Erratum: pH-Sensitive Nano-Complexes Overcome Drug Resistance and Inhibit Metastasis of Breast Cancer by Silencing Akt Expression: Erratum.

abstract：:Rationale: The evaluation of early treatment response is critical for patient prognosis and treatment planning. When the current methods rely on invasive protocols that evaluate the expression of DNA damage markers on patient biopsy samples, we aim to evaluate a non-invasive PET imaging approach to monitor the early e...

journal_title：Theranostics

authors： Poty S,Mandleywala K,O'Neill E,Knight JC,Cornelissen B,Lewis JS

更新日期：2020-04-27 00:00:00

abstract：PURPOSE:The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared 68Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) for diagnosis and tumour delineation in patients with primary PCa based on slice by slice correlation ...

journal_title：Theranostics

authors： Zamboglou C,Drendel V,Jilg CA,Rischke HC,Beck TI,Schultze-Seemann W,Krauss T,Mix M,Schiller F,Wetterauer U,Werner M,Langer M,Bock M,Meyer PT,Grosu AL

更新日期：2017-01-01 00:00:00

abstract：:Rationale: Following an ever-increased focus on personalized medicine, there is a continuing need to develop preclinical molecular imaging modalities to guide the development and optimization of targeted therapies. Near-Infrared (NIR) Macroscopic Fluorescence Lifetime Förster Resonance Energy Transfer (MFLI-FRET) imag...

journal_title：Theranostics

authors： Rudkouskaya A,Sinsuebphon N,Ochoa M,Chen SJ,Mazurkiewicz JE,Intes X,Barroso M

更新日期：2020-08-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in a variety of tumor cells, but not most normal cells. Nevertheless, its therapeutic potential is limited due to the frequent occurrence of resistance in tumor cells, especially hepatocellular carcinoma cell lines. Theref...

journal_title：Theranostics

authors： Shi K,Xue J,Fang Y,Bi H,Gao S,Yang D,Lu A,Li Y,Chen Y,Ke L

更新日期：2017-10-12 00:00:00

abstract：:Rationale: Treating diseases of the brain such as Alzheimer's disease (AD) is challenging as the blood-brain barrier (BBB) effectively restricts access of a large number of potentially useful drugs. A potential solution to this problem is presented by therapeutic ultrasound, a novel treatment modality that can achieve...

journal_title：Theranostics

authors： Pelekanos M,Leinenga G,Odabaee M,Odabaee M,Saifzadeh S,Steck R,Götz J

更新日期：2018-04-03 00:00:00

abstract：:Radiotherapy is an extensively used treatment modality in the clinic and can kill malignant cells by generating cytotoxic reactive oxygen species (ROS). Unfortunately, excessive dosages of radiation are typically required because only a small proportion of the radiative energy is adsorbed by the soft tissues of a tumo...

journal_title：Theranostics

authors： Chen Y,Li N,Wang J,Zhang X,Pan W,Yu L,Tang B

更新日期：2019-01-01 00:00:00

abstract：:Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...

journal_title：Theranostics

authors： Tang Q,Hu Z,Jin H,Zheng G,Yu X,Wu G,Liu H,Zhu Z,Xu H,Zhang C,Shen L

更新日期：2019-01-30 00:00:00

abstract：:High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to co...

journal_title：Theranostics

authors： El Kaffas A,Gangeh MJ,Farhat G,Tran WT,Hashim A,Giles A,Czarnota GJ

更新日期：2018-01-01 00:00:00

abstract：:Recent studies have highlighted the biological significance of RNA N6-methyladenosine (m6A) modification in tumorigenicity and progression. However, it remains unclear whether m6A modifications also have potential roles in immune regulation and tumor microenvironment (TME) formation. Methods: In this study, we curated...

journal_title：Theranostics

authors： Chong W,Shang L,Liu J,Fang Z,Du F,Wu H,Liu Y,Wang Z,Chen Y,Jia S,Chen L,Li L,Chen H

更新日期：2021-01-01 00:00:00

abstract：:Model observers play an important role in the optimization and assessment of imaging devices. In this review paper, we first discuss the basic concepts of model observers, which include the mathematical foundations and psychophysical considerations in designing both optimal observers for optimizing imaging systems and...

journal_title：Theranostics

authors： He X,Park S

更新日期：2013-10-04 00:00:00

abstract：:Due to their tunable surface plasmon and photothermal effects, gold nanorods (AuNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery. All these applications can be remotely controlled by near infrared (NIR) light which can penetrate deep in...

