Mitochondrial PAK6 inhibits prostate cancer cell apoptosis via the PAK6-SIRT4-ANT2 complex.

abstract：:Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during...

journal_title：Theranostics

authors： Liu Z,Wang F,Chen X

更新日期：2011-03-01 00:00:00

abstract：:Rationale: Following an ever-increased focus on personalized medicine, there is a continuing need to develop preclinical molecular imaging modalities to guide the development and optimization of targeted therapies. Near-Infrared (NIR) Macroscopic Fluorescence Lifetime Förster Resonance Energy Transfer (MFLI-FRET) imag...

journal_title：Theranostics

authors： Rudkouskaya A,Sinsuebphon N,Ochoa M,Chen SJ,Mazurkiewicz JE,Intes X,Barroso M

更新日期：2020-08-15 00:00:00

abstract：:In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel netrin-1 interference therapy requires the assessment of netrin-1 expression prior to ...

journal_title：Theranostics

authors： Wischhusen J,Wilson KE,Delcros JG,Molina-Peña R,Gibert B,Jiang S,Ngo J,Goldschneider D,Mehlen P,Willmann JK,Padilla F

更新日期：2018-10-06 00:00:00

abstract：:Rationale: Within the field of personalized medicine there is an increasing focus on designing flexible, multifunctional drug delivery systems that combine high efficacy with minimal side effects, by tailoring treatment to the individual. Methods: We synthesized a chemically stabilized ~4 nm nucleic acid nanoscaffold,...

journal_title：Theranostics

authors： Andersen VL,Vinther M,Kumar R,Ries A,Wengel J,Nielsen JS,Kjems J

更新日期：2019-04-13 00:00:00

abstract：:Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent thrombus organization limits direct blood contact with fibrin, the target of blood-based fibri...

journal_title：Theranostics

authors： Stein-Merlob AF,Kessinger CW,Erdem SS,Zelada H,Hilderbrand SA,Lin CP,Tearney GJ,Jaff MR,Reed GL,Henke PK,McCarthy JR,Jaffer FA

更新日期：2015-09-13 00:00:00

abstract：:Background: Patients with advanced soft tissue sarcomas (STS) have a dismal prognosis with few effective therapeutic options. A defect in the homologous recombination repair (HRR) pathway can accumulate DNA repair errors and gene mutations, which can lead to tumorigenesis. BRCAness describes tumors with an HRR deficie...

journal_title：Theranostics

authors： Li H,Tu J,Zhao Z,Chen L,Qu Y,Li H,Yao H,Wang X,Lee DF,Shen J,Wen L,Huang G,Xie X

更新日期：2020-07-25 00:00:00

abstract：:Rationale: To test whether novel biomarkers, such as microribonucleic acids (miRNAs), and nonstandard predictive models, such as decision tree learning, provide useful information for medical decision-making in patients on hemodialysis (HD). Methods: Samples from patients with end-stage renal disease receiving HD incl...

journal_title：Theranostics

authors： de Gonzalo-Calvo D,Martínez-Camblor P,Bär C,Duarte K,Girerd N,Fellström B,Schmieder RE,Jardine AG,Massy ZA,Holdaas H,Rossignol P,Zannad F,Thum T

更新日期：2020-07-09 00:00:00

abstract：:Sepsis is a major cause of patient mortality and morbidity from bacterial infections. Although neutrophils are known to be important in the development of sepsis, how distinctive neutrophil subtypes regulate inflammatory processes involved in septicemia remains unclear. Preconditioning protects organisms against subse...

journal_title：Theranostics

authors： Yang Z,Wang L,Yu H,Wang R,Gou Y,Zhang M,Kang C,Liu T,Lan Y,Wang X,Liu J,Cooper MA,Li X,Yue K,Yu Y,Wang L,Kim BYS,Jiang W,Sun W

更新日期：2019-08-14 00:00:00

abstract：:Due to their lower systemic toxicity, faster kidney clearance and higher tumor accumulation, ultrasmall gold nanoparticles (less than 10 nm in diameter) have been proved to be promising in biomedical applications. However, their potential applications in cancer imaging and treatment have not been reviewed yet. This re...

journal_title：Theranostics

authors： Fan M,Han Y,Gao S,Yan H,Cao L,Li Z,Liang XJ,Zhang J

更新日期：2020-03-31 00:00:00

abstract：:High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to co...

