Circulating Tumor Cells: Moving Biological Insights into Detection.

abstract：:SIRT6, NAD+-dependent deacetylase sirtuin 6, has recently shown to suppress tumor growth in several types of cancer. Colon cancer is a challenging carcinoma associated with high morbidity and death. However, whether SIRT6 play a direct role in colon tumorigenesis and the underlying mechanism are not understood. Method...

journal_title：Theranostics

authors： Zhang Y,Nie L,Xu K,Fu Y,Zhong J,Gu K,Zhang L

更新日期：2019-04-13 00:00:00

abstract：:Bacteria-based anticancer therapies aim to overcome the limitations of current cancer therapy by actively targeting and efficiently removing cancer. To achieve this goal, new approaches that target and maintain bacterial drugs at sufficient concentrations during the therapeutic window are essential. Here, we examined ...

journal_title：Theranostics

authors： Park SH,Zheng JH,Nguyen VH,Jiang SN,Kim DY,Szardenings M,Min JH,Hong Y,Choy HE,Min JJ

更新日期：2016-06-20 00:00:00

abstract：:In advanced atherosclerotic plaques, defective efferocytosis of apoptotic foam cells and decreased cholesterol efflux contribute to lesion progression. In our previous study, we demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (SDT) could induce foam cells apoptosis via the mitochondrial-casp...

journal_title：Theranostics

authors： Wang H,Yang Y,Sun X,Tian F,Guo S,Wang W,Tian Z,Jin H,Zhang Z,Tian Y

更新日期：2018-09-29 00:00:00

abstract：:Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recen...

journal_title：Theranostics

authors： Yong KT,Wang Y,Roy I,Rui H,Swihart MT,Law WC,Kwak SK,Ye L,Liu J,Mahajan SD,Reynolds JL

更新日期：2012-01-01 00:00:00

abstract：:Rationale: Basal-like breast cancer (BLBC) is associated with high grade, distant metastasis, and poor prognosis; however, the mechanism underlying aggressiveness of BLBC is still unclear. Emerging evidence has suggested that phospholipid scramblase 1 (PLSCR1) is involved in tumor progression. Here, we aimed to study ...

journal_title：Theranostics

authors： Huang P,Liao R,Chen X,Wu X,Li X,Wang Y,Cao Q,Dong C

更新日期：2020-03-25 00:00:00

abstract：:RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and ...

journal_title：Theranostics

authors： Lin YX,Wang Y,Blake S,Yu M,Mei L,Wang H,Shi J

更新日期：2020-01-01 00:00:00

abstract：:We report a new technique to detect enzyme activity inside cells. The method based on Fluorescence Lifetime Imaging (FLIM) technology allows one to follow sensor cleavage by proteolytic enzyme caspase-3. Specifically, we use the FLIM FRET of living cells via the confocal fluorescence microscopy. A specially designed l...

journal_title：Theranostics

authors： Savitsky AP,Rusanov AL,Zherdeva VV,Gorodnicheva TV,Khrenova MG,Nemukhin AV

更新日期：2012-01-01 00:00:00

abstract：:Conventional immunosuppressants cause side effects and do not prevent the recurrence of autoimmune diseases. Moreover, they may not inhibit autoimmunity mediated by pathogenic memory T-cells. Dihydroartemisinin (DHA) has been shown to regulate autoimmunity. However, it remains unknown whether DHA impacts psoriasis and...

journal_title：Theranostics

authors： Chen Y,Yan Y,Liu H,Qiu F,Liang CL,Zhang Q,Huang RY,Han L,Lu C,Dai Z

更新日期：2020-08-21 00:00:00

abstract：OBJECTIVE:Ultrasound molecular imaging (UMI) of glycoprotein (GP) IIb/IIIa receptor on activated platelets offers a unique means of identifying high-risk atherosclerosis. We hypothesized that contrast-enhanced ultrasound with microbubbles (MBs) targeted to GP IIb/IIIa could be used to detect and quantify activated plat...

journal_title：Theranostics

authors： Guo S,Shen S,Wang J,Wang H,Li M,Liu Y,Hou F,Liao Y,Bin J

更新日期：2015-02-05 00:00:00

abstract：:Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, unders...

journal_title：Theranostics

authors： De Sarno F,Ponsiglione AM,Russo M,Grimaldi AM,Forte E,Netti PA,Torino E

更新日期：2019-02-28 00:00:00

abstract：:Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a crucial role in tumor progression, is mainly regulated by alterations to genes and post-transcriptional processes. The recent discovery of the N6-met...

