Emerging role of mTOR in tumor immune contexture: Impact on chemokine-related immune cells migration.

abstract：:Rationale: Saliva as a sample matrix is rapidly gaining interest for disease diagnosis and point-of-care assays because it is easy to collect (non-invasive) and contains many health-related biomarkers. However, saliva poses particular problems relative to more common urine and blood matrices, which includes low analyt...

journal_title：Theranostics

authors： Noiphung J,Nguyen MP,Punyadeera C,Wan Y,Laiwattanapaisal W,Henry CS

更新日期：2018-06-13 00:00:00

abstract：:Rationale: Colitis-associated colorectal cancer (CAC) usually exhibits an accelerated disease progression, an increased resistance to therapeutic drugs and a higher mortality rate than sporadic colorectal cancer (CRC). PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family; however, little is known...

journal_title：Theranostics

authors： Ma J,Yang Y,Fu Y,Guo F,Zhang X,Xiao S,Zhu W,Huang Z,Zhang J,Chen J

更新日期：2018-04-30 00:00:00

abstract：:Rationale: Chromodomain Y-like 2 (CDYL2) is a member of the CDY gene family involved in spermatogenesis, but its role in human cancer has not been reported. Analyses of publicly available databases demonstrate that CDYL2 is abundantly expressed in breast tumors. However, whether CDYL2 is involved in breast cancer prog...

journal_title：Theranostics

authors： Yang LF,Yang F,Zhang FL,Xie YF,Hu ZX,Huang SL,Shao ZM,Li DQ

更新日期：2020-04-06 00:00:00

abstract：:Blood vessels are conduits distributed throughout the body, supporting tissue growth and homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the linings of the blood vessels, and together with pericytes, are essential for organ development and tissue homeostasis through producing ...

journal_title：Theranostics

authors： Zhu S,Bennett S,Kuek V,Xiang C,Xu H,Rosen V,Xu J

更新日期：2020-05-01 00:00:00

abstract：:The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat an...

journal_title：Theranostics

authors： Yu J,Yin W,Zheng X,Tian G,Zhang X,Bao T,Dong X,Wang Z,Gu Z,Ma X,Zhao Y

更新日期：2015-05-20 00:00:00

abstract：PURPOSE:The efficacy of pro-angiogenic therapy is difficult to evaluate with current diagnostic modalities. The objectives were to develop a non-invasive imaging strategy to define the temporal characteristics of angiogenesis and to evaluate the response to pro-angiogenic therapy in diabetic stroke mouse models. METHO...

journal_title：Theranostics

authors： Bai YY,Gao X,Wang YC,Peng XG,Chang D,Zheng S,Li C,Ju S

更新日期：2014-05-25 00:00:00

abstract：:In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel netrin-1 interference therapy requires the assessment of netrin-1 expression prior to ...

journal_title：Theranostics

authors： Wischhusen J,Wilson KE,Delcros JG,Molina-Peña R,Gibert B,Jiang S,Ngo J,Goldschneider D,Mehlen P,Willmann JK,Padilla F

更新日期：2018-10-06 00:00:00

abstract：:Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recen...

journal_title：Theranostics

authors： Yong KT,Wang Y,Roy I,Rui H,Swihart MT,Law WC,Kwak SK,Ye L,Liu J,Mahajan SD,Reynolds JL

更新日期：2012-01-01 00:00:00

abstract：:Dynamic positron emission tomography (PET) can monitor spatiotemporal distribution of radiotracer in vivo. The spatiotemporal information can be used to estimate parametric images of radiotracer kinetics that are of physiological and biochemical interests. Direct estimation of parametric images from raw projection dat...

journal_title：Theranostics

authors： Wang G,Qi J

更新日期：2013-11-20 00:00:00

abstract：:Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...

journal_title：Theranostics

authors： Tang Q,Hu Z,Jin H,Zheng G,Yu X,Wu G,Liu H,Zhu Z,Xu H,Zhang C,Shen L

更新日期：2019-01-30 00:00:00

abstract：:The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant ex...

