Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress.

abstract：:[This retracts the article DOI: 10.7150/thno.14306.]. ...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2020-09-30 00:00:00

abstract：:Treatments of high specificity are desirable for cancer therapy. Light-triggered nanotheranostics (LTN) mediated cancer therapy could be one such treatment, as they make it possible to visualize and treat the tumor specifically in a light-controlled manner with a single injection. Because of their great potential in c...

journal_title：Theranostics

authors： Zhang P,Hu C,Ran W,Meng J,Yin Q,Li Y

更新日期：2016-04-27 00:00:00

abstract：:Biological cancer therapies, such as oncolytic, or replication-selective viruses have advantages over traditional therapeutics as they can employ multiple different mechanisms to target and destroy cancers (including direct cell lysis, immune activation and vascular collapse). This has led to their rapid recent clinic...

journal_title：Theranostics

authors： Rojas JJ,Thorne SH

更新日期：2012-01-01 00:00:00

abstract：:[This retracts the article on p. 3 in vol. 1, PMID: 21547151.]. ...

journal_title：Theranostics

authors： Lukianova-Hleb EY,Oginsky AO,Samaniego AP,Shenefelt DL,Wagner DS,Hafner JH,Farach-Carson MC,Lapotko DO

更新日期：2017-01-07 00:00:00

abstract：:Rationale: Tumor microenvironment interacts with tumor cells to regulate their stemness properties through various cytokines and cytokine receptors. Previous studies revealed the possible role of interleukin 20 receptor subunit alpha (IL20RA) signaling in the progression of several types of tumors. However, its regula...

journal_title：Theranostics

authors： Gao W,Wen H,Liang L,Dong X,Du R,Zhou W,Zhang X,Zhang C,Xiang R,Li N

更新日期：2021-01-01 00:00:00

abstract：:Rationale: Malignant ascites caused by cancer cells results in poor prognosis and short average survival time. No effective treatment is currently available for malignant ascites. In this study, the effects of lentinan (LNT)-functionalized selenium nanoparticles (Selene) on malignant ascites were evaluated. Furthermor...

journal_title：Theranostics

authors： Liu HJ,Qin Y,Zhao ZH,Zhang Y,Yang JH,Zhai DH,Cui F,Luo C,Lu MX,Liu PP,Xu HW,Li K,Sun B,Chen S,Zhou HG,Yang C,Sun T

更新日期：2020-07-11 00:00:00

abstract：:Norepinephrine modulates cognitive processes such as working and episodic memory. Pathological changes in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the whole norepinephrine system, disrupting cognitive processes. Monitor...

journal_title：Theranostics

authors： López-Picón FR,Kirjavainen AK,Forsback S,Takkinen JS,Peters D,Haaparanta-Solin M,Solin O

更新日期：2019-01-01 00:00:00

abstract：:Exosomes play critical roles in intercellular communication in both nearby and distant cells in individuals and organs. Polymerase I and transcript release factor (PTRF), also known as Cavin1, has previously been described as a critical factor in caveola formation, and aberrant PTRF expression has been reported in var...

journal_title：Theranostics

authors： Huang K,Fang C,Yi K,Liu X,Qi H,Tan Y,Zhou J,Li Y,Liu M,Zhang Y,Yang J,Zhang J,Li M,Kang C

更新日期：2018-02-07 00:00:00

abstract：:A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positi...

journal_title：Theranostics

authors： Hou FQ,Song LW,Yuan Q,Fang LL,Ge SX,Zhang J,Sheng JF,Xie DY,Shang J,Wu SH,Sun YT,Wei SF,Wang MR,Wan MB,Jia JD,Luo GH,Tang H,Li SC,Niu JQ,Zhou WD,Sun L,Xia NS,Wang GQ

更新日期：2015-01-01 00:00:00

abstract：:New ways to target and treat metastatic disease are urgently needed. Tumor "self-homing" describes the recruitment of circulating tumor cells (CTCs) back to a previously excised primary tumor location, contributing to tumor recurrence, as well as their migration to established metastatic lesions. Recently, self-homing...

journal_title：Theranostics

authors： Parkins KM,Dubois VP,Kelly JJ,Chen Y,Knier NN,Foster PJ,Ronald JA

更新日期：2020-06-29 00:00:00

abstract：:Background: Tobacco smoke (TS) critically contributes to the development of lung cancer; however, the underlying molecular mechanisms remain unclear. The induction of cancer stem cells (CSCs) by TS represents an early event in tumor initiation. The lung cancer-related gene ΔNp63α is highly expressed in epithelial tiss...