journal_title：Theranostics

authors： Ye J,Wang Z,Chen X,Jiang X,Dong Z,Hu S,Li W,Liu Y,Liao B,Han W,Shen J,Xiao M

更新日期：2020-10-26 00:00:00

abstract：:Near-infrared (NIR) fluorescence imaging has relied on fluorophores that emit in the 700-900 nm NIR-Ia or 1,000-1,700 nm NIR-II window for generating deep-tissue images. Up until now, there have been few fluorophores developed for the 900-1,000 nm NIR-Ib window. This is largely because NIR-Ib light is thought to be st...

journal_title：Theranostics

authors： Deng G,Li S,Sun Z,Li W,Zhou L,Zhang J,Gong P,Cai L

更新日期：2018-07-16 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous in their clinical behavior and require therapies specially tailored according to staging, grading, origin and expression of peptide receptors. Despite extensive scientific efforts, the therapy options are still not satisfactory. The main reasons are due...

journal_title：Theranostics

authors： Briest F,Grabowski P

更新日期：2014-01-29 00:00:00

abstract：:Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. Here, we show the upregulated expression of EGFR ligand epiregulin in a subset of SACC cells correlates with lung metastasis and unfavora...

journal_title：Theranostics

authors： Yang WW,Yang LQ,Zhao F,Chen CW,Xu LH,Fu J,Li SL,Ge XY

更新日期：2017-08-23 00:00:00

abstract：:Periodontitis is a widespread oral disease that results in the loss of alveolar bone. Low-intensity pulsed ultrasound (LIPUS), which is a new therapeutic option, promotes alveolar bone regeneration in periodontal bone injury models. This study investigated the protective effect of LIPUS on oxidative stress in periodon...

journal_title：Theranostics

authors： Ying S,Tan M,Feng G,Kuang Y,Chen D,Li J,Song J

更新日期：2020-08-01 00:00:00

abstract：:Rationale: To test whether novel biomarkers, such as microribonucleic acids (miRNAs), and nonstandard predictive models, such as decision tree learning, provide useful information for medical decision-making in patients on hemodialysis (HD). Methods: Samples from patients with end-stage renal disease receiving HD incl...

journal_title：Theranostics

authors： de Gonzalo-Calvo D,Martínez-Camblor P,Bär C,Duarte K,Girerd N,Fellström B,Schmieder RE,Jardine AG,Massy ZA,Holdaas H,Rossignol P,Zannad F,Thum T

更新日期：2020-07-09 00:00:00

abstract：:Immuno-oncological treatment strategies that target abnormal receptor profiles of tumors are an increasingly important feature of cancer therapy. Yet, assessing receptor availability (RA) and drug-target engagement, important determinants of therapeutic efficacy, is challenging with current imaging strategies, largely...

journal_title：Theranostics

authors： Meng B,Folaron MR,Strawbridge RR,Sadeghipour N,Samkoe KS,Tichauer K,Davis SC

更新日期：2020-09-14 00:00:00

abstract：:Rationale: Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor alpha (ER-α), human epidermal growth factor receptor 2 (HER2) and progesterone receptor (PR) expression, but the effect of lacking the three factors on TNBC is unclear. Whether loss of the three factors contributes to ...

journal_title：Theranostics

authors： Zhao Z,Li L,Du P,Ma L,Zhang W,Zheng L,Lan B,Zhang B,Ma F,Xu B,Zhan Q,Song Y

更新日期：2019-02-20 00:00:00

abstract：:Objective: Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are essential for vascular remodeling. Natural compounds with diterpene chinone or phenolic acid structure from Salvia miltiorrhiza, an eminent medicinal herb widely used to treat cardiovascular diseases in China, can effectively a...

journal_title：Theranostics

authors： Yang GS,Zheng B,Qin Y,Zhou J,Yang Z,Zhang XH,Zhao HY,Yang HJ,Wen JK

更新日期：2020-06-19 00:00:00

abstract：:Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channe...

journal_title：Theranostics

authors： Burks SR,Lorsung RM,Nagle ME,Tu TW,Frank JA

更新日期：2019-07-28 00:00:00

abstract：:Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the enhanced response obtained by combinatorial treatments. Methods: We com...

journal_title：Theranostics

authors： Chavez M,Silvestrini MT,Ingham ES,Fite BZ,Mahakian LM,Tam SM,Ilovitsh A,Monjazeb AM,Murphy WJ,Hubbard NE,Davis RR,Tepper CG,Borowsky AD,Ferrara KW

