Quantification of Tumor Vascular Permeability and Blood Volume by Positron Emission Tomography.

abstract：:Cerebrospinal fluid (CSF) leakage can lead to brain and spine pathologies and there is an urgent need for a rapid diagnostic method for determining CSF leakage. Beta-2 transferrin (β2TF), asialotransferrin, is a specific CSF glycoprotein biomarker used to determine CSF leakage when distinguished from serum sialotransf...

journal_title：Theranostics

authors： Oh J,Kwon SJ,Dordick JS,Sonstein WJ,Linhardt RJ,Kim MG

更新日期：2019-05-31 00:00:00

abstract：:Targeting cancer stem cells (CSCs) has been proposed as a new strategy to eradicate malignancies, including hepatocellular carcinoma (HCC). However, the mechanisms by which CSCs sustain their self-renewal and chemoresistance remain elusive. Nanog is a master transcriptional regulator of stemness, especially in CSCs. I...

journal_title：Theranostics

authors： Cao J,Zhao M,Liu J,Zhang X,Pei Y,Wang J,Yang X,Shen B,Zhang J

更新日期：2019-01-24 00:00:00

abstract：:Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro; thus, we hypothesize that this pathway can mitigate cardiomyocyte ...

journal_title：Theranostics

authors： Grisanti LA,Thomas TP,Carter RL,de Lucia C,Gao E,Koch WJ,Benovic JL,Tilley DG

更新日期：2018-09-09 00:00:00

abstract：:Comprehensive analysis of the expression level and location of tumor-associated membrane proteins (TMPs) is of vital importance for the profiling of tumor cells. Currently, two kinds of independent techniques, i.e. ex situ detection and in situ imaging, are usually required for the quantification and localization of T...

journal_title：Theranostics

authors： Chen X,Zhao J,Chen T,Gao T,Zhu X,Li G

更新日期：2018-01-01 00:00:00

abstract：:Rationale: P21-activated kinase 6 (PAK6) is a member of the class II PAKs family, which is a conserved family of serine/threonine kinases. Although the effects of PAK6 on many malignancies, especially in prostate cancer, have been studied for a long time, the role of PAK6 in mitochondria remains unknown. Methods: The ...

journal_title：Theranostics

authors： Li T,Li Y,Liu T,Hu B,Li J,Liu C,Liu T,Li F

更新日期：2020-02-03 00:00:00

abstract：:Rationale: To test whether novel biomarkers, such as microribonucleic acids (miRNAs), and nonstandard predictive models, such as decision tree learning, provide useful information for medical decision-making in patients on hemodialysis (HD). Methods: Samples from patients with end-stage renal disease receiving HD incl...

journal_title：Theranostics

authors： de Gonzalo-Calvo D,Martínez-Camblor P,Bär C,Duarte K,Girerd N,Fellström B,Schmieder RE,Jardine AG,Massy ZA,Holdaas H,Rossignol P,Zannad F,Thum T

更新日期：2020-07-09 00:00:00

abstract：:Inhibitor of apoptosis proteins (IAP) are cell death regulators that bind caspases and interfere with apoptotic signalling via death receptors or intrinsic cell death pathways. BIRC4/XIAP is the most potent anti-apoptotic IAP-member and it physically interacts with caspases via its BIR2 and its BIR3 domain. These doma...

journal_title：Theranostics

authors： Hagenbuchner J,Oberacher H,Arnhard K,Kiechl-Kohlendorfer U,Ausserlechner MJ

更新日期：2019-07-09 00:00:00

abstract：:Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells (HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with transcriptional and epigenetic remodeling. We aimed to characterize t...

journal_title：Theranostics

authors： Jiang Y,Xiang C,Zhong F,Zhang Y,Wang L,Zhao Y,Wang J,Ding C,Jin L,He F,Wang H

更新日期：2021-01-01 00:00:00

abstract：:Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread pathogen- and host-derived molecules duri...

journal_title：Theranostics

authors： Rodrigues M,Fan J,Lyon C,Wan M,Hu Y

更新日期：2018-04-09 00:00:00

abstract：:This work reports that when PEG-lipid-shelled microbubbles with fluorocarbon interior (C4F10, C5F12, or C6F14) are subjected to ultrasound pulses, they produce metastable, fluid-filled nanoparticles that can be re-imaged upon administration of HIFU. The nanoparticles produced by destruction of the microbubbles (MBNPs)...

