Epiregulin Promotes Lung Metastasis of Salivary Adenoid Cystic Carcinoma.

abstract：:High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to co...

journal_title：Theranostics

authors： El Kaffas A,Gangeh MJ,Farhat G,Tran WT,Hashim A,Giles A,Czarnota GJ

更新日期：2018-01-01 00:00:00

abstract：:Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...

journal_title：Theranostics

authors： Tang Q,Hu Z,Jin H,Zheng G,Yu X,Wu G,Liu H,Zhu Z,Xu H,Zhang C,Shen L

更新日期：2019-01-30 00:00:00

abstract：:Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis...

journal_title：Theranostics

authors： Jiang Y,Mao C,Yang R,Yan B,Shi Y,Liu X,Lai W,Liu Y,Wang X,Xiao D,Zhou H,Cheng Y,Yu F,Cao Y,Liu S,Yan Q,Tao Y

更新日期：2017-07-23 00:00:00

abstract：:During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells chemotaxis being accompanied by activation of diverse intercellular s...

journal_title：Theranostics

authors： Jin J,Zhao Q

更新日期：2020-05-15 00:00:00

abstract：:Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against "self" antigens (Ags). In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust activation of T-cells against tumor Ags pr...

journal_title：Theranostics

authors： Kwon S,Velasquez FC,Rasmussen JC,Greives MR,Turner KD,Morrow JR,Hwu WJ,Ross RF,Zhang S,Sevick-Muraca EM

更新日期：2019-10-22 00:00:00

abstract：:Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilize...

journal_title：Theranostics

authors： Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

更新日期：2021-01-01 00:00:00

abstract：:MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-...

journal_title：Theranostics

authors： Novák J,Kružliak P,Bienertová-Vašků J,Slabý O,Novák M

更新日期：2014-01-02 00:00:00

abstract：:Arachidonic acid (AA) is a polyunsaturated fatty acid present at high concentrations in the ovarian cancer (OC) microenvironment and associated with a poor clinical outcome. In the present study, we have unraveled a potential link between AA and macrophage functions. Methods: AA-triggered signal transduction was studi...

journal_title：Theranostics

authors： Dietze R,Hammoud MK,Gómez-Serrano M,Unger A,Bieringer T,Finkernagel F,Sokol AM,Nist A,Stiewe T,Reinartz S,Ponath V,Preußer C,von Strandmann EP,Müller-Brüsselbach S,Graumann J,Müller R

更新日期：2021-01-01 00:00:00

abstract：:Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic administration. Here...

journal_title：Theranostics

authors： Fan B,Kang L,Chen L,Sun P,Jin M,Wang Q,Bae YH,Huang W,Gao Z

更新日期：2017-01-01 00:00:00

abstract：:Cancer vaccines have encountered their ideal personalized partner along with evidence for great breakthroughs in the identification and synthesis of neoantigens. Individual cancer neoantigen vaccines are capable of eliciting robust T-cell responses and have been demonstrated to achieve striking clinical efficacy due t...

journal_title：Theranostics

authors： Chu Y,Liu Q,Wei J,Liu B

更新日期：2018-07-30 00:00:00

abstract：:The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat an...

journal_title：Theranostics

authors： Yu J,Yin W,Zheng X,Tian G,Zhang X,Bao T,Dong X,Wang Z,Gu Z,Ma X,Zhao Y

更新日期：2015-05-20 00:00:00

abstract：:Model observers play an important role in the optimization and assessment of imaging devices. In this review paper, we first discuss the basic concepts of model observers, which include the mathematical foundations and psychophysical considerations in designing both optimal observers for optimizing imaging systems and...

journal_title：Theranostics

authors： He X,Park S

更新日期：2013-10-04 00:00:00

abstract：:The structural modification of existing AMPs is an effective strategy to develop antimicrobial agents with high-efficiency, low-cost and low-toxicity antimicrobial agents. Methods: Here, we truncated 14-amino-acids at the N-terminus of MSI-78 to obtain MSI and further modified MSI to obtain four peptide analogs: MSI-1...

