Abstract:
:Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared their bone targeting efficiency, biodistribution, and blood clearance. Since the targeting moiety, PAM, is highly negatively charged but small, the overall in vivo bone targeting and biodistribution were mediated by the physicochemical properties of conjugated fluorophores.
journal_name
Theranosticsjournal_title
Theranosticsauthors
Bao K,Nasr KA,Hyun H,Lee JH,Gravier J,Gibbs SL,Choi HSdoi
10.7150/thno.11222subject
Has Abstractpub_date
2015-03-01 00:00:00pages
609-17issue
6issn
1838-7640pii
thnov05p0609journal_volume
5pub_type
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