In vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis.

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in a variety of tumor cells, but not most normal cells. Nevertheless, its therapeutic potential is limited due to the frequent occurrence of resistance in tumor cells, especially hepatocellular carcinoma cell lines. Theref...

journal_title：Theranostics

authors： Shi K,Xue J,Fang Y,Bi H,Gao S,Yang D,Lu A,Li Y,Chen Y,Ke L

更新日期：2017-10-12 00:00:00

abstract：PURPOSE:The efficacy of pro-angiogenic therapy is difficult to evaluate with current diagnostic modalities. The objectives were to develop a non-invasive imaging strategy to define the temporal characteristics of angiogenesis and to evaluate the response to pro-angiogenic therapy in diabetic stroke mouse models. METHO...

journal_title：Theranostics

authors： Bai YY,Gao X,Wang YC,Peng XG,Chang D,Zheng S,Li C,Ju S

更新日期：2014-05-25 00:00:00

abstract：:The most frequent malignancy of the pancreas is the pancreatic ductal adenocarcinoma (PDAC). Despite many efforts PDAC has still a dismal prognosis. Biomarkers for early disease stage diagnosis as a prerequisite for a potentially curative treatment are still missing. Novel blood-based markers may help to overcome this...

journal_title：Theranostics

authors： Berger AW,Schwerdel D,Reinacher-Schick A,Uhl W,Algül H,Friess H,Janssen KP,König A,Ghadimi M,Gallmeier E,Bartsch DK,Geissler M,Staib L,Tannapfel A,Kleger A,Beutel A,Schulte LA,Kornmann M,Ettrich TJ,Seufferlein T

更新日期：2019-02-12 00:00:00

abstract：:[This retracts the article DOI: 10.7150/thno.14306.]. ...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2020-09-30 00:00:00

abstract：:In the field of ischemic cerebral injury, precise characterization of neurovascular hemodynamic is required to select candidates for reperfusion treatments. It is thus admitted that advanced imaging-based approaches would be able to better diagnose and prognose those patients and would contribute to better clinical ca...

journal_title：Theranostics

authors： Hingot V,Brodin C,Lebrun F,Heiles B,Chagnot A,Yetim M,Gauberti M,Orset C,Tanter M,Couture O,Deffieux T,Vivien D

更新日期：2020-06-12 00:00:00

abstract：:Rationale: Loss of DNA damage repair (DDR) in the tumor is an established hallmark of sensitivity to DNA damaging agents such as chemotherapy. However, there has been scant investigation into gain-of-function alterations of DDR genes in cancer. This study aims to investigate to what extent copy number amplification of...

journal_title：Theranostics

authors： Wu Z,Li S,Tang X,Wang Y,Guo W,Cao G,Chen K,Zhang M,Guan M,Yang D

更新日期：2020-03-04 00:00:00

abstract：OBJECTIVE:Ultrasound molecular imaging (UMI) of glycoprotein (GP) IIb/IIIa receptor on activated platelets offers a unique means of identifying high-risk atherosclerosis. We hypothesized that contrast-enhanced ultrasound with microbubbles (MBs) targeted to GP IIb/IIIa could be used to detect and quantify activated plat...

journal_title：Theranostics

authors： Guo S,Shen S,Wang J,Wang H,Li M,Liu Y,Hou F,Liao Y,Bin J

更新日期：2015-02-05 00:00:00

abstract：:Molecular photoacoustic imaging (PA) is a promising technology to understand tumor pathology and guide precision therapeutics. Despite the capability of activatable PA probes to image tumor-specific biomarkers, limitations in their molecular structure hamper them from effective drug delivery and the drug release monit...

journal_title：Theranostics

authors： Yang Z,Song J,Tang W,Fan W,Dai Y,Shen Z,Lin L,Cheng S,Liu Y,Niu G,Rong P,Wang W,Chen X

更新日期：2019-01-01 00:00:00

abstract：:Rationale: The evaluation of early treatment response is critical for patient prognosis and treatment planning. When the current methods rely on invasive protocols that evaluate the expression of DNA damage markers on patient biopsy samples, we aim to evaluate a non-invasive PET imaging approach to monitor the early e...

journal_title：Theranostics

authors： Poty S,Mandleywala K,O'Neill E,Knight JC,Cornelissen B,Lewis JS

更新日期：2020-04-27 00:00:00

abstract：:Intraoperative fluorescence imaging is particularly well-suited for surgical applications due to its inherently high sensitivity, resolution, and ability to provide images in real-time. To date, the intraoperative observation of fluorescence has largely been subjective. With the need to show objective evidence in orde...

