Photosensitizer-conjugated human serum albumin nanoparticles for effective photodynamic therapy.

abstract：:Up to one-third of diffuse large B cell lymphoma (DLBCL) patients eventually develop resistance to R-CHOP regimen, while the remaining therapeutic options are limited. Thus, understanding the underlying mechanisms and developing therapeutic approaches are urgently needed. Methods: We generated two germinal center B ce...

journal_title：Theranostics

authors： Chen J,Ge X,Zhang W,Ding P,Du Y,Wang Q,Li L,Fang L,Sun Y,Zhang P,Zhou Y,Zhang L,Lv X,Li L,Zhang X,Zhang Q,Xue K,Gu H,Lei Q,Wong J,Hu W

更新日期：2020-02-10 00:00:00

abstract：:Extracellular vesicles, in particular exosomes, have recently gained interest as novel drug delivery vectors due to their biological origin and inherent intercellular biomolecule delivery capability. An in-depth knowledge of their in vivo biodistribution is therefore essential. This work aimed to develop a novel, reli...

journal_title：Theranostics

authors： Faruqu FN,Wang JT,Xu L,McNickle L,Chong EM,Walters A,Gurney M,Clayton A,Smyth LA,Hider R,Sosabowski J,Al-Jamal KT

更新日期：2019-02-28 00:00:00

abstract：:In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic app...

journal_title：Theranostics

authors： Xie W,Guo Z,Gao F,Gao Q,Wang D,Liaw BS,Cai Q,Sun X,Wang X,Zhao L

更新日期：2018-05-11 00:00:00

abstract：:Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recen...

journal_title：Theranostics

authors： Yong KT,Wang Y,Roy I,Rui H,Swihart MT,Law WC,Kwak SK,Ye L,Liu J,Mahajan SD,Reynolds JL

更新日期：2012-01-01 00:00:00

abstract：:Small interfering RNA (siRNA) has proved to be a powerful tool for target-specific gene silencing via RNA interference (RNAi). Its ability to control targeted gene expression gives new hope to gene therapy as a treatment for cancers and genetic diseases. However, siRNA shows poor pharmacological properties, such as lo...

journal_title：Theranostics

authors： Hong CA,Nam YS

更新日期：2014-09-19 00:00:00

abstract：:Reactive oxygen species (ROS) play a crucial role in cancer formation and development, especially cancer metastasis. However, lack of a precise tool, which could accurately distinguish specific types of ROS, restricts an in-depth study of ROS in cancer development and progression. Herein, we designed smart and versati...

journal_title：Theranostics

authors： Chen X,Wang T,Le W,Huang X,Gao M,Chen Q,Xu S,Yin D,Fu Q,Shao C,Chen B,Shi D

更新日期：2020-02-10 00:00:00

abstract：:Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...

journal_title：Theranostics

authors： Tang Q,Hu Z,Jin H,Zheng G,Yu X,Wu G,Liu H,Zhu Z,Xu H,Zhang C,Shen L

更新日期：2019-01-30 00:00:00

abstract：:Background: Lung cancer has a high mortality rate and is resistant to multiple chemotherapeutics. Natural Borneol (NB) is a monoterpenoid compound that facilitates the bioavailability of drugs. In this study, we investigated the effects of NB on chemosensitivity in the A549 human lung adenocarcinoma cell line and to e...

journal_title：Theranostics

authors： Lai H,Liu C,Hou L,Lin W,Chen T,Hong A

更新日期：2020-08-13 00:00:00

abstract：:Targeting cancer stem cells (CSCs) has been proposed as a new strategy to eradicate malignancies, including hepatocellular carcinoma (HCC). However, the mechanisms by which CSCs sustain their self-renewal and chemoresistance remain elusive. Nanog is a master transcriptional regulator of stemness, especially in CSCs. I...

journal_title：Theranostics

authors： Cao J,Zhao M,Liu J,Zhang X,Pei Y,Wang J,Yang X,Shen B,Zhang J

更新日期：2019-01-24 00:00:00

abstract：:Sodium/iodide symporter (NIS)-mediated iodide uptake in thyroid follicular cells is the basis of clinical utilization of radioiodines. The cloning of the NIS gene enabled applications of NIS as a reporter gene in both preclinical and translational research. Non-invasive NIS imaging with radioactive iodides and iodide ...

journal_title：Theranostics

authors： Jiang H,DeGrado TR

更新日期：2018-06-24 00:00:00

abstract：:The application of blood plasma for soft tissue wound healing is receiving much more attention recently. Exosomes are critical paracrine mediators that can be obtained from biological fluids including plasma and be able to induce regenerative effects by transferring bioactive molecules such as microRNAs (miRNAs). This...