journal_title：Theranostics

authors： El Kaffas A,Gangeh MJ,Farhat G,Tran WT,Hashim A,Giles A,Czarnota GJ

更新日期：2018-01-01 00:00:00

abstract：:Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, copper homeostasis is considered as an emerging target for anticancer drug design. Monitoring copper levels in vivo is therefore of paramount importance when assessing the efficacy of copper-targeting drugs. ...

journal_title：Theranostics

authors： Parmar A,Pascali G,Voli F,Lerra L,Yee E,Ahmed-Cox A,Kimpton K,Cirillo G,Arthur A,Zahra D,Rahardjo G,Liu GJ,Lengkeek N,Saletta F,Charil A,Kavallaris M,Vittorio O

更新日期：2018-11-09 00:00:00

abstract：:This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using 225Ac and its theranostic pair, 111In. We call our novel tumor-targeting DOTA-hapten PRIT system "proteus-DOTA" or "Pr." Herein we report the first results of radiochemistry development, radiopharmacology, and stoichiometry of tumor ...

journal_title：Theranostics

authors： Cheal SM,McDevitt MR,Santich BH,Patel M,Yang G,Fung EK,Veach DR,Bell M,Ahad A,Vargas DB,Punzalan B,Pillarsetty NVK,Xu H,Guo HF,Monette S,Michel AO,Piersigilli A,Scheinberg DA,Ouerfelli O,Cheung NV,Larson SM

更新日期：2020-09-14 00:00:00

abstract：:Intraoperative fluorescence imaging is particularly well-suited for surgical applications due to its inherently high sensitivity, resolution, and ability to provide images in real-time. To date, the intraoperative observation of fluorescence has largely been subjective. With the need to show objective evidence in orde...

journal_title：Theranostics

authors： Tummers WS,Warram JM,van den Berg NS,Miller SE,Swijnenburg RJ,Vahrmeijer AL,Rosenthal EL

更新日期：2018-10-22 00:00:00

abstract：:Rationale: Mesenchymal cell-derived osteosarcoma is a rare malignant bone tumor affecting children and adolescents. PTEN down-regulation or function-loss mutation is associated with the aggressive of osteosarcoma. Explicating the regulatory mechanism of PTEN might highlight new targets for improving the survival rate ...

journal_title：Theranostics

authors： Wu W,Jing D,Meng Z,Hu B,Zhong B,Deng X,Jin X,Shao Z

更新日期：2020-02-03 00:00:00

abstract：:Rationale: Treating diseases of the brain such as Alzheimer's disease (AD) is challenging as the blood-brain barrier (BBB) effectively restricts access of a large number of potentially useful drugs. A potential solution to this problem is presented by therapeutic ultrasound, a novel treatment modality that can achieve...

journal_title：Theranostics

authors： Pelekanos M,Leinenga G,Odabaee M,Odabaee M,Saifzadeh S,Steck R,Götz J

更新日期：2018-04-03 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent in Asia. The survival rate of OSCC patients has not improved over the past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes. Improvement in therapeutic st...

journal_title：Theranostics

authors： Su SC,Lin CW,Liu YF,Fan WL,Chen MK,Yu CP,Yang WE,Su CW,Chuang CY,Li WH,Chung WH,Yang SF

更新日期：2017-02-26 00:00:00

abstract：:Chronic kidney disease (CKD) is a serious healthcare dilemma, associated with specific changes in gut microbiota and circulating metabolome. Yet, the functional capacity of CKD microbiome and its intricate relationship with the host metabolism at different stages of disease are less understood. METHODS:Here, shotgun ...

journal_title：Theranostics

authors： Wu IW,Gao SS,Chou HC,Yang HY,Chang LC,Kuo YL,Dinh MCV,Chung WH,Yang CW,Lai HC,Hsieh WP,Su SC

更新日期：2020-04-06 00:00:00

abstract：:The delivery of therapeutics into tumors remains a challenge in nanoparticle-mediated drug delivery. However, effective therapies such as photothermal therapy (PTT) are limited by quick systemic clearance and non-specific biodistribution. Anti-tumor strategies tailored to accommodate both tumor accumulation/retention ...

journal_title：Theranostics

authors： Cherukula K,Uthaman S,Park IK

更新日期：2019-04-13 00:00:00

abstract：:Aberrant activation of the Src kinase is implicated in the development of a variety of human malignancies. However, it is almost impossible to monitor Src activity in an in vivo setting with current biochemical techniques. To facilitate the noninvasive investigation of the activity of Src kinase both in vitro and in v...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2016-02-24 00:00:00

abstract：:Treatments of high specificity are desirable for cancer therapy. Light-triggered nanotheranostics (LTN) mediated cancer therapy could be one such treatment, as they make it possible to visualize and treat the tumor specifically in a light-controlled manner with a single injection. Because of their great potential in c...