journal_title：Theranostics

authors： Tummers WS,Warram JM,van den Berg NS,Miller SE,Swijnenburg RJ,Vahrmeijer AL,Rosenthal EL

更新日期：2018-10-22 00:00:00

abstract：:Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...

journal_title：Theranostics

authors： Tang Q,Hu Z,Jin H,Zheng G,Yu X,Wu G,Liu H,Zhu Z,Xu H,Zhang C,Shen L

更新日期：2019-01-30 00:00:00

abstract：:Purpose: Cancer immunotherapy depends on a systemic immune response, but the basic underlying mechanisms are still largely unknown. Despite the very successful and widespread use of checkpoint inhibitors in the clinic, the majority of cancer patients do not benefit from this type of treatment. In this translational st...

journal_title：Theranostics

authors： Schwenck J,Schörg B,Fiz F,Sonanini D,Forschner A,Eigentler T,Weide B,Martella M,Gonzalez-Menendez I,Campi C,Sambuceti G,Seith F,Quintanilla-Martinez L,Garbe C,Pfannenberg C,Röcken M,la Fougere C,Pichler BJ,Kneilling M

更新日期：2020-01-01 00:00:00

abstract：:CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface protein that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2. Its potential as a cancer target is supported by studies showing that anti-CDCP1 antibodies inhibit cell migration and survival in vitro, and tumor g...

journal_title：Theranostics

authors： Harrington BS,He Y,Khan T,Puttick S,Conroy PJ,Kryza T,Cuda T,Sokolowski KA,Tse BW,Robbins KK,Arachchige BJ,Stehbens SJ,Pollock PM,Reed S,Weroha SJ,Haluska P,Salomon C,Lourie R,Perrin LC,Law RHP,Whisstock JC,Hoop

更新日期：2020-01-12 00:00:00

abstract：:Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic administration. Here...

journal_title：Theranostics

authors： Fan B,Kang L,Chen L,Sun P,Jin M,Wang Q,Bae YH,Huang W,Gao Z

更新日期：2017-01-01 00:00:00

abstract：:Angiogenesis enhances cancer metastasis and progression, however, the roles of transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc-finger transcription factor. Here, we demonstrate a new mechanism of Kras mutation-driven ZNF322A transcriptional activation and elucidate the inte...

journal_title：Theranostics

authors： Lin CC,Kuo IY,Wu LT,Kuan WH,Liao SY,Jen J,Yang YE,Tang CW,Chen YR,Wang YC

更新日期：2020-08-08 00:00:00

abstract：:In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel netrin-1 interference therapy requires the assessment of netrin-1 expression prior to ...

journal_title：Theranostics

authors： Wischhusen J,Wilson KE,Delcros JG,Molina-Peña R,Gibert B,Jiang S,Ngo J,Goldschneider D,Mehlen P,Willmann JK,Padilla F

更新日期：2018-10-06 00:00:00

abstract：:Fast clearance, metabolism and systemic toxicity are major limits for the clinical use of anti-cancer drugs. Histone deacetylase inhibitors (HDACi) present these defects despite displaying promising anti-tumor properties on tumor cells in vitro and in in vivo model of cancers. Specific delivery of anti-cancer drugs in...

journal_title：Theranostics

authors： El Bahhaj F,Denis I,Pichavant L,Delatouche R,Collette F,Linot C,Pouliquen D,Grégoire M,Héroguez V,Blanquart C,Bertrand P

更新日期：2016-03-25 00:00:00

abstract：:Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression in human chondrocytes. The aim of this study was to determine whether microRNA-193b-3p (miR-193b-3p) regulates the expression of HDAC3 during chondrogenesis and chondrocyte metabolism. Methods: miR-193b-3p expres...

journal_title：Theranostics

authors： Meng F,Li Z,Zhang Z,Yang Z,Kang Y,Zhao X,Long D,Hu S,Gu M,He S,Wu P,Chang Z,He A,Liao W

更新日期：2018-04-15 00:00:00

abstract：:Cancer theranostics is one of the most important approaches for detecting and treating patients at an early stage. To develop such a technique, accurate detection, specific targeting, and controlled delivery are the key components. Various kinds of nanoparticles have been proposed and demonstrated as potential nanoveh...

journal_title：Theranostics

authors： Ray S,Li Z,Hsu CH,Hwang LP,Lin YC,Chou PT,Lin YY

更新日期：2018-11-29 00:00:00

abstract：:Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent for novel cancer treatment by using an NB-encapsulated hybrid nanosystem that can be monitored by US and fluorescent imaging and acti...

