Theranostic potential of oncolytic vaccinia virus.

abstract：:Rationale: Subjects unable to sustain β-cell compensation develop type 2 diabetes. Early growth response-1 protein (EGR-1), implicated in the regulation of cell differentiation, proliferation, and apoptosis, is induced by diverse metabolic challenges, such as glucose or other nutrients. Therefore, we hypothesized that...

journal_title：Theranostics

authors： Leu SY,Kuo LH,Weng WT,Lien IC,Yang CC,Hsieh TT,Cheng YN,Chien PH,Ho LC,Chen SH,Shan YS,Chen YW,Tsai PJ,Sung JM,Tsai YS

更新日期：2020-03-04 00:00:00

abstract：:The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat an...

journal_title：Theranostics

authors： Yu J,Yin W,Zheng X,Tian G,Zhang X,Bao T,Dong X,Wang Z,Gu Z,Ma X,Zhao Y

更新日期：2015-05-20 00:00:00

abstract：:Purpose: Cancer immunotherapy depends on a systemic immune response, but the basic underlying mechanisms are still largely unknown. Despite the very successful and widespread use of checkpoint inhibitors in the clinic, the majority of cancer patients do not benefit from this type of treatment. In this translational st...

journal_title：Theranostics

authors： Schwenck J,Schörg B,Fiz F,Sonanini D,Forschner A,Eigentler T,Weide B,Martella M,Gonzalez-Menendez I,Campi C,Sambuceti G,Seith F,Quintanilla-Martinez L,Garbe C,Pfannenberg C,Röcken M,la Fougere C,Pichler BJ,Kneilling M

更新日期：2020-01-01 00:00:00

abstract：:The most frequent malignancy of the pancreas is the pancreatic ductal adenocarcinoma (PDAC). Despite many efforts PDAC has still a dismal prognosis. Biomarkers for early disease stage diagnosis as a prerequisite for a potentially curative treatment are still missing. Novel blood-based markers may help to overcome this...

journal_title：Theranostics

authors： Berger AW,Schwerdel D,Reinacher-Schick A,Uhl W,Algül H,Friess H,Janssen KP,König A,Ghadimi M,Gallmeier E,Bartsch DK,Geissler M,Staib L,Tannapfel A,Kleger A,Beutel A,Schulte LA,Kornmann M,Ettrich TJ,Seufferlein T

更新日期：2019-02-12 00:00:00

abstract：:Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome. Here we performed an integrative genomic analysis and identified the bromodomain and extraterminal domain (BET) protein BRD4 as a potential therapeutic target ...

journal_title：Theranostics

authors： Zhang Z,Ma P,Jing Y,Yan Y,Cai MC,Zhang M,Zhang S,Peng H,Ji ZL,Di W,Gu Z,Gao WQ,Zhuang G

更新日期：2016-01-01 00:00:00

abstract：:Metastasis is the primary cause of death in patients with advanced cancer. Recently, a high-fat diet was shown to specifically promote the metastatic potential of specific cancer cells in a CD36-dependent manner. However, the molecular basis of the fatty acid (FA)-induced upregulation of CD36 has remained unclear. Met...

journal_title：Theranostics

authors： Jiang M,Wu N,Xu B,Chu Y,Li X,Su S,Chen D,Li W,Shi Y,Gao X,Zhang H,Zhang Z,Du W,Nie Y,Liang J,Fan D

更新日期：2019-07-09 00:00:00

abstract：:Near-infrared (NIR) fluorescence imaging has relied on fluorophores that emit in the 700-900 nm NIR-Ia or 1,000-1,700 nm NIR-II window for generating deep-tissue images. Up until now, there have been few fluorophores developed for the 900-1,000 nm NIR-Ib window. This is largely because NIR-Ib light is thought to be st...

journal_title：Theranostics

authors： Deng G,Li S,Sun Z,Li W,Zhou L,Zhang J,Gong P,Cai L

更新日期：2018-07-16 00:00:00

abstract：:This paper reports a sensitive method with electrochemical technique to detect various proteases, which can be used for the diagnosis of prostate cancer. For the proposed assay method, the working electrode is modified with the peptide probes for the target proteases. These probes contain the substrate sequence of tar...

journal_title：Theranostics

authors： Li H,Huang Y,Zhang B,Yang D,Zhu X,Li G

更新日期：2014-04-25 00:00:00

abstract：:Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for d...

journal_title：Theranostics

authors： Son DJ,Zheng J,Jung YY,Hwang CJ,Lee HP,Woo JR,Baek SY,Ham YW,Kang MW,Shong M,Kweon GR,Song MJ,Jung JK,Han SB,Kim BY,Yoon DY,Choi BY,Hong JT

更新日期：2017-10-16 00:00:00

abstract：:Cell-based immunotherapy for the treatment of hematologic malignancies, such as leukemia and lymphoma, has seen much success and played an increasingly important role in clinical studies. Nevertheless, the efficacy of immunotherapy in solid tumors still needs improvements due to the immunosuppressive properties of tum...

