Abstract:
:Reactive oxygen species (ROS)-based photodynamic therapy (PDT) has a widespread application in cancer therapy. Nevertheless, the efficiency of PDT is far from satisfactory. One major impediment is the overexpression of glutathione (GSH) in tumor cells, which could deplete the level of PDT-generated ROS. Herein, we develop a novel type of cytochrome P450 enzyme-mediated auto-enhanced photodynamic co-nanoassembly between clopidogrel (CPG) and photosensitizer pyropheophorbide a (PPa). Methods: In this work, we prepare the co-assembled nanoparticles of CPG and PPa (CPG/PPa NPs) by using one-step precipitation method. The assembly mechanism, drug release behavior, GSH consumption, ROS generation, cellular uptake, cytotoxicity of CPG/PPa NPs are investigated in vitro. The mice bearing 4T1 tumor are employed to evaluate in vivo biodistribution and anti-tumor effect of CPG/PPa NPs. Results: Such CPG/PPa NPs could disrupt the intracellular redox homeostasis, resulting from the elimination of GSH by CPG active metabolite mediated by cytochrome P450 enzyme (CYP2C19). The in vivo assays reveal that CPG/PPa NPs not only increase the drug accumulation in tumor sites but also significantly suppress tumor growth in BALB/c mice bearing 4T1 tumor. With CPG-mediated GSH consumption and PPa-triggered ROS generation, CPG/PPa NPs show the enhanced PDT treatment effect by breaking intracellular redox balance. Conclusion: Our findings provide a valuable knowledge for the rational design of the PDT-based combinational cancer therapy.
journal_name
Theranosticsjournal_title
Theranosticsauthors
Wang Q,Sun M,Li D,Li C,Luo C,Wang Z,Zhang W,Yang Z,Feng Y,Wang S,He Z,Zhang H,Kan Q,Sun W,Sun Jdoi
10.7150/thno.42633subject
Has Abstractpub_date
2020-04-15 00:00:00pages
5550-5564issue
12issn
1838-7640pii
thnov10p5550journal_volume
10pub_type
杂志文章相关文献
Theranostics文献大全abstract::Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor 2 (Klf2) in ECs, ameliorates press...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.48153
更新日期:2021-01-01 00:00:00
abstract::Rationale: P21-activated kinase 6 (PAK6) is a member of the class II PAKs family, which is a conserved family of serine/threonine kinases. Although the effects of PAK6 on many malignancies, especially in prostate cancer, have been studied for a long time, the role of PAK6 in mitochondria remains unknown. Methods: The ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42874
更新日期:2020-02-03 00:00:00
abstract::Meniscus deficiency, the most common and refractory disease in human knee joints, often progresses to osteoarthritis (OA) due to abnormal biomechanical distribution and articular cartilage abrasion. However, due to its anisotropic spatial architecture, complex biomechanical microenvironment, and limited vascularity, m...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44270
更新日期:2020-04-06 00:00:00
abstract::Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic administration. Here...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.16855
更新日期:2017-01-01 00:00:00
abstract::With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO2 core-shell nanoparticles, which showed that they could selectivel...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35418
更新日期:2019-07-09 00:00:00
abstract::Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome. Here we performed an integrative genomic analysis and identified the bromodomain and extraterminal domain (BET) protein BRD4 as a potential therapeutic target ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.13178
更新日期:2016-01-01 00:00:00
abstract::Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a crucial role in tumor progression, is mainly regulated by alterations to genes and post-transcriptional processes. The recent discovery of the N6-met...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.51231
更新日期:2020-10-26 00:00:00
abstract::Overexpression of CD146 has been correlated with aggressiveness, recurrence rate, and poor overall survival in hepatocellular carcinoma (HCC) patients. In this study, we set out to develop a CD146-targeting probe for high-contrast noninvasive in vivo positron emission tomography (PET) and near-infrared fluorescence (N...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.15568
更新日期:2016-08-08 00:00:00
abstract::Recent studies have highlighted the biological significance of RNA N6-methyladenosine (m6A) modification in tumorigenicity and progression. However, it remains unclear whether m6A modifications also have potential roles in immune regulation and tumor microenvironment (TME) formation. Methods: In this study, we curated...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.52717
更新日期:2021-01-01 00:00:00
abstract::Great progress has been made in the field of tumor immunotherapy in the past decade. However, the therapeutic effects of immune checkpoint blockade (ICB) against ovarian cancer are still limited. Recently, an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6i) has been reported to enhance antitumor immunity in pre...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44871
更新日期:2020-08-25 00:00:00
abstract::Granzyme B (GrB) is an essential cytotoxic effector in cancer immunotherapy as it can be a potential biomarker to predict the efficacy of immunotherapies including checkpoint inhibitors. Monitoring the Granzyme B activity in cells would help determine a patient's clinical response to treatment and lead to better treat...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.37728
更新日期:2020-01-01 00:00:00
abstract::This paper reports a sensitive method with electrochemical technique to detect various proteases, which can be used for the diagnosis of prostate cancer. For the proposed assay method, the working electrode is modified with the peptide probes for the target proteases. These probes contain the substrate sequence of tar...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.8803
更新日期:2014-04-25 00:00:00
abstract::The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant ex...
