Neurogliovascular dysfunction in a model of repeated traumatic brain injury.

abstract：:Aplastic anemia (AA) is characterized as hypoplasia of bone marrow hematopoietic cells and hematopenia of peripheral blood cells. Though the supplement of exogenous erythropoietin (EPO) has been clinically approved for AA treatment, the side-effects hinder its further application. Here a robust treatment for AA induce...

journal_title：Theranostics

authors： Jia W,Zhen M,Li L,Zhou C,Sun Z,Liu S,Zhao Z,Li J,Wang C,Bai C

更新日期：2020-05-23 00:00:00

abstract：:Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field still suffers from poor data reproducibility. This is especially true in cases of infants, conside...

journal_title：Theranostics

authors： Prieto-Fernández E,Aransay AM,Royo F,González E,Lozano JJ,Santos-Zorrozua B,Macias-Camara N,González M,Garay RP,Benito J,Garcia-Orad A,Falcón-Pérez JM

更新日期：2019-06-19 00:00:00

abstract：:Smart drug delivery system with strategic drug distribution is the future state-of-the-art treatment for any malignancy. To investigate therapeutic potential of such nanoparticle mediated delivery system, we examined the efficacy of dual drug-loaded, pH and thermo liable lipid coated mesoporous iron oxide-based magnet...

journal_title：Theranostics

authors： Pradhan L,Thakur B,Srivastava R,Ray P,Bahadur D

更新日期：2016-06-18 00:00:00

abstract：:Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute myeloid leukemia (AML). The uridine-cytidine kinase 1 (UCK1) has an established role in activating 5'-AZA and its protein level is significantly downregulated in patients resistant to the drug. H...

journal_title：Theranostics

authors： Zhang H,Huang H,Feng X,Song H,Zhang Z,Shen A,Qiu X

更新日期：2020-01-01 00:00:00

abstract：:Protein therapeutics is playing an increasingly critical role in treatment of human diseases. However, current vectors are captured by the digestive endo-lysosomal system, which results in an extremely low fraction (<2%) of protein being released in the cytoplasm. This paper reports a drug-delivering-drug platform (HA...

journal_title：Theranostics

authors： Xin X,Teng C,Du X,Lv Y,Xiao Q,Wu Y,He W,Yin L

更新日期：2018-06-06 00:00:00

abstract：:Topical administration permits targeted, sustained delivery of therapeutics to human skin. Delivery to the skin, however, is typically limited to lipophilic molecules with molecular weight of < 500 Da, capable of crossing the stratum corneum. Nevertheless, there are indications protein delivery may be possible in barr...

journal_title：Theranostics

authors： Giulbudagian M,Yealland G,Hönzke S,Edlich A,Geisendörfer B,Kleuser B,Hedtrich S,Calderón M

更新日期：2018-01-01 00:00:00

abstract：:In this study, we investigated the induction of apoptosis by ultrasound in the presence of the novel porphyrin derivative DCPH-P-Na(I). HL-60 cells were exposed to ultrasound for up to 3 min in the presence and absence of DCPH-P-Na(I), and the induction of apoptosis was examined by analyzing cell morphology, DNA fragm...

journal_title：Theranostics

authors： Yumita N,Iwase Y,Nishi K,Komatsu H,Takeda K,Onodera K,Fukai T,Ikeda T,Umemura S,Okudaira K,Momose Y

更新日期：2012-01-01 00:00:00

abstract：:Intraoperative imaging with antibodies labeled with both a radionuclide for initial guidance and a near-infrared dye for adequate tumor delineation may overcome the main limitation of fluorescence imaging: the limited penetration depth of light in biological tissue. In this study, we demonstrate the feasibility and sa...

journal_title：Theranostics

authors： Hekman MC,Rijpkema M,Muselaers CH,Oosterwijk E,Hulsbergen-Van de Kaa CA,Boerman OC,Oyen WJ,Langenhuijsen JF,Mulders PF

更新日期：2018-03-08 00:00:00

abstract：:Optical sensing plays an important role in theranostics due to its capability to detect hint biochemical entities or molecular targets as well as to precisely monitor specific fundamental psychological processes. Rare-earth (RE) doped upconversion nanoparticles (UCNPs) are promising for these endeavors due to their un...

