Abstract:
:One of the major challenges in the hepatocellular carcinoma (HCC) treatment is its insensitivity to chemotherapeutic drugs. Here, we report the development of novel lipid-coated cisplatin nanoparticles co-loaded with microRNA-375 (NPC/miR-375) as a potential treatment for chemotherapy insensitive HCC. The NPC/miR-375 was fabricated by mixing two reverse microemulsions containing KCl solution and a highly soluble cis-diaminedihydroplatinum (II) coated with a cationic lipid layer. Subsequently, the miR-375 was incorporated into the lipid-coated cisplatin nanoparticles. The NPC/miR375 nanoparticles were expected to further decrease cell proliferation and to enhance the anti-tumor effect of cisplatin in chemotherapy resistant HCC cells. In vitro analysis of intracellular trafficking revealed that NPC/miR-375 were able to escape from the late endosomes instead of lysosomes thus avoiding degradation of the miR-375 in lysosomes. Importantly, NPC/miR-375 enhanced apoptosis and induced cell cycle arrest in HCC cells in vitro. In the double oncogenes Akt/Ras-induced primary HCC mouse model, multiple doses of NPC/miR-375 significantly inhibited tumor growth and delayed the tumor relapse. Our results indicate that cisplatin nanoparticles co-loaded with miR-375 represent a potential therapeutic agent for chemotherapy-insensitive HCC.
journal_name
Theranosticsjournal_title
Theranosticsauthors
Yang T,Zhao P,Rong Z,Li B,Xue H,You J,He C,Li W,He X,Lee RJ,Ma X,Xiang Gdoi
10.7150/thno.13130subject
Has Abstractpub_date
2016-01-01 00:00:00pages
142-54issue
1issn
1838-7640pii
thnov06p0142journal_volume
6pub_type
杂志文章相关文献
Theranostics文献大全abstract::Background: Lung cancer has a high mortality rate and is resistant to multiple chemotherapeutics. Natural Borneol (NB) is a monoterpenoid compound that facilitates the bioavailability of drugs. In this study, we investigated the effects of NB on chemosensitivity in the A549 human lung adenocarcinoma cell line and to e...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.45861
更新日期:2020-08-13 00:00:00
abstract::Cancer metastasis is a Gordian knot for tumor diagnosis and therapy. Many studies have demonstrated that metastatic processes are inevitably affected by the tumor microenvironment. Histopathology is used universally as the gold standard for cancer diagnosis despite the lengthy preparation process and invasiveness. Met...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.40869
更新日期:2020-01-01 00:00:00
abstract::With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO2 core-shell nanoparticles, which showed that they could selectivel...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35418
更新日期:2019-07-09 00:00:00
abstract::Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could a...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17073
更新日期:2017-01-05 00:00:00
abstract::Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19988
更新日期:2017-07-23 00:00:00
abstract::Rationale: Mesenchymal cell-derived osteosarcoma is a rare malignant bone tumor affecting children and adolescents. PTEN down-regulation or function-loss mutation is associated with the aggressive of osteosarcoma. Explicating the regulatory mechanism of PTEN might highlight new targets for improving the survival rate ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41279
更新日期:2020-02-03 00:00:00
abstract::Background: Biofilm infection caused by multidrug-resistant bacteria is difficult to eradicate by conventional therapies. Photodynamic therapy (PDT) is an effective antibacterial method for fighting against biofilm infection. However, the blocked photosensitizers outside of biofilm greatly limit the efficacy of PDT. M...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42922
更新日期:2020-03-26 00:00:00
abstract::Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno/v01p0201
更新日期:2011-03-01 00:00:00
abstract::Objective: Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are essential for vascular remodeling. Natural compounds with diterpene chinone or phenolic acid structure from Salvia miltiorrhiza, an eminent medicinal herb widely used to treat cardiovascular diseases in China, can effectively a...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.46911
更新日期:2020-06-19 00:00:00
abstract::The delivery of therapeutics into tumors remains a challenge in nanoparticle-mediated drug delivery. However, effective therapies such as photothermal therapy (PTT) are limited by quick systemic clearance and non-specific biodistribution. Anti-tumor strategies tailored to accommodate both tumor accumulation/retention ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33280
更新日期:2019-04-13 00:00:00
abstract::RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and ...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.35568
更新日期:2020-01-01 00:00:00
abstract::Rationale: Malignant ascites caused by cancer cells results in poor prognosis and short average survival time. No effective treatment is currently available for malignant ascites. In this study, the effects of lentinan (LNT)-functionalized selenium nanoparticles (Selene) on malignant ascites were evaluated. Furthermor...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.46467
更新日期:2020-07-11 00:00:00
abstract:PURPOSE:The ability to longitudinally monitor cell grafts and assess their condition is critical for the clinical translation of stem cell therapy in regenerative medicine. Developing an inducible genetic magnetic resonance imaging (MRI) reporter will enable non-invasive and longitudinal monitoring of stem cell grafts ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.9436
更新日期:2014-07-27 00:00:00
abstract::Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.11918
更新日期:2016-01-01 00:00:00