journal_title：Theranostics

authors： Hu Y,Rao SS,Wang ZX,Cao J,Tan YJ,Luo J,Li HM,Zhang WS,Chen CY,Xie H

更新日期：2018-01-01 00:00:00

abstract：:Autophagy is a dynamic and complicated catabolic process. Imaging autophagic flux can clearly advance knowledge of its pathophysiology significance. While the most common way autophagy is imaged relies on fluorescent protein-based probes, this method requires substantial genetic manipulation that severely restricts th...

journal_title：Theranostics

authors： Lei Y,Ren W,Wang CK,Tao RR,Xiang HJ,Feng LL,Gao YP,Jiang Q,Li X,Hu Y,Han F

更新日期：2019-08-01 00:00:00

abstract：:Rationale: P21-activated kinase 6 (PAK6) is a member of the class II PAKs family, which is a conserved family of serine/threonine kinases. Although the effects of PAK6 on many malignancies, especially in prostate cancer, have been studied for a long time, the role of PAK6 in mitochondria remains unknown. Methods: The ...

journal_title：Theranostics

authors： Li T,Li Y,Liu T,Hu B,Li J,Liu C,Liu T,Li F

更新日期：2020-02-03 00:00:00

abstract：:Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor 2 (Klf2) in ECs, ameliorates press...

journal_title：Theranostics

authors： Li H,Wang Y,Liu J,Chen X,Duan Y,Wang X,Shen Y,Kuang Y,Zhuang T,Tomlinson B,Chan P,Yu Z,Cheng Y,Zhang L,Liu Z,Zhang Y,Zhao Z,Zhang Q,Liu J

更新日期：2021-01-01 00:00:00

abstract：:We report a new technique to detect enzyme activity inside cells. The method based on Fluorescence Lifetime Imaging (FLIM) technology allows one to follow sensor cleavage by proteolytic enzyme caspase-3. Specifically, we use the FLIM FRET of living cells via the confocal fluorescence microscopy. A specially designed l...

journal_title：Theranostics

authors： Savitsky AP,Rusanov AL,Zherdeva VV,Gorodnicheva TV,Khrenova MG,Nemukhin AV

更新日期：2012-01-01 00:00:00

abstract：:The mineral dust-induced gene (mdig) is overexpressed in a number of human cancers, suggesting critical roles of this gene played on the pathogenesis of cancers. Unlike several other JmjC-domain containing proteins that exhibit histone demethylase activity, it remains enigmatic whether mdig is involved in the demethyl...

journal_title：Theranostics

authors： Zhang Q,Thakur C,Fu Y,Bi Z,Wadgaonkar P,Xu L,Liu Z,Liu W,Wang J,Kidder BL,Chen F

更新日期：2020-01-01 00:00:00

abstract：:Purpose: Positron emission tomography (PET) imaging of apoptosis is very important for early evaluation of tumor therapeutic efficacy. A stimuli-responsive probe based on the peptide sequence Asp-Glu-Val-Asp (DEVD), [18F]DEVD-Cys(StBu)-PPG(CBT)-AmBF3 ([18F]1), for PET imaging of tumor apoptosis was designed and prepar...

journal_title：Theranostics

authors： Qiu L,Wang W,Li K,Peng Y,Lv G,Liu Q,Gao F,Seimbille Y,Xie M,Lin J

更新日期：2019-09-21 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.27882.]. ...

journal_title：Theranostics

authors： Qin C,Liu Q,Hu ZW,Zhou LQ,Shang K,Bosco DB,Wu LJ,Tian DS,Wang W

更新日期：2020-07-10 00:00:00

abstract：:Rational: Ischemic injury of the skeletal muscle remains a serious clinical problem and currently there is no effective therapy. The aim of the present study is to determine whether human umbilical cord mesenchymal stem cells- derived exosomes (UMSC-Exo) could repair ischemic injury by releasing circular RNA. Methods ...

journal_title：Theranostics

authors： Yan B,Zhang Y,Liang C,Liu B,Ding F,Wang Y,Zhu B,Zhao R,Yu XY,Li Y

更新日期：2020-05-18 00:00:00

abstract：:Host-guest motifs are likely the most recognizable manifestation of supramolecular chemistry. These complexes are characterized by the organization of small molecules on the basis of preferential association of a guest within the portal of a host. In the context of their therapeutic use, the primary application of the...

