Imaging and therapy of ovarian cancer: clinical application of nanoparticles and future perspectives.

abstract：:Generating oxidative stress is a critical mechanism by which host cells defend against infection by pathogenic microorganisms. Radiation resistance is a critical problem in radiotherapy against cancer. Epstein-Barr virus (EBV) is a cancer-causing virus and its reactivation plays an important role in the development of...

journal_title：Theranostics

authors： Hu J,Li Y,Li H,Shi F,Xie L,Zhao L,Tang M,Luo X,Jia W,Fan J,Zhou J,Gao Q,Qiu S,Wu W,Zhang X,Liao W,Bode AM,Cao Y

更新日期：2020-10-25 00:00:00

abstract：:Model observers play an important role in the optimization and assessment of imaging devices. In this review paper, we first discuss the basic concepts of model observers, which include the mathematical foundations and psychophysical considerations in designing both optimal observers for optimizing imaging systems and...

journal_title：Theranostics

authors： He X,Park S

更新日期：2013-10-04 00:00:00

abstract：:RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mice when administered...

journal_title：Theranostics

authors： Gao S,Hein S,Dagnæs-Hansen F,Weyer K,Yang C,Nielsen R,Christensen EI,Fenton RA,Kjems J

更新日期：2014-08-13 00:00:00

abstract：:Rationale: Malignant ascites caused by cancer cells results in poor prognosis and short average survival time. No effective treatment is currently available for malignant ascites. In this study, the effects of lentinan (LNT)-functionalized selenium nanoparticles (Selene) on malignant ascites were evaluated. Furthermor...

journal_title：Theranostics

authors： Liu HJ,Qin Y,Zhao ZH,Zhang Y,Yang JH,Zhai DH,Cui F,Luo C,Lu MX,Liu PP,Xu HW,Li K,Sun B,Chen S,Zhou HG,Yang C,Sun T

更新日期：2020-07-11 00:00:00

abstract：:Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine. Nerve autograft is the gold standard for clinical PNI repair. Due to its significant drawbacks, artificial nerve guidance conduits (NGCs) have drawn much attention as replacement therapies. We developed a combinatorial NGC consist...

journal_title：Theranostics

authors： Zheng C,Yang Z,Chen S,Zhang F,Rao Z,Zhao C,Quan D,Bai Y,Shen J

更新日期：2021-01-01 00:00:00

abstract：:Bacteria-based anticancer therapies aim to overcome the limitations of current cancer therapy by actively targeting and efficiently removing cancer. To achieve this goal, new approaches that target and maintain bacterial drugs at sufficient concentrations during the therapeutic window are essential. Here, we examined ...

journal_title：Theranostics

authors： Park SH,Zheng JH,Nguyen VH,Jiang SN,Kim DY,Szardenings M,Min JH,Hong Y,Choy HE,Min JJ

更新日期：2016-06-20 00:00:00

abstract：:In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic app...

journal_title：Theranostics

authors： Xie W,Guo Z,Gao F,Gao Q,Wang D,Liaw BS,Cai Q,Sun X,Wang X,Zhao L

更新日期：2018-05-11 00:00:00

abstract：:Metastasis is the primary cause of death in patients with advanced cancer. Recently, a high-fat diet was shown to specifically promote the metastatic potential of specific cancer cells in a CD36-dependent manner. However, the molecular basis of the fatty acid (FA)-induced upregulation of CD36 has remained unclear. Met...

journal_title：Theranostics

authors： Jiang M,Wu N,Xu B,Chu Y,Li X,Su S,Chen D,Li W,Shi Y,Gao X,Zhang H,Zhang Z,Du W,Nie Y,Liang J,Fan D

更新日期：2019-07-09 00:00:00

abstract：:Many drug controlled release methods have been integrated in multifunctional nanoparticles, such as pH-, redox-, temperature-, enzyme-, and light-responsive release. However, few report is associated with the ROS responsive drug controlled release. Herein, a thioketal linker-based ROS responsive drug (camptothecin con...

journal_title：Theranostics

authors： Yue C,Zhang C,Alfranca G,Yang Y,Jiang X,Yang Y,Pan F,de la Fuente JM,Cui D

更新日期：2016-02-05 00:00:00

abstract：:RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and ...

