Loss of EGR-1 uncouples compensatory responses of pancreatic β cells.

abstract：:Rationale: To test whether novel biomarkers, such as microribonucleic acids (miRNAs), and nonstandard predictive models, such as decision tree learning, provide useful information for medical decision-making in patients on hemodialysis (HD). Methods: Samples from patients with end-stage renal disease receiving HD incl...

journal_title：Theranostics

authors： de Gonzalo-Calvo D,Martínez-Camblor P,Bär C,Duarte K,Girerd N,Fellström B,Schmieder RE,Jardine AG,Massy ZA,Holdaas H,Rossignol P,Zannad F,Thum T

更新日期：2020-07-09 00:00:00

abstract：:In advanced atherosclerotic plaques, defective efferocytosis of apoptotic foam cells and decreased cholesterol efflux contribute to lesion progression. In our previous study, we demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (SDT) could induce foam cells apoptosis via the mitochondrial-casp...

journal_title：Theranostics

authors： Wang H,Yang Y,Sun X,Tian F,Guo S,Wang W,Tian Z,Jin H,Zhang Z,Tian Y

更新日期：2018-09-29 00:00:00

abstract：:5-Fluorouracil (5-FU) combined with radiotherapy is a common treatment strategy to treat human cancers, but the underlying mechanisms of this combination treatment remain unclear. Here, we report that NAD+-dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due to 5-FU exposure rendering colorectal c...

journal_title：Theranostics

authors： Tang M,Lu X,Zhang C,Du C,Cao L,Hou T,Li Z,Tu B,Cao Z,Li Y,Chen Y,Jiang L,Wang H,Wang L,Liu B,Xu X,Luo J,Wang J,Gu J,Wang H,Zhu WG

更新日期：2017-03-22 00:00:00

abstract：:CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface protein that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2. Its potential as a cancer target is supported by studies showing that anti-CDCP1 antibodies inhibit cell migration and survival in vitro, and tumor g...

journal_title：Theranostics

authors： Harrington BS,He Y,Khan T,Puttick S,Conroy PJ,Kryza T,Cuda T,Sokolowski KA,Tse BW,Robbins KK,Arachchige BJ,Stehbens SJ,Pollock PM,Reed S,Weroha SJ,Haluska P,Salomon C,Lourie R,Perrin LC,Law RHP,Whisstock JC,Hoop

更新日期：2020-01-12 00:00:00

abstract：:High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to co...

journal_title：Theranostics

authors： El Kaffas A,Gangeh MJ,Farhat G,Tran WT,Hashim A,Giles A,Czarnota GJ

更新日期：2018-01-01 00:00:00

abstract：:Uncontrollable cell proliferation and irreversible neurological damage make glioma one of the most deadly diseases in clinic. Besides the multiple biological barriers, glioma stem cells (GSCs) that are responsible for the maintenance and recurrence of tumor tissues also hinder the therapeutic efficacy of chemotherapy....

journal_title：Theranostics

authors： Ran D,Zhou J,Chai Z,Li J,Xie C,Mao J,Lu L,Zhang Y,Wu S,Zhan C,Lu W

更新日期：2020-03-04 00:00:00

abstract：:Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of soyasaponin II in acute liver failure and establish the...

journal_title：Theranostics

authors： Wang F,Gong S,Wang T,Li L,Luo H,Wang J,Huang C,Zhou H,Chen G,Liu Z,Zhang Q,Jiang Y,Chen P

更新日期：2020-02-03 00:00:00

abstract：:Developing ultrasensitive contrast agents for the early detection of malignant tumors in liver is highly demanded. Constructing hepatic tumors specific targeting probes could provide more sensitive imaging information but still faces great challenges. Here we report a novel approach for the synthesis of ultra-small Fe...

journal_title：Theranostics

authors： Jia Z,Song L,Zang F,Song J,Zhang W,Yan C,Xie J,Ma Z,Ma M,Teng G,Gu N,Zhang Y

更新日期：2016-07-15 00:00:00

abstract：:Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression in human chondrocytes. The aim of this study was to determine whether microRNA-193b-3p (miR-193b-3p) regulates the expression of HDAC3 during chondrogenesis and chondrocyte metabolism. Methods: miR-193b-3p expres...

journal_title：Theranostics

authors： Meng F,Li Z,Zhang Z,Yang Z,Kang Y,Zhao X,Long D,Hu S,Gu M,He S,Wu P,Chang Z,He A,Liao W

更新日期：2018-04-15 00:00:00

abstract：:Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome. Here we performed an integrative genomic analysis and identified the bromodomain and extraterminal domain (BET) protein BRD4 as a potential therapeutic target ...

