A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine.

abstract：:In pancreatic cancer (PDAC) intratumor infiltration of polymorphonuclear neutrophils (PMN) is associated with histologically apparent alterations of the tumor growth pattern. The aim of this study was to examine possible associations between PMN infiltration, tumor microarchitecture, and water diffusivity in diffusion...

journal_title：Theranostics

authors： Mayer P,Dinkic C,Jesenofsky R,Klauss M,Schirmacher P,Dapunt U,Hackert T,Uhle F,Hänsch GM,Gaida MM

更新日期：2018-01-01 00:00:00

abstract：:Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative ...

journal_title：Theranostics

authors： Bai J,Wang JT,Rubio N,Protti A,Heidari H,Elgogary R,Southern P,Al-Jamal WT,Sosabowski J,Shah AM,Bals S,Pankhurst QA,Al-Jamal KT

更新日期：2016-01-01 00:00:00

abstract：:Purpose: To identify extracellular vesicle (EV)-delivered microRNAs in the patient's serum as indicators for bone-metastatic prostate cancer. Methods: First, the profiling change of serum EV-delivered miRNAs in patients with either benign prostatic hyperplasia (BPH), non-bone metastatic prostate cancer or bone-metasta...

journal_title：Theranostics

authors： Wang Y,Fang YX,Dong B,Du X,Wang J,Wang X,Gao WQ,Xue W

更新日期：2021-01-01 00:00:00

abstract：:The limited clinical efficacy of monotherapies in the clinic has urged the development of novel combination platforms. Taking advantage of light-triggered photodynamic treatment combined together with the controlled release of nanomedicine, it has been possible to treat cancer without eliciting any adverse effects. Ho...

journal_title：Theranostics

authors： Hameed S,Bhattarai P,Liang X,Zhang N,Xu Y,Chen M,Dai Z

更新日期：2018-11-03 00:00:00

abstract：:Circulating tumor cells (CTCs) have shown promising potential as liquid biopsies that facilitate early detection, prognosis, therapeutic target selection and monitoring treatment response. CTCs in most cancer patients are low in abundance and heterogeneous in morphological and phenotypic profiles, which complicate the...

journal_title：Theranostics

authors： Chen L,Bode AM,Dong Z

更新日期：2017-06-25 00:00:00

abstract：:Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic administration. Here...

journal_title：Theranostics

authors： Fan B,Kang L,Chen L,Sun P,Jin M,Wang Q,Bae YH,Huang W,Gao Z

更新日期：2017-01-01 00:00:00

abstract：:In a report from 2008, The International Agency for Research on Cancer predicted a tripled cancer incidence from 1975, projecting a possible 13-17 million cancer deaths worldwide by 2030. While new treatments are evolving and reaching approval for different cancer types, the main prevention of cancer mortality is thro...

journal_title：Theranostics

authors： Gobbo OL,Sjaastad K,Radomski MW,Volkov Y,Prina-Mello A

更新日期：2015-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) research has focused on moderate to severe injuries as their outcomes are significantly worse than those of a mild TBI (mTBI). However, recent epidemiological evidence has indicated that a series of even mild TBIs greatly increases the risk of neurodegenerative and psychiatric disorders. N...

journal_title：Theranostics

authors： Adams C,Bazzigaluppi P,Beckett TL,Bishay J,Weisspapir I,Dorr A,Mester JR,Steinman J,Hirschler L,Warnking JM,Barbier EL,McLaurin J,Sled JG,Stefanovic B

更新日期：2018-09-09 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a transmembrane cell surface receptor that is frequently overexpressed and/or mutated in many cancers. Therapies targeting EGFR have poor outcomes due to the lack of reliable diagnostic tests to monitor EGFR. Current in vitro EGFR diagnostic methods are invasive, requiring bi...

journal_title：Theranostics

authors： Bernhard W,El-Sayed A,Barreto K,Gonzalez C,Fonge H,Geyer CR

更新日期：2019-01-30 00:00:00

abstract：:The development of nanomedicine is expected to provide an innovative direction for addressing challenges associated with multidrug-resistant (MDR) bacteria. In the past decades, although nanotechnology-based phototherapy has been developed for antimicrobial treatment since it rarely causes bacterial resistance, the cl...

journal_title：Theranostics

authors： Wei G,Yang G,Wang Y,Jiang H,Fu Y,Yue G,Ju R

更新日期：2020-10-30 00:00:00

abstract：:In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic app...