journal_title：Theranostics

authors： Corti A,Belcastro E,Pompella A

更新日期：2018-11-15 00:00:00

abstract：:Heart diseases are one of the leading causes of death for humans in the world. Increasing evidence has shown that myocardial injury induced innate and adaptive immune responses upon early cellular damage but also during chronic phases post-injury. The immune cells can not only aggravate the injury but also play an ess...

journal_title：Theranostics

authors： Wang J,Duan Y,Sluijter JP,Xiao J

更新日期：2019-05-31 00:00:00

abstract：:Elastin-like polypeptide (ELP)-based drug delivery has been utilized for various applications including cancer therapies for many years. Genetic incorporation of internalization ligands and cell-targeting peptides along with ELP polymer enhanced tumor accumulation and retention time as well as stability and activities...

journal_title：Theranostics

authors： Sarangthem V,Kim Y,Singh TD,Seo BY,Cheon SH,Lee YJ,Lee BH,Park RW

更新日期：2016-09-25 00:00:00

abstract：:We describe the preparation of monodisperse, lanthanide-doped hexagonal-phase NaYF4 upconverting luminescent nanoparticles for protein conjugation. Their core was coated with a silica shell which then was modified with a poly(ethylene glycol) spacer and N-hydroxysuccinimide ester groups. The nanoparticles were charact...

journal_title：Theranostics

authors： Wilhelm S,Hirsch T,Patterson WM,Scheucher E,Mayr T,Wolfbeis OS

更新日期：2013-03-13 00:00:00

abstract：:Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute myeloid leukemia (AML). The uridine-cytidine kinase 1 (UCK1) has an established role in activating 5'-AZA and its protein level is significantly downregulated in patients resistant to the drug. H...

journal_title：Theranostics

authors： Zhang H,Huang H,Feng X,Song H,Zhang Z,Shen A,Qiu X

更新日期：2020-01-01 00:00:00

abstract：:Targeted therapy and immunotherapy have become mainstream in cancer treatment. However, only patient subsets benefit from these expensive therapies, and often responses are short-lived or coincide with side effects. A growing modality in precision oncology is the development of theranostics, as this enables patient se...

journal_title：Theranostics

authors： Lecocq Q,De Vlaeminck Y,Hanssens H,D'Huyvetter M,Raes G,Goyvaerts C,Keyaerts M,Devoogdt N,Breckpot K

更新日期：2019-10-15 00:00:00

abstract：:Marfan syndrome (MFS) is a rare genetic disease characterized by a matrix metalloproteases (MMPs) dysregulation that leads to extracellular matrix degradation. Consequently, MFS patients are prone to develop progressive thoracic aortic enlargement and detrimental aneurysm. Since MMPs are activated by the extracellular...

journal_title：Theranostics

authors： Rurali E,Perrucci GL,Gaetano R,Pini A,Moschetta D,Gentilini D,Nigro P,Pompilio G

更新日期：2019-04-12 00:00:00

abstract：:Rationale: Treating diseases of the brain such as Alzheimer's disease (AD) is challenging as the blood-brain barrier (BBB) effectively restricts access of a large number of potentially useful drugs. A potential solution to this problem is presented by therapeutic ultrasound, a novel treatment modality that can achieve...

journal_title：Theranostics

authors： Pelekanos M,Leinenga G,Odabaee M,Odabaee M,Saifzadeh S,Steck R,Götz J

更新日期：2018-04-03 00:00:00

abstract：:Smart drug delivery system with strategic drug distribution is the future state-of-the-art treatment for any malignancy. To investigate therapeutic potential of such nanoparticle mediated delivery system, we examined the efficacy of dual drug-loaded, pH and thermo liable lipid coated mesoporous iron oxide-based magnet...

journal_title：Theranostics

authors： Pradhan L,Thakur B,Srivastava R,Ray P,Bahadur D

更新日期：2016-06-18 00:00:00

abstract：:MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-...

journal_title：Theranostics

authors： Novák J,Kružliak P,Bienertová-Vašků J,Slabý O,Novák M

更新日期：2014-01-02 00:00:00

abstract：:Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. Here, we show the upregulated expression of EGFR ligand epiregulin in a subset of SACC cells correlates with lung metastasis and unfavora...