journal_title：Theranostics

authors： Braegelman AS,Webber MJ

更新日期：2019-05-15 00:00:00

abstract：PURPOSE:The efficacy of pro-angiogenic therapy is difficult to evaluate with current diagnostic modalities. The objectives were to develop a non-invasive imaging strategy to define the temporal characteristics of angiogenesis and to evaluate the response to pro-angiogenic therapy in diabetic stroke mouse models. METHO...

journal_title：Theranostics

authors： Bai YY,Gao X,Wang YC,Peng XG,Chang D,Zheng S,Li C,Ju S

更新日期：2014-05-25 00:00:00

abstract：:[This retracts the article on p. 3 in vol. 1, PMID: 21547151.]. ...

journal_title：Theranostics

authors： Lukianova-Hleb EY,Oginsky AO,Samaniego AP,Shenefelt DL,Wagner DS,Hafner JH,Farach-Carson MC,Lapotko DO

更新日期：2017-01-07 00:00:00

abstract：:Biological cancer therapies, such as oncolytic, or replication-selective viruses have advantages over traditional therapeutics as they can employ multiple different mechanisms to target and destroy cancers (including direct cell lysis, immune activation and vascular collapse). This has led to their rapid recent clinic...

journal_title：Theranostics

authors： Rojas JJ,Thorne SH

更新日期：2012-01-01 00:00:00

abstract：:Objective: Vascular smooth muscle cells (VSMCs) undergo the phenotypic changes from contractile to synthetic state during vascular remodeling after ischemia. SIRT1 protects against stress-induced vascular remodeling via maintaining VSMC differentiated phenotype. However, the effect of smooth muscle SIRT1 on the functi...

journal_title：Theranostics

authors： Dou YQ,Kong P,Li CL,Sun HX,Li WW,Yu Y,Nie L,Zhao LL,Miao SB,Li XK,Dong C,Zhang JW,Liu Y,Huo XX,Chi K,Gao X,Zhang N,Weng L,Yang H,Zhang F,Han M

更新日期：2020-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (...

journal_title：Theranostics

authors： Chi YH,Hsiao JK,Lin MH,Chang C,Lan CH,Wu HC

更新日期：2017-04-10 00:00:00

abstract：:Non-invasive PET imaging of CXCR4 expression in cancer and inflammation as well as CXCR4-targeted radioligand therapy (RLT) have recently found their way into clinical research by the development of the theranostic agents [68Ga]PentixaFor (cyclo(D-Tyr1-D-[NMe]Orn2(AMBS-[68Ga]DOTA)-Arg3-Nal4-Gly5) = [68Ga]DOTA-AMBS-CPC...

journal_title：Theranostics

authors： Osl T,Schmidt A,Schwaiger M,Schottelius M,Wester HJ

更新日期：2020-07-09 00:00:00

abstract：:Norepinephrine modulates cognitive processes such as working and episodic memory. Pathological changes in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the whole norepinephrine system, disrupting cognitive processes. Monitor...

journal_title：Theranostics

authors： López-Picón FR,Kirjavainen AK,Forsback S,Takkinen JS,Peters D,Haaparanta-Solin M,Solin O

更新日期：2019-01-01 00:00:00

abstract：:Blood vessels are conduits distributed throughout the body, supporting tissue growth and homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the linings of the blood vessels, and together with pericytes, are essential for organ development and tissue homeostasis through producing ...

journal_title：Theranostics

authors： Zhu S,Bennett S,Kuek V,Xiang C,Xu H,Rosen V,Xu J

更新日期：2020-05-01 00:00:00

abstract：:Hypoxic zones are common features of metastatic tumors. Due to inactivation of the von Hippel-Lindau gene (VHL), renal cell carcinomas (RCC) show constitutive stabilization of the alpha subunit of the hypoxia-inducible factor (HIF). Thus, RCC represents a model of chronic hypoxia. Development of the lymphatic network ...

journal_title：Theranostics

authors： Ndiaye PD,Dufies M,Giuliano S,Douguet L,Grépin R,Durivault J,Lenormand P,Glisse N,Mintcheva J,Vouret-Craviari V,Mograbi B,Wurmser M,Ambrosetti D,Rioux-Leclercq N,Maire P,Pagès G

更新日期：2019-01-21 00:00:00

abstract：:Stem cell tracking is a highly important subject. Current techniques based on nanoparticle-labeling, such as magnetic resonance imaging, fluorescence microscopy, and micro-computed tomography, are plagued by limitations including relatively low sensitivity or penetration depth, involvement of ionizing irradiation, and...

journal_title：Theranostics

authors： Zhang YS,Wang Y,Wang L,Wang Y,Cai X,Zhang C,Wang LV,Xia Y

更新日期：2013-07-19 00:00:00