journal_title：Theranostics

authors： Zhang Z,Wang J,Chen C

更新日期：2013-01-01 00:00:00

abstract：:Natural polysaccharides have received a lot of attention in the biomedical field. Indeed, sources of polysaccharides, extracted or produced from plants, bacteria, fungi or algae, are diverse and renewable. Moreover, recent progresses in polysaccharide chemistry and nanotechnologies allow elaborating new dedicated nano...

journal_title：Theranostics

authors： Silva AK,Letourneur D,Chauvierre C

更新日期：2014-03-11 00:00:00

abstract：:Aberrant activation of the Src kinase is implicated in the development of a variety of human malignancies. However, it is almost impossible to monitor Src activity in an in vivo setting with current biochemical techniques. To facilitate the noninvasive investigation of the activity of Src kinase both in vitro and in v...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2016-02-24 00:00:00

abstract：:Aim: Immune responsive 12/15 lipoxygenase (12/15LOX)-orchestrate biosynthesis of essential inflammation-resolution mediators during acute inflammatory response in post-myocardial infarction (MI). Lack of 12/15LOX dampens proinflammatory mediator 12-(S)-hydroxyeicosatetraenoic acid (12-(S)-HETE), improves post-MI survi...

journal_title：Theranostics

authors： Kain V,Ingle KA,Rajasekaran NS,Halade GV

更新日期：2021-01-01 00:00:00

abstract：:Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor 2 (Klf2) in ECs, ameliorates press...

journal_title：Theranostics

authors： Li H,Wang Y,Liu J,Chen X,Duan Y,Wang X,Shen Y,Kuang Y,Zhuang T,Tomlinson B,Chan P,Yu Z,Cheng Y,Zhang L,Liu Z,Zhang Y,Zhao Z,Zhang Q,Liu J

更新日期：2021-01-01 00:00:00

abstract：:Hypoxic zones are common features of metastatic tumors. Due to inactivation of the von Hippel-Lindau gene (VHL), renal cell carcinomas (RCC) show constitutive stabilization of the alpha subunit of the hypoxia-inducible factor (HIF). Thus, RCC represents a model of chronic hypoxia. Development of the lymphatic network ...

journal_title：Theranostics

authors： Ndiaye PD,Dufies M,Giuliano S,Douguet L,Grépin R,Durivault J,Lenormand P,Glisse N,Mintcheva J,Vouret-Craviari V,Mograbi B,Wurmser M,Ambrosetti D,Rioux-Leclercq N,Maire P,Pagès G

更新日期：2019-01-21 00:00:00

abstract：:The distorted and unique expression of microRNAs (miRNAs) in cancer makes them an attractive source of biomarker. There is much evidence indicating that a panel of miRNAs, termed "miRNA fingerprints", is more specific and informative than an individual miRNA as biomarker. Thus, multiplex assays for simultaneous quanti...

journal_title：Theranostics

authors： Xu F,Zhou W,Cao J,Xu Q,Jiang D,Chen Y

更新日期：2017-07-08 00:00:00

abstract：:Treatments of high specificity are desirable for cancer therapy. Light-triggered nanotheranostics (LTN) mediated cancer therapy could be one such treatment, as they make it possible to visualize and treat the tumor specifically in a light-controlled manner with a single injection. Because of their great potential in c...

journal_title：Theranostics

authors： Zhang P,Hu C,Ran W,Meng J,Yin Q,Li Y

更新日期：2016-04-27 00:00:00

abstract：:Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilize...

journal_title：Theranostics

authors： Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

更新日期：2021-01-01 00:00:00

abstract：:Generating oxidative stress is a critical mechanism by which host cells defend against infection by pathogenic microorganisms. Radiation resistance is a critical problem in radiotherapy against cancer. Epstein-Barr virus (EBV) is a cancer-causing virus and its reactivation plays an important role in the development of...

journal_title：Theranostics

authors： Hu J,Li Y,Li H,Shi F,Xie L,Zhao L,Tang M,Luo X,Jia W,Fan J,Zhou J,Gao Q,Qiu S,Wu W,Zhang X,Liao W,Bode AM,Cao Y

更新日期：2020-10-25 00:00:00

abstract：:Rationale: Loss of DNA damage repair (DDR) in the tumor is an established hallmark of sensitivity to DNA damaging agents such as chemotherapy. However, there has been scant investigation into gain-of-function alterations of DDR genes in cancer. This study aims to investigate to what extent copy number amplification of...

journal_title：Theranostics

authors： Wu Z,Li S,Tang X,Wang Y,Guo W,Cao G,Chen K,Zhang M,Guan M,Yang D

更新日期：2020-03-04 00:00:00

abstract：:Background: Tobacco smoke (TS) critically contributes to the development of lung cancer; however, the underlying molecular mechanisms remain unclear. The induction of cancer stem cells (CSCs) by TS represents an early event in tumor initiation. The lung cancer-related gene ΔNp63α is highly expressed in epithelial tiss...