journal_title：Theranostics

authors： Blum NT,Yildirim A,Chattaraj R,Goodwin AP

更新日期：2017-01-15 00:00:00

abstract：:In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bon...

journal_title：Theranostics

authors： Peng Y,Wu S,Li Y,Crane JL

更新日期：2020-01-01 00:00:00

abstract：:Body fluids are a rich source of extracellular vesicles (EVs), which carry cargo derived from the secreting cells. So far, biomarkers for pathological conditions have been mainly searched from their protein, (mi)RNA, DNA and lipid cargo. Here, we explored the small molecule metabolites from urinary and platelet EVs re...

journal_title：Theranostics

authors： Puhka M,Takatalo M,Nordberg ME,Valkonen S,Nandania J,Aatonen M,Yliperttula M,Laitinen S,Velagapudi V,Mirtti T,Kallioniemi O,Rannikko A,Siljander PR,Af Hällström TM

更新日期：2017-08-23 00:00:00

abstract：:The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX ...

journal_title：Theranostics

authors： Yin J,Lang T,Cun D,Zheng Z,Huang Y,Yin Q,Yu H,Li Y

更新日期：2017-09-26 00:00:00

abstract：:Molecular subtyping of breast cancer is of considerable interest owing to its potential for personalized therapy and prognosis. However, current methodologies cannot be used for precise subtyping, thereby posing a challenge in clinical practice. The aim of the present study is to develop a cell-specific single-strande...

journal_title：Theranostics

authors： Liu M,Wang Z,Tan T,Chen Z,Mou X,Yu X,Deng Y,Lu G,He N

更新日期：2018-11-10 00:00:00

abstract：:Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, unders...

journal_title：Theranostics

authors： De Sarno F,Ponsiglione AM,Russo M,Grimaldi AM,Forte E,Netti PA,Torino E

更新日期：2019-02-28 00:00:00

abstract：:Identification of novel targets for triple-negative breast cancer (TNBC) is an urgent task as targeted therapies have increased the lifespans of Oestrogen Receptor +/ Progesterone Receptor + and HER2+ cancer patients. Methods: genes involved in protein processing in the endoplasmic reticulum, which have been reported ...

journal_title：Theranostics

authors： Fu W,Sun H,Zhao Y,Chen M,Yang X,Liu Y,Jin W

更新日期：2019-08-21 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.27882.]. ...

journal_title：Theranostics

authors： Qin C,Liu Q,Hu ZW,Zhou LQ,Shang K,Bosco DB,Wu LJ,Tian DS,Wang W

更新日期：2020-07-10 00:00:00

abstract：:The most frequent malignancy of the pancreas is the pancreatic ductal adenocarcinoma (PDAC). Despite many efforts PDAC has still a dismal prognosis. Biomarkers for early disease stage diagnosis as a prerequisite for a potentially curative treatment are still missing. Novel blood-based markers may help to overcome this...

journal_title：Theranostics

authors： Berger AW,Schwerdel D,Reinacher-Schick A,Uhl W,Algül H,Friess H,Janssen KP,König A,Ghadimi M,Gallmeier E,Bartsch DK,Geissler M,Staib L,Tannapfel A,Kleger A,Beutel A,Schulte LA,Kornmann M,Ettrich TJ,Seufferlein T

更新日期：2019-02-12 00:00:00

abstract：:The α-chemokine CXCL12 (stromal derived factor-1; SDF-1) and its corresponding G(αI) protein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell niches. CXCL12 has also been identified as a strong chemoattractant for HSPCs and imp...

journal_title：Theranostics

authors： Ratajczak MZ,Serwin K,Schneider G

更新日期：2013-01-01 00:00:00

abstract：:Luminal androgen receptor (LAR) breast cancer accounts for 10% of all triple-negative breast cancers (TNBC). Anti-androgen therapy for this subtype is in development, but yields only partial clinical benefits. In this study, we aimed to characterize the genomic alterations of LAR TNBC, to analyze activation of the PI3...

journal_title：Theranostics

authors： Coussy F,Lavigne M,de Koning L,Botty RE,Nemati F,Naguez A,Bataillon G,Ouine B,Dahmani A,Montaudon E,Painsec P,Chateau-Joubert S,Laetitia F,Larcher T,Vacher S,Chemlali W,Briaux A,Melaabi S,Salomon AV,Guinebretiere JM