journal_title：Theranostics

authors： Qian X,Shi Z,Qi H,Zhao M,Huang K,Han D,Zhou J,Liu C,Liu Y,Lu Y,Yuan X,Zhao J,Kang C

更新日期：2019-10-14 00:00:00

abstract：:Intraoperative imaging with antibodies labeled with both a radionuclide for initial guidance and a near-infrared dye for adequate tumor delineation may overcome the main limitation of fluorescence imaging: the limited penetration depth of light in biological tissue. In this study, we demonstrate the feasibility and sa...

journal_title：Theranostics

authors： Hekman MC,Rijpkema M,Muselaers CH,Oosterwijk E,Hulsbergen-Van de Kaa CA,Boerman OC,Oyen WJ,Langenhuijsen JF,Mulders PF

更新日期：2018-03-08 00:00:00

abstract：:Hypoxic zones are common features of metastatic tumors. Due to inactivation of the von Hippel-Lindau gene (VHL), renal cell carcinomas (RCC) show constitutive stabilization of the alpha subunit of the hypoxia-inducible factor (HIF). Thus, RCC represents a model of chronic hypoxia. Development of the lymphatic network ...

journal_title：Theranostics

authors： Ndiaye PD,Dufies M,Giuliano S,Douguet L,Grépin R,Durivault J,Lenormand P,Glisse N,Mintcheva J,Vouret-Craviari V,Mograbi B,Wurmser M,Ambrosetti D,Rioux-Leclercq N,Maire P,Pagès G

更新日期：2019-01-21 00:00:00

abstract：:Background: Patients with advanced soft tissue sarcomas (STS) have a dismal prognosis with few effective therapeutic options. A defect in the homologous recombination repair (HRR) pathway can accumulate DNA repair errors and gene mutations, which can lead to tumorigenesis. BRCAness describes tumors with an HRR deficie...

journal_title：Theranostics

authors： Li H,Tu J,Zhao Z,Chen L,Qu Y,Li H,Yao H,Wang X,Lee DF,Shen J,Wen L,Huang G,Xie X

更新日期：2020-07-25 00:00:00

abstract：:With the newly released impact factor from Thomson Reuters, we look at the first two years of the journal Theranostics under the scope of a new bibliometric designed for the analysis of emerging specialties and also for journals with a multidisciplinary approach. With this method, we are able to look at characteristic...

journal_title：Theranostics

authors： Ho DN,Choi KY,Lee SJ

更新日期：2013-07-03 00:00:00

abstract：:Rationale: Basal-like breast cancer (BLBC) is associated with high grade, distant metastasis, and poor prognosis; however, the mechanism underlying aggressiveness of BLBC is still unclear. Emerging evidence has suggested that phospholipid scramblase 1 (PLSCR1) is involved in tumor progression. Here, we aimed to study ...

journal_title：Theranostics

authors： Huang P,Liao R,Chen X,Wu X,Li X,Wang Y,Cao Q,Dong C

更新日期：2020-03-25 00:00:00

abstract：:Constructing nanosystems that synergistically combine therapeutic and diagnostic features is of great interest to the nanomedicine community but also remains a tremendous challenge. Methods: In this work, we report novel catalytic nanoparticles composed of the enzyme catalase, encapsulated in a polymer shell and surfa...

journal_title：Theranostics

authors： Zhu J,Li Z,Zhang C,Lin L,Cao S,Che H,Shi X,Wang H,van Hest JCM

更新日期：2019-10-17 00:00:00

abstract：:We describe the preparation of monodisperse, lanthanide-doped hexagonal-phase NaYF4 upconverting luminescent nanoparticles for protein conjugation. Their core was coated with a silica shell which then was modified with a poly(ethylene glycol) spacer and N-hydroxysuccinimide ester groups. The nanoparticles were charact...

journal_title：Theranostics

authors： Wilhelm S,Hirsch T,Patterson WM,Scheucher E,Mayr T,Wolfbeis OS

更新日期：2013-03-13 00:00:00

abstract：:Non-invasive PET imaging of CXCR4 expression in cancer and inflammation as well as CXCR4-targeted radioligand therapy (RLT) have recently found their way into clinical research by the development of the theranostic agents [68Ga]PentixaFor (cyclo(D-Tyr1-D-[NMe]Orn2(AMBS-[68Ga]DOTA)-Arg3-Nal4-Gly5) = [68Ga]DOTA-AMBS-CPC...

journal_title：Theranostics

authors： Osl T,Schmidt A,Schwaiger M,Schottelius M,Wester HJ

更新日期：2020-07-09 00:00:00

abstract：:Periodontitis is a widespread oral disease that results in the loss of alveolar bone. Low-intensity pulsed ultrasound (LIPUS), which is a new therapeutic option, promotes alveolar bone regeneration in periodontal bone injury models. This study investigated the protective effect of LIPUS on oxidative stress in periodon...

