuan W,Shu X

更新日期：2021-01-01 00:00:00

abstract：:Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for d...

journal_title：Theranostics

authors： Son DJ,Zheng J,Jung YY,Hwang CJ,Lee HP,Woo JR,Baek SY,Ham YW,Kang MW,Shong M,Kweon GR,Song MJ,Jung JK,Han SB,Kim BY,Yoon DY,Choi BY,Hong JT

更新日期：2017-10-16 00:00:00

abstract：:Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, unders...

journal_title：Theranostics

authors： De Sarno F,Ponsiglione AM,Russo M,Grimaldi AM,Forte E,Netti PA,Torino E

更新日期：2019-02-28 00:00:00

abstract：:The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat an...

journal_title：Theranostics

authors： Yu J,Yin W,Zheng X,Tian G,Zhang X,Bao T,Dong X,Wang Z,Gu Z,Ma X,Zhao Y

更新日期：2015-05-20 00:00:00

abstract：:Host-guest motifs are likely the most recognizable manifestation of supramolecular chemistry. These complexes are characterized by the organization of small molecules on the basis of preferential association of a guest within the portal of a host. In the context of their therapeutic use, the primary application of the...

journal_title：Theranostics

authors： Braegelman AS,Webber MJ

更新日期：2019-05-15 00:00:00

abstract：:Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we d...

journal_title：Theranostics

authors： Bao K,Nasr KA,Hyun H,Lee JH,Gravier J,Gibbs SL,Choi HS

更新日期：2015-03-01 00:00:00

abstract：:CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface protein that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2. Its potential as a cancer target is supported by studies showing that anti-CDCP1 antibodies inhibit cell migration and survival in vitro, and tumor g...

journal_title：Theranostics

authors： Harrington BS,He Y,Khan T,Puttick S,Conroy PJ,Kryza T,Cuda T,Sokolowski KA,Tse BW,Robbins KK,Arachchige BJ,Stehbens SJ,Pollock PM,Reed S,Weroha SJ,Haluska P,Salomon C,Lourie R,Perrin LC,Law RHP,Whisstock JC,Hoop

更新日期：2020-01-12 00:00:00

abstract：:The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant ex...

journal_title：Theranostics

authors： Corti A,Belcastro E,Pompella A

更新日期：2018-11-15 00:00:00

abstract：:Compared with other diagnostic methods, ultrasound is proven to be a safe, simple, non-invasive and cost-effective imaging technique, but the resolution is not comparable to that of magnetic resonance imaging (MRI). Contrast-enhanced ultrasound employing microbubbles can gain a better resolution and is now widely used...

journal_title：Theranostics

authors： Cai X,Yang F,Gu N

更新日期：2012-01-01 00:00:00

abstract：:In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bon...

journal_title：Theranostics

authors： Peng Y,Wu S,Li Y,Crane JL

更新日期：2020-01-01 00:00:00

abstract：:Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, copper homeostasis is considered as an emerging target for anticancer drug design. Monitoring copper levels in vivo is therefore of paramount importance when assessing the efficacy of copper-targeting drugs. ...

journal_title：Theranostics

authors： Parmar A,Pascali G,Voli F,Lerra L,Yee E,Ahmed-Cox A,Kimpton K,Cirillo G,Arthur A,Zahra D,Rahardjo G,Liu GJ,Lengkeek N,Saletta F,Charil A,Kavallaris M,Vittorio O

更新日期：2018-11-09 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a transmembrane cell surface receptor that is frequently overexpressed and/or mutated in many cancers. Therapies targeting EGFR have poor outcomes due to the lack of reliable diagnostic tests to monitor EGFR. Current in vitro EGFR diagnostic methods are invasive, requiring bi...

journal_title：Theranostics

authors： Bernhard W,El-Sayed A,Barreto K,Gonzalez C,Fonge H,Geyer CR

更新日期：2019-01-30 00:00:00

abstract：:Uncontrollable cell proliferation and irreversible neurological damage make glioma one of the most deadly diseases in clinic. Besides the multiple biological barriers, glioma stem cells (GSCs) that are responsible for the maintenance and recurrence of tumor tissues also hinder the therapeutic efficacy of chemotherapy....

journal_title：Theranostics

authors： Ran D,Zhou J,Chai Z,Li J,Xie C,Mao J,Lu L,Zhang Y,Wu S,Zhan C,Lu W

更新日期：2020-03-04 00:00:00

abstract：:Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during...

journal_title：Theranostics

authors： Liu Z,Wang F,Chen X

更新日期：2011-03-01 00:00:00

abstract：:Rationale: Mesenchymal cell-derived osteosarcoma is a rare malignant bone tumor affecting children and adolescents. PTEN down-regulation or function-loss mutation is associated with the aggressive of osteosarcoma. Explicating the regulatory mechanism of PTEN might highlight new targets for improving the survival rate ...

journal_title：Theranostics

authors： Wu W,Jing D,Meng Z,Hu B,Zhong B,Deng X,Jin X,Shao Z

更新日期：2020-02-03 00:00:00

abstract：:Elastin-like polypeptide (ELP)-based drug delivery has been utilized for various applications including cancer therapies for many years. Genetic incorporation of internalization ligands and cell-targeting peptides along with ELP polymer enhanced tumor accumulation and retention time as well as stability and activities...

journal_title：Theranostics

authors： Sarangthem V,Kim Y,Singh TD,Seo BY,Cheon SH,Lee YJ,Lee BH,Park RW

更新日期：2016-09-25 00:00:00

abstract：:Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against "self" antigens (Ags). In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust activation of T-cells against tumor Ags pr...