abstract::Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb) localize within a tumor by virtue of its anti-tumor binding site(s) before administering a small, fast-clearing radiolabeled compound that then attaches to the other portion of the bsMAb. The compound's rapid clearance signifi...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.3582
更新日期:2012-01-01 00:00:00
abstract::Because of the unparalleled efficiency and universal utility in treating a variety of disease types, siRNA agents have evolved as the future drug-of-choice. Yet, the inability of the polyanionic siRNA macromolecules to cross the cell membrane remains as the bottleneck of possible clinical applications. With the cell p...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19863
更新日期:2017-06-25 00:00:00
abstract::We report a new technique to detect enzyme activity inside cells. The method based on Fluorescence Lifetime Imaging (FLIM) technology allows one to follow sensor cleavage by proteolytic enzyme caspase-3. Specifically, we use the FLIM FRET of living cells via the confocal fluorescence microscopy. A specially designed l...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.3885
更新日期:2012-01-01 00:00:00
abstract::Cell sheet technology opens new perspectives in tissue regeneration therapy by providing readily implantable, scaffold-free 3D tissue constructs. Many studies have focused on the therapeutic effects of cell sheet implantation while relatively little attention has concerned the fate of the implanted cells in vivo. The ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.14064
更新日期:2016-03-21 00:00:00
abstract::This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using 225Ac and its theranostic pair, 111In. We call our novel tumor-targeting DOTA-hapten PRIT system "proteus-DOTA" or "Pr." Herein we report the first results of radiochemistry development, radiopharmacology, and stoichiometry of tumor ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.48810
更新日期:2020-09-14 00:00:00
abstract::Inadequate diagnostic methods for prostate cancer lead to over- and undertreatment, and the inability to intraoperatively visualize positive margins may limit the success of surgical resection. Prostate cancer visualization could be improved by combining the complementary modalities of immuno-positron emission tomogra...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.27679
更新日期:2018-11-12 00:00:00
abstract::Purpose: Clinical success of precision medicine is severely limited by de novo or acquired drug resistance. It remains a clinically unmet need to treat these patients. Tumor suppressor genes (TSGs) play a critical role in tumorigenesis and impact the therapeutic effect of various treatments. Experimental Design: Using...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44829
更新日期:2020-09-16 00:00:00
abstract::Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17573
更新日期:2017-04-10 00:00:00
abstract::Hypoxic zones are common features of metastatic tumors. Due to inactivation of the von Hippel-Lindau gene (VHL), renal cell carcinomas (RCC) show constitutive stabilization of the alpha subunit of the hypoxia-inducible factor (HIF). Thus, RCC represents a model of chronic hypoxia. Development of the lymphatic network ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.27794
更新日期:2019-01-21 00:00:00
abstract::Comprehensive analysis of the expression level and location of tumor-associated membrane proteins (TMPs) is of vital importance for the profiling of tumor cells. Currently, two kinds of independent techniques, i.e. ex situ detection and in situ imaging, are usually required for the quantification and localization of T...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22794
更新日期:2018-01-01 00:00:00
abstract::Due to their lower systemic toxicity, faster kidney clearance and higher tumor accumulation, ultrasmall gold nanoparticles (less than 10 nm in diameter) have been proved to be promising in biomedical applications. However, their potential applications in cancer imaging and treatment have not been reviewed yet. This re...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.42471
更新日期:2020-03-31 00:00:00
abstract::INTRODUCTION: According to the "glymphatic system" hypothesis, brain waste clearance is mediated by a continuous replacement of the interstitial milieu by a bulk flow of cerebrospinal fluid (CSF). Previous reports suggested that this cerebral CSF circulation is only active during general anesthesia or sleep, an effect...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19154
更新日期:2018-01-01 00:00:00
abstract::Rationale: Within the field of personalized medicine there is an increasing focus on designing flexible, multifunctional drug delivery systems that combine high efficacy with minimal side effects, by tailoring treatment to the individual. Methods: We synthesized a chemically stabilized ~4 nm nucleic acid nanoscaffold,...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.32060
更新日期:2019-04-13 00:00:00
abstract::A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positi...
journal_title:Theranostics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.7150/thno.10636
更新日期:2015-01-01 00:00:00
abstract::Due to their tunable surface plasmon and photothermal effects, gold nanorods (AuNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery. All these applications can be remotely controlled by near infrared (NIR) light which can penetrate deep in...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.5409
更新日期:2013-01-01 00:00:00
abstract::Monocyte derived macrophages (MDMs) infiltrate sites of infection or injury and upregulate cyclooxygenase-2 (COX-2), an enzyme that stimulates prostaglandin-E2 (PgE2). Nanotheranostics combine therapeutic and diagnostic agents into a single nanosystem. In previous studies, we demonstrated that a nanotheranostic strate...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41309
更新日期:2020-01-01 00:00:00