journal_title：Theranostics

authors： Xie C,Zhu J,Jiang Y,Chen J,Wang X,Geng S,Wu J,Zhong C,Li X,Meng Z

更新日期：2019-07-09 00:00:00

abstract：:Rationale: Glioma stem-like cells (GSCs) contribute to temozolomide (TMZ) resistance in gliomas, although the mechanisms have not been delineated. Methods:In vitro functional experiments (colony formation assay, flow cytometric analysis, TUNEL assay) were used to assess the ability of extracellular vesicles (EVs) from...

journal_title：Theranostics

authors： Yin J,Ge X,Shi Z,Yu C,Lu C,Wei Y,Zeng A,Wang X,Yan W,Zhang J,You Y

更新日期：2021-01-01 00:00:00

abstract：:Purpose: The tumor homing characteristics of mesenchymal stem cells (MSCs) make them attractive vehicles for the tumor-specific delivery of therapeutic agents, such as the sodium iodide symporter (NIS). NIS is a theranostic protein that allows non-invasive monitoring of the in vivo biodistribution of functional NIS ex...

journal_title：Theranostics

authors： Tutter M,Schug C,Schmohl KA,Urnauer S,Schwenk N,Petrini M,Lokerse WJM,Zach C,Ziegler S,Bartenstein P,Weber WA,Wagner E,Lindner LH,Nelson PJ,Spitzweg C

更新日期：2020-03-15 00:00:00

abstract：:Near-infrared (NIR) fluorescence imaging has relied on fluorophores that emit in the 700-900 nm NIR-Ia or 1,000-1,700 nm NIR-II window for generating deep-tissue images. Up until now, there have been few fluorophores developed for the 900-1,000 nm NIR-Ib window. This is largely because NIR-Ib light is thought to be st...

journal_title：Theranostics

authors： Deng G,Li S,Sun Z,Li W,Zhou L,Zhang J,Gong P,Cai L

更新日期：2018-07-16 00:00:00

abstract：:Rationale: The incidence of hepatocellular carcinoma is rising worldwide. It is predicted that nearly half of the early-stage hepatocellular carcinoma (E-HCC) patients will develop recurrence. Dysregulated pH, a hallmark of E-HCC, is correlated with poor prognosis. The acidic microenvironment has been shown to promote...

journal_title：Theranostics

authors： Tian XP,Wang CY,Jin XH,Li M,Wang FW,Huang WJ,Yun JP,Xu RH,Cai QQ,Xie D

更新日期：2019-03-16 00:00:00

abstract：:Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. Here, we show the upregulated expression of EGFR ligand epiregulin in a subset of SACC cells correlates with lung metastasis and unfavora...

journal_title：Theranostics

authors： Yang WW,Yang LQ,Zhao F,Chen CW,Xu LH,Fu J,Li SL,Ge XY

更新日期：2017-08-23 00:00:00

abstract：:Rationale: Chromodomain Y-like 2 (CDYL2) is a member of the CDY gene family involved in spermatogenesis, but its role in human cancer has not been reported. Analyses of publicly available databases demonstrate that CDYL2 is abundantly expressed in breast tumors. However, whether CDYL2 is involved in breast cancer prog...

journal_title：Theranostics

authors： Yang LF,Yang F,Zhang FL,Xie YF,Hu ZX,Huang SL,Shao ZM,Li DQ

更新日期：2020-04-06 00:00:00

abstract：:Acute myocardial infarction (AMI) is one of the leading causes of mortality around the world, and the inflammatory response plays a pivotal role in the progress of myocardial necrosis and ventricular remodeling, dysfunction and heart failure after AMI. Therapies aimed at modulating immune response after AMI on a molec...

journal_title：Theranostics

authors： Xiong YY,Gong ZT,Tang RJ,Yang YJ

更新日期：2021-01-01 00:00:00

abstract：:Due to their tunable surface plasmon and photothermal effects, gold nanorods (AuNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery. All these applications can be remotely controlled by near infrared (NIR) light which can penetrate deep in...

journal_title：Theranostics

authors： Zhang Z,Wang J,Chen C

更新日期：2013-01-01 00:00:00

abstract：:Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb) localize within a tumor by virtue of its anti-tumor binding site(s) before administering a small, fast-clearing radiolabeled compound that then attaches to the other portion of the bsMAb. The compound's rapid clearance signifi...

journal_title：Theranostics

authors： Goldenberg DM,Chang CH,Rossi EA,J W,McBride,Sharkey RM

更新日期：2012-01-01 00:00:00

abstract：:Zinc-finger proteins (ZFPs) are the largest transcription factor family in mammals, involved in the regulation of multiple physiologic processes including cell differentiation, proliferation, apoptosis and neoplastic transformation. Approximately one-third of ZFPs are Krüppel-associated box domain (KRAB)-ZFPs. Methods...