journal_title：Theranostics

authors： Hao S,Chen G,Yang C

更新日期：2013-03-26 00:00:00

abstract：:Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread pathogen- and host-derived molecules duri...

journal_title：Theranostics

authors： Rodrigues M,Fan J,Lyon C,Wan M,Hu Y

更新日期：2018-04-09 00:00:00

abstract：:Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the im...

journal_title：Theranostics

authors： Chen Y,Zhang M,Jin H,Li D,Xu F,Wu A,Wang J,Huang Y

更新日期：2017-08-15 00:00:00

abstract：:Immuno-oncological treatment strategies that target abnormal receptor profiles of tumors are an increasingly important feature of cancer therapy. Yet, assessing receptor availability (RA) and drug-target engagement, important determinants of therapeutic efficacy, is challenging with current imaging strategies, largely...

journal_title：Theranostics

authors： Meng B,Folaron MR,Strawbridge RR,Sadeghipour N,Samkoe KS,Tichauer K,Davis SC

更新日期：2020-09-14 00:00:00

abstract：:We report a new technique to detect enzyme activity inside cells. The method based on Fluorescence Lifetime Imaging (FLIM) technology allows one to follow sensor cleavage by proteolytic enzyme caspase-3. Specifically, we use the FLIM FRET of living cells via the confocal fluorescence microscopy. A specially designed l...

journal_title：Theranostics

authors： Savitsky AP,Rusanov AL,Zherdeva VV,Gorodnicheva TV,Khrenova MG,Nemukhin AV

更新日期：2012-01-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an emerging theranostic modality for various cancers and diseases. The focus of this study was the development of tumor-targeting albumin nanoparticles containing photosensitizers for efficient PDT. To produce tumor-targeting albumin nanoparticles, the hydrophobic photosensitizer, chlorin...

journal_title：Theranostics

authors： Jeong H,Huh M,Lee SJ,Koo H,Kwon IC,Jeong SY,Kim K

更新日期：2011-04-06 00:00:00

abstract：:The ability of brain tissue to regenerate is limited; therefore, brain diseases (i.e., trauma, stroke, tumors) often lead to irreversible motor and cognitive impairments. Therapeutic interventions using various types of injectable biomaterials have been investigated to promote endogenous neural differentiation. Despit...

journal_title：Theranostics

authors： Park GK,Kim SH,Kim K,Das P,Kim BG,Kashiwagi S,Choi HS,Hwang NS

更新日期：2019-05-31 00:00:00

abstract：:Rationale: Mesenchymal cell-derived osteosarcoma is a rare malignant bone tumor affecting children and adolescents. PTEN down-regulation or function-loss mutation is associated with the aggressive of osteosarcoma. Explicating the regulatory mechanism of PTEN might highlight new targets for improving the survival rate ...

journal_title：Theranostics

authors： Wu W,Jing D,Meng Z,Hu B,Zhong B,Deng X,Jin X,Shao Z

更新日期：2020-02-03 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in a variety of tumor cells, but not most normal cells. Nevertheless, its therapeutic potential is limited due to the frequent occurrence of resistance in tumor cells, especially hepatocellular carcinoma cell lines. Theref...

journal_title：Theranostics

authors： Shi K,Xue J,Fang Y,Bi H,Gao S,Yang D,Lu A,Li Y,Chen Y,Ke L

更新日期：2017-10-12 00:00:00

abstract：:Periodontitis is a widespread oral disease that results in the loss of alveolar bone. Low-intensity pulsed ultrasound (LIPUS), which is a new therapeutic option, promotes alveolar bone regeneration in periodontal bone injury models. This study investigated the protective effect of LIPUS on oxidative stress in periodon...

journal_title：Theranostics

authors： Ying S,Tan M,Feng G,Kuang Y,Chen D,Li J,Song J

更新日期：2020-08-01 00:00:00

abstract：:Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine. Nerve autograft is the gold standard for clinical PNI repair. Due to its significant drawbacks, artificial nerve guidance conduits (NGCs) have drawn much attention as replacement therapies. We developed a combinatorial NGC consist...

journal_title：Theranostics

authors： Zheng C,Yang Z,Chen S,Zhang F,Rao Z,Zhao C,Quan D,Bai Y,Shen J

更新日期：2021-01-01 00:00:00

abstract：:Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb) localize within a tumor by virtue of its anti-tumor binding site(s) before administering a small, fast-clearing radiolabeled compound that then attaches to the other portion of the bsMAb. The compound's rapid clearance signifi...