更新日期：2018-06-07 00:00:00

abstract：:Purpose: Evans Blue (EB) is an azo dye that binds quantitatively with serum albumin. With an albumin binding, NOTA conjugated truncated Evan's blue (NEB) dye derived PET tracer, we aimed to establish a strategy for evaluating vascular permeability in malignant tumors via non-invasive PET. Experimental design: Sixty-mi...

journal_title：Theranostics

authors： Chen H,Tong X,Lang L,Jacobson O,Yung BC,Yang X,Bai R,Kiesewetter DO,Ma Y,Wu H,Niu G,Chen X

更新日期：2017-06-14 00:00:00

abstract：:Overexpression of CD146 has been correlated with aggressiveness, recurrence rate, and poor overall survival in hepatocellular carcinoma (HCC) patients. In this study, we set out to develop a CD146-targeting probe for high-contrast noninvasive in vivo positron emission tomography (PET) and near-infrared fluorescence (N...

journal_title：Theranostics

authors： Hernandez R,Sun H,England CG,Valdovinos HF,Ehlerding EB,Barnhart TE,Yang Y,Cai W

更新日期：2016-08-08 00:00:00

abstract：:Peripheral arterial disease affects nearly 202 million individuals worldwide, sometimes leading to non-healing ulcers or limb amputations in severe cases. Genetically modified stem cells offer potential advantages for therapeutically inducing angiogenesis via augmented paracrine release mechanisms and tuned dynamic re...

journal_title：Theranostics

authors： Deveza L,Choi J,Lee J,Huang N,Cooke J,Yang F

更新日期：2016-05-23 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated gene regulatory networks (GRNs), but their implication in advanced or treatment-refractory malignancy is unknown. Methods: We combined high-throughput transcriptomic approaches with bioinformatics and structure modeling to search for ...

journal_title：Theranostics

authors： Logotheti S,Marquardt S,Gupta SK,Richter C,Edelhäuser BAH,Engelmann D,Brenmoehl J,Söhnchen C,Murr N,Alpers M,Singh KP,Wolkenhauer O,Heckl D,Spitschak A,Pützer BM

更新日期：2020-07-29 00:00:00

abstract：:Ocular neovascularization is a pathological sequel of multiple eye diseases. Based on the anatomical site into which the abnormal neovessels grow, ocular neovascularization can be categorized into corneal neovascularization, choroidal neovascularization, and retinal neovascularization. Each category is intractable, an...

journal_title：Theranostics

authors： Zhang Y,Cai S,Jia Y,Qi C,Sun J,Zhang H,Wang F,Cao Y,Li X

更新日期：2017-07-22 00:00:00

abstract：:The diseases caused by viruses posed a great challenge to human health, the development of which was driven by the imbalanced host immune response. Host innate immunity is an evolutionary old defense system that is critical for the elimination of the virus. The overactive innate immune response also leads to inflammat...

journal_title：Theranostics

authors： Wang Y,Wang Y,Luo W,Song X,Huang L,Xiao J,Jin F,Ren Z,Wang Y

更新日期：2020-07-23 00:00:00

abstract：:Constructing nanosystems that synergistically combine therapeutic and diagnostic features is of great interest to the nanomedicine community but also remains a tremendous challenge. Methods: In this work, we report novel catalytic nanoparticles composed of the enzyme catalase, encapsulated in a polymer shell and surfa...

journal_title：Theranostics

authors： Zhu J,Li Z,Zhang C,Lin L,Cao S,Che H,Shi X,Wang H,van Hest JCM

更新日期：2019-10-17 00:00:00

abstract：:Extracellular vesicles (EVs), including exosomes and microvesicles, derived from bone marrow stromal cells (BMSCs) have been demonstrated as key factors in the progression and drug resistance of multiple myeloma (MM). EV uptake involves a variety of mechanisms which largely depend on the vesicle origin and recipient c...

journal_title：Theranostics

authors： Tu C,Du Z,Zhang H,Feng Y,Qi Y,Zheng Y,Liu J,Wang J

更新日期：2021-01-01 00:00:00

abstract：:Norepinephrine modulates cognitive processes such as working and episodic memory. Pathological changes in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the whole norepinephrine system, disrupting cognitive processes. Monitor...

journal_title：Theranostics

authors： López-Picón FR,Kirjavainen AK,Forsback S,Takkinen JS,Peters D,Haaparanta-Solin M,Solin O

更新日期：2019-01-01 00:00:00