Abstract：
BACKGROUND:Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumour of salivary glands that was first described as a distinct entity in 1994 by Milchgrub et al. EWSR1-ATF1 fusion was found to be specific for this tumour. The majority of the reported cases of HCCC arise from minor salivary glands within the oral cavity. Primary HCCC of the paranasal sinus is extremely uncommon. To our knowledge, only three cases have been reported in the English literature. Herein, we present a case of HCCC of the posterior ethmoid/maxillary sinus. CASE PRESENTATION:A 63-year-old lady who presented with a long history of epistaxis. CT scan revealed a destructive mass in the left ethmoid/posterior maxillary sinus extending to the nasal cavity. Surgical excision was done and microscopic evaluation showed a tumour composed mainly of nests of clear epithelial cells separated by fibrocellular and hyalinized septa with extensive bone destruction. The tumour cells expressed CK5/6, EMA and p63 immunohistochemically but were negative for S100 protein, PAX-8, RCC and CK7. Sinonasal renal cell-like adenocarcinomas, myoepithelial carcinoma and metastatic renal cell carcinoma were excluded by radiological and immunohistochemical studies. Fluorescence in situ hybridization analysis revealed an EWSR1 gene rearrangement. Postoperative radiation was administrated and the patient did not show recurrence or distant metastasis 4 months after the surgery. CONCLUSION:Head and neck region have many tumours that demonstrate clear cell changes on histology. Thus, the differential diagnosis for HCCC is wide. Awareness of this rare entity and the possibility of it is arising in unusual location is necessary. EWSR1-AFT1 fusion, a consistent finding in HCCC, can be used to confirm the diagnosis.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
AlAli BM,Alyousef MJ,Kamel AS,Al Hamad MA,Al-Bar MH,Algowiez RMdoi
10.1186/s13000-017-0659-7subject
Has Abstractpub_date
2017-09-25 00:00:00pages
70issue
1issn
1746-1596pii
10.1186/s13000-017-0659-7journal_volume
12pub_type
杂志文章abstract：BACKGROUND:Prostate cancer patients with rectal involvement are rare, and the factors associated with the survival of these patients are yet to be elucidated. PATIENTS AND METHODS:We collected data on patients who were admitted to our hospital for prostate cancer in the last thirteen years and of those in studies in t...
journal_title：Diagnostic pathology
pub_type： 杂志文章
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abstract：BACKGROUND:The histopathological subtype, nuclear grade and presence or absence of comedonecrosis are established as critical elements in the reporting of ductal carcinoma in situ (DCIS) of the breast. The aims of this study were to determine the frequencies of morphological subtypes of DCIS, nuclear grade and comedone...
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journal_title：Diagnostic pathology
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doi：10.1186/1746-1596-8-124
更新日期：2013-07-31 00:00:00
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journal_title：Diagnostic pathology
pub_type： 信件
doi：10.1186/1746-1596-9-62
更新日期：2014-03-19 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-16
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journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-117
更新日期：2012-09-03 00:00:00
abstract：BACKGROUND:The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc finger E-box-binding homeobox 1 (ZEB1), a key nuclear transcription factor in an epithelial-mesenchyma...
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pub_type： 杂志文章
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更新日期：2020-10-08 00:00:00
abstract：BACKGROUND:c-MET is an oncogene protein that plays important role in gastric carcinogenesis and has been introduced as a prognostic marker and potential therapeutic target. The aim of this study was to evaluate the frequency of c-MET overexpression and its relationship with clinicopathological variables in gastric canc...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-57
更新日期：2012-05-28 00:00:00
abstract：BACKGROUND:Colorectal cancer (CRC) remains a major worldwide cause of cancer-related morbidity and mortality largely due to the insidious onset of the disease. The current clinical procedures utilized for disease diagnosis are invasive, unpleasant, and inconvenient. Hence, the need for simple blood tests that could be ...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-53
更新日期：2014-03-12 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-016-0462-x
更新日期：2016-01-20 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-2-48
更新日期：2007-12-18 00:00:00
abstract：BACKGROUND:Morphine has been widely used as a clinical anesthetic and analgesic. However, abuse of morphine might result in psychological and physiological dependence. Previous studies have indicated that memory mechanisms play critical roles in morphine dependence. METHODS:Morphine dependence was established in mice ...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-142
更新日期：2014-07-10 00:00:00
abstract：BACKGROUND:Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in Rheumatoid Arthritis. The Multidrug resistance Related Protein and Multi Drug Resistance protein 1,...
journal_title：Diagnostic pathology
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doi：10.1186/s13000-015-0447-1
更新日期：2015-12-30 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/1746-1596-8-6
更新日期：2013-01-15 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-30
更新日期：2012-03-21 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-016-0548-5
更新日期：2016-10-19 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-4-13
更新日期：2009-04-23 00:00:00
abstract：BACKGROUND:The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 fatal cases worldwide. The SARS-CoV-2 outbreak is a major challenge for clinicians. In our clinic, w...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-020-00994-0
更新日期：2020-06-29 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-020-00936-w
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更新日期：2015-08-07 00:00:00
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更新日期：2013-11-25 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章
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更新日期：2011-06-23 00:00:00
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pub_type： 杂志文章
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更新日期：2013-09-25 00:00:00
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journal_title：Diagnostic pathology
pub_type： 杂志文章
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更新日期：2019-07-03 00:00:00
abstract：BACKGROUND:Choriocarcinoma is a highly aggressive, malignant trophoblastic neoplasm that can be gestational or non-gestational in origin. Accurate discrimination between these two subtypes, the causative pregnancy type, and the pregnancy-to-treatment interval for gestational choriocarcinoma are vital for clinical manag...
journal_title：Diagnostic pathology
pub_type： 杂志文章
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更新日期：2019-08-17 00:00:00
abstract：BACKGROUND:The development of inhibitors against factor 8 (F8) is the most serious complication of replacement therapy with F8 in children with severe hemophilia. It was suggested that mismatched F8 replacement therapy may be a risk factor for the development of anti-factor F8 alloantibodies. Recently four single nucle...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-6-54
更新日期：2011-06-17 00:00:00
abstract：BACKGROUND:Acute promyelocytic leukemia is a cytogenetically well defined entity. Nevertheless, some features observed at diagnosis are related to a worse outcome of the patients. METHODS:In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation status of CDKN2B, CDKN2A and TP73...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-75
更新日期：2012-06-28 00:00:00
abstract：BACKGROUND:It is not clear if sentinel lymph node (SLN) mapping can improve outcomes in patients with colorectal cancers. The purpose of this study was to determine the prognostic values of ex vivo sentinel lymph node (SLN) mapping and immunohistochemical (IHC) detection of SLN micrometastasis in colorectal cancers. M...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-71
更新日期：2012-06-22 00:00:00
abstract：BACKGROUND:The uterine endometrial polyp (EMP) has a potential risk of developing malignant tumors especially in postmenopausal women. These malignancies include endometrial intraepithelial carcinoma (EIC). PATIENTS AND METHODS:Eight patients with EIC in the EMP, who were postmenopausal with ages ranging from 49 to 76...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-8-25
更新日期：2013-02-15 00:00:00