journal_title:Theranostics
pub_type: 评论,社论
doi:10.7150/thno.29864
更新日期:2018-11-15 00:00:00
abstract::Optical sensing plays an important role in theranostics due to its capability to detect hint biochemical entities or molecular targets as well as to precisely monitor specific fundamental psychological processes. Rare-earth (RE) doped upconversion nanoparticles (UCNPs) are promising for these endeavors due to their un...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.5305
更新日期:2013-03-26 00:00:00
abstract::One of the major challenges in the hepatocellular carcinoma (HCC) treatment is its insensitivity to chemotherapeutic drugs. Here, we report the development of novel lipid-coated cisplatin nanoparticles co-loaded with microRNA-375 (NPC/miR-375) as a potential treatment for chemotherapy insensitive HCC. The NPC/miR-375 ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.13130
更新日期:2016-01-01 00:00:00
abstract::Identification of novel targets for triple-negative breast cancer (TNBC) is an urgent task as targeted therapies have increased the lifespans of Oestrogen Receptor +/ Progesterone Receptor + and HER2+ cancer patients. Methods: genes involved in protein processing in the endoplasmic reticulum, which have been reported ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35383
更新日期:2019-08-21 00:00:00
abstract::Colitis-associated colon cancer (CAC) is a widely recognized cancer, while treatment with the existing chemotherapeutic drugs affords limited clinical benefits. Herein we proposed a site-specific, combination nanotherapy strategy for targeted treatment of CAC by the oral route. Methods: A reactive oxygen species (ROS)...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.34377
更新日期:2019-05-31 00:00:00
abstract::Theranostics is a multidisciplinary journal that publishes innovative and original research papers reflecting the field of molecular imaging, molecular therapeutics, multifunctional nanoparticle platforms, image-guided therapy, and translational nanomedicine. A broad spectrum of biomedical research that can be applied...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno/v01p0001
更新日期:2011-01-08 00:00:00
abstract::Cancer metastasis is a Gordian knot for tumor diagnosis and therapy. Many studies have demonstrated that metastatic processes are inevitably affected by the tumor microenvironment. Histopathology is used universally as the gold standard for cancer diagnosis despite the lengthy preparation process and invasiveness. Met...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.40869
更新日期:2020-01-01 00:00:00
abstract::Background: Circular RNAs (circRNAs) are a new class of non-coding RNAs (ncRNAs) that are derived from exons or introns by special selective shearing. circRNAs have been shown to play critical roles in various human cancers. However, their roles in renal cell carcinoma (RCC) and the underlying mechanisms remain largel...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.47239
更新日期:2020-08-29 00:00:00
abstract::Detection of biomarkers is extremely important for the early diagnosis of diseases. Here, we developed an easy and highly sensitive fluorescence detection system for the determination of biomarkers by combining the rapid separation of magnetic beads and silver nanoparticles labeled antibodies. An ultrasensitive silver...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17575
更新日期:2017-02-08 00:00:00
abstract::Rationale: Tumor metastasis is the main cause for cancer-related death. However, the driving molecules of metastasis remain largely unknown. Here, we aim to identify long non-coding RNAs (lncRNAs) critical for human hepatocellular carcinoma (HCC) metastasis. Methods: Microarrays were used to screen a comprehensive set...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.32854
更新日期:2019-06-09 00:00:00
abstract::Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19988
更新日期:2017-07-23 00:00:00
abstract::Liquid biopsy of tumor through isolation of circulating tumor cells (CTCs) allows non-invasive, repetitive, and systemic sampling of disease. Although detecting and enumerating CTCs is of prognostic significance in metastatic cancer, it is conceivable that performing molecular and functional characterization on CTCs w...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.15359
更新日期:2016-06-15 00:00:00
abstract::Rationale: Mesenchymal cell-derived osteosarcoma is a rare malignant bone tumor affecting children and adolescents. PTEN down-regulation or function-loss mutation is associated with the aggressive of osteosarcoma. Explicating the regulatory mechanism of PTEN might highlight new targets for improving the survival rate ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41279
更新日期:2020-02-03 00:00:00
abstract::Purpose: Systemic administration of free chemotherapeutic drugs leads to severe toxic effects, and physiological characteristics of solid tumors restrain the drugs from reaching the hypoxic regions. E. coli Nissle 1917 (EcN) has been known to penetrate the barrier and proliferate in the interface between the viable an...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21575
更新日期:2018-02-12 00:00:00
abstract::Traumatic brain injury (TBI) research has focused on moderate to severe injuries as their outcomes are significantly worse than those of a mild TBI (mTBI). However, recent epidemiological evidence has indicated that a series of even mild TBIs greatly increases the risk of neurodegenerative and psychiatric disorders. N...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.24747
更新日期:2018-09-09 00:00:00
abstract::[This corrects the article DOI: 10.7150/thno.21516.]. ...
journal_title:Theranostics
pub_type: 已发布勘误
doi:10.7150/thno.42847
更新日期:2020-01-18 00:00:00
abstract::Uncontrollable cell proliferation and irreversible neurological damage make glioma one of the most deadly diseases in clinic. Besides the multiple biological barriers, glioma stem cells (GSCs) that are responsible for the maintenance and recurrence of tumor tissues also hinder the therapeutic efficacy of chemotherapy....
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41382
更新日期:2020-03-04 00:00:00
abstract::Exosomes play critical roles in intercellular communication in both nearby and distant cells in individuals and organs. Polymerase I and transcript release factor (PTRF), also known as Cavin1, has previously been described as a critical factor in caveola formation, and aberrant PTRF expression has been reported in var...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22952
更新日期:2018-02-07 00:00:00