journal_title：Theranostics

authors： Ma L,Xie X,Liu H,Huang Y,Wu H,Jiang M,Xu P,Ye X,Zhou C

更新日期：2020-01-01 00:00:00

abstract：:Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent for novel cancer treatment by using an NB-encapsulated hybrid nanosystem that can be monitored by US and fluorescent imaging and acti...

journal_title：Theranostics

authors： Huang WT,Chan MH,Chen X,Hsiao M,Liu RS

更新日期：2020-01-01 00:00:00

abstract：:Aberrant activation of the Src kinase is implicated in the development of a variety of human malignancies. However, it is almost impossible to monitor Src activity in an in vivo setting with current biochemical techniques. To facilitate the noninvasive investigation of the activity of Src kinase both in vitro and in v...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2016-02-24 00:00:00

abstract：:Although the prognosis of differentiated thyroid cancer (DTC) is relatively good, 30-40% of patients with distant metastases develop resistance to radioactive iodine therapy due to tumor dedifferentiation. For DTC patients harboring BRAFV600E mutation, Vemurafenib, a BRAF kinase inhibitor, has dramatically changed the...

journal_title：Theranostics

authors： Wei WJ,Sun ZK,Shen CT,Song HJ,Zhang XY,Qiu ZL,Luo QY

更新日期：2017-02-23 00:00:00

abstract：:Background: Colorectal cancer (CRC) progression and related mortality are highly associated with metabolic disorders. However, the molecular mechanism involved in the regulation of hyperlipidemia-associated CRC metastasis remains unclear. This study aimed to investigate the effects of angiopoietin-like 4 (ANGPTL4) on ...

journal_title：Theranostics

authors： Shen CJ,Chang KY,Lin BW,Lin WT,Su CM,Tsai JP,Liao YH,Hung LY,Chang WC,Chen BK

更新日期：2020-05-30 00:00:00

abstract：:Prolonged occlusion of multiple microvessels causes microvascular injury. G protein-coupled receptor 124 (GPR124) has been reported to be required for maintaining central nervous system (CNS) angiogenesis and blood-brain barrier integrity. However, the molecular mechanisms by which GPR124 regulates pericytes during is...

journal_title：Theranostics

authors： Chen DY,Sun NH,Lu YP,Hong LJ,Cui TT,Wang CK,Chen XH,Wang SS,Feng LL,Shi WX,Fukunaga K,Chen Z,Lu YM,Han F

更新日期：2019-08-14 00:00:00

abstract：:Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channe...

journal_title：Theranostics

authors： Burks SR,Lorsung RM,Nagle ME,Tu TW,Frank JA

更新日期：2019-07-28 00:00:00

abstract：:Targeted therapy and immunotherapy have become mainstream in cancer treatment. However, only patient subsets benefit from these expensive therapies, and often responses are short-lived or coincide with side effects. A growing modality in precision oncology is the development of theranostics, as this enables patient se...

journal_title：Theranostics

authors： Lecocq Q,De Vlaeminck Y,Hanssens H,D'Huyvetter M,Raes G,Goyvaerts C,Keyaerts M,Devoogdt N,Breckpot K

更新日期：2019-10-15 00:00:00

abstract：:Due to their tunable surface plasmon and photothermal effects, gold nanorods (AuNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery. All these applications can be remotely controlled by near infrared (NIR) light which can penetrate deep in...

journal_title：Theranostics

authors： Zhang Z,Wang J,Chen C

更新日期：2013-01-01 00:00:00

abstract：:RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and ...

journal_title：Theranostics

authors： Lin YX,Wang Y,Blake S,Yu M,Mei L,Wang H,Shi J

更新日期：2020-01-01 00:00:00

abstract：:Background: Biofilm infection caused by multidrug-resistant bacteria is difficult to eradicate by conventional therapies. Photodynamic therapy (PDT) is an effective antibacterial method for fighting against biofilm infection. However, the blocked photosensitizers outside of biofilm greatly limit the efficacy of PDT. M...

