Direct estimation of kinetic parametric images for dynamic PET.

Abstract:

:Dynamic positron emission tomography (PET) can monitor spatiotemporal distribution of radiotracer in vivo. The spatiotemporal information can be used to estimate parametric images of radiotracer kinetics that are of physiological and biochemical interests. Direct estimation of parametric images from raw projection data allows accurate noise modeling and has been shown to offer better image quality than conventional indirect methods, which reconstruct a sequence of PET images first and then perform tracer kinetic modeling pixel-by-pixel. Direct reconstruction of parametric images has gained increasing interests with the advances in computing hardware. Many direct reconstruction algorithms have been developed for different kinetic models. In this paper we review the recent progress in the development of direct reconstruction algorithms for parametric image estimation. Algorithms for linear and nonlinear kinetic models are described and their properties are discussed.

journal_name

Theranostics

journal_title

Theranostics

authors

Wang G,Qi J

doi

10.7150/thno.5130

subject

Has Abstract

pub_date

2013-11-20 00:00:00

pages

802-15

issue

10

issn

1838-7640

pii

thnov03p0802

journal_volume

3

pub_type

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