journal_title：Theranostics

authors： Zhang P,Hu C,Ran W,Meng J,Yin Q,Li Y

更新日期：2016-04-27 00:00:00

abstract：:Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could a...

journal_title：Theranostics

authors： Ai XY,Liu HJ,Lu C,Liang CL,Sun Y,Chen S,Sun B,Li Y,Liu YR,Zhang Q,Liu XQ,Xiao T,Jing XS,Sun T,Zhou HG,Yang C

更新日期：2017-01-05 00:00:00

abstract：:Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute myeloid leukemia (AML). The uridine-cytidine kinase 1 (UCK1) has an established role in activating 5'-AZA and its protein level is significantly downregulated in patients resistant to the drug. H...

journal_title：Theranostics

authors： Zhang H,Huang H,Feng X,Song H,Zhang Z,Shen A,Qiu X

更新日期：2020-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.21516.]. ...

journal_title：Theranostics

authors： Yin J,Lang T,Cun D,Zheng Z,Huang Y,Yin Q,Yu H,Li Y

更新日期：2020-01-18 00:00:00

abstract：:Rationale: Hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (hiPSCs) have been developed to address the shortage of primary human hepatocytes (PHHs) for therapeutic applications. However, the in vivo repopulation capacity of HLCs remains limited. This study investigated the roles of agoni...

journal_title：Theranostics

authors： Yuan L,Zhang Y,Liu X,Chen Y,Zhang L,Cao J,Li X,Wang M,Wu K,Zhang J,Liu G,Tang Q,Yuan Q,Cheng T,Xia N

更新日期：2019-04-06 00:00:00

abstract：:Exosomes (Exo) secreted from hypoxia-conditioned bone marrow mesenchymal stem cells (BM-MSCs) were found to be protective for ischemic disease. However, the role of exosomal miRNA in the protective effect of hypoxia-conditioned BM-MSCs-derived Exo (Hypo-Exo) remains largely uncharacterized and the poor specificity of ...

journal_title：Theranostics

authors： Zhu LP,Tian T,Wang JY,He JN,Chen T,Pan M,Xu L,Zhang HX,Qiu XT,Li CC,Wang KK,Shen H,Zhang GG,Bai YP

更新日期：2018-11-29 00:00:00

abstract：:Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been a popular strategy...

journal_title：Theranostics

authors： Johnsen KB,Bak M,Kempen PJ,Melander F,Burkhart A,Thomsen MS,Nielsen MS,Moos T,Andresen TL

更新日期：2018-05-24 00:00:00

abstract：:Elastin-like polypeptide (ELP)-based drug delivery has been utilized for various applications including cancer therapies for many years. Genetic incorporation of internalization ligands and cell-targeting peptides along with ELP polymer enhanced tumor accumulation and retention time as well as stability and activities...

journal_title：Theranostics

authors： Sarangthem V,Kim Y,Singh TD,Seo BY,Cheon SH,Lee YJ,Lee BH,Park RW

更新日期：2016-09-25 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated gene regulatory networks (GRNs), but their implication in advanced or treatment-refractory malignancy is unknown. Methods: We combined high-throughput transcriptomic approaches with bioinformatics and structure modeling to search for ...

journal_title：Theranostics

authors： Logotheti S,Marquardt S,Gupta SK,Richter C,Edelhäuser BAH,Engelmann D,Brenmoehl J,Söhnchen C,Murr N,Alpers M,Singh KP,Wolkenhauer O,Heckl D,Spitschak A,Pützer BM

更新日期：2020-07-29 00:00:00

abstract：:RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mice when administered...

journal_title：Theranostics

authors： Gao S,Hein S,Dagnæs-Hansen F,Weyer K,Yang C,Nielsen R,Christensen EI,Fenton RA,Kjems J

更新日期：2014-08-13 00:00:00

abstract：:Rationale: Tumor microenvironment interacts with tumor cells to regulate their stemness properties through various cytokines and cytokine receptors. Previous studies revealed the possible role of interleukin 20 receptor subunit alpha (IL20RA) signaling in the progression of several types of tumors. However, its regula...

journal_title：Theranostics

authors： Gao W,Wen H,Liang L,Dong X,Du R,Zhou W,Zhang X,Zhang C,Xiang R,Li N

更新日期：2021-01-01 00:00:00