Abstract:
BACKGROUND:To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). METHODS:LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration. RESULTS:The sensitivity and specificity of LMO2 negative for detecting BL were 98.67 and 100%, respectively; those of CD38 positive were 98.67 and 66.67%, respectively. The sensitivity and specificity of a combination of both for detecting BL were 97.33 and 100%, respectively. In our study, the combined LMO2 negative and CD38 positive results had a higher area under the curve than either LMO2 negative or CD38 positive alone. CONCLUSIONS:A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Liu Y,Bian T,Zhang Y,Zheng Y,Zhang J,Zhou X,Xie Jdoi
10.1186/s13000-019-0876-3subject
Has Abstractpub_date
2019-09-04 00:00:00pages
100issue
1issn
1746-1596pii
10.1186/s13000-019-0876-3journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Evaluation of core needle biopsies (CNB) is a standard procedure for the diagnosis of breast cancer. However, tissue processing and image preparation is a time- consuming procedure and instant on-site availability of high-quality images could substantially improve the efficacy of the diagnostic procedure. Co...
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