journal_title：Theranostics

authors： Kwon S,Velasquez FC,Rasmussen JC,Greives MR,Turner KD,Morrow JR,Hwu WJ,Ross RF,Zhang S,Sevick-Muraca EM

更新日期：2019-10-22 00:00:00

abstract：:The diseases caused by viruses posed a great challenge to human health, the development of which was driven by the imbalanced host immune response. Host innate immunity is an evolutionary old defense system that is critical for the elimination of the virus. The overactive innate immune response also leads to inflammat...

journal_title：Theranostics

authors： Wang Y,Wang Y,Luo W,Song X,Huang L,Xiao J,Jin F,Ren Z,Wang Y

更新日期：2020-07-23 00:00:00

abstract：:Although the prognosis of differentiated thyroid cancer (DTC) is relatively good, 30-40% of patients with distant metastases develop resistance to radioactive iodine therapy due to tumor dedifferentiation. For DTC patients harboring BRAFV600E mutation, Vemurafenib, a BRAF kinase inhibitor, has dramatically changed the...

journal_title：Theranostics

authors： Wei WJ,Sun ZK,Shen CT,Song HJ,Zhang XY,Qiu ZL,Luo QY

更新日期：2017-02-23 00:00:00

abstract：:Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression in human chondrocytes. The aim of this study was to determine whether microRNA-193b-3p (miR-193b-3p) regulates the expression of HDAC3 during chondrogenesis and chondrocyte metabolism. Methods: miR-193b-3p expres...

journal_title：Theranostics

authors： Meng F,Li Z,Zhang Z,Yang Z,Kang Y,Zhao X,Long D,Hu S,Gu M,He S,Wu P,Chang Z,He A,Liao W

更新日期：2018-04-15 00:00:00

abstract：:[This retracts the article DOI: 10.7150/thno.14306.]. ...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2020-09-30 00:00:00

abstract：:Successful anticancer chemotherapy requires targeting tumors efficiently and further potential to eliminate cancer stem cell (CSC) subpopulations. Since CD44 is present on many types of CSCs, and it binds specially to hyaluronic acid (HA), we tested whether coating solid lipid nanoparticles with hyaluronan (HA-SLNs)wo...

journal_title：Theranostics

authors： Shen H,Shi S,Zhang Z,Gong T,Sun X

更新日期：2015-04-05 00:00:00

abstract：:In biology, as every science student is made to learn, ontology recapitulates phylogeny. In medicine, however, oncology recapitulates polemology, the science of warfare: The medical establishment is transitioning from highly toxic poisons that kill rapidly dividing normal and malignant cells with little specificity to...

journal_title：Theranostics

authors： Paulmurugan R,Oronsky B,Brouse CF,Reid T,Knox S,Scicinski J

更新日期：2013-05-25 00:00:00

abstract：:18F-Fluciclovine (trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid; anti-18F-FACBC) is a positron emission tomography (PET) tracer for diagnosing cancers (e.g., prostate and breast cancer). The most frequent metastatic organ of these cancers is bone. Fluciclovine-PET can visualize bony lesions in clinical practice...

journal_title：Theranostics

authors： Oka S,Kanagawa M,Doi Y,Schuster DM,Goodman MM,Yoshimura H

更新日期：2017-05-15 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.21477.]. ...

journal_title：Theranostics

authors： Cao J,Wang X,Dai T,Wu Y,Zhang M,Cao R,Zhang R,Wang G,Jiang R,Zhou BP,Shi J,Kang T

更新日期：2021-01-01 00:00:00

abstract：:Metastasis is a major cause of death in patients with colorectal cancer (CRC). Cysteine-rich protein 2 (CSRP2) has been recently implicated in the progression and metastasis of a variety of cancers. However, the biological functions and underlying mechanisms of CSRP2 in the regulation of CRC progression are largely un...

journal_title：Theranostics

authors： Chen L,Long X,Duan S,Liu X,Chen J,Lan J,Liu X,Huang W,Geng J,Zhou J

更新日期：2020-09-02 00:00:00

abstract：:Rationale: Glioma stem-like cells (GSCs) contribute to temozolomide (TMZ) resistance in gliomas, although the mechanisms have not been delineated. Methods:In vitro functional experiments (colony formation assay, flow cytometric analysis, TUNEL assay) were used to assess the ability of extracellular vesicles (EVs) from...

journal_title：Theranostics

authors： Yin J,Ge X,Shi Z,Yu C,Lu C,Wei Y,Zeng A,Wang X,Yan W,Zhang J,You Y

更新日期：2021-01-01 00:00:00

abstract：:Aplastic anemia (AA) is characterized as hypoplasia of bone marrow hematopoietic cells and hematopenia of peripheral blood cells. Though the supplement of exogenous erythropoietin (EPO) has been clinically approved for AA treatment, the side-effects hinder its further application. Here a robust treatment for AA induce...

journal_title：Theranostics

authors： Jia W,Zhen M,Li L,Zhou C,Sun Z,Liu S,Zhao Z,Li J,Wang C,Bai C

更新日期：2020-05-23 00:00:00

abstract：:The α-chemokine CXCL12 (stromal derived factor-1; SDF-1) and its corresponding G(αI) protein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell niches. CXCL12 has also been identified as a strong chemoattractant for HSPCs and imp...

journal_title：Theranostics

authors： Ratajczak MZ,Serwin K,Schneider G

更新日期：2013-01-01 00:00:00

abstract：:In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic app...

journal_title：Theranostics

authors： Xie W,Guo Z,Gao F,Gao Q,Wang D,Liaw BS,Cai Q,Sun X,Wang X,Zhao L

更新日期：2018-05-11 00:00:00