journal_title：Theranostics

authors： Lin YX,Wang Y,Blake S,Yu M,Mei L,Wang H,Shi J

更新日期：2020-01-01 00:00:00

abstract：:Compared with other diagnostic methods, ultrasound is proven to be a safe, simple, non-invasive and cost-effective imaging technique, but the resolution is not comparable to that of magnetic resonance imaging (MRI). Contrast-enhanced ultrasound employing microbubbles can gain a better resolution and is now widely used...

journal_title：Theranostics

authors： Cai X,Yang F,Gu N

更新日期：2012-01-01 00:00:00

abstract：:[This retracts the article DOI: 10.7150/thno.14306.]. ...

journal_title：Theranostics

authors： Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

更新日期：2020-09-30 00:00:00

abstract：:Extracellular vesicles (EVs), including exosomes and microvesicles, derived from bone marrow stromal cells (BMSCs) have been demonstrated as key factors in the progression and drug resistance of multiple myeloma (MM). EV uptake involves a variety of mechanisms which largely depend on the vesicle origin and recipient c...

journal_title：Theranostics

authors： Tu C,Du Z,Zhang H,Feng Y,Qi Y,Zheng Y,Liu J,Wang J

更新日期：2021-01-01 00:00:00

abstract：:Exosomes play critical roles in intercellular communication in both nearby and distant cells in individuals and organs. Polymerase I and transcript release factor (PTRF), also known as Cavin1, has previously been described as a critical factor in caveola formation, and aberrant PTRF expression has been reported in var...

journal_title：Theranostics

authors： Huang K,Fang C,Yi K,Liu X,Qi H,Tan Y,Zhou J,Li Y,Liu M,Zhang Y,Yang J,Zhang J,Li M,Kang C

更新日期：2018-02-07 00:00:00

abstract：:A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS8, which is ...

journal_title：Theranostics

authors： Li X,Zheng BY,Ke MR,Zhang Y,Huang JD,Yoon J

更新日期：2017-07-07 00:00:00

abstract：:The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX ...

journal_title：Theranostics

authors： Yin J,Lang T,Cun D,Zheng Z,Huang Y,Yin Q,Yu H,Li Y

更新日期：2017-09-26 00:00:00

abstract：:The human skin is an attractive anti-tumor vaccination site due to the vast network of dendritic cell (DC) subsets that carry antigens to the draining lymph nodes and stimulate tumor specific CD4+ and CD8+ T cells in. Specific vaccine delivery to skin DC can be accomplished by targeting glycan coated antigens to C-typ...

journal_title：Theranostics

authors： Duinkerken S,Horrevorts SK,Kalay H,Ambrosini M,Rutte L,de Gruijl TD,Garcia-Vallejo JJ,van Kooyk Y

更新日期：2019-08-12 00:00:00

abstract：:The most important requirements of biomedical substitutes used in muscle tissue regeneration are appropriate topographical cues and bioactive components for the induction of myogenic differentiation/maturation. Here, we developed an electric field-assisted 3D cell-printing process to fabricate cell-laden fibers with a...

journal_title：Theranostics

authors： Yang GH,Kim W,Kim J,Kim G

更新日期：2021-01-01 00:00:00

abstract：:Purpose: Evans Blue (EB) is an azo dye that binds quantitatively with serum albumin. With an albumin binding, NOTA conjugated truncated Evan's blue (NEB) dye derived PET tracer, we aimed to establish a strategy for evaluating vascular permeability in malignant tumors via non-invasive PET. Experimental design: Sixty-mi...

journal_title：Theranostics

authors： Chen H,Tong X,Lang L,Jacobson O,Yung BC,Yang X,Bai R,Kiesewetter DO,Ma Y,Wu H,Niu G,Chen X

更新日期：2017-06-14 00:00:00

abstract：:Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of soyasaponin II in acute liver failure and establish the...

journal_title：Theranostics

authors： Wang F,Gong S,Wang T,Li L,Luo H,Wang J,Huang C,Zhou H,Chen G,Liu Z,Zhang Q,Jiang Y,Chen P

更新日期：2020-02-03 00:00:00

abstract：:The mineral dust-induced gene (mdig) is overexpressed in a number of human cancers, suggesting critical roles of this gene played on the pathogenesis of cancers. Unlike several other JmjC-domain containing proteins that exhibit histone demethylase activity, it remains enigmatic whether mdig is involved in the demethyl...