journal_title：Theranostics

authors： Goldenberg DM,Chang CH,Rossi EA,J W,McBride,Sharkey RM

更新日期：2012-01-01 00:00:00

abstract：:Rationale: Glioma stem-like cells (GSCs) contribute to temozolomide (TMZ) resistance in gliomas, although the mechanisms have not been delineated. Methods:In vitro functional experiments (colony formation assay, flow cytometric analysis, TUNEL assay) were used to assess the ability of extracellular vesicles (EVs) from...

journal_title：Theranostics

authors： Yin J,Ge X,Shi Z,Yu C,Lu C,Wei Y,Zeng A,Wang X,Yan W,Zhang J,You Y

更新日期：2021-01-01 00:00:00

abstract：:In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic app...

journal_title：Theranostics

authors： Xie W,Guo Z,Gao F,Gao Q,Wang D,Liaw BS,Cai Q,Sun X,Wang X,Zhao L

更新日期：2018-05-11 00:00:00

abstract：:Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against "self" antigens (Ags). In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust activation of T-cells against tumor Ags pr...

journal_title：Theranostics

authors： Kwon S,Velasquez FC,Rasmussen JC,Greives MR,Turner KD,Morrow JR,Hwu WJ,Ross RF,Zhang S,Sevick-Muraca EM

更新日期：2019-10-22 00:00:00

abstract：:CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface protein that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2. Its potential as a cancer target is supported by studies showing that anti-CDCP1 antibodies inhibit cell migration and survival in vitro, and tumor g...

journal_title：Theranostics

authors： Harrington BS,He Y,Khan T,Puttick S,Conroy PJ,Kryza T,Cuda T,Sokolowski KA,Tse BW,Robbins KK,Arachchige BJ,Stehbens SJ,Pollock PM,Reed S,Weroha SJ,Haluska P,Salomon C,Lourie R,Perrin LC,Law RHP,Whisstock JC,Hoop

更新日期：2020-01-12 00:00:00

abstract：:RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mice when administered...

journal_title：Theranostics

authors： Gao S,Hein S,Dagnæs-Hansen F,Weyer K,Yang C,Nielsen R,Christensen EI,Fenton RA,Kjems J

更新日期：2014-08-13 00:00:00

abstract：:Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent thrombus organization limits direct blood contact with fibrin, the target of blood-based fibri...

journal_title：Theranostics

authors： Stein-Merlob AF,Kessinger CW,Erdem SS,Zelada H,Hilderbrand SA,Lin CP,Tearney GJ,Jaff MR,Reed GL,Henke PK,McCarthy JR,Jaffer FA

更新日期：2015-09-13 00:00:00

abstract：:Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared...

journal_title：Theranostics

authors： Li Y,Li Y,Zhang X,Xu X,Zhang Z,Hu C,He Y,Gu Z

更新日期：2016-06-05 00:00:00

abstract：:Extracellular vesicles, in particular exosomes, have recently gained interest as novel drug delivery vectors due to their biological origin and inherent intercellular biomolecule delivery capability. An in-depth knowledge of their in vivo biodistribution is therefore essential. This work aimed to develop a novel, reli...

journal_title：Theranostics

authors： Faruqu FN,Wang JT,Xu L,McNickle L,Chong EM,Walters A,Gurney M,Clayton A,Smyth LA,Hider R,Sosabowski J,Al-Jamal KT

更新日期：2019-02-28 00:00:00

abstract：:Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, unders...

journal_title：Theranostics

authors： De Sarno F,Ponsiglione AM,Russo M,Grimaldi AM,Forte E,Netti PA,Torino E

更新日期：2019-02-28 00:00:00

abstract：:Metastasis is the primary cause of death in patients with advanced cancer. Recently, a high-fat diet was shown to specifically promote the metastatic potential of specific cancer cells in a CD36-dependent manner. However, the molecular basis of the fatty acid (FA)-induced upregulation of CD36 has remained unclear. Met...

journal_title：Theranostics

authors： Jiang M,Wu N,Xu B,Chu Y,Li X,Su S,Chen D,Li W,Shi Y,Gao X,Zhang H,Zhang Z,Du W,Nie Y,Liang J,Fan D

更新日期：2019-07-09 00:00:00