journal_title：Theranostics

authors： Yang WW,Yang LQ,Zhao F,Chen CW,Xu LH,Fu J,Li SL,Ge XY

更新日期：2017-08-23 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of several human cancers, including breast cancer (BC), as strong evidence has been found that miRNAs can act as oncogenes or tumor suppressor genes. This review presents the state of the art on the role of miRNAs in the diagnosis, progn...

journal_title：Theranostics

authors： Bertoli G,Cava C,Castiglioni I

更新日期：2015-07-13 00:00:00

abstract：:Proper selection and effective delivery of combination drugs targeting multiple pathophysiological pathways key to spinal cord injury (SCI) hold promise to address the thus far scarce clinical therapeutics for improving recovery after SCI. In this study, we aim to develop a clinically feasible way for targeted deliver...

journal_title：Theranostics

authors： Wang Q,Zhang H,Xu H,Zhao Y,Li Z,Li J,Wang H,Zhuge D,Guo X,Xu H,Jones S,Li X,Jia X,Xiao J

更新日期：2018-08-07 00:00:00

abstract：:Background: Colorectal cancer (CRC) progression and related mortality are highly associated with metabolic disorders. However, the molecular mechanism involved in the regulation of hyperlipidemia-associated CRC metastasis remains unclear. This study aimed to investigate the effects of angiopoietin-like 4 (ANGPTL4) on ...

journal_title：Theranostics

authors： Shen CJ,Chang KY,Lin BW,Lin WT,Su CM,Tsai JP,Liao YH,Hung LY,Chang WC,Chen BK

更新日期：2020-05-30 00:00:00

abstract：:Intrinsic and acquired resistance to targeted therapies is a significant clinical problem in cancer. We previously showed that resistance to regorafenib, a multi-kinase inhibitor for treating colorectal cancer (CRC) patients, can be caused by mutations in the tumor suppressor FBW7, which block degradation of the pro-s...

journal_title：Theranostics

authors： Song X,Shen L,Tong J,Kuang C,Zeng S,Schoen RE,Yu J,Pei H,Zhang L

更新日期：2020-07-09 00:00:00

abstract：:Rationale: The overall success rate of prostate cancer (PCa) diagnosis and therapy has been improved over the years. However, genomic and phenotypic heterogeneity remains a major challenge for effective detection and treatment of PCa. Efforts to better classify PCa into functional subtypes and elucidate the molecular ...

journal_title：Theranostics

authors： Bai Y,Yang Y,Yan Y,Zhong J,Blee AM,Pan Y,Ma T,Karnes RJ,Jimenez R,Xu W,Huang H

更新日期：2019-05-24 00:00:00

abstract：:Periodontitis is a widespread oral disease that results in the loss of alveolar bone. Low-intensity pulsed ultrasound (LIPUS), which is a new therapeutic option, promotes alveolar bone regeneration in periodontal bone injury models. This study investigated the protective effect of LIPUS on oxidative stress in periodon...

journal_title：Theranostics

authors： Ying S,Tan M,Feng G,Kuang Y,Chen D,Li J,Song J

更新日期：2020-08-01 00:00:00

abstract：:Immunity is the most critical and well-regulated protection to the body. Immunity is implicated in a wide range of diseases and serves as the foundation for immunotherapy. Immunotheranostics is the idea of improving immunotherapy through the organic integration of therapeutic, diagnostic, and screening technologies. T...

journal_title：Theranostics

authors： Chen X,Chen M

更新日期：2020-06-11 00:00:00

abstract：:Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been a popular strategy...

journal_title：Theranostics

authors： Johnsen KB,Bak M,Kempen PJ,Melander F,Burkhart A,Thomsen MS,Nielsen MS,Moos T,Andresen TL

更新日期：2018-05-24 00:00:00

abstract：:Compared with other diagnostic methods, ultrasound is proven to be a safe, simple, non-invasive and cost-effective imaging technique, but the resolution is not comparable to that of magnetic resonance imaging (MRI). Contrast-enhanced ultrasound employing microbubbles can gain a better resolution and is now widely used...

journal_title：Theranostics

authors： Cai X,Yang F,Gu N

更新日期：2012-01-01 00:00:00