journal_title：Theranostics

authors： Zhang Q,Thakur C,Fu Y,Bi Z,Wadgaonkar P,Xu L,Liu Z,Liu W,Wang J,Kidder BL,Chen F

更新日期：2020-01-01 00:00:00

abstract：:Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared...

journal_title：Theranostics

authors： Li Y,Li Y,Zhang X,Xu X,Zhang Z,Hu C,He Y,Gu Z

更新日期：2016-06-05 00:00:00

abstract：:Background: Circular RNAs (circRNAs) are a new class of non-coding RNAs (ncRNAs) that are derived from exons or introns by special selective shearing. circRNAs have been shown to play critical roles in various human cancers. However, their roles in renal cell carcinoma (RCC) and the underlying mechanisms remain largel...

journal_title：Theranostics

authors： Liu H,Hu G,Wang Z,Liu Q,Zhang J,Chen Y,Huang Y,Xue W,Xu Y,Zhai W

更新日期：2020-08-29 00:00:00

abstract：:Tumor hypoxia is an important reason for the limited therapeutic efficacy of photodynamic therapy (PDT) because of the oxygen requirement of the therapeutic process. PDT consumes tissue oxygen and destroys tumor vasculature, further hampering its own efficacy in promoting tumor deterioration. Therefore, overcoming the...

journal_title：Theranostics

authors： Yang Z,Wang J,Ai S,Sun J,Mai X,Guan W

更新日期：2019-09-20 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.21516.]. ...

journal_title：Theranostics

authors： Yin J,Lang T,Cun D,Zheng Z,Huang Y,Yin Q,Yu H,Li Y

更新日期：2020-01-18 00:00:00

abstract：:Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis...

journal_title：Theranostics

authors： Jiang Y,Mao C,Yang R,Yan B,Shi Y,Liu X,Lai W,Liu Y,Wang X,Xiao D,Zhou H,Cheng Y,Yu F,Cao Y,Liu S,Yan Q,Tao Y

更新日期：2017-07-23 00:00:00

abstract：:Rationale: The overall success rate of prostate cancer (PCa) diagnosis and therapy has been improved over the years. However, genomic and phenotypic heterogeneity remains a major challenge for effective detection and treatment of PCa. Efforts to better classify PCa into functional subtypes and elucidate the molecular ...

journal_title：Theranostics

authors： Bai Y,Yang Y,Yan Y,Zhong J,Blee AM,Pan Y,Ma T,Karnes RJ,Jimenez R,Xu W,Huang H

更新日期：2019-05-24 00:00:00

abstract：:Inadequate diagnostic methods for prostate cancer lead to over- and undertreatment, and the inability to intraoperatively visualize positive margins may limit the success of surgical resection. Prostate cancer visualization could be improved by combining the complementary modalities of immuno-positron emission tomogra...

journal_title：Theranostics

authors： Tsai WK,Zettlitz KA,Tavaré R,Kobayashi N,Reiter RE,Wu AM

更新日期：2018-11-12 00:00:00

abstract：:Purpose: The tumor homing characteristics of mesenchymal stem cells (MSCs) make them attractive vehicles for the tumor-specific delivery of therapeutic agents, such as the sodium iodide symporter (NIS). NIS is a theranostic protein that allows non-invasive monitoring of the in vivo biodistribution of functional NIS ex...

journal_title：Theranostics

authors： Tutter M,Schug C,Schmohl KA,Urnauer S,Schwenk N,Petrini M,Lokerse WJM,Zach C,Ziegler S,Bartenstein P,Weber WA,Wagner E,Lindner LH,Nelson PJ,Spitzweg C

更新日期：2020-03-15 00:00:00

abstract：:Dendritic cells (DC) and tumor cell fusion vaccine (DC/tumor cell fusion vaccine) is considered an effective approach in cancer biotherapy. However, its therapeutic effects in early clinical trials have been suboptimal partially due to the immunosuppressive tumor environment. In this study, we used nanoparticles of fo...

journal_title：Theranostics

authors： Hu Z,Chen J,Zhou S,Yang N,Duan S,Zhang Z,Su J,He J,Zhang Z,Lu X,Zhao Y

更新日期：2017-05-02 00:00:00