journal_title：Theranostics

authors： Xie W,Guo Z,Gao F,Gao Q,Wang D,Liaw BS,Cai Q,Sun X,Wang X,Zhao L

更新日期：2018-05-11 00:00:00

abstract：:Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a crucial role in tumor progression, is mainly regulated by alterations to genes and post-transcriptional processes. The recent discovery of the N6-met...

journal_title：Theranostics

authors： Ye J,Wang Z,Chen X,Jiang X,Dong Z,Hu S,Li W,Liu Y,Liao B,Han W,Shen J,Xiao M

更新日期：2020-10-26 00:00:00

abstract：:Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channe...

journal_title：Theranostics

authors： Burks SR,Lorsung RM,Nagle ME,Tu TW,Frank JA

更新日期：2019-07-28 00:00:00

abstract：:Rationale: Treating diseases of the brain such as Alzheimer's disease (AD) is challenging as the blood-brain barrier (BBB) effectively restricts access of a large number of potentially useful drugs. A potential solution to this problem is presented by therapeutic ultrasound, a novel treatment modality that can achieve...

journal_title：Theranostics

authors： Pelekanos M,Leinenga G,Odabaee M,Odabaee M,Saifzadeh S,Steck R,Götz J

更新日期：2018-04-03 00:00:00

abstract：:Generating oxidative stress is a critical mechanism by which host cells defend against infection by pathogenic microorganisms. Radiation resistance is a critical problem in radiotherapy against cancer. Epstein-Barr virus (EBV) is a cancer-causing virus and its reactivation plays an important role in the development of...

journal_title：Theranostics

authors： Hu J,Li Y,Li H,Shi F,Xie L,Zhao L,Tang M,Luo X,Jia W,Fan J,Zhou J,Gao Q,Qiu S,Wu W,Zhang X,Liao W,Bode AM,Cao Y

更新日期：2020-10-25 00:00:00

abstract：:To enhance effective drug accumulation in drug-resistant tumors, a site-specific drug-releasing polypeptide system (PEG-Phis/Pasp-DOX/CA4) was exploited in response to tumor extracellular and intracellular pH. This system could firstly release the embedded tumor vascular inhibitor (CA4) to transiently 'normalize' vasc...

journal_title：Theranostics

authors： Dong Y,Yang J,Liu H,Wang T,Tang S,Zhang J,Zhang X

更新日期：2015-04-28 00:00:00

abstract：:Gold nanoparticles (AuNPs) have been reported to promote osteogenic differentiation of mesenchymal stem cells and osteoblasts, but little is known about their effects on human periodontal ligament progenitor cells (PDLPs). In this study, we evaluated the effects of AuNPs with various diameters (5, 13 and 45 nm) on the...

journal_title：Theranostics

authors： Zhang Y,Kong N,Zhang Y,Yang W,Yan F

更新日期：2017-03-06 00:00:00

abstract：:The most important requirements of biomedical substitutes used in muscle tissue regeneration are appropriate topographical cues and bioactive components for the induction of myogenic differentiation/maturation. Here, we developed an electric field-assisted 3D cell-printing process to fabricate cell-laden fibers with a...

journal_title：Theranostics

authors： Yang GH,Kim W,Kim J,Kim G

更新日期：2021-01-01 00:00:00

abstract：:Rationale: Spatial-temporal control of cell fate in vivo is of great importance for regenerative medicine. Currently, there remain no practical strategies to tune cell-fate spatial-temporally. Optogenetics is a biological technique that widely used to control cell activity in genetically defined neurons in a spatiotem...

journal_title：Theranostics

authors： Wang W,Huang D,Ren J,Li R,Feng Z,Guan C,Bao B,Cai B,Ling J,Zhou C

更新日期：2019-10-18 00:00:00

abstract：:Background: By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. Accurate imaging of PCa recurrent lymph node metastases (LNM) is crucial for metasta...

journal_title：Theranostics

authors： Jilg CA,Drendel V,Rischke HC,Beck T,Vach W,Schaal K,Wetterauer U,Schultze-Seemann W,Meyer PT

更新日期：2017-04-10 00:00:00

abstract：:Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly understood. Methods: Mass spectrometry analysis and immunoprecip...

