Abstract:
:Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enrichment in animals. Furthermore, PnAg could upregulate the promoter activity of Jak, Stat3, and Stat3 downstream proteins. Therefore, PnAg may serve as an effective therapeutic compound for wound healing through regulating the gp130/Jak/Stat3 signaling pathway.
journal_name
Theranosticsjournal_title
Theranosticsauthors
Ai XY,Liu HJ,Lu C,Liang CL,Sun Y,Chen S,Sun B,Li Y,Liu YR,Zhang Q,Liu XQ,Xiao T,Jing XS,Sun T,Zhou HG,Yang Cdoi
10.7150/thno.17073subject
Has Abstractpub_date
2017-01-05 00:00:00pages
425-435issue
2issn
1838-7640pii
thnov07p0425journal_volume
7pub_type
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