journal_title：Theranostics

authors： Wang C,Chen P,Qiao Y,Kang Y,Yan C,Yu Z,Wang J,He X,Wu H

更新日期：2020-03-26 00:00:00

abstract：:Inhibitor of apoptosis proteins (IAP) are cell death regulators that bind caspases and interfere with apoptotic signalling via death receptors or intrinsic cell death pathways. BIRC4/XIAP is the most potent anti-apoptotic IAP-member and it physically interacts with caspases via its BIR2 and its BIR3 domain. These doma...

journal_title：Theranostics

authors： Hagenbuchner J,Oberacher H,Arnhard K,Kiechl-Kohlendorfer U,Ausserlechner MJ

更新日期：2019-07-09 00:00:00

abstract：:Treatments of high specificity are desirable for cancer therapy. Light-triggered nanotheranostics (LTN) mediated cancer therapy could be one such treatment, as they make it possible to visualize and treat the tumor specifically in a light-controlled manner with a single injection. Because of their great potential in c...

journal_title：Theranostics

authors： Zhang P,Hu C,Ran W,Meng J,Yin Q,Li Y

更新日期：2016-04-27 00:00:00

abstract：:Rationale: Tumor angiogenesis promotes tumor development, progression, growth, and metastasis. Metronomic chemotherapy involves the frequent administration of low-dose chemotherapeutic agents to block angiogenic activity and reduce side effects. Methods: MDA-MB-231 cells were treated with various concentrations of art...

journal_title：Theranostics

authors： Tsui KH,Wu MY,Lin LT,Wen ZH,Li YH,Chu PY,Li CJ

更新日期：2019-09-17 00:00:00

abstract：:Rationale: To test whether novel biomarkers, such as microribonucleic acids (miRNAs), and nonstandard predictive models, such as decision tree learning, provide useful information for medical decision-making in patients on hemodialysis (HD). Methods: Samples from patients with end-stage renal disease receiving HD incl...

journal_title：Theranostics

authors： de Gonzalo-Calvo D,Martínez-Camblor P,Bär C,Duarte K,Girerd N,Fellström B,Schmieder RE,Jardine AG,Massy ZA,Holdaas H,Rossignol P,Zannad F,Thum T

更新日期：2020-07-09 00:00:00

abstract：:Rationale: Mesenchymal cell-derived osteosarcoma is a rare malignant bone tumor affecting children and adolescents. PTEN down-regulation or function-loss mutation is associated with the aggressive of osteosarcoma. Explicating the regulatory mechanism of PTEN might highlight new targets for improving the survival rate ...

journal_title：Theranostics

authors： Wu W,Jing D,Meng Z,Hu B,Zhong B,Deng X,Jin X,Shao Z

更新日期：2020-02-03 00:00:00

abstract：:Lateral flow assay (LFA) has become one of the most widely used point-of-care diagnostic methods due to its simplicity and low cost. While easy to use, LFA suffers from its low sensitivity and poor quantification, which largely limits its applications for early disease diagnosis and requires further testing to elimina...

journal_title：Theranostics

authors： Ye H,Liu Y,Zhan L,Liu Y,Qin Z

更新日期：2020-03-15 00:00:00

abstract：:The combination of chemotherapy and RNA interference is a promising approach for efficient cancer therapy. However, the success of such a strategy is hampered by the lack of suitable vectors to coordinate small interfering RNA (siRNA) and chemotherapeutic drug into one single platform. We herein report a novel triple-...

journal_title：Theranostics

authors： Yu H,Guo C,Feng B,Liu J,Chen X,Wang D,Teng L,Li Y,Yin Q,Zhang Z,Li Y

更新日期：2016-01-01 00:00:00