journal_title：Theranostics

authors： Zhang Z,Ma P,Jing Y,Yan Y,Cai MC,Zhang M,Zhang S,Peng H,Ji ZL,Di W,Gu Z,Gao WQ,Zhuang G

更新日期：2016-01-01 00:00:00

abstract：:Rationale: Tumor angiogenesis promotes tumor development, progression, growth, and metastasis. Metronomic chemotherapy involves the frequent administration of low-dose chemotherapeutic agents to block angiogenic activity and reduce side effects. Methods: MDA-MB-231 cells were treated with various concentrations of art...

journal_title：Theranostics

authors： Tsui KH,Wu MY,Lin LT,Wen ZH,Li YH,Chu PY,Li CJ

更新日期：2019-09-17 00:00:00

abstract：:The most important requirements of biomedical substitutes used in muscle tissue regeneration are appropriate topographical cues and bioactive components for the induction of myogenic differentiation/maturation. Here, we developed an electric field-assisted 3D cell-printing process to fabricate cell-laden fibers with a...

journal_title：Theranostics

authors： Yang GH,Kim W,Kim J,Kim G

更新日期：2021-01-01 00:00:00

abstract：:The mineral dust-induced gene (mdig) is overexpressed in a number of human cancers, suggesting critical roles of this gene played on the pathogenesis of cancers. Unlike several other JmjC-domain containing proteins that exhibit histone demethylase activity, it remains enigmatic whether mdig is involved in the demethyl...

journal_title：Theranostics

authors： Zhang Q,Thakur C,Fu Y,Bi Z,Wadgaonkar P,Xu L,Liu Z,Liu W,Wang J,Kidder BL,Chen F

更新日期：2020-01-01 00:00:00

abstract：:Periodontitis is a widespread oral disease that results in the loss of alveolar bone. Low-intensity pulsed ultrasound (LIPUS), which is a new therapeutic option, promotes alveolar bone regeneration in periodontal bone injury models. This study investigated the protective effect of LIPUS on oxidative stress in periodon...

journal_title：Theranostics

authors： Ying S,Tan M,Feng G,Kuang Y,Chen D,Li J,Song J

更新日期：2020-08-01 00:00:00

abstract：:The structural modification of existing AMPs is an effective strategy to develop antimicrobial agents with high-efficiency, low-cost and low-toxicity antimicrobial agents. Methods: Here, we truncated 14-amino-acids at the N-terminus of MSI-78 to obtain MSI and further modified MSI to obtain four peptide analogs: MSI-1...

journal_title：Theranostics

authors： Ma L,Xie X,Liu H,Huang Y,Wu H,Jiang M,Xu P,Ye X,Zhou C

更新日期：2020-01-01 00:00:00

abstract：:Rationale: P21-activated kinase 6 (PAK6) is a member of the class II PAKs family, which is a conserved family of serine/threonine kinases. Although the effects of PAK6 on many malignancies, especially in prostate cancer, have been studied for a long time, the role of PAK6 in mitochondria remains unknown. Methods: The ...

journal_title：Theranostics

authors： Li T,Li Y,Liu T,Hu B,Li J,Liu C,Liu T,Li F

更新日期：2020-02-03 00:00:00

abstract：:Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine. Nerve autograft is the gold standard for clinical PNI repair. Due to its significant drawbacks, artificial nerve guidance conduits (NGCs) have drawn much attention as replacement therapies. We developed a combinatorial NGC consist...

journal_title：Theranostics

authors： Zheng C,Yang Z,Chen S,Zhang F,Rao Z,Zhao C,Quan D,Bai Y,Shen J

更新日期：2021-01-01 00:00:00

abstract：:Dynamic positron emission tomography (PET) can monitor spatiotemporal distribution of radiotracer in vivo. The spatiotemporal information can be used to estimate parametric images of radiotracer kinetics that are of physiological and biochemical interests. Direct estimation of parametric images from raw projection dat...

journal_title：Theranostics

authors： Wang G,Qi J

更新日期：2013-11-20 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated gene regulatory networks (GRNs), but their implication in advanced or treatment-refractory malignancy is unknown. Methods: We combined high-throughput transcriptomic approaches with bioinformatics and structure modeling to search for ...

journal_title：Theranostics

authors： Logotheti S,Marquardt S,Gupta SK,Richter C,Edelhäuser BAH,Engelmann D,Brenmoehl J,Söhnchen C,Murr N,Alpers M,Singh KP,Wolkenhauer O,Heckl D,Spitschak A,Pützer BM

更新日期：2020-07-29 00:00:00

abstract：:With the newly released impact factor from Thomson Reuters, we look at the first two years of the journal Theranostics under the scope of a new bibliometric designed for the analysis of emerging specialties and also for journals with a multidisciplinary approach. With this method, we are able to look at characteristic...