journal_title：Theranostics

authors： Xie C,Zhu J,Jiang Y,Chen J,Wang X,Geng S,Wu J,Zhong C,Li X,Meng Z

更新日期：2019-07-09 00:00:00

abstract：:Molecular subtyping of breast cancer is of considerable interest owing to its potential for personalized therapy and prognosis. However, current methodologies cannot be used for precise subtyping, thereby posing a challenge in clinical practice. The aim of the present study is to develop a cell-specific single-strande...

journal_title：Theranostics

authors： Liu M,Wang Z,Tan T,Chen Z,Mou X,Yu X,Deng Y,Lu G,He N

更新日期：2018-11-10 00:00:00

abstract：:Reactive oxygen species (ROS)-based photodynamic therapy (PDT) has a widespread application in cancer therapy. Nevertheless, the efficiency of PDT is far from satisfactory. One major impediment is the overexpression of glutathione (GSH) in tumor cells, which could deplete the level of PDT-generated ROS. Herein, we dev...

journal_title：Theranostics

authors： Wang Q,Sun M,Li D,Li C,Luo C,Wang Z,Zhang W,Yang Z,Feng Y,Wang S,He Z,Zhang H,Kan Q,Sun W,Sun J

更新日期：2020-04-15 00:00:00

abstract：:In advanced atherosclerotic plaques, defective efferocytosis of apoptotic foam cells and decreased cholesterol efflux contribute to lesion progression. In our previous study, we demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (SDT) could induce foam cells apoptosis via the mitochondrial-casp...

journal_title：Theranostics

authors： Wang H,Yang Y,Sun X,Tian F,Guo S,Wang W,Tian Z,Jin H,Zhang Z,Tian Y

更新日期：2018-09-29 00:00:00

abstract：:Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly understood. Methods: Mass spectrometry analysis and immunoprecip...

journal_title：Theranostics

authors： Huang Y,Hu K,Zhang S,Dong X,Yin Z,Meng R,Zhao Y,Dai X,Zhang T,Yang K,Liu L,Huang K,Shi S,Zhang Y,Chen J,Wu G,Xu S

更新日期：2018-02-02 00:00:00

abstract：:Folate receptor (FR) has proven to be a valuable target for chemotherapy using folic acid (FA) conjugates. However, FA-conjugated chemotherapeutics still have low therapeutic efficacy accompanied with side effects, resulting from complications such as short circulation half-life, limited tumor delivery, as well as hig...

journal_title：Theranostics

authors： Shan L,Zhuo X,Zhang F,Dai Y,Zhu G,Yung BC,Fan W,Zhai K,Jacobson O,Kiesewetter DO,Ma Y,Gao G,Chen X

更新日期：2018-02-16 00:00:00

abstract：:Intraoperative imaging with antibodies labeled with both a radionuclide for initial guidance and a near-infrared dye for adequate tumor delineation may overcome the main limitation of fluorescence imaging: the limited penetration depth of light in biological tissue. In this study, we demonstrate the feasibility and sa...

journal_title：Theranostics

authors： Hekman MC,Rijpkema M,Muselaers CH,Oosterwijk E,Hulsbergen-Van de Kaa CA,Boerman OC,Oyen WJ,Langenhuijsen JF,Mulders PF

更新日期：2018-03-08 00:00:00

abstract：:Purpose: The tumor homing characteristics of mesenchymal stem cells (MSCs) make them attractive vehicles for the tumor-specific delivery of therapeutic agents, such as the sodium iodide symporter (NIS). NIS is a theranostic protein that allows non-invasive monitoring of the in vivo biodistribution of functional NIS ex...

journal_title：Theranostics

authors： Tutter M,Schug C,Schmohl KA,Urnauer S,Schwenk N,Petrini M,Lokerse WJM,Zach C,Ziegler S,Bartenstein P,Weber WA,Wagner E,Lindner LH,Nelson PJ,Spitzweg C

更新日期：2020-03-15 00:00:00

abstract：:Colitis-associated colon cancer (CAC) is a widely recognized cancer, while treatment with the existing chemotherapeutic drugs affords limited clinical benefits. Herein we proposed a site-specific, combination nanotherapy strategy for targeted treatment of CAC by the oral route. Methods: A reactive oxygen species (ROS)...

journal_title：Theranostics

authors： Zhang Q,Zhang F,Li S,Liu R,Jin T,Dou Y,Zhou Z,Zhang J

更新日期：2019-05-31 00:00:00