LncRNA AY promotes hepatocellular carcinoma metastasis by stimulating ITGAV transcription.

abstract：:Inadequate diagnostic methods for prostate cancer lead to over- and undertreatment, and the inability to intraoperatively visualize positive margins may limit the success of surgical resection. Prostate cancer visualization could be improved by combining the complementary modalities of immuno-positron emission tomogra...

journal_title：Theranostics

authors： Tsai WK,Zettlitz KA,Tavaré R,Kobayashi N,Reiter RE,Wu AM

更新日期：2018-11-12 00:00:00

abstract：:Cancer theranostics is one of the most important approaches for detecting and treating patients at an early stage. To develop such a technique, accurate detection, specific targeting, and controlled delivery are the key components. Various kinds of nanoparticles have been proposed and demonstrated as potential nanoveh...

journal_title：Theranostics

authors： Ray S,Li Z,Hsu CH,Hwang LP,Lin YC,Chou PT,Lin YY

更新日期：2018-11-29 00:00:00

abstract：:A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS8, which is ...

journal_title：Theranostics

authors： Li X,Zheng BY,Ke MR,Zhang Y,Huang JD,Yoon J

更新日期：2017-07-07 00:00:00

abstract：:Detection of biomarkers is extremely important for the early diagnosis of diseases. Here, we developed an easy and highly sensitive fluorescence detection system for the determination of biomarkers by combining the rapid separation of magnetic beads and silver nanoparticles labeled antibodies. An ultrasensitive silver...

journal_title：Theranostics

authors： Zhao LJ,Yu RJ,Ma W,Han HX,Tian H,Qian RC,Long YT

更新日期：2017-02-08 00:00:00

abstract：:The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX ...

journal_title：Theranostics

authors： Yin J,Lang T,Cun D,Zheng Z,Huang Y,Yin Q,Yu H,Li Y

更新日期：2017-09-26 00:00:00

abstract：:Dendritic cells (DC) and tumor cell fusion vaccine (DC/tumor cell fusion vaccine) is considered an effective approach in cancer biotherapy. However, its therapeutic effects in early clinical trials have been suboptimal partially due to the immunosuppressive tumor environment. In this study, we used nanoparticles of fo...

journal_title：Theranostics

authors： Hu Z,Chen J,Zhou S,Yang N,Duan S,Zhang Z,Su J,He J,Zhang Z,Lu X,Zhao Y

更新日期：2017-05-02 00:00:00

abstract：:Rationale: Tumor microenvironment interacts with tumor cells to regulate their stemness properties through various cytokines and cytokine receptors. Previous studies revealed the possible role of interleukin 20 receptor subunit alpha (IL20RA) signaling in the progression of several types of tumors. However, its regula...

journal_title：Theranostics

authors： Gao W,Wen H,Liang L,Dong X,Du R,Zhou W,Zhang X,Zhang C,Xiang R,Li N

更新日期：2021-01-01 00:00:00

abstract：:Peptide-derived nanocomposites have been exhibiting fascinating biological advantages, including but not limited to excellent biocompatibility, biological degradation, high targetability and subsequent potent therapeutic efficacy. While some successes have been achieved in the nanoengineering of peptide-based architec...

journal_title：Theranostics

authors： Yan J,Ji F,Yan S,You W,Ma F,Li F,Huang Y,Liu W,He W

更新日期：2020-07-09 00:00:00

abstract：:Purpose: Evans Blue (EB) is an azo dye that binds quantitatively with serum albumin. With an albumin binding, NOTA conjugated truncated Evan's blue (NEB) dye derived PET tracer, we aimed to establish a strategy for evaluating vascular permeability in malignant tumors via non-invasive PET. Experimental design: Sixty-mi...

journal_title：Theranostics

authors： Chen H,Tong X,Lang L,Jacobson O,Yung BC,Yang X,Bai R,Kiesewetter DO,Ma Y,Wu H,Niu G,Chen X

更新日期：2017-06-14 00:00:00

abstract：:Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor 2 (Klf2) in ECs, ameliorates press...