journal_title：Theranostics

authors： Huang Y,Hu K,Zhang S,Dong X,Yin Z,Meng R,Zhao Y,Dai X,Zhang T,Yang K,Liu L,Huang K,Shi S,Zhang Y,Chen J,Wu G,Xu S

更新日期：2018-02-02 00:00:00

abstract：:Objective: Vascular smooth muscle cells (VSMCs) undergo the phenotypic changes from contractile to synthetic state during vascular remodeling after ischemia. SIRT1 protects against stress-induced vascular remodeling via maintaining VSMC differentiated phenotype. However, the effect of smooth muscle SIRT1 on the functi...

journal_title：Theranostics

authors： Dou YQ,Kong P,Li CL,Sun HX,Li WW,Yu Y,Nie L,Zhao LL,Miao SB,Li XK,Dong C,Zhang JW,Liu Y,Huo XX,Chi K,Gao X,Zhang N,Weng L,Yang H,Zhang F,Han M

更新日期：2020-01-01 00:00:00

abstract：:Comprehensive analysis of the expression level and location of tumor-associated membrane proteins (TMPs) is of vital importance for the profiling of tumor cells. Currently, two kinds of independent techniques, i.e. ex situ detection and in situ imaging, are usually required for the quantification and localization of T...

journal_title：Theranostics

authors： Chen X,Zhao J,Chen T,Gao T,Zhu X,Li G

更新日期：2018-01-01 00:00:00

abstract：:Rationale: Chromodomain Y-like 2 (CDYL2) is a member of the CDY gene family involved in spermatogenesis, but its role in human cancer has not been reported. Analyses of publicly available databases demonstrate that CDYL2 is abundantly expressed in breast tumors. However, whether CDYL2 is involved in breast cancer prog...

journal_title：Theranostics

authors： Yang LF,Yang F,Zhang FL,Xie YF,Hu ZX,Huang SL,Shao ZM,Li DQ

更新日期：2020-04-06 00:00:00

abstract：:Model observers play an important role in the optimization and assessment of imaging devices. In this review paper, we first discuss the basic concepts of model observers, which include the mathematical foundations and psychophysical considerations in designing both optimal observers for optimizing imaging systems and...

journal_title：Theranostics

authors： He X,Park S

更新日期：2013-10-04 00:00:00

abstract：:Producing keratinocyte cells (KCs) in large scale is difficult due to their slow proliferation, disabling their use as seed cells for skin regeneration and wound healing. Cell reprogramming is a promising inducer-based approach to KC production but only reaches very low cellular conversion. Here we reported a unique c...

journal_title：Theranostics

authors： Zhang F,Zhang D,Cheng K,Zhou Z,Liu S,Chen L,Hu Y,Mao C,Liu S

更新日期：2019-07-09 00:00:00

abstract：:Norepinephrine modulates cognitive processes such as working and episodic memory. Pathological changes in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the whole norepinephrine system, disrupting cognitive processes. Monitor...

journal_title：Theranostics

authors： López-Picón FR,Kirjavainen AK,Forsback S,Takkinen JS,Peters D,Haaparanta-Solin M,Solin O

更新日期：2019-01-01 00:00:00

abstract：:Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of soyasaponin II in acute liver failure and establish the...

journal_title：Theranostics

authors： Wang F,Gong S,Wang T,Li L,Luo H,Wang J,Huang C,Zhou H,Chen G,Liu Z,Zhang Q,Jiang Y,Chen P

更新日期：2020-02-03 00:00:00

abstract：:Inadequate diagnostic methods for prostate cancer lead to over- and undertreatment, and the inability to intraoperatively visualize positive margins may limit the success of surgical resection. Prostate cancer visualization could be improved by combining the complementary modalities of immuno-positron emission tomogra...

journal_title：Theranostics

authors： Tsai WK,Zettlitz KA,Tavaré R,Kobayashi N,Reiter RE,Wu AM

更新日期：2018-11-12 00:00:00

abstract：:Targeting cancer stem cells (CSCs) has been proposed as a new strategy to eradicate malignancies, including hepatocellular carcinoma (HCC). However, the mechanisms by which CSCs sustain their self-renewal and chemoresistance remain elusive. Nanog is a master transcriptional regulator of stemness, especially in CSCs. I...

journal_title：Theranostics

authors： Cao J,Zhao M,Liu J,Zhang X,Pei Y,Wang J,Yang X,Shen B,Zhang J

更新日期：2019-01-24 00:00:00