journal_title：Theranostics

authors： Sun R,Xiang T,Tang J,Peng W,Luo J,Li L,Qiu Z,Tan Y,Ye L,Zhang M,Ren G,Tao Q

更新日期：2020-01-12 00:00:00

abstract：:In this study, we investigated the induction of apoptosis by ultrasound in the presence of the novel porphyrin derivative DCPH-P-Na(I). HL-60 cells were exposed to ultrasound for up to 3 min in the presence and absence of DCPH-P-Na(I), and the induction of apoptosis was examined by analyzing cell morphology, DNA fragm...

journal_title：Theranostics

authors： Yumita N,Iwase Y,Nishi K,Komatsu H,Takeda K,Onodera K,Fukai T,Ikeda T,Umemura S,Okudaira K,Momose Y

更新日期：2012-01-01 00:00:00

abstract：:To generate a more efficient in vivo reporter and therapeutic gene, we optimized the coding sequence of the human sodium/iodide symporter (NIS) gene by replacing NIS DNA codons from wild type to new codons having the highest usage in human gene translation. The Codon Adaptation Index (CAI), representing the number of ...

journal_title：Theranostics

authors： Kim YH,Youn H,Na J,Hong KJ,Kang KW,Lee DS,Chung JK

更新日期：2015-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.27882.]. ...

journal_title：Theranostics

authors： Qin C,Liu Q,Hu ZW,Zhou LQ,Shang K,Bosco DB,Wu LJ,Tian DS,Wang W

更新日期：2020-07-10 00:00:00

abstract：:Recent studies have highlighted the biological significance of RNA N6-methyladenosine (m6A) modification in tumorigenicity and progression. However, it remains unclear whether m6A modifications also have potential roles in immune regulation and tumor microenvironment (TME) formation. Methods: In this study, we curated...

journal_title：Theranostics

authors： Chong W,Shang L,Liu J,Fang Z,Du F,Wu H,Liu Y,Wang Z,Chen Y,Jia S,Chen L,Li L,Chen H

更新日期：2021-01-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in a variety of tumor cells, but not most normal cells. Nevertheless, its therapeutic potential is limited due to the frequent occurrence of resistance in tumor cells, especially hepatocellular carcinoma cell lines. Theref...

journal_title：Theranostics

authors： Shi K,Xue J,Fang Y,Bi H,Gao S,Yang D,Lu A,Li Y,Chen Y,Ke L

更新日期：2017-10-12 00:00:00

abstract：:Although the prognosis of differentiated thyroid cancer (DTC) is relatively good, 30-40% of patients with distant metastases develop resistance to radioactive iodine therapy due to tumor dedifferentiation. For DTC patients harboring BRAFV600E mutation, Vemurafenib, a BRAF kinase inhibitor, has dramatically changed the...

journal_title：Theranostics

authors： Wei WJ,Sun ZK,Shen CT,Song HJ,Zhang XY,Qiu ZL,Luo QY

更新日期：2017-02-23 00:00:00

abstract：:Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a crucial role in tumor progression, is mainly regulated by alterations to genes and post-transcriptional processes. The recent discovery of the N6-met...

journal_title：Theranostics

authors： Ye J,Wang Z,Chen X,Jiang X,Dong Z,Hu S,Li W,Liu Y,Liao B,Han W,Shen J,Xiao M

更新日期：2020-10-26 00:00:00

abstract：:Model observers play an important role in the optimization and assessment of imaging devices. In this review paper, we first discuss the basic concepts of model observers, which include the mathematical foundations and psychophysical considerations in designing both optimal observers for optimizing imaging systems and...

journal_title：Theranostics

authors： He X,Park S

更新日期：2013-10-04 00:00:00

abstract：:Recently, researchers identified a distinct vessel subtype called type H vessels that couple angiogenesis and osteogenesis. We previously found that type H vessels are reduced in ovariectomy (OVX)-induced osteoporotic mice, and preosteoclasts are able to secrete platelet-derived growth factor-BB (PDGF-BB) to stimulate...

journal_title：Theranostics

authors： Huang J,Yin H,Rao SS,Xie PL,Cao X,Rao T,Liu SY,Wang ZX,Cao J,Hu Y,Zhang Y,Luo J,Tan YJ,Liu ZZ,Wu B,Hu XK,Chen TH,Chen CY,Xie H

更新日期：2018-03-28 00:00:00