journal_title：Theranostics

authors： Li H,Wang Y,Liu J,Chen X,Duan Y,Wang X,Shen Y,Kuang Y,Zhuang T,Tomlinson B,Chan P,Yu Z,Cheng Y,Zhang L,Liu Z,Zhang Y,Zhao Z,Zhang Q,Liu J

更新日期：2021-01-01 00:00:00

abstract：:We report a new technique to detect enzyme activity inside cells. The method based on Fluorescence Lifetime Imaging (FLIM) technology allows one to follow sensor cleavage by proteolytic enzyme caspase-3. Specifically, we use the FLIM FRET of living cells via the confocal fluorescence microscopy. A specially designed l...

journal_title：Theranostics

authors： Savitsky AP,Rusanov AL,Zherdeva VV,Gorodnicheva TV,Khrenova MG,Nemukhin AV

更新日期：2012-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) play a crucial role in cancer formation and development, especially cancer metastasis. However, lack of a precise tool, which could accurately distinguish specific types of ROS, restricts an in-depth study of ROS in cancer development and progression. Herein, we designed smart and versati...

journal_title：Theranostics

authors： Chen X,Wang T,Le W,Huang X,Gao M,Chen Q,Xu S,Yin D,Fu Q,Shao C,Chen B,Shi D

更新日期：2020-02-10 00:00:00

abstract：:Background: Tumor cells require proficient autophagy to meet high metabolic demands and resist chemotherapy, which suggests that reducing autophagic flux might be an attractive route for cancer therapy. However, this theory in clinical cancer research remains controversial due to the limited number of drugs that speci...

journal_title：Theranostics

authors： Liu PF,Tsai KL,Hsu CJ,Tsai WL,Cheng JS,Chang HW,Shiau CW,Goan YG,Tseng HH,Wu CH,Reed JC,Yang LW,Shu CW

更新日期：2018-01-01 00:00:00

abstract：:Sodium/iodide symporter (NIS)-mediated iodide uptake in thyroid follicular cells is the basis of clinical utilization of radioiodines. The cloning of the NIS gene enabled applications of NIS as a reporter gene in both preclinical and translational research. Non-invasive NIS imaging with radioactive iodides and iodide ...

journal_title：Theranostics

authors： Jiang H,DeGrado TR

更新日期：2018-06-24 00:00:00

abstract：:Background: By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. Accurate imaging of PCa recurrent lymph node metastases (LNM) is crucial for metasta...

journal_title：Theranostics

authors： Jilg CA,Drendel V,Rischke HC,Beck T,Vach W,Schaal K,Wetterauer U,Schultze-Seemann W,Meyer PT

更新日期：2017-04-10 00:00:00

abstract：:Using non-covalent interactions between nucleic acids (DNA, siRNA, miRNA, and mRNA) with peptides or nucleopeptides is a promising strategy to construct supramolecular assemblies for gene delivery and therapy. Comparing to conventional strategies for gene delivery, the assemblies of peptides or nucleopeptides provide ...

journal_title：Theranostics

authors： Wang H,Feng Z,Xu B

更新日期：2019-05-18 00:00:00

abstract：:The α-chemokine CXCL12 (stromal derived factor-1; SDF-1) and its corresponding G(αI) protein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell niches. CXCL12 has also been identified as a strong chemoattractant for HSPCs and imp...

journal_title：Theranostics

authors： Ratajczak MZ,Serwin K,Schneider G

更新日期：2013-01-01 00:00:00

abstract：:[This retracts the article on p. 3 in vol. 1, PMID: 21547151.]. ...

journal_title：Theranostics

authors： Lukianova-Hleb EY,Oginsky AO,Samaniego AP,Shenefelt DL,Wagner DS,Hafner JH,Farach-Carson MC,Lapotko DO

更新日期：2017-01-07 00:00:00

abstract：:Treatments of high specificity are desirable for cancer therapy. Light-triggered nanotheranostics (LTN) mediated cancer therapy could be one such treatment, as they make it possible to visualize and treat the tumor specifically in a light-controlled manner with a single injection. Because of their great potential in c...