journal_title：Theranostics

authors： Huang WT,Chan MH,Chen X,Hsiao M,Liu RS

更新日期：2020-01-01 00:00:00

abstract：:Background: By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. Accurate imaging of PCa recurrent lymph node metastases (LNM) is crucial for metasta...

journal_title：Theranostics

authors： Jilg CA,Drendel V,Rischke HC,Beck T,Vach W,Schaal K,Wetterauer U,Schultze-Seemann W,Meyer PT

更新日期：2017-04-10 00:00:00

abstract：:Generating oxidative stress is a critical mechanism by which host cells defend against infection by pathogenic microorganisms. Radiation resistance is a critical problem in radiotherapy against cancer. Epstein-Barr virus (EBV) is a cancer-causing virus and its reactivation plays an important role in the development of...

journal_title：Theranostics

authors： Hu J,Li Y,Li H,Shi F,Xie L,Zhao L,Tang M,Luo X,Jia W,Fan J,Zhou J,Gao Q,Qiu S,Wu W,Zhang X,Liao W,Bode AM,Cao Y

更新日期：2020-10-25 00:00:00

abstract：:Aim: Immune responsive 12/15 lipoxygenase (12/15LOX)-orchestrate biosynthesis of essential inflammation-resolution mediators during acute inflammatory response in post-myocardial infarction (MI). Lack of 12/15LOX dampens proinflammatory mediator 12-(S)-hydroxyeicosatetraenoic acid (12-(S)-HETE), improves post-MI survi...

journal_title：Theranostics

authors： Kain V,Ingle KA,Rajasekaran NS,Halade GV

更新日期：2021-01-01 00:00:00

abstract：:Uncontrollable cell proliferation and irreversible neurological damage make glioma one of the most deadly diseases in clinic. Besides the multiple biological barriers, glioma stem cells (GSCs) that are responsible for the maintenance and recurrence of tumor tissues also hinder the therapeutic efficacy of chemotherapy....

journal_title：Theranostics

authors： Ran D,Zhou J,Chai Z,Li J,Xie C,Mao J,Lu L,Zhang Y,Wu S,Zhan C,Lu W

更新日期：2020-03-04 00:00:00

abstract：:Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channe...

journal_title：Theranostics

authors： Burks SR,Lorsung RM,Nagle ME,Tu TW,Frank JA

更新日期：2019-07-28 00:00:00

abstract：:Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome. Here we performed an integrative genomic analysis and identified the bromodomain and extraterminal domain (BET) protein BRD4 as a potential therapeutic target ...

journal_title：Theranostics

authors： Zhang Z,Ma P,Jing Y,Yan Y,Cai MC,Zhang M,Zhang S,Peng H,Ji ZL,Di W,Gu Z,Gao WQ,Zhuang G

更新日期：2016-01-01 00:00:00

abstract：:Constructing nanosystems that synergistically combine therapeutic and diagnostic features is of great interest to the nanomedicine community but also remains a tremendous challenge. Methods: In this work, we report novel catalytic nanoparticles composed of the enzyme catalase, encapsulated in a polymer shell and surfa...

journal_title：Theranostics

authors： Zhu J,Li Z,Zhang C,Lin L,Cao S,Che H,Shi X,Wang H,van Hest JCM

更新日期：2019-10-17 00:00:00

abstract：:18F-Fluciclovine (trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid; anti-18F-FACBC) is a positron emission tomography (PET) tracer for diagnosing cancers (e.g., prostate and breast cancer). The most frequent metastatic organ of these cancers is bone. Fluciclovine-PET can visualize bony lesions in clinical practice...

journal_title：Theranostics

authors： Oka S,Kanagawa M,Doi Y,Schuster DM,Goodman MM,Yoshimura H

更新日期：2017-05-15 00:00:00

abstract：:Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilize...

journal_title：Theranostics

authors： Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

更新日期：2021-01-01 00:00:00

abstract：:Background: Tobacco smoke (TS) critically contributes to the development of lung cancer; however, the underlying molecular mechanisms remain unclear. The induction of cancer stem cells (CSCs) by TS represents an early event in tumor initiation. The lung cancer-related gene ΔNp63α is highly expressed in epithelial tiss...

journal_title：Theranostics

authors： Xie C,Zhu J,Jiang Y,Chen J,Wang X,Geng S,Wu J,Zhong C,Li X,Meng Z

更新日期：2019-07-09 00:00:00