journal_title：Theranostics

authors： Ho DN,Choi KY,Lee SJ

更新日期：2013-07-03 00:00:00

abstract：:Angiogenesis enhances cancer metastasis and progression, however, the roles of transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc-finger transcription factor. Here, we demonstrate a new mechanism of Kras mutation-driven ZNF322A transcriptional activation and elucidate the inte...

journal_title：Theranostics

authors： Lin CC,Kuo IY,Wu LT,Kuan WH,Liao SY,Jen J,Yang YE,Tang CW,Chen YR,Wang YC

更新日期：2020-08-08 00:00:00

abstract：:Cell sheet technology opens new perspectives in tissue regeneration therapy by providing readily implantable, scaffold-free 3D tissue constructs. Many studies have focused on the therapeutic effects of cell sheet implantation while relatively little attention has concerned the fate of the implanted cells in vivo. The ...

journal_title：Theranostics

authors： Rahmi G,Pidial L,Silva AK,Blondiaux E,Meresse B,Gazeau F,Autret G,Balvay D,Cuenod CA,Perretta S,Tavitian B,Wilhelm C,Cellier C,Clément O

更新日期：2016-03-21 00:00:00

abstract：:Blood vessels are conduits distributed throughout the body, supporting tissue growth and homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the linings of the blood vessels, and together with pericytes, are essential for organ development and tissue homeostasis through producing ...

journal_title：Theranostics

authors： Zhu S,Bennett S,Kuek V,Xiang C,Xu H,Rosen V,Xu J

更新日期：2020-05-01 00:00:00

abstract：:The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX ...

journal_title：Theranostics

authors： Yin J,Lang T,Cun D,Zheng Z,Huang Y,Yin Q,Yu H,Li Y

更新日期：2017-09-26 00:00:00

abstract：:Background: Patients with advanced soft tissue sarcomas (STS) have a dismal prognosis with few effective therapeutic options. A defect in the homologous recombination repair (HRR) pathway can accumulate DNA repair errors and gene mutations, which can lead to tumorigenesis. BRCAness describes tumors with an HRR deficie...

journal_title：Theranostics

authors： Li H,Tu J,Zhao Z,Chen L,Qu Y,Li H,Yao H,Wang X,Lee DF,Shen J,Wen L,Huang G,Xie X

更新日期：2020-07-25 00:00:00

abstract：:Exosomes play critical roles in intercellular communication in both nearby and distant cells in individuals and organs. Polymerase I and transcript release factor (PTRF), also known as Cavin1, has previously been described as a critical factor in caveola formation, and aberrant PTRF expression has been reported in var...

journal_title：Theranostics

authors： Huang K,Fang C,Yi K,Liu X,Qi H,Tan Y,Zhou J,Li Y,Liu M,Zhang Y,Yang J,Zhang J,Li M,Kang C

更新日期：2018-02-07 00:00:00

abstract：:During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells chemotaxis being accompanied by activation of diverse intercellular s...

journal_title：Theranostics

authors： Jin J,Zhao Q

更新日期：2020-05-15 00:00:00

abstract：:Talazoparib, a potent PARP inhibitor, has shown promising clinical and pre-clinical activity by inducing synthetic lethality in cancers with germline Brca1/2 mutations. Conventional oral delivery of Talazoparib is associated with significant off-target effects, therefore we sought to develop new delivery systems in th...

journal_title：Theranostics

authors： Belz JE,Kumar R,Baldwin P,Ojo NC,Leal AS,Royce DB,Zhang D,van de Ven AL,Liby KT,Sridhar S

更新日期：2017-09-26 00:00:00

abstract：:Small interfering RNA (siRNA) has proved to be a powerful tool for target-specific gene silencing via RNA interference (RNAi). Its ability to control targeted gene expression gives new hope to gene therapy as a treatment for cancers and genetic diseases. However, siRNA shows poor pharmacological properties, such as lo...

journal_title：Theranostics

authors： Hong CA,Nam YS

更新日期：2014-09-19 00:00:00

abstract：:Sepsis is a major cause of patient mortality and morbidity from bacterial infections. Although neutrophils are known to be important in the development of sepsis, how distinctive neutrophil subtypes regulate inflammatory processes involved in septicemia remains unclear. Preconditioning protects organisms against subse...

journal_title：Theranostics

authors： Yang Z,Wang L,Yu H,Wang R,Gou Y,Zhang M,Kang C,Liu T,Lan Y,Wang X,Liu J,Cooper MA,Li X,Yue K,Yu Y,Wang L,Kim BYS,Jiang W,Sun W

更新日期：2019-08-14 00:00:00