更新日期：2020-01-01 00:00:00

abstract：:Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome. Here we performed an integrative genomic analysis and identified the bromodomain and extraterminal domain (BET) protein BRD4 as a potential therapeutic target ...

journal_title：Theranostics

authors： Zhang Z,Ma P,Jing Y,Yan Y,Cai MC,Zhang M,Zhang S,Peng H,Ji ZL,Di W,Gu Z,Gao WQ,Zhuang G

更新日期：2016-01-01 00:00:00

abstract：:Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly understood. Methods: Mass spectrometry analysis and immunoprecip...

journal_title：Theranostics

authors： Huang Y,Hu K,Zhang S,Dong X,Yin Z,Meng R,Zhao Y,Dai X,Zhang T,Yang K,Liu L,Huang K,Shi S,Zhang Y,Chen J,Wu G,Xu S

更新日期：2018-02-02 00:00:00

abstract：:During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells chemotaxis being accompanied by activation of diverse intercellular s...

journal_title：Theranostics

authors： Jin J,Zhao Q

更新日期：2020-05-15 00:00:00

abstract：:Rationale: Colitis-associated colorectal cancer (CAC) usually exhibits an accelerated disease progression, an increased resistance to therapeutic drugs and a higher mortality rate than sporadic colorectal cancer (CRC). PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family; however, little is known...

journal_title：Theranostics

authors： Ma J,Yang Y,Fu Y,Guo F,Zhang X,Xiao S,Zhu W,Huang Z,Zhang J,Chen J

更新日期：2018-04-30 00:00:00

abstract：:Lateral flow assay (LFA) has become one of the most widely used point-of-care diagnostic methods due to its simplicity and low cost. While easy to use, LFA suffers from its low sensitivity and poor quantification, which largely limits its applications for early disease diagnosis and requires further testing to elimina...

journal_title：Theranostics

authors： Ye H,Liu Y,Zhan L,Liu Y,Qin Z

更新日期：2020-03-15 00:00:00

abstract：:Background: Accumulating evidences indicate that nanomedicines greatly decrease the side effects and enhance the efficacy of colorectal cancer (CRC) treatment. In particular, the use of rectal delivery of nanomedicines, with advantages such as fast therapeutic effects and a diminishing hepatic first-pass effect, is cu...

journal_title：Theranostics

authors： Zhao R,Du S,Liu Y,Lv C,Song Y,Chen X,Zhang B,Li D,Gao S,Cui W,Plikus MV,Hou X,Wu K,Liu Z,Liu Z,Cong Y,Li Y,Yu Z

更新日期：2020-02-18 00:00:00

abstract：:Rationale: PLAGL2 (pleomorphic adenoma gene like-2), a zinc finger PLAG transcription factor, is aberrantly expressed in several malignant tumors. However, the biological roles of PLAGL2 and its underlying mechanism in gastric cancer (GC) remain unclear. Methods: A series of experiments in vitro and in vivo were condu...

journal_title：Theranostics

authors： Wu L,Zhao N,Zhou Z,Chen J,Han S,Zhang X,Bao H,Yuan W,Shu X

更新日期：2021-01-01 00:00:00

abstract：:Liquid biopsy of tumor through isolation of circulating tumor cells (CTCs) allows non-invasive, repetitive, and systemic sampling of disease. Although detecting and enumerating CTCs is of prognostic significance in metastatic cancer, it is conceivable that performing molecular and functional characterization on CTCs w...

journal_title：Theranostics

authors： Chen JF,Zhu Y,Lu YT,Hodara E,Hou S,Agopian VG,Tomlinson JS,Posadas EM,Tseng HR

更新日期：2016-06-15 00:00:00

abstract：:Purpose: To identify extracellular vesicle (EV)-delivered microRNAs in the patient's serum as indicators for bone-metastatic prostate cancer. Methods: First, the profiling change of serum EV-delivered miRNAs in patients with either benign prostatic hyperplasia (BPH), non-bone metastatic prostate cancer or bone-metasta...

journal_title：Theranostics

authors： Wang Y,Fang YX,Dong B,Du X,Wang J,Wang X,Gao WQ,Xue W

更新日期：2021-01-01 00:00:00

abstract：:Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during...

journal_title：Theranostics

authors： Liu Z,Wang F,Chen X

更新日期：2011-03-01 00:00:00