journal_title：Theranostics

authors： Ying S,Tan M,Feng G,Kuang Y,Chen D,Li J,Song J

更新日期：2020-08-01 00:00:00

abstract：:Rational: Ischemic injury of the skeletal muscle remains a serious clinical problem and currently there is no effective therapy. The aim of the present study is to determine whether human umbilical cord mesenchymal stem cells- derived exosomes (UMSC-Exo) could repair ischemic injury by releasing circular RNA. Methods ...

journal_title：Theranostics

authors： Yan B,Zhang Y,Liang C,Liu B,Ding F,Wang Y,Zhu B,Zhao R,Yu XY,Li Y

更新日期：2020-05-18 00:00:00

abstract：:The application of blood plasma for soft tissue wound healing is receiving much more attention recently. Exosomes are critical paracrine mediators that can be obtained from biological fluids including plasma and be able to induce regenerative effects by transferring bioactive molecules such as microRNAs (miRNAs). This...

journal_title：Theranostics

authors： Hu Y,Rao SS,Wang ZX,Cao J,Tan YJ,Luo J,Li HM,Zhang WS,Chen CY,Xie H

更新日期：2018-01-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) leakage can lead to brain and spine pathologies and there is an urgent need for a rapid diagnostic method for determining CSF leakage. Beta-2 transferrin (β2TF), asialotransferrin, is a specific CSF glycoprotein biomarker used to determine CSF leakage when distinguished from serum sialotransf...

journal_title：Theranostics

authors： Oh J,Kwon SJ,Dordick JS,Sonstein WJ,Linhardt RJ,Kim MG

更新日期：2019-05-31 00:00:00

abstract：:Rationale: Glioma stem-like cells (GSCs) contribute to temozolomide (TMZ) resistance in gliomas, although the mechanisms have not been delineated. Methods:In vitro functional experiments (colony formation assay, flow cytometric analysis, TUNEL assay) were used to assess the ability of extracellular vesicles (EVs) from...

journal_title：Theranostics

authors： Yin J,Ge X,Shi Z,Yu C,Lu C,Wei Y,Zeng A,Wang X,Yan W,Zhang J,You Y

更新日期：2021-01-01 00:00:00

abstract：:Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor 2 (Klf2) in ECs, ameliorates press...

journal_title：Theranostics

authors： Li H,Wang Y,Liu J,Chen X,Duan Y,Wang X,Shen Y,Kuang Y,Zhuang T,Tomlinson B,Chan P,Yu Z,Cheng Y,Zhang L,Liu Z,Zhang Y,Zhao Z,Zhang Q,Liu J

更新日期：2021-01-01 00:00:00

abstract：:Theranostics is a multidisciplinary journal that publishes innovative and original research papers reflecting the field of molecular imaging, molecular therapeutics, multifunctional nanoparticle platforms, image-guided therapy, and translational nanomedicine. A broad spectrum of biomedical research that can be applied...

journal_title：Theranostics

authors： Chen XS

更新日期：2011-01-08 00:00:00

abstract：:The unique features of noble-metal nanostructures (NMNs) are leading to unprecedented expansion of research and exploration of their application in therapeutics, diagnostics and bioimaging fields. With the ever-growing applications of NMNs, both therapeutic and environmental NMNs are likely to be exposed to tissues an...

journal_title：Theranostics

authors： Huang Q,Zhang J,Zhang Y,Timashev P,Ma X,Liang XJ

更新日期：2020-04-27 00:00:00

abstract：:Uncontrollable cell proliferation and irreversible neurological damage make glioma one of the most deadly diseases in clinic. Besides the multiple biological barriers, glioma stem cells (GSCs) that are responsible for the maintenance and recurrence of tumor tissues also hinder the therapeutic efficacy of chemotherapy....

journal_title：Theranostics

authors： Ran D,Zhou J,Chai Z,Li J,Xie C,Mao J,Lu L,Zhang Y,Wu S,Zhan C,Lu W

更新日期：2020-03-04 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.21477.]. ...

journal_title：Theranostics

authors： Cao J,Wang X,Dai T,Wu Y,Zhang M,Cao R,Zhang R,Wang G,Jiang R,Zhou BP,Shi J,Kang T

更新日期：2021-01-01 00:00:00

abstract：:Hypoxia is a key hallmark of solid tumors and tumor hypoxia usually contributes to cancer progression, therapeutic resistance and poor outcome. Accurately detecting and imaging tumor hypoxia with high spatial resolution would be conducive to formulating optimized treatment plan and thus achieving better patient outcom...

journal_title：Theranostics

authors： Huang J,Wu Y,Zeng F,Wu S

更新日期：2019-09-25 00:00:00

abstract：:Exosomes play critical roles in intercellular communication in both nearby and distant cells in individuals and organs. Polymerase I and transcript release factor (PTRF), also known as Cavin1, has previously been described as a critical factor in caveola formation, and aberrant PTRF expression has been reported in var...

journal_title：Theranostics

authors： Huang K,Fang C,Yi K,Liu X,Qi H,Tan Y,Zhou J,Li Y,Liu M,Zhang Y,Yang J,Zhang J,Li M,Kang C

更新日期：2018-02-07 00:00:00