Abstract:
:MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-206, which belongs to the group of so-called "myomiRs", is one of the most studied miRs thus far. In addition to being involved in skeletal muscle development and pathology, it has also been established that it is involved in the pathogenesis of numerous diseases including heart failure, chronic obstructive pulmonary disease, Alzheimer's disease and various types of cancers. The aim of this review is to provide a complex overview of microRNA-206, including regulating its expression, a brief description of its known functions in skeletal muscle and a complex overview of its roles in the biology and pathology of other tissues, emphasizing its significant diagnostic and therapeutic potential.
journal_name
Theranosticsjournal_title
Theranosticsauthors
Novák J,Kružliak P,Bienertová-Vašků J,Slabý O,Novák Mdoi
10.7150/thno.7552subject
Has Abstractpub_date
2014-01-02 00:00:00pages
119-33issue
2issn
1838-7640pii
thnov04p0119journal_volume
4pub_type
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