journal_title：Theranostics

authors： Zhang P,Hu C,Ran W,Meng J,Yin Q,Li Y

更新日期：2016-04-27 00:00:00

abstract：:Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for d...

journal_title：Theranostics

authors： Son DJ,Zheng J,Jung YY,Hwang CJ,Lee HP,Woo JR,Baek SY,Ham YW,Kang MW,Shong M,Kweon GR,Song MJ,Jung JK,Han SB,Kim BY,Yoon DY,Choi BY,Hong JT

更新日期：2017-10-16 00:00:00

abstract：:In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bon...

journal_title：Theranostics

authors： Peng Y,Wu S,Li Y,Crane JL

更新日期：2020-01-01 00:00:00

abstract：:RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mice when administered...

journal_title：Theranostics

authors： Gao S,Hein S,Dagnæs-Hansen F,Weyer K,Yang C,Nielsen R,Christensen EI,Fenton RA,Kjems J

更新日期：2014-08-13 00:00:00

abstract：:Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared...

journal_title：Theranostics

authors： Li Y,Li Y,Zhang X,Xu X,Zhang Z,Hu C,He Y,Gu Z

更新日期：2016-06-05 00:00:00

abstract：:Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...

journal_title：Theranostics

authors： Tang Q,Hu Z,Jin H,Zheng G,Yu X,Wu G,Liu H,Zhu Z,Xu H,Zhang C,Shen L

更新日期：2019-01-30 00:00:00

abstract：:Dynamic positron emission tomography (PET) can monitor spatiotemporal distribution of radiotracer in vivo. The spatiotemporal information can be used to estimate parametric images of radiotracer kinetics that are of physiological and biochemical interests. Direct estimation of parametric images from raw projection dat...

journal_title：Theranostics

authors： Wang G,Qi J

更新日期：2013-11-20 00:00:00

abstract：:Zinc-finger proteins (ZFPs) are the largest transcription factor family in mammals, involved in the regulation of multiple physiologic processes including cell differentiation, proliferation, apoptosis and neoplastic transformation. Approximately one-third of ZFPs are Krüppel-associated box domain (KRAB)-ZFPs. Methods...

journal_title：Theranostics

authors： Sun R,Xiang T,Tang J,Peng W,Luo J,Li L,Qiu Z,Tan Y,Ye L,Zhang M,Ren G,Tao Q

更新日期：2020-01-12 00:00:00

abstract：:Overexpression of CD146 has been correlated with aggressiveness, recurrence rate, and poor overall survival in hepatocellular carcinoma (HCC) patients. In this study, we set out to develop a CD146-targeting probe for high-contrast noninvasive in vivo positron emission tomography (PET) and near-infrared fluorescence (N...

journal_title：Theranostics

authors： Hernandez R,Sun H,England CG,Valdovinos HF,Ehlerding EB,Barnhart TE,Yang Y,Cai W

更新日期：2016-08-08 00:00:00

abstract：:The relatively new field of nanotheranostics combines the advantages of in vivo diagnosis with the ability to administer treatment through a single nano-sized carrier, offering new opportunities for cancer diagnosis and therapy. Nanotheranostics has facilitated the development of nanomedicine through direct visualizat...

journal_title：Theranostics

authors： Luk BT,Fang RH,Zhang L

更新日期：2012-01-01 00:00:00

abstract：:Aberrant activation of the Src kinase is implicated in the development of a variety of human malignancies. However, it is almost impossible to monitor Src activity in an in vivo setting with current biochemical techniques. To facilitate the noninvasive investigation of the activity of Src kinase both in vitro and in v...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2016-02-24 00:00:00

abstract：:Cell sheet technology opens new perspectives in tissue regeneration therapy by providing readily implantable, scaffold-free 3D tissue constructs. Many studies have focused on the therapeutic effects of cell sheet implantation while relatively little attention has concerned the fate of the implanted cells in vivo. The ...

journal_title：Theranostics

authors： Rahmi G,Pidial L,Silva AK,Blondiaux E,Meresse B,Gazeau F,Autret G,Balvay D,Cuenod CA,Perretta S,Tavitian B,Wilhelm C,Cellier C,Clément O

